Investigation of regenerative nutrology of cells/molecules to the organism: a systematic review

Alessandra Leal de Oliveira, Thuany da Silva Teixeira, Mariana Carolina Braga, Lucas Emanuel de Lima Azevedo, Lara Souza Crepaldi, Renata Cristina Taveira Azevedo, Nathalia Galindo Cordeiro, Rodrigo siqueira de Carvalho, Cristiana Alvarenga Spadinger Soares
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Abstract

Introduction: In the context of tissue regeneration and nutrology, stem cells from adult tissue mediate homeostasis and regeneration of tissues and organs. These decisions are directly integrated with the body's energy balance and nutritional status. Endogenous metabolites and dietary nutrients can directly influence epigenetic enzymes. Objective: It was to carry out a systematic review of the regenerative nutrology of cells and molecules in the body. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from April to June 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 112 articles were found. A total of 45 articles were evaluated in full and 25 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 18 studies with a high risk of bias and 18 studies that did not meet GRADE. It was evidenced that the metabolism of stem cells was centered on the central metabolism of carbon and the balance between glycolysis versus oxidative phosphorylation in the regulation of cell destiny. Epigenetic modifications to DNA and histones, proteins that alter cellular fate, control chromatin accessibility and downstream gene expression. In addition to the connection between metabolism and epigenetic pathways, nutrients can impact cellular status by modulating signaling pathway activity. A clear example is through the mechanistic targeting of the rapamycin (mTOR) signaling pathway, and in particular the mTOR 1 complex. Nutritional supplementation accelerated the healing of skin ulcers and reduced the intensity of wound care in non-malnourished patients.
细胞/分子对机体的再生营养学研究:系统综述
导言在组织再生和营养学方面,来自成人组织的干细胞介导组织和器官的平衡和再生。这些决定与人体的能量平衡和营养状况直接相关。内源性代谢物和膳食营养素可直接影响表观遗传酶。研究目的对体内细胞和分子的再生营养学进行系统综述。方法:遵循 PRISMA 平台的系统综述规则。研究于 2023 年 4 月至 6 月在 Scopus、PubMed、Science Direct、Scielo 和 Google Scholar 数据库中进行。研究质量根据 GRADE 工具进行评估,偏倚风险根据 Cochrane 工具进行分析。结果与结论:共找到 112 篇文章。共对 45 篇文章进行了全面评估,25 篇文章被纳入本系统综述研究。考虑到科克伦工具的偏倚风险,总体评估结果为 18 项研究具有较高的偏倚风险,18 项研究不符合 GRADE 标准。有证据表明,干细胞的新陈代谢以碳的中心代谢和糖酵解与氧化磷酸化之间的平衡为中心,调节细胞的命运。DNA和组蛋白的表观遗传修饰是改变细胞命运的蛋白质,控制着染色质的可及性和下游基因的表达。除了新陈代谢和表观遗传途径之间的联系外,营养物质还能通过调节信号途径的活性来影响细胞状态。雷帕霉素(mTOR)信号通路,尤其是 mTOR 1 复合物的机理靶向作用就是一个明显的例子。营养补充能加速皮肤溃疡的愈合,并降低非营养不良患者的伤口护理强度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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