International Journal of Antimicrobial Agents最新文献

{"title":"Antimicrobial suppressive therapy in prosthetic valve endocarditis rejected from surgery despite indication","authors":"Jérémie Tillement ,&nbsp;Nahema Issa ,&nbsp;Julien Ternacle ,&nbsp;Victor Hémar ,&nbsp;Antoine Beurton ,&nbsp;Olivier Busuttil ,&nbsp;Hélène Chaussade ,&nbsp;Marina Dijos ,&nbsp;Carine Greib ,&nbsp;Louis Labrousse ,&nbsp;Julien Peltan ,&nbsp;Olivia Peuchant ,&nbsp;Gaetane Wirth ,&nbsp;Claire Roubaud-Baudron ,&nbsp;Fabrice Camou ,&nbsp;Romain Boulestreau","doi":"10.1016/j.ijantimicag.2025.107526","DOIUrl":"10.1016/j.ijantimicag.2025.107526","url":null,"abstract":"<div><h3>Background</h3><div>Prosthetic valve endocarditis (PVE) incidence is rising in older patients, often rejected for surgery, leading them to a poor prognosis. Optimal antibiotic management is unknown for these patients. We compared the efficacy and safety of suppressive (SAT) versus conventional antimicrobial therapy (CAT) in this setting.</div></div><div><h3>Methods</h3><div>We conducted a prospective, multicentric, cohort study in southwest France including patients with PVE rejected from surgery despite indication, and surviving the initial 6 weeks of intravenous therapy. Beyond this period, patients could or not receive SAT, according to endocarditis team decision. Primary outcome was a composite endpoint of one-year all-cause mortality and PVE-related hospitalization. Secondary outcome was the incidence and nature of SAT-related adverse events.</div></div><div><h3>Results</h3><div>Between 2012 and 2022, 88 patients were included in the study, 42 receiving SAT and 46 CAT. Mean age was 69.4 ± 16.4 years and patients were highly comorbid (mean Charlson Comorbidity Index 5.6 ± 2.7). Main organisms included <em>Streptococcus</em> spp. (26/88, 29.5%) and <em>Staphylococcus aureus</em> (25/88, 28.4%). The primary composite outcome occurred in 7/42 (16.7%) patients in the SAT group, and 16/46 (34.8%) in the CAT group. Using a Cox model, SAT was significantly and independently associated with a lower incidence of one-year primary outcome (Hazard ratio 0.23, 95% CI 0.08–0.67, <em>P = 0.</em>007). Adverse effects in the SAT group were reported for 6/42 patients (14.3%). These effects were limited, causing only one treatment discontinuation.</div></div><div><h3>Conclusion</h3><div>In patients with PVE rejected from surgery despite indication, SAT may be safe and associated with better outcomes than CAT.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"66 3","pages":"Article 107526"},"PeriodicalIF":4.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of recently discovered mechanisms of cephalosporin resistance in Pseudomonas aeruginosa","authors":"Madeleine T. Hardie Boys,&nbsp;Daniel Pletzer","doi":"10.1016/j.ijantimicag.2025.107527","DOIUrl":"10.1016/j.ijantimicag.2025.107527","url":null,"abstract":"<div><div><em>Pseudomonas aeruginosa</em> frequently causes respiratory tract infections in immunocompromised patients as well as bloodstream, urinary tract, skin, and soft tissue infections. The increasing prevalence of multidrug-resistant <em>P. aeruginosa</em> strains poses a significant clinical challenge. Cephalosporin antibiotics from the β-lactam class are commonly prescribed to treat infections owing to their broad spectrum of activity and generally low host toxicity. <em>P. aeruginosa</em> utilizes β-lactamase enzymes, efflux pumps, and mutations in outer membrane porins/transporters and target proteins, all of which confer resistance to cephalosporin antibiotics.</div><div>This review categorizes resistance mechanisms into (i) well-characterized pathways, such as AmpC β-lactamase and Mex efflux pumps, (ii) recently described mutations linked to cephalosporin resistance (e.g., <em>ygfB, sltB1, pbp3, galU, pmrAB, fusA1</em>, and <em>gyrA</em>), and (iii) hypothetical β-lactamases and other mechanisms requiring further validation.</div><div>A variety of β-lactamase inhibitors have been developed to overcome β-lactamase-mediated resistance, but resistance has already been observed toward inhibitors via the accumulation of mutations within the targeted β-lactamase enzyme or increased activity of efflux pumps.</div><div>Understanding the regulation and pathways that lead to resistance is crucial in developing effective strategies to combat <em>P. aeruginosa</em> infections and extending the therapeutic lifespan of cephalosporin antibiotics.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"66 2","pages":"Article 107527"},"PeriodicalIF":4.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Society of Antimicrobial Chemotherapy (ISAC) News and Information Page","authors":"","doi":"10.1016/j.ijantimicag.2025.107525","DOIUrl":"10.1016/j.ijantimicag.2025.107525","url":null,"abstract":"","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"66 1","pages":"Article 107525"},"PeriodicalIF":4.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of antibiotics with Stevens–Johnson syndrome and toxic epidermal necrolysis: A real-world pharmacovigilance study","authors":"Xin Yan ,&nbsp;Junlong Ma ,&nbsp;Chengxian Guo ,&nbsp;Guoping Yang","doi":"10.1016/j.ijantimicag.2025.107524","DOIUrl":"10.1016/j.ijantimicag.2025.107524","url":null,"abstract":"<div><h3>Background</h3><div>Recent reports suggest antibiotics may cause severe allergic reactions, such as Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), exacerbating concerns about antibiotic safety.</div></div><div><h3>Objective</h3><div>Given the limited real-world evidence, this study aims to analyse the FDA Adverse Event Reporting System to investigate the association between various antibiotics and SJS/TEN risk.</div></div><div><h3>Methods</h3><div>Reports from infected patients (Q1 2014–Q4 2023) were extracted from the FDA Adverse Event Reporting System. Disproportionality analysis using information component identified risk signals of antibiotics associated with SJS/TEN. Subgroup analyses investigated the impact of age and gender on antibiotic-associated SJS/TEN. Also, a time of onset analysis was performed.</div></div><div><h3>Results</h3><div>Among 78 593 infected patients, 1221 cases of SJS/TEN were identified from 30 369 antibiotic administrations. The median age of patients with SJS was 63 y, and with TEN was 60 y. Eleven positive signal drugs were detected through disproportionality analysis. Amoxicillin, piperacillin, ceftriaxone, cefuroxime, cefotaxime, azithromycin, sulfamethoxazole, trimethoprim, vancomycin, doxycycline, and gentamicin exhibited significant risk associations with SJS/TEN. Sulfamethoxazole had the highest risk. Patients with pneumonia, urinary tract infections, and sepsis had higher risks than those with respiratory tract infections. Male patients using specific antibiotics may have a higher risk than females, with no significant age difference.</div></div><div><h3>Conclusions</h3><div>Antibiotics including penicillins, cephalosporins, azithromycin, sulfamethoxazole, trimethoprim, vancomycin, doxycycline, and gentamicin are associated with an increased risk of SJS/TEN, with sulfamethoxazole presenting the highest risk. Patients with pneumonia, urinary tract infections, and sepsis are particularly vulnerable. These findings highlight the need for personalized antibiotic regimens based on infection site and patient gender.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"66 2","pages":"Article 107524"},"PeriodicalIF":4.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-level ceftazidime-avibactam resistance by in-host evolution of blaKPC genes: Emergence of a novel blaKPC-102 variant and increase of blaKPC-33 copy number in Klebsiella pneumoniae strains from a lung transplantation recipient","authors":"Yulin Zhang ,&nbsp;Ziyao Li ,&nbsp;Huihui Shi ,&nbsp;Zichen Lei ,&nbsp;Dongya Pu ,&nbsp;Qi Liu ,&nbsp;Feilong Zhang ,&nbsp;Jiankang Zhao ,&nbsp;Xinmeng Liu ,&nbsp;Binghuai Lu ,&nbsp;Bin Cao","doi":"10.1016/j.ijantimicag.2025.107521","DOIUrl":"10.1016/j.ijantimicag.2025.107521","url":null,"abstract":"<div><h3>Objective</h3><div>KPC-producing <em>Klebsiella pneumoniae</em> (Kp) infections have become one of the major threats to public health in China. Recently, the emergence of ceftazidime-avibactam (CZA) resistance due to the <em>bla</em>_KPC mutations has been increasingly reported.</div></div><div><h3>Methods</h3><div>Two CZA-susceptible Kp strains (Kp36854 carrying <em>bla</em>_KPC-2 and Kp37523 without <em>bla</em>_KPC) and two CZA-resistant Kp strains (Kp38935 carrying double copies of <em>bla</em>_KPC-33 and Kp38097 carrying a newly identified <em>bla</em>_KPC-102 gene) were isolated from a lung-transplanted patient during CZA treatment. This study analyzed the within-host evolutionary dynamics of <em>bla</em>_KPC in KPC-Kp strains.</div></div><div><h3>Results</h3><div>Compared with KPC-2, KPC-33 possessed only a D179Y substitution while KPC-102 harbored both D179Y and Y241D substitutions. We constructed KPC-δ33 with only a Y241D substitution, which means the correction of the first mutation that is also present in KPC-33 (D179Y). Cloning and expression experiments showed that CZA-MIC value of <em>E. coli</em> DH5α/pKPC102 was 512 mg/L, while CZA-MIC values of both <em>E. coli</em> DH5α/pKPC-33 and <em>E. coli</em> DH5α/pKPC-δ33 were 32/4 mg/L. Enzymatic kinetic analysis revealed that KPC-2 demonstrated the highest catalytic efficiency to nitrocefin and meropenem, whereas KPC-33 displayed higher catalytic efficiency against ceftazidime compared to other tested KPC variants. Regarding avibactam, KPC-2 showed the highest sensitivity, while KPC-δ33 and KPC-102 were less sensitive.</div></div><div><h3>Conclusion</h3><div>High-level CZA resistance was mediated by the novel <em>bla</em>_KPC-102 and double copies of <em>bla</em>_KPC-33 gene, respectively, in two porin-deficient Kp strains from one patient. The CZA resistance resulting from <em>bla</em>_KPC mutation could be selected and evolved to be more diverse and heterogeneous within the host after CZA therapy. It is very essential to perform the surveillance of CZA-resistance for clinicians during treatment.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"66 2","pages":"Article 107521"},"PeriodicalIF":4.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic activity of menadione in combination with colistin against colistin-susceptible and colistin-resistant Gram-negative bacteria","authors":"Jun Yang ,&nbsp;Huiying Yue ,&nbsp;Weifeng Wang ,&nbsp;Caiying Lin ,&nbsp;Chenchen Li ,&nbsp;Jiakuo Chen ,&nbsp;Jian-Hua Liu ,&nbsp;Yi-Yun Liu","doi":"10.1016/j.ijantimicag.2025.107523","DOIUrl":"10.1016/j.ijantimicag.2025.107523","url":null,"abstract":"<div><h3>Objective</h3><div>Antibiotic resistance poses a formidable challenge, especially with the emergence of multidrug-resistant Gram-negative bacteria. Colistin serves as a last-resort antibiotic to combat multidrug-resistance, but it is limited by its nephrotoxicity and rising resistance. This study introduces menadione, a synthetic form of vitamin K, as a potential adjuvant to enhance colistin's efficacy against both susceptible and resistant strains of Gram-negative bacteria.</div></div><div><h3>Methods</h3><div>Through checkerboard dilution assays, we demonstrate that menadione significantly lowers the MICs of colistin, with fractional inhibitory concentration indices ranging from 0.031 to 0.375. Furthermore, synergistic effects were confirmed via time–kill kinetics, indicating effective bacterial growth inhibition. The study also explores the mechanism underlying this synergy, revealing that menadione in combination with colistin disrupts the bacterial outer membrane, reduces the proton motive force and adenosine triphosphate content, and amplify the production of reactive oxygen species, contributing to bacterial cell death.</div></div><div><h3>Results</h3><div>Menadione was shown to prevent the evolution of colistin resistance.</div></div><div><h3>Conclusions</h3><div>This research highlights the potential of using menadione as a colistin adjuvant to combat antibiotic-resistant Gram-negative bacteria, providing a promising approach to extend the utility of existing antibiotics in clinical settings.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"66 2","pages":"Article 107523"},"PeriodicalIF":4.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of RNA-binding proteins as host-targeting antivirals against RNA viruses","authors":"Cleo Anastassopoulou ,&nbsp;Antonios-Periklis Panagiotopoulos ,&nbsp;Nikolaos Siafakas ,&nbsp;Athanasios Tsakris","doi":"10.1016/j.ijantimicag.2025.107522","DOIUrl":"10.1016/j.ijantimicag.2025.107522","url":null,"abstract":"<div><div>RNA-binding proteins (RBPs) are essential regulators of cellular RNA processes, including RNA stability, translation, and post-translational regulation. During viral infections, RBPs are key regulators of the viral cycle due to their interaction with both host and viral RNAs. Herein, we initially explore the roles of specific RBP families, namely heterogeneous nuclear ribonucleoproteins (hnRNPs), DEAD-box helicases, human antigen R (HuR), and the eukaryotic initiation factors of the eIF4F complex, in viral RNA replication, translation, and assembly. Next, we examine the potential of these RBPs as host-targeting antivirals against pandemic-prone RNA viruses that have been gaining momentum in recent years. Targeting RBPs could disrupt cellular homeostasis, leading to unintended effects on host cells; however, RBPs have been successfully targeted mainly in anticancer therapies, showcasing that their modulation can be safely achieved by drug repurposing. By disrupting key viral-RBP interactions or modulating RBP functions, such therapeutic interventions aim to inhibit viral propagation and restore normal host processes. Thus, conceivable benefits of targeting RBPs as alternative antiviral strategies include their broad-spectrum activity and potential for combination therapies with conventional antivirals, reduced or delayed resistance development, and concomitant enhancement of host immune responses. Our discussion also highlights the broader implications of leveraging host-directed therapies in an attempt to overcome viral resistance. Finally, we emphasise the need for continued innovation to refine these strategies for broad-spectrum antiviral applications.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"66 2","pages":"Article 107522"},"PeriodicalIF":4.9,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug resistance phenotypes of clinical Klebsiella pneumoniae isolates in the past 20 years in China: A systematic review and meta-analysis","authors":"Wei Wei ,&nbsp;Yueran Lian ,&nbsp;Yao Peng ,&nbsp;Biao Kan ,&nbsp;Zhenpeng Li ,&nbsp;Xin Lu","doi":"10.1016/j.ijantimicag.2025.107520","DOIUrl":"10.1016/j.ijantimicag.2025.107520","url":null,"abstract":"<div><h3>Objectives</h3><div>Monitoring the drug resistance phenotypes of <em>Klebsiella pneumoniae</em> is crucial in clinical practice. This study aims to evaluate the prevalence of drug resistance of clinical <em>K. pneumoniae</em> isolates in China over the past two decades using a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>We systematically searched five databases for relevant articles published between January 1, 2003 and November 21, 2023. We assessed the resistance of clinical <em>K. pneumoniae</em> strains isolated in China over the past 20 years to 15 antibiotics, which were divided into three subgroups.</div></div><div><h3>Results</h3><div>A total of 177 studies derived from 160 articles were eligible for meta-analysis. The pooled antibiotic resistance rate ranged from 5.01% (for imipenem) to 96.03% (for ampicillin). The pooled rate of resistance to the carbapenem antibiotics imipenem and meropenem was relatively low, and subgroup analyses showed that these rates increased over time. The antibiotic resistance rate showed a geographic trend, being highest in central China and lowest in northwest China. The drug resistance rate was highest in strains isolated from specimens from patients with urinary tract infections.</div></div><div><h3>Conclusion</h3><div>This meta-analysis provides reliable data on the rate of antibiotic resistance of <em>K. pneumoniae</em> grouped according to isolation region, time, and source, which may be helpful for the selection of antibiotics for clinical treatment. Areas requiring specific attention include management of the use of carbapenem, improving the prevention and treatment of <em>K. pneumoniae</em> in patients with urinary tract infections, and control of transmission of strains from one region to another.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"66 2","pages":"Article 107520"},"PeriodicalIF":4.9,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular and genetic changes during and after fluconazole exposure in Cryptococcus neoformans","authors":"Samah H. Albehaijani ,&nbsp;Tien Huynh ,&nbsp;Kylie J. Boyce","doi":"10.1016/j.ijantimicag.2025.107519","DOIUrl":"10.1016/j.ijantimicag.2025.107519","url":null,"abstract":"<div><div>The validity of genome replication is fundamental to fungal survival, and errors in this process can result in ploidy changes. These changes can have negative effects, such as developmental defects or reduced fitness, or positive effects such as fungal adaptation and resilience. In the fungal pathogen <em>Cryptococcus neoformans</em>, ploidy changes have been consistently observed in clinical populations, and isolates exposed to the antifungal drug fluconazole commonly exhibit chromosome 1 aneuploidy. Chromosomal and putative metabolic function changes due to drug exposure are not well studied and are important for understanding resistance. Objectives: This study examined the fluconazole influence on <em>C. neoformans</em> transient aneuploidy and identified any potential genetic pathways that may be implicated. Methods: The study investigated 30 genes predicted to have a role in transient aneuploidy, which are related to chromosome organisation, DNA damage checkpoints and stress signalling. Other factors including ploidy status (haploid, diploid, polyploid) and species were also investigated to observe commonalities for a universal drug treatment strategy. Results: Fluconazole treatment increased DNA content, cell size and chromosomal changes in the wildtype and mutants. When fluconazole was removed, permanent changes were observed and were highly variable in the wildtypes and the 30 mutants. Additionally, some mutants lacked chromosomal changes such as <em>tel1∆, mrc1∆</em> and <em>hog1∆</em>, highlighting the potential involvement in the aneuploidy process. Conclusions: These findings highlight that fluconazole influences the entire genome rather than specific chromosomes, which increases the heterogeneity in permanent changes after fluconazole removal. This heterogeneity may result in long–term consequences, including drug resistance.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"66 2","pages":"Article 107519"},"PeriodicalIF":4.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the genome of a Klebsiella pneumoniae clinical strain carrying a novel KPC-205 variant associated with resistance to ceftazidime/avibactam and cefiderocol","authors":"Stefano Amadesi ,&nbsp;Annarita Mazzariol ,&nbsp;Gabriele Bianco ,&nbsp;Davide Gibellini ,&nbsp;Cristina Costa ,&nbsp;Paolo Gaibani","doi":"10.1016/j.ijantimicag.2025.107514","DOIUrl":"10.1016/j.ijantimicag.2025.107514","url":null,"abstract":"","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"66 2","pages":"Article 107514"},"PeriodicalIF":4.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}