International Journal of Nutrology最新文献

{"title":"Nutrological modulation of cannabidiol in the inflammatory processes of athletes: a systematic review","authors":"Ricardo de Oliveira Carvalho, Hugo Menezes Lopes, Mateus Antunes Nogueira, Márcia Cavalheiro Alves, Ana Claudia Santana Cano, Vittor Cândido Soares, Frederico Teixeira Izidorio, Juliana da Silva Pereira, Marília de Andrade Salvá, Thamyres Veras Alves","doi":"10.54448/ijn24s301","DOIUrl":"https://doi.org/10.54448/ijn24s301","url":null,"abstract":"Introduction: The correct interaction between the elements of the endocannabinoid system plays an important role in the development of the central nervous system. Clinical and preclinical studies suggest that cannabidiol (CBD) may be useful for athletes due to its anti-inflammatory, analgesic, anxiolytic, and neuroprotective properties and its influence on the sleep-wake cycle. Furthermore, a series of implications for epigenetic processes were also proven, through changes in the expression of exosomes and microRNAs responsible for modulating the immune and inflammatory systems. Objective: It was to list the main clinical considerations of the nutritional modulation of cannabidiol in inflammatory and immunological processes in athletes through a systematic review. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from January to March 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and AMSTAR-2, and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 88 articles were found. A total of 36 articles were evaluated in full and 18 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 26 studies with a high risk of bias and 12 studies that did not meet GRADE and AMSTAR-2. CBD has been reported to exert a range of physiological, biochemical, and psychological effects with the potential to benefit human health. For example, there is preliminary supporting evidence for CBD's anti-inflammatory, neuroprotective, analgesic, and anxiolytic actions and the possibility that it may protect against gastrointestinal damage associated with inflammation and promote the healing of traumatic skeletal injuries. The combination of Δ9-THC and CBD can alter the activity of microRNAs responsible for increasing the biosynthesis of inflammatory mediators, leading to a reduction in the inflammatory profile. Despite these findings, there is still a lack of randomized and/or prospective controlled clinical studies with a robust sample size to better understand the safety and effectiveness of the use of cannabidiol by medium to high-performance athletes, as well as better understand the dosages for each type of sports performance.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"65 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141346761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota and skeletal muscle axis in sports performance through nutrological activation of irisin and microRNAs: a systematic review","authors":"Hugo Menezes Lopes, Mateus Antunes Nogueira, Márcia Cavalheiro Alves, Ricardo de Oliveira Carvalho, Ana Claudia Santana Cano, Vittor Cândido Soares, Frederico Teixeira Izidorio, Juliana da Silva Pereira, Marília de Andrade Salvá, Thamyres Veras Alves","doi":"10.54448/ijn24303","DOIUrl":"https://doi.org/10.54448/ijn24303","url":null,"abstract":"Introduction: Several discoveries have accumulated evidence regarding gut microbiota, regenerative nutrition, and skeletal muscle metabolism. Exercise volume and intensity have been shown to influence gastrointestinal health status, including the role of growth factors, signaling pathways, oxidative stress, metabolic factors, irisin, and microRNAs. Objective: To present, through a systematic review, the main approaches and outcomes of clinical studies of the gut microbiota and skeletal muscle axis in sports performance through the nutritional activation of irisin and microRNAs. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from January to April 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 121 articles were found. A total of 40 articles were evaluated in full and 19 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 16 studies with a high risk of bias and 25 studies that did not meet GRADE. It was concluded that exercise-induced stimulation of irisin (bioactive cytokines), through muscle-bone-fat crosstalk, increases muscle anabolism, bone formation, mitochondrial biogenesis, glucose utilization, and fatty acid oxidation and Attenuates chronic low-grade inflammation. A current focus in the field of sports and metabolism is the investigation of how specific metabolites and nutrients affect the progression and treatment of muscle injuries. Nutrients can also regulate normal homeostatic processes by altering the decisions of muscle stem and satellite cells. MicroRNAs have emerged as important players in the regulation of gene expression, being involved in most of the biological processes examined to date, given that microRNAs are mainly involved in the cell's stress response making them ideal candidates for mediating the skeletal muscle response to changes in contractile activity. Identifying and validating target genes will help understand the molecular mechanism through which microRNAs regulate skeletal muscle in response to exercise.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"31 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141353479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus of the Brazilian Association of Nutrology and the Brazilian Society for Food and Nutrition on the consumption of cow's milk by humans","authors":"C. A. Nogueira‐de‐Almeida, Durval Ribas Filho, E. A. Soriano, Nádia Juliana Beraldo Goulart Borges Haubert, Sueli Longo, Olga Maria Silverio Amancio","doi":"10.54448/ijn24302","DOIUrl":"https://doi.org/10.54448/ijn24302","url":null,"abstract":"","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"221 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141375952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and mental disorders: prevalence analysis in a group of employees of a large multinational company in Brazil","authors":"Leonardo Benhame Rodrigues Kyrillos, Amanda Medeiros Rocha","doi":"10.54448//ijn24301","DOIUrl":"https://doi.org/10.54448//ijn24301","url":null,"abstract":"Obesity is a 21st-century pandemic that is associated with cognitive and mental health problems, non-communicable diseases, and premature death. Several studies have associated obesity with the occurrence of mental disorders, including depression. Considering the high prevalence of the two comorbidities and the importance of their impact on people's lives, the objective of this work was to analyze the correlation between obesity and mental disorders, including depression, in adult employees of a large multinational company based in Brazil. This study followed a prospective observational longitudinal and comparative model, following the STROBE rules. This study was approved by the Ethics and Research Committee. 3706 electronic medical records of occupational medicine consultations of employees from different regions of Brazil of a large multinational company were evaluated, between the years 2020 and 2021. For the present study, the BMI profile was crossed, according to the BMI classification. Brazilian Association of Nutrology (ABRAN) with data from the assessment of the mental state of employees considering the results of the Self Report Questionnaire (SQR20). The results obtained showed an association between the two variables and allowed us to conclude that overweight/obese employees have a higher incidence of mental disorders; employees with low and normal weight are primarily in the age group under 40; overweight/obese employees are preferably between the ages of 40 and 60; men have a higher incidence of overweight and a lower rate of mental disorders; women have a higher incidence of normal weight and a higher rate of mental disorders; Underweight employees are less likely to suffer from mental disorders.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"94 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141388314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intradialytic parenteral nutrition in malnourished patients with chronic kidney disease: a systematic review","authors":"Jeovany Martínez-Mesa, Rafaela Cabeda, Veronica Albrecht, Natalia Bassani Schuch, Yudeisy Rodriguez-Hernandez, Nádia Juliana Beraldo Goulart Borges Haubert","doi":"10.54448/ijn24207","DOIUrl":"https://doi.org/10.54448/ijn24207","url":null,"abstract":"Introduction: Malnutrition is a prevalent condition among patients with chronic kidney disease (CKD). Objective: To answer the question of the effect of intradialytic parenteral nutrition (IPN) on malnourished CKD patients undergoing dialysis, a systematic review of clinical trials was performed. Methods: The systematic review was performed according with PRISMA. The review was carried out between September and October 2022. The search strategy included PubMed, Web of Science and LILACS databases. The selection of articles was carried out using the Rayyan platform and to assess the chance of bias, the Rob2 instrument recommended by Cochrane was employed. Results and Conclusions: From 762 article retrieved in the initial strategy only 4 articles were included in the review. In a general view, the use of IPN increased the levels of prealbumin and albumin in the participants. Studies evaluating this topic are sparse. More studies are needed to recommend the use of IPN universally in the context of malnourished patients with CKD.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":" 54","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140993519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of regenerative nutrology of cells/molecules to the organism: a systematic review","authors":"Alessandra Leal de Oliveira, Thuany da Silva Teixeira, Mariana Carolina Braga, Lucas Emanuel de Lima Azevedo, Lara Souza Crepaldi, Renata Cristina Taveira Azevedo, Nathalia Galindo Cordeiro, Rodrigo siqueira de Carvalho, Cristiana Alvarenga Spadinger Soares","doi":"10.54448/ijn24201","DOIUrl":"https://doi.org/10.54448/ijn24201","url":null,"abstract":"Introduction: In the context of tissue regeneration and nutrology, stem cells from adult tissue mediate homeostasis and regeneration of tissues and organs. These decisions are directly integrated with the body's energy balance and nutritional status. Endogenous metabolites and dietary nutrients can directly influence epigenetic enzymes. Objective: It was to carry out a systematic review of the regenerative nutrology of cells and molecules in the body. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from April to June 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 112 articles were found. A total of 45 articles were evaluated in full and 25 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 18 studies with a high risk of bias and 18 studies that did not meet GRADE. It was evidenced that the metabolism of stem cells was centered on the central metabolism of carbon and the balance between glycolysis versus oxidative phosphorylation in the regulation of cell destiny. Epigenetic modifications to DNA and histones, proteins that alter cellular fate, control chromatin accessibility and downstream gene expression. In addition to the connection between metabolism and epigenetic pathways, nutrients can impact cellular status by modulating signaling pathway activity. A clear example is through the mechanistic targeting of the rapamycin (mTOR) signaling pathway, and in particular the mTOR 1 complex. Nutritional supplementation accelerated the healing of skin ulcers and reduced the intensity of wound care in non-malnourished patients.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"308 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140233090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major considerations of enteral nutritional therapy in patients with congestive heart failure: a systematic review","authors":"Alexsandro Pereira de Andrade, Alline Noleto Lima Luna, Rafael de Andrade Luna, Luiz Luna Barbosa, Lyenka Maria do Monte Pinto, Raimundo Pereira de Oliveira Neto, Huggo Luan Barros Medeiros, Ted Igor Praga Xavier de Brito","doi":"10.54448/ijn24s201","DOIUrl":"https://doi.org/10.54448/ijn24s201","url":null,"abstract":"Introduction: Nutrition in the cardiovascular area has focused on improving lifestylerelated diseases such as hypertension, diabetes, dyslipidemia, obesity, and metabolic syndrome from the point of view of primary and secondary prevention, that is, “nutrition for weight loss ” and nutritional guidance has been required. Congestive heart failure (CHF) is a serious and growing public health problem worldwide. Approximately 25 million people are carriers of this disease and two million new cases are diagnosed each year, and enteral nutrition has been highlighted. Objective: It was to develop a systematic review of the main clinical outcomes that highlight the importance of enteral nutritional therapy in patients with congestive heart failure. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from October to November 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 143 articles were found. A total of 45 articles were evaluated and 34 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 21 studies with a high risk of bias and 17 studies that did not meet GRADE and AMSTAR-2. It was concluded enteral nutrition is highly recommended in an attempt to mitigate weight loss in these patients. Enteral diet therapy can be infused continuously or intermittently. Studies have shown that more debilitated and less active patients better accept the diet via continuous tube, slowly and for a long period, even in those with heart disease.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"85 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140231875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrological and pharmacological approaches to cancer cachexia: a systematic review","authors":"Roberto Claudio Correia Filho, Mariana Britez Mustafá Correia, Vinícius Santos Mustafá, Marcelo José Diesel","doi":"10.54448/ijn24108","DOIUrl":"https://doi.org/10.54448/ijn24108","url":null,"abstract":"Introduction: Cancer cachexia (CC) is a multifactorial syndrome that is generally characterized by the continuous loss of skeletal muscle mass with or without fat loss, often accompanied by anorexia, weakness, and fatigue. Cancer cachexia is associated with poor tolerance to antitumor treatments, reduced quality of life, and a negative impact on survival. Unintentional weight loss has been associated with a negative impact on multiple outcomes in cancer patients, including survival and quality of life. Objective: It was to present the main evidence of the nutrological and pharmacological treatment of cancer cachexia through a systematic review. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from October a December 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 127 articles were found. A total of 67 articles were evaluated and 24 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 10 studies with a high risk of bias and 10 studies that did not meet GRADE. Most studies showed homogeneity in their results, with X2=74.5%>50%. Based on the results, symptoms associated with cancer cachexia are thought to be caused by tumor-induced changes in host metabolism that result in systemic inflammation and abnormal neurohormonal responses. The sarcopenia seen in many patients with cancer cachexia is caused, in part, by increased activation of circulating proteolysis-inducing factor (PIF) and skeletal muscle protein breakdown by the ubiquitin-proteasome pathways. The nutritional consequences of cancer treatments must be identified early with screening and assessment of nutritional status. Nutritional intervention includes screening and appropriate nutritional assessment, which should begin early in the disease course to reduce or delay negative effects on therapy and quality of life. Liquid nutritional supplements may be useful to help increase caloric intake. Numerous investigations have reported orexigenic activity associated with progestational agents such as megestrol acetate and medroxyprogesterone. Megestrol acetate has received the most attention in randomized controlled trials of cancer patients. Also noteworthy was the use of corticosteroids and mirtazapine for weight gain and pain control.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of vitamin D deficiency in patients with COVID-19 admitted to a tertiary hospital in Rio Grande do Sul","authors":"Maria Julia de Diniz Jacob, Juliana Cardozo Fernandes, Paloma Dias da Cruz, Carolina Garcia Soares Leães Rech","doi":"10.54448/ijn24105","DOIUrl":"https://doi.org/10.54448/ijn24105","url":null,"abstract":"Background: Increasing data suggests a connection between vitamin D (vitD) and COVID-19. VitD may impact COVID-19 by affecting innate cellular immunity and exacerbating cytokine storms linked to severe respiratory syndrome from the virus. Objective: To assess the prevalence of vitD deficiency in COVID-19 patients hospitalized at Hospital Ernesto Dornelles and examine its links to in-hospital mortality, the need for Intensive Care Unit (ICU), patient demographics, and hospital stay duration. Methods: A cross-sectional study was performed, in which 3518 hospitalized patients with a confirmed diagnosis of COVID-19 were evaluated to obtain the prevalence of vitD deficiency, from March 2020 to August 2022. Data collection was performed using electronic medical records, excluding patients without serum levels of vitD measured during hospitalization, and including those with the exam in their medical records, which were later placed for statistical analysis. Results: 486 patients had their serum level of vitD measured, with a mean age of 68.3 years, 57.2% female, and 42.8% male. The prevalence of vitD deficiency was 60.1% (292 patients). There was no difference between the groups with and without vitD deficiency when comparing age, gender, and comorbidities. The median length of hospital stay, the need for ICU admission, and the outcome of death were significantly higher in the group with vitD deficiency (p<0.001; p=0.005; p=0.03). After adjusting for confounding factors, only the risk of ICU admission remained 1.38x higher in the group with vitD deficiency than in the group without (p=0.015), as well as age and CRF were factors with a higher risk for ICU admission. Conclusions: The prevalence of vitD deficiency in patients with COVID-19 was 60%, being associated with a higher risk of ICU admission, possibly presenting or not an association with higher mortality rates and length of stay. Therefore, further studies are needed to establish a cause-and-effect association.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":" 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139623752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influences of probiotics and gut microbiota on immunomodulation for the treatment of patients with cancer: a systematic review","authors":"Mariana Carolina Braga, Alessandra Leal de Oliveira, Thuany da Silva Teixeira, Lucas Emanuel de Lima Azevedo, Lara Souza Crepaldi, Renata Cristina Taveira Azevedo, Nathalia Galindo Cordeiro, Rodrigo siqueira de Carvalho, Mariana Magalhães Bandeira Gomes, Willdenberg Xavier Lira","doi":"10.54448/ijn24103","DOIUrl":"https://doi.org/10.54448/ijn24103","url":null,"abstract":"Introduction: Immunomodulation and immunostimulation are the main mechanisms of action of probiotics in the fight against cancer. Objective: It was to carry out a systematic review of the influences of probiotics and gut microbiota on immunomodulation for the treatment of cancer patients. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from September to October 2023 in the Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 125 articles were found, and 35 articles were evaluated in full and 18 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 45 studies with a high risk of bias and 15 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=55.4%>50%. It was concluded that probiotics suppress inflammation by inhibiting several signaling pathways and reducing the global activation of NF-κβ and the production of pro-inflammatory cytokines. Probiotics influence receptor antagonism, receptor expression, binding and expression of adapter proteins, expression of negative regulatory signal molecules, and mainly the induction of microRNAs. These microRNAs can modulate the gene expression of tumor cells together with regulatory T cells that have important functions in the tumor microenvironment, mainly in inducing immune evasion. Some modulatory effects of probiotics include the production of cytokines by epithelial cells, increased mucin secretion and phagocytosis and NK cell activity, activation of T and NKT cells, stimulation of IgA production, and decreased proliferation of T cells. The gut microbiota has a major impact on the systemic immune system. The specific microbiota controls cell differentiation in which CD4+ T cells (Th17 cells) secrete IL-17. The presence of Th17 cells and regulatory T cells is associated with the gut microbiota.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"21 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139443281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}