International Journal of Nutrology最新文献

{"title":"Major approaches to cannabidiol in the treatment of binge eating and obesity: a systematic review","authors":"Laís Lopes Mascarenhas de Lacerda, D. S. Ribeiro, Valdir Cerqueira de Sant’Ana Filho, Murilo Costa Safira Andrade, Joaquim Paulo Castro de Santana","doi":"10.54448/ijn23208","DOIUrl":"https://doi.org/10.54448/ijn23208","url":null,"abstract":"Introduction: Obesity represents a multifactorial disease that causes serious public health problems. There are more than 2.50 billion overweight and obese people in the world, and Brazil is in fifth place in the world ranking. In this context, a factor associated with eating disorders is anxiety, which affects 33.7% of the general population. In this sense, cannabidiol (CBD) was identified 50 years ago and has effects that can change mood, sensation, perception, tension, appetite, and pain. Also, CBD showed anxiolytic, antipsychotic, neuroprotective, anti-inflammatory, and antiemetic properties. Objective: It was to analyze, through a systematic review, the main considerations and results in animal and human models of the use of cannabidiol in anxiety and obesity. Methods: The model followed for the systematic review was PRISMA. The search strategy was performed in PubMed, Embase, Ovid and Cochrane Library, Web Of Science, Science Direct Journals (Elsevier), Scopus (Elsevier), and OneFile (Gale) databases. Results: In the context of anxiety and binge eating and the consequent increase in the incidence of obese people, the activation of CB1 receptors improves feeding, modulating the activity of hypothalamic neurons and, subsequently, the release of orexigenic and anorexigenic neuropeptides. Thus, in obesity, the endocannabinoid system (ECS) is generally down-regulated in central and peripheral tissues, as indicated by high and/or overexpression of the CB1 receptor. Therefore, CBD is beneficial for anxiety-related disorders. Thus, CBD has been shown to have anxiolytic, antipsychotic, and neuroprotective properties. Conclusion: Growing evidence indicates that CBD acts as an antipsychotic and anxiolytic, and several reports suggest neuroprotective effects. Furthermore, CBD attenuates the harmful effects of trans-Δ9-tetrahydrocannabinol, both acutely and chronically, including psychotogenic, anxiogenic, and deleterious cognitive effects. This suggests that CBD may improve the disease trajectory of individuals with early psychosis and cannabis misuse in particular.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125898748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteral nutrition and congestive heart failure: a systematic review","authors":"Laís Lopes Mascarenhas de Lacerda, D. S. Ribeiro, Valdir Cerqueira de Sant’Ana Filho, Murilo Costa Safira Andrade, Joaquim Paulo Castro de Santana","doi":"10.54448/ijn23206","DOIUrl":"https://doi.org/10.54448/ijn23206","url":null,"abstract":"Introduction: Congestive heart failure (CHF) is a serious and growing public health problem worldwide. Approximately 23 million people are carriers of this disease and two million new cases are diagnosed each year. The clinical evolution of patients with CHF is moving towards variable malnutrition, making it necessary to adhere to enteral nutrition (EN). This picture can occur due to inadequate intake, altered metabolism, proinflammatory state, increased oxidative stress, and greater loss of nutrients, even due to drug interactions. Objective: It was to carry out a systematic review of the main clinical outcomes that demonstrate the importance of enteral nutrition in patients with congestive heart failure. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to October 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 122 articles were found. A total of 87 articles were evaluated and 28 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 7 studies with a high risk of bias and 8 studies that did not meet GRADE. There is moderate scientific evidence of the effectiveness of enteral nutrition in increasing survival and reducing morbidity in patients with congestive heart failure, as there are few randomized clinical trials that have evaluated this issue, however, enteral nutrition is highly indicated in the attempt to mitigate weight loss in these patients.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129141620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal medicine and climacteric: a systematic review of the main clinical outcomes","authors":"Fernanda Christie Batista, Mariana Paula da Silva, I. J. Zotarelli Filho, M. G. Duarte","doi":"10.54448/ijn23205","DOIUrl":"https://doi.org/10.54448/ijn23205","url":null,"abstract":"Introduction: The climacteric is the stage of life in which the transition from the productive or fertile period to the non-reproductive period occurs. Climacteric and menopause are intrinsically linked and may bring about various psychological and physiological changes. The use of medicinal plants (Herbal Medicine) is an important tool in an attempt to relieve symptoms. Objective: It was to develop a systematic review to present the main considerations and scientific evidence of the use of herbal medicines in climacteric and menopause to the reduction of symptoms and improvement of quality of life. Methods: The systematic review rules (PRISMA) were followed. The research was carried out from September to October 2022 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, covering scientific articles from various eras to the present day. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 121 articles were found. A total of 32 articles were fully evaluated and 23 were included in this systematic review. Most studies showed homogeneity in their results, with I2 =96.7% >50%. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 30 studies with a high risk of bias and 37 studies that did not meet GRADE. An asymmetrical funnel plot does not suggest a risk of bias among small sample-size studies. In search of symptom relief and based on knowledge of the side effects of hormone replacement therapy, many women resort to alternative therapy with herbal medicines. The main results support that supplementation with soy isoflavones as a natural source of phytohormones is associated with a reduction in the frequency and intensity of hot flashes, a recurrent symptom in the climacteric. The formulated blend of four herbal extracts (Glycine max, Cimicifuga racemosa, Vitex agnus-castus, and Oenothera biennis) supports skin health and antioxidant status in women of menopausal age. Furthermore, purified pollen cytoplasm can be considered an effective non-hormonal treatment alternative for the treatment of vasomotor symptoms, as well as mood and sleep disturbances in peri and post-menopause. Three clinical trials using the Danggui Buxue Tang herbal formula have been shown to alleviate menopausal syndrome, providing solid scientific evidence of its effectiveness.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134426767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence from clinical studies of the nutrological modulation of the gut microbiota in inflammatory bowel diseases: a systematic review","authors":"Pedro Paulo Barbosa Nunes","doi":"10.54448/ijn23204","DOIUrl":"https://doi.org/10.54448/ijn23204","url":null,"abstract":"Introduction: The main risk factor for inflammatory bowel disease (IBD) is a positive family history in 10-25% of patients. Crohn's disease (CD) can affect individuals from 15 to 40 years old and from 50 to 80 years old, more frequently in women. Ulcerative colitis (UC) can start at any age. The pathogenesis of IBD is linked to genetically susceptible individuals, dysregulated gut microbiota (dysbiosis), chronic inflammation, and poor dietary patterns. Diet plays an important role in modulating the gut microbiota and can be applied as a therapeutic tool to improve the course of the disease. Objective: To carry out a systematic review of the main interactions between dietary therapy, gut microbiota, and inflammatory bowel disease, to elucidate the main clinical outcomes after nutrological treatment. Methods: The present study followed the international model of systematic review (PRISMA). Clinical studies were included, involving randomized controlled, prospective, and retrospective studies published from 2010 to 2022. Results: It was founded 87 studies on diet modulation in the control of IBD. These studies showed reductions in persistent intestinal symptoms, improvement of gut microbiota, reduction of inflammation markers, and improvement in quality of life, with p<0.05 (95% CI). The studies were homogeneous (X2 = 98.9%), which increases the reliability of the clinical results on the dietary importance in the modulation of IBD. Conclusion: The important role of diet modulation in the control and even in the remission of IBD was evidenced.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115860998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major influences of the gut microbiota on thyroid metabolism: a concise systematic review","authors":"R. D. Gomes","doi":"10.54448/ijn23203","DOIUrl":"https://doi.org/10.54448/ijn23203","url":null,"abstract":"The objective was to discuss the influence of the gut microbiota on the functions of the thyroid gland, elucidating the main aspects of rebalancing intestinal function and its importance in the regulation of thyroid functions. The present study followed a systematic review of the literature in periodicals published between 2010 and 2023. The microbiota of the healthy gastrointestinal system presents around 800 species of bacteria, and a hundred of these microorganisms together with bacteriophage viruses and fungi species characterize each human being, with maximum concentration in the colon. In the presence of dysbiosis, the malfunction of the epithelial barrier leads to intestinal and systemic disorders, mainly immunological and metabolic. The functions of the gut microbiota are fundamental and determinant in the metabolism of nutrients, drugs, and hormones, including exogenous and endogenous iodothyronines, as well as micronutrients involved in thyroid homeostasis. The state of the art of effects of the gut microbiota on the regulation of thyroid functions has not been fully elucidated. The intestinal tract is of great importance for the balance of exogenous and endogenous thyroid hormones, but the analysis of the composition of the microbiota is not an easy task. A recent study revealed that individuals with hyperthyroidism had significantly lower levels of Bifidobacteria and Lactobacilli and significantly higher levels of Enterococcus species compared to healthy controls.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133787277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major considerations and outcomes of clinical trials of vitamin D in athlete performance: a systematic review","authors":"R. D. Gomes","doi":"10.54448/ijn23202","DOIUrl":"https://doi.org/10.54448/ijn23202","url":null,"abstract":"Introduction: In addition to influencing physical performance, some studies verify the impact of vitamin D on body composition. It is known that their high levels favor the gain of fibers of fast contraction, favoring the increase of force due to the increase of muscular areas and it prevents loss of lean mass. Objective: It was present, through a systematic review, the main correlations and outcomes of clinical studies between vitamin D and physical exercise practitioners, analyzing the effects of vitamin D deficiency, sufficiency, and supplementation on sports performance. Methods: Following the criteria of literary search with the use of the Mesh Terms that were cited in the item below on \"Search strategies\", a total of 94 papers that were submitted to the eligibility analysis were collated and, after that, 65 studies were selected, following the rules of systematic review - PRISMA. The review protocol was based on literary search criteria using mesh terms in major databases such as PubMed, Scopus, Medline, Bireme, EBSCO, and Scielo. It followed the following steps: search for MeSH Terms: Vitamin D. Clinical trials. Physical exercises. Athletes. Quality of life. Conclusion: The present study aimed to present, through a systematic review, the main correlations and outcomes of clinical studies between vitamin D and physical exercise practitioners, analyzing the effects of vitamin D deficiency, sufficiency, and supplementation on sports performance.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127175926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major evidence of clinical studies on the triad gut microbiota, ubiquinone and physical exercise: a systematic review","authors":"Fernanda Rossi Schmechel","doi":"10.54448/ijn23201","DOIUrl":"https://doi.org/10.54448/ijn23201","url":null,"abstract":"Introduction: In the scenario of sports practices, the human gut microbiota is currently the focus of convergent interest in many diseases and sports performance. Sports performance studies have also shown interesting and promising results. Supplementation with certain antioxidants such as ubiquinone [Coenzyme Q10 (CoQ10)] is important for physically active individuals to speed recovery from fatigue and prevent exercise damage. Objective: It was to demonstrate the influence of the gut microbiota and ubiquinone on the performance of athletes. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to November 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 104 articles were found. A total of 54 articles were evaluated and 27 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 13 studies with a high risk of bias and 27 studies that did not meet GRADE. Most studies showed homogeneity in their results, with X 2 =97.2% >50%. The composition and activity of the gut microbiota are influenced by many different factors, such as diet and physical activity. Cumulative data indicate that gut bacteria are sensitive to modulation by physical activity, as demonstrated by studies using models of training and hypoactivity. Supplementation with the antioxidant Coenzyme Q10 is important for physically active individuals to accelerate recovery from fatigue and prevent damage caused by exercise, in addition to optimizing training and improving sports performance. Clinical studies have shown that in physical fatigue concerning physical exercise, patients have low plasma concentrations of Coenzyme Q10.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125657089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus of the Brazilian Association of Nutrology on diagnosis, prophylaxis, and treatment of vitamin B12 deficiency","authors":"C. A. Nogueira‐de‐Almeida, S. Fernandes, E. A. Soriano, D. Lourenço, I. J. Zotarelli Filho, N. Iucif Junior, Durval Ribas Filho","doi":"10.54448/ijn23111","DOIUrl":"https://doi.org/10.54448/ijn23111","url":null,"abstract":"Introduction: Vitamin B12 deficiency is quite prevalent in all age groups and all regions of the country, however, there is a need for standardization of clinical management recommendations. Objective: It was to achieve a consensus on the diagnosis, prophylaxis, and treatment of vitamin B12 deficiency. Methods: An integrative review of the scientific literature was carried out in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases and on governmental and regulatory websites. Results: According to the literary search carried out by the authors of this study, 84 scientific works were selected. Based on these findings, in the timeline from 1999 to 2022, randomized controlled clinical studies represented the majority, and prospective and retrospective studies with significant sample sizes were elucidated in this consensus on the vitamin B12 administration for all patient populations. The basis of this scientific evidence was determined by appropriate clinical trials, with additional endpoints including patient clinical symptoms and biochemical parameters in addition to serum and marginal B12 level. Conclusions: Based on the scientific literature, the recommendations of the Brazilian Association of Nutrology for diagnosis, prophylaxis, and treatment of vitamin B12 deficiency were presented.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"289 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115130828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status of patients at the moment of primary cleft lip and palate surgery","authors":"Renan Canale Peres Montanher, Suely Prieto de Barros, Paula Lanza Montanher, Durval Ribas Filho, N. Alonso, C. Tonello","doi":"10.54448/ijn22405","DOIUrl":"https://doi.org/10.54448/ijn22405","url":null,"abstract":"Objective: This study aimed to analyze the nutritional status of patients with cleft lip and palate at the time of admission and time of performing primary lip and/or palate surgeries at the Hospital for Rehabilitation of Craniofacial Anomalies of Bauru, Universidade São Paulo. Methods: A retrospective observational study was conducted using medical records of individuals with cleft lip and/or palate who underwent primary lip and/or palate surgeries between 2011 and 2021. Anthropometric data were collected upon hospital admission and before primary lip and/or lip surgery. The Z-scores of the growth curves were calculated according to age and sex using the World Health Organization (WHO) Anthro and WHO AnthroPlus programs. Statistical analysis was performed using the Spearman, analysis of variance (ANOVA), and Student’s t-tests. Results: Of the 218 participants, 50.46% were men, and most of the patients originated from the southeast region (87.16%) with prevalence of cleft palate (52.75%). A correlation was found between weight/height and weight/age indices with the delay in performing primary lip surgery and height/age with the delay in primary palate and lip surgery (Student’s t-test, p < 0.05), and no correlation was found between the nutritional/nutrological status and socioeconomic profile (Spearman correlation test, p < 0.05) and with the place of origin (ANOVA test, p < 0.05). Conclusion: A correlation was found between the weight/height and height/age indices with the delay in performing primary lip surgery and height/age with the delay in primary surgery of the palate and lip.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126989684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence of the functions of vitamin D in pregnant women in COVID-19: a systematic review","authors":"Sueli Tapigliani Baptista, Renato de Macedo Pereira Filho, Ramon de Macedo Pereira, J. Milanezi, Isabela Gonçalves Assumpção, Márcia Baptista","doi":"10.54448/ijn23110","DOIUrl":"https://doi.org/10.54448/ijn23110","url":null,"abstract":"Introduction: In the world, about 1 million people suffer from vitamin D deficiency. Vitamin D deficiency in pregnant women increases maternal mortality and morbidity rates. In the scenario of COVID-19, it is known that the immune response, inflammation, and coagulation are modulated by vitamin D activity. Objective: It was to analyze the main considerations of the effects of vitamin D on pregnant women and fetuses in the scenario of COVID-19, presenting the mechanisms of inflammatory and immunological processes in an attempt to mitigate the worsening of comorbidities and deaths. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to October 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 210 articles were found, 82 articles were evaluated and 32 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 28 studies with a high risk of bias and 28 studies that did not meet GRADE. Most studies showed homogeneity in their results, with I2 =98.9% >50%. There is a relationship between vitamin D status and the severity of COVID-19 in pregnant women. Vitamin D levels are low in pregnant women with COVID-19. Furthermore, there is a significant difference regarding the level of vitamin D and the severity of COVID-19 in pregnant women. Maintaining adequate vitamin D levels may be useful as an approach to preventing an aggressive course of inflammation induced by this novel coronavirus in pregnant women.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132676320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}