Devis Bellucci, Francesco Basoli, Simone De Micco, Simone Grasso, Marcella Trombetta, Valeria Cannillo
{"title":"Zinc/Potassium-Doped Bioactive Glass With Enhanced Antimicrobial Activity Against Gram-Negative Bacteria","authors":"Devis Bellucci, Francesco Basoli, Simone De Micco, Simone Grasso, Marcella Trombetta, Valeria Cannillo","doi":"10.1111/ijag.70032","DOIUrl":"https://doi.org/10.1111/ijag.70032","url":null,"abstract":"<p>Bioactive glasses (BGs) are widely investigated for biomedical applications due to their bioactivity, ion release capability, and potential antimicrobial behavior. In this work, a novel zinc/potassium-doped BG, designated as Gaia-GN, was synthesized using the melt-quench technique. The thermal behavior was characterized through differential thermal analysis (DTA), thermogravimetry (TG), and heating microscopy (HM), which revealed a glass transition temperature of 513°C and a broad processing window suitable for viscous-flow sintering. Subsequently, Gaia-GN powders were thermally processed to obtain sintered specimens. XRD analysis showed that sintering at relatively low temperatures, namely 600°C, produced a compact and predominantly amorphous structure, minimizing the formation of crystalline phases. In addition, mechanical properties were evaluated by Vickers micro-indentation, determining Vickers hardness, Young's modulus, and fracture toughness using four different theoretical models. The results suggest that the combined presence of Zn and K improves thermal stability and mechanical performance compared with conventional formulations such as 45S5 Bioglass and S53P4. Finally, antimicrobial assays were conducted, revealing a strong antimicrobial action of the glass against Gram-negative bacteria. Overall, these findings underscore the potential of the new K/Zn-doped BG not only for its antibacterial properties but also for applications requiring thermal processing, such as the fabrication of scaffolds or coatings on metallic substrates.</p>","PeriodicalId":13850,"journal":{"name":"International Journal of Applied Glass Science","volume":"17 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijag.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148049091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Devis Bellucci, Francesco Basoli, Simone De Micco, Simone Grasso, Marcella Trombetta, Valeria Cannillo
{"title":"Zinc/Potassium-Doped Bioactive Glass With Enhanced Antimicrobial Activity Against Gram-Negative Bacteria","authors":"Devis Bellucci, Francesco Basoli, Simone De Micco, Simone Grasso, Marcella Trombetta, Valeria Cannillo","doi":"10.1111/ijag.70032","DOIUrl":"https://doi.org/10.1111/ijag.70032","url":null,"abstract":"<p>Bioactive glasses (BGs) are widely investigated for biomedical applications due to their bioactivity, ion release capability, and potential antimicrobial behavior. In this work, a novel zinc/potassium-doped BG, designated as Gaia-GN, was synthesized using the melt-quench technique. The thermal behavior was characterized through differential thermal analysis (DTA), thermogravimetry (TG), and heating microscopy (HM), which revealed a glass transition temperature of 513°C and a broad processing window suitable for viscous-flow sintering. Subsequently, Gaia-GN powders were thermally processed to obtain sintered specimens. XRD analysis showed that sintering at relatively low temperatures, namely 600°C, produced a compact and predominantly amorphous structure, minimizing the formation of crystalline phases. In addition, mechanical properties were evaluated by Vickers micro-indentation, determining Vickers hardness, Young's modulus, and fracture toughness using four different theoretical models. The results suggest that the combined presence of Zn and K improves thermal stability and mechanical performance compared with conventional formulations such as 45S5 Bioglass and S53P4. Finally, antimicrobial assays were conducted, revealing a strong antimicrobial action of the glass against Gram-negative bacteria. Overall, these findings underscore the potential of the new K/Zn-doped BG not only for its antibacterial properties but also for applications requiring thermal processing, such as the fabrication of scaffolds or coatings on metallic substrates.</p>","PeriodicalId":13850,"journal":{"name":"International Journal of Applied Glass Science","volume":"17 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijag.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148049092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haodong Tian, Hemin Zhou, Shuang Xu, Runqi Shi, Chi Xu, Chengkui Zu, Haizheng Tao
{"title":"Impacts of Post-Annealing Parameters on Structure and Mechanical Properties of Chemically Strengthened LAS Glasses","authors":"Haodong Tian, Hemin Zhou, Shuang Xu, Runqi Shi, Chi Xu, Chengkui Zu, Haizheng Tao","doi":"10.1111/ijag.70031","DOIUrl":"https://doi.org/10.1111/ijag.70031","url":null,"abstract":"<div>\u0000 \u0000 <p>The structure and mechanical response of peraluminous chemically strengthened lithium aluminosilicate glass under different post-annealing conditions below the glass transition temperature were investigated. Changes in surface structure and mechanical properties were evaluated based on measurements of the compressive stress, depth of layer, electron probe microanalysis, Raman spectroscopy, hardness, and coaxial double-ring flexural strength after sub-T<sub>g</sub> post-annealing at various temperatures and times. The results demonstrate that sub-T<sub>g</sub> post-annealing in two-step chemically strengthened peraluminous LAS glass is associated with a coupled evolution of residual stress relaxation and alkali-ion redistribution, rather than reconstruction of the aluminosilicate network. Raman spectroscopy shows that post-annealing below T<sub>g</sub> does not induce significant changes in the average bonding configuration of the aluminosilicate network or in the stretching-dominated network connectivity, indicating that the silicate backbone remains essentially stable. Under this structural constraint, post-annealing promotes a coupled evolution of residual stress relaxation and alkali-ion redistribution. As the post-annealing temperature and time increase, K<sup>+</sup> ions migrate inward from the near-surface region, whereas Na<sup>+</sup> ions undergo bidirectional redistribution toward both the surface and the glass interior. This process involves reorganization of alkali charge-compensation environments around tetrahedral [AlO<sub>4</sub>]<sup>−</sup> units, together with a progressive redistribution of alkali ions within the near-surface compressive stress layer, and is associated with the opposite evolution of CS and DOL. Therefore, the compressive stress decreases while depth of layer increases, accompanied by a reduction in effective packing efficiency in the near-surface region. The reduced packing efficiency leads to gradual degradation of mechanical properties, manifested by decreases in flexural strength and Vickers hardness. These findings provide quantitative insight into the thermal stability of the compressive stress layer in chemically strengthened LAS glass and offer practical guidance for strength reliability after coating-related sub-T<sub>g</sub> thermal cycles, such as those encountered during post-annealing of conductive ITO thin films.</p>\u0000 </div>","PeriodicalId":13850,"journal":{"name":"International Journal of Applied Glass Science","volume":"17 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148045776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haodong Tian, Hemin Zhou, Shuang Xu, Runqi Shi, Chi Xu, Chengkui Zu, Haizheng Tao
{"title":"Impacts of Post-Annealing Parameters on Structure and Mechanical Properties of Chemically Strengthened LAS Glasses","authors":"Haodong Tian, Hemin Zhou, Shuang Xu, Runqi Shi, Chi Xu, Chengkui Zu, Haizheng Tao","doi":"10.1111/ijag.70031","DOIUrl":"https://doi.org/10.1111/ijag.70031","url":null,"abstract":"<div>\u0000 \u0000 <p>The structure and mechanical response of peraluminous chemically strengthened lithium aluminosilicate glass under different post-annealing conditions below the glass transition temperature were investigated. Changes in surface structure and mechanical properties were evaluated based on measurements of the compressive stress, depth of layer, electron probe microanalysis, Raman spectroscopy, hardness, and coaxial double-ring flexural strength after sub-T<sub>g</sub> post-annealing at various temperatures and times. The results demonstrate that sub-T<sub>g</sub> post-annealing in two-step chemically strengthened peraluminous LAS glass is associated with a coupled evolution of residual stress relaxation and alkali-ion redistribution, rather than reconstruction of the aluminosilicate network. Raman spectroscopy shows that post-annealing below T<sub>g</sub> does not induce significant changes in the average bonding configuration of the aluminosilicate network or in the stretching-dominated network connectivity, indicating that the silicate backbone remains essentially stable. Under this structural constraint, post-annealing promotes a coupled evolution of residual stress relaxation and alkali-ion redistribution. As the post-annealing temperature and time increase, K<sup>+</sup> ions migrate inward from the near-surface region, whereas Na<sup>+</sup> ions undergo bidirectional redistribution toward both the surface and the glass interior. This process involves reorganization of alkali charge-compensation environments around tetrahedral [AlO<sub>4</sub>]<sup>−</sup> units, together with a progressive redistribution of alkali ions within the near-surface compressive stress layer, and is associated with the opposite evolution of CS and DOL. Therefore, the compressive stress decreases while depth of layer increases, accompanied by a reduction in effective packing efficiency in the near-surface region. The reduced packing efficiency leads to gradual degradation of mechanical properties, manifested by decreases in flexural strength and Vickers hardness. These findings provide quantitative insight into the thermal stability of the compressive stress layer in chemically strengthened LAS glass and offer practical guidance for strength reliability after coating-related sub-T<sub>g</sub> thermal cycles, such as those encountered during post-annealing of conductive ITO thin films.</p>\u0000 </div>","PeriodicalId":13850,"journal":{"name":"International Journal of Applied Glass Science","volume":"17 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148045777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}