International Journal of Nutrology最新文献

{"title":"Prospective randomized controlled trial of the closure of gastrojejunal anastomosis in RYGB with absorbable and inabsorbable thread","authors":"Mário Flamini Júnior, I. J. Zotarelli-Filho, L. Quadros, M. G. Galvão Neto, Maurício Vecchi Carmo, Maisa Ramos Buissa, R. K. Kaiser Junior","doi":"10.54448/ijn22204","DOIUrl":"https://doi.org/10.54448/ijn22204","url":null,"abstract":"Introduction: The Roux-en-Y gastric bypass (RYGB) is, currently, the most performed technique in Brazil. Suture threads are classified according to their degradation properties. Objective: To analyze the influence on the size of the gastrojejunal anastomosis performed in Roux-en-Y gastric bypass surgery, as well as the main complications with the use of absorbable or inabsorbable thread. Methods: This study followed a prospective and randomized clinical trial, initially with 40 participants, with only 37 participants being duly selected, 19 of whom underwent gastrojejunostomy closure with an absorbable (Abs) polydioxanone suture (PDS II®) and 18 with the inabsorbable (Inb) ETHIBOND®. Statistical analysis was performed using the ANOVA and logistic regression tools (p<0.05 significant). Results: General complications and Upper Digestive Endoscopy (UDE) were less frequent at the end of 12 months in both groups. At the end of twelve months, the number of complications of the Inb thread decreased considerably, while the number of complications of the Abs thread showed an increase in other complications, including marginal ulcer and intrusive thread. Despite this, there was no significant difference between groups in terms of total weight loss. There was no statistically significant difference between the final values of the anastomotic diameter. The percentage of weight loss over the 12 months was 33.77 ± 6.97% for the Inb group and 36.10 ± 4.89% for the Abs group (p<0.05). Conclusion: Both suture threads (Inb and Abs) presented similar complications and did not present significant differences between the values of weight, gastrojejunal anastomosis, and pouch.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126729588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative nutrition and gut microbiota signaling in skeletal muscle metabolism: a concise systematic review","authors":"M. S. Rocha, Lorenna Lemos de Aquino, Clarice Paiva de Oliveira, Juliana Leite Salviano, Lucas Ramos Patrício, Thiago Rodrigues dos Santos, Vinícius Bezerra Lopes, Weyller Camargo Dias, Ágda Tamires da Silva Rodrigues, I. J. Zotarelli-Filho","doi":"10.54448/ijn22s101","DOIUrl":"https://doi.org/10.54448/ijn22s101","url":null,"abstract":"Introduction: Recent progress has been made to gut microbiota, regenerative nutrition and skeletal muscle metabolism. In this context, regular physical training associated with nutrological health has broad benefits for the health of the intestinal microbiota. The triad physical exercise, nutrition and intestinal microbiota for the process of muscle regeneration, adult stem cells stand out as gut stem cells. Objective: the present study aimed to carry out a systematic review on the main cellular and molecular aspects of regenerative nutrition in the modulation of the intestinal microbiota and the metabolism of skeletal muscle. Methods: The rules of the Systematic Review-PRISMA Platform. The research was carried out from June 2021 to January 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 215 studies were analyzed, with only 32 medium and high-quality studies selected, according to the rules of the GRADE, and with bias risks that do not compromise scientific development, based on the Cochrane instrument. A current focus in the field of sport and metabolism is the investigation of how specific metabolites and nutrients affect the progression and treatment of muscle injuries. Nutrients can also regulate normal homeostatic processes, altering the decisions of muscle stem cells and satellites. Thus, the implications for understanding how diet influences cellular transitions are immense and will guide precision-based nutrition to improve overall health and therapeutic strategies for muscle injuries. Thus, metabolic pathways and chromatin modifications are closely linked, and hence many changes in metabolism influence epigenetic changes and alter gene expression. For example, signaling pathways including mTORC, AMPK, MAPK, and others are all sensitive to changes in nutrient levels.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126457102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-image disorders and susceptibility for the development of eating disorders in medicine academics: a cross-sectional observational study","authors":"A. Travaini, Gabriela Anjona Gregorini, Giulia Ramos Custódio, Iasmin Ribeiro Payno, João Felipe Pissolito, Lucca Vieira Cerretto, Vinícius Jimenes de Campos, Tainara Costa, Durval Ribas Filho","doi":"10.54448/ijn22202","DOIUrl":"https://doi.org/10.54448/ijn22202","url":null,"abstract":"Introduction: when talking about eating disorders (ED), reflects a lot on how it affects young people and, currently, it is known that the most varied types of ED are quite prevalent in the university environment, with medical students being part of this groups that are significantly exposed to the onset of ED. The development of these disorders is commonly associated with self-image disorders, while body dissatisfaction is precisely one of the diagnostic criteria for ED. Objective: identify the prevalence of body dissatisfaction among medical students and how it affects the susceptibility to the development of eating disorders, relating this information to the impact of the pandemic and the gender of the participants. Methods: a cross-sectional observational study, with a quality-quantitative data approach. The research was carried out with medical students of both sexes, over 18 years old, through the application of an online questionnaire, which allowed the sample to be characterized in terms of sociodemographic and anthropometric aspects. In addition, the occurrence of self-image disorders was evaluated through the Kakeshita Silhouette Scale and the risk of developing ED through the Eating Attitudes Test (EAT 26). For statistical analysis, differences in EAT scores between categories were assessed using the Independent T-Test and the proportion of participants with self-image disorder was compared using Fisher's exact test. Results: 268 participants were included in the research, with a mean age of 21.23 years (standard deviation = 2.47), with 216 female participants (80.6%) and 52 male participants (19.4%). The body mass and height were self-reported by the students to calculate the body mass index (BMI), whose mean value was 23.57 (standard deviation = 4.79), showing that 27.6% of the participants are above the weight or obesity (BMI > 25) and 4.85% with low weight (BMI < 18.5). The present study showed a positive correlation between self-image disorders and eating disorders (p = 0.0002), regardless of the individual's gender. For the variables evaluated, there was no significant difference between genders (p = 0). Furthermore, the current COVID-19 pandemic is not an influential factor in the increase in self-image disorders among participants. Conclusion: through the study, it became evident that students who have self-image disorders have a higher risk of developing eating disorders. In addition, a significant part of the participants is dissatisfied with their bodies, regardless of gender or the impacts brought about by the pandemic.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129494055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenteral nutrition: how to prescribe your inputs","authors":"H. Boemer","doi":"10.54448/ijn22203","DOIUrl":"https://doi.org/10.54448/ijn22203","url":null,"abstract":"Parenteral nutrition (PN) is a vital therapeutic modality for a specific group of patients in need of nutritional support. The proper use of this complex therapy is capable of maximizing its clinical benefits, minimizing the potential risks of adverse events. In certain situations, the clinical lability in which the patient finds himself requires the prescription of customized parenteral formulas. Due to the number of components used in these solutions, the possibilities of Physico-chemical incompatibilities are common and represent a serious problem. For this, prescribers must be familiar with its composition process in order to guarantee a safe formula for infusion. The objective of this work is to present the various inputs (amino acids, carbohydrates, lipids, vitamins, trace elements, electrolytes, and drugs) commonly prescribed in PN formulas, as well as their possibilities of interaction for the formation of precipitates. The concept of osmolarity and its relationship with infusion sites (central or peripheral) will also be addressed. However, an excellent understanding of the different types of inputs used in PN formulas, and also of their physical-chemical interactions capabilities, associated with good clinical judgment in the individualization of these solutions, has reduced sources of errors and ensured greater safety and quality in this type. of intervention to patients.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126385176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myo-inositol in polycystic ovary syndrome: a systematic review and positioning of its use","authors":"Durval Ribas Filho, C. A. Nogueira‐de‐Almeida, I. J. Zotarelli-Filho","doi":"10.54448/ijn22201","DOIUrl":"https://doi.org/10.54448/ijn22201","url":null,"abstract":"Introduction: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disease among women of reproductive age 6 to 15% its presentation is complex and heterogeneous and is characterized by clinical and laboratory findings of hyperandrogenism, oligo-anovulation, metabolic abnormalities such as insulin resistance (IR), overweight, obesity, type 2 diabetes mellitus, dyslipidemia and increased risk of cardiovascular disease. Objective: To evaluate the effects of myo-inositol in pregnant and non-pregnant women with polycystic ovary syndrome in relation to fertility improvement, gestational outcomes, and metabolic and hormonal parameters. Methods: Data from randomized clinical trials on the efficacy of myo-inositol in women with PCOS were used in this review. The PubMed database was used for literature search. Results: Insulin resistance is one of the mechanisms that explain the emergence of metabolic and reproductive changes in women with PCOS. When compared to placebo, myo-inositol was effective in improving fertility, increasing ovulation and fertilization rates, in addition to improving metabolic parameters as indicators of insulin resistance (HOMA index). Even when compared to more traditional insulin sensitizers like metformin, myoinositol showed similar efficacy in restoring fertility. Myo-inositol was also effective when associated with clomiphene acetate and in women undergoing in vitro fertilization processes. There was also an improvement in pregnancy outcomes and a reduction in the risk of developing gestational diabetes with the use of myo-inositol. Conclusions: Myo-inositol improves clinical and laboratory parameters in both pregnant and non-pregnant PCOS patients, increasing the fertility rate and improving pregnancy outcomes.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133167949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The culture of the perfect body: analysis of the use of dietary and anorectic elements to weight loss and eating disorders","authors":"Erika Bueno Marouelli, Stéfanne Sara Ferreira, A. Scriboni","doi":"10.54448/ijn22112","DOIUrl":"https://doi.org/10.54448/ijn22112","url":null,"abstract":"Eating disorders are psychological disorders that directly affect the physical health of those who suffer from them, with a high mortality rate. Women are more prone to eating disorders than men, which is why most research focuses on women. Thus, 10% of patients with eating disorders are men. The results of bibliographical research are presented through in-depth interviews about the perception of the body that Social Work and Psychology professionals, who worked in both the public and private sectors, as an element that can influence eating disorders. This perception has been analyzed as an element that influences eating disorders. This research reaches three main conclusions: First, the body is considered by professionals as an instrument to stop time when personal identity problems arise, especially when the patient is a woman. Second, professionals perceive their patients' bodies as a responsibility in open conflict with social perceptions seen as something unattainable, ideal, and subject to unattainable parameters. Finally, the perception of the body is guided by social imaginaries in which morality (taboo and sin) and the biological are predominant.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116539688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of severe diarrhea in an AIDS patient with inflammatory bowel disease with Short Bowel Syndrome","authors":"Jóyce da Rosa Bisotto, Albert Pinto Coelho Gorini, Luana Dias Claudino, João Vitor Dal Ponte Zatt, Daniel Trahtman de Boer, Gustavo Matas Kern, Y. A. Abdalla, Vanessa Cardoso Fontana, Geórgia Savicki Schneider, J. C. Coelho","doi":"10.54448/ijn22108","DOIUrl":"https://doi.org/10.54448/ijn22108","url":null,"abstract":"Introduction: The human immunodeficiency virus (HIV) can lead to a loss of lymphoid tissue through the intestinal mucosa, making the intestine susceptible to infections and inflammation. As a result, the patient may present with Crohn's Disease (CD), a chronic inflammatory bowel disease (IBD). Short Bowel Syndrome (SBS) results from loss of bowel absorption capacity after extensive bowel resection and is associated with several complications. Objective: To report the case of a patient presenting with acute chronic diarrhea, of probable multifactorial etiology, secondary to HIV, CD, and SBS. Methods: The information contained in this report was obtained through a review of the medical record and a review of the literature. Case Report: This is the report of E. F. C, male, 49 years old, who was admitted to the ICU of Hospital Ernesto Dornelles, in Porto Alegre, from 12/04/2020 to 01/07/2021, with HIV, CD, and SBS. The patient was admitted complaining of diarrhea that had started 15 days ago, which had worsened in the last 7 days, with loss of appetite, vomiting episodes, and mental confusion. Using empirical Lamivudine, Zidovudine, Tenofovir, Ciprofloxacin and Metronidazole, Methotrexate and Prednisone. On physical examination, he was sleepy, afebrile, with a normotensive abdomen, severe dehydration, and edema 3+/4+. From anthropometry, the measured weight of 50 kg, reported height of 1.70 m, and BMI of 17 kg/m2. On laboratory tests, he had severe pancytopenia and electrolyte disturbances. Although the cause of diarrhea was not clarified, bowel rest and the use of glutamine and enteral symbiotic were chosen, while treating HIV and CD, to improve enterocyte nutrition and reduce bacterial translocation capable of causing septic conditions. Despite this, diarrhea was untreatable, mean greater than 1,000 ml/day, with indication, but without the possibility of total parenteral nutrition, due to thrombocytopenia. On 12/06, E. F. C was in poor general condition, anasarca, tachycardic, hypotensive, treating septicemia caused by Candida tropicalis. On 12/07, he presented no spontaneous breathing, absence of central pulses and pupillary reflexes, opted not to institute invasive measures, and died. Final Considerations: The report highlights the need to cover IBD and opportunistic infections in the differential diagnosis of diarrhea in AIDS patients with CD and SBS. It also demonstrates the challenge of nurturing the patient who does not have conditions for enteral and/or parenteral nutrition, with a high risk of malnutrition due to the catabolism of such pathologies.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127774983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal expectations about breastfeeding: a prospective observational study of pre-partum and post-partum evaluation","authors":"Cynthia Mariana Gonçalves Arroyo Marchi, Daniele Cristina dos Santos Bofo, V. Santos","doi":"10.54448/ijn22110","DOIUrl":"https://doi.org/10.54448/ijn22110","url":null,"abstract":"Introduction: Breastfeeding is one of the main experiences that occur in the relationship between mother and baby. As stated in the Child Health Manual, breastfeeding is much more than nurturing the child, it is a process that involves deep interaction between mother and child. The view or psychological reading of the pregnant mother about the act of breastfeeding her baby and the socio-cultural image of the mother/woman who breastfeeds impact the sphere of the future personality of the newborn. Objectives: to map the set of intervening factors that interfere in the breastfeeding process, taking into account the expectations conceived by the pregnant woman before breastfeeding, in addition to the analysis of the positive and negative experiences of nursing mothers during breastfeeding in the postpartum period. Methods: an exploratory and descriptive cohort study, using qualitative and quantitative variables resulting from a questionnaire applied to 35 pregnant women during pregnant women and subsequently interviewed with them in postpartum situations. Results: Regarding the age group, the highest concentration of age was between 26 and 33 years old, but there was the participation of women in the extremes of reproductive life; the association between the time of pregnancy and the search for content/guidance on breastfeeding, most participants were between the 20th and 30th week of the pregnancy period, when they sought information on the subject; to the level of education and information on when breastfeeding should be started, among the 19 pregnant women who had higher education, 17 said it should be started during the baby's first hour of life and 02 said it should be after the first hour; among the 15 participants who had completed high school, 14 responded that it should be in the first hour and only 01 responded after the first hour, and 01 participants who reported having completed elementary school, responded that breastfeeding should be started after the first hour of life. of the baby; when asked if they were breastfed and if they had breastfed previously, 04 pregnant women answered that they had not received breast milk and of these, 03 had already breastfed children before the current pregnancy, among the 31 participants who had been breastfed, 27 said they had not yet breastfed and 04 informed that who had already lived the experience with other children. When approached in the puerperium, the most frequent findings were: 14 reported having received professional help; 13 intended to breastfeed exclusively until the 6th month; 15 had already started formula milk; 17 intended to continue breastfeeding after the baby was six months old and 09 were unable to latch on. Conclusion: Breastfeeding is shown to be one of the biggest factors of doubt and insecurity for pregnant women who enter the puerperium in search of humanized and comprehensive care. Thus, the participation of the health professional becomes essential for the success of brea","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127327883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report on the septic arthritis in a newborn: therapeutic approaches and major considerations","authors":"Glendha Stephanie Martins, Mateus Garcia Zilio, Daniel Pimenta Queiroz, G. Vendramini, Marcelo Borgo, Luis Otávio Garcia de Oliveira, F. Rego, A. Mendes","doi":"10.54448/ijn22111","DOIUrl":"https://doi.org/10.54448/ijn22111","url":null,"abstract":"Introduction: The prevalence of septic arthritis (SA) is higher in underdeveloped countries than in developed countries, and the number of hospitalizations of children for this cause is decreasing and the most prevalent age group is between 0 and 4 years of age. Clinical history and detailed physical examination are essential to make an accurate diagnosis, but the neonatal period has certain limitations. Objective: To report a case of septic arthritis that occurred in a newborn admitted to the Neonatal Intensive Care Unit (ICU) due to its serious condition, morbidity, and unusual evolution of the pathology in the pediatric population, scarcity of epidemiological data on the subject, still aiming address aspects of the treatment of the disease. Case report: Male patient, born on 09/11/2020 at Santa Casa de Tupã, Sao Paulo, with a gestational age of 36 weeks and 6 days, through cesarean delivery and without complications, obtaining APGAR 9 and 10, and maintained in a room with the mother. The morning after birth, the newborn (NB) began to groan and have mild respiratory distress. The patient evolved with worsening of the breathing pattern and oxygen was concentrated at 6L/min in Hood's Halo, presenting hyperthermia, hyperemia, and edema in the right elbow. Laboratory tests showed an increase in C-Reactive Protein and worsened hematimetric indices of the blood count, and antibiotic therapy was then started with oxacillin 50 mg/kg/dose and amikacin 15 mg/kg/day. The ultrasound of the right elbow showed skin thickening, absence of collections, and no changes in vasculature, being suggestive of cellulite. A new ultrasound of the right elbow showed bulging, intra-articular collection, and discreet collection with extra-articular communication in the medial region, being suggestive of septic arthritis. Blood culture collection resulted in the growth of gram-positive cocci (Staphylococcus aureus) in a pair of samples. The patient received intravenous treatment with Vancomycin for 14 days with clinical and laboratory improvement of the infection and was discharged with the use of oral Clindamycin for another 14 days and physical therapy follow-up for rehabilitation of movement of the affected limb. Final considerations: Due to the unusual evolution of SA in the neonatal period, and the scarcity of literature on the pathology in this age group, the importance of further studies on the subject, and greater surveillance for neonatal diagnosis, in addition to early treatment to reduce of complications.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":"15 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114001450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of the action of gut microbiota and nutrology in celiac disease: state of the art","authors":"Giovana Sales Longhini, Layra Rayanne de Oliveira Ferraz Santos, Luca Campassi Bonini, Luiza Braile Verdi, Marcela Vayego Lourenço, Thiago Salomão Munhoz, V. Favaretto, I. J. Zotarelli-Filho, J. Vidanapathirana, Manudi Vidanapathirana, Durval Ribas Filho","doi":"10.54448/ijn22107","DOIUrl":"https://doi.org/10.54448/ijn22107","url":null,"abstract":"Introduction: Celiac disease (CD) is one of the most common disorders related to diet, with a global prevalence of about 1%. The aggravations caused by CD promote an imbalance in the gut microbiota (GM). However, it is not yet known specifically how the gut microbiota plays a role in the pathogeny of this disease, and whether microbiota dysbiosis would be the cause or consequence of CD. Objective: The present study aimed to correlate the main results of the action of the gut microbiota and functional nutrition for the treatment of celiac disease. Methods: This study followed the rules of PRISMA. The research was carried out from June 2021 to 2022 and developed at Scopus, PubMed/Medline, Science Direct, Google Scholar, and Ovid. The quality of the evidence was classified according to the GRADE. The Cochrane instrument was adopted to assess the risk of bias of included studies. For data analysis, Minitab 18® statistical program was used. A common descriptive statistical analysis was performed. The One-Way test (ANOVA) was applied, adopting the α level lower than 0.05 with a statistically significant difference for the 95% CI. Results: The present study found thirteen (13) important clinical studies, of which 12 were Randomized Controlled Studies (RCTs) and one (1) Cross-Sectional Observational study of the total of 113 studies evaluated, showing a high quality of scientific evidence in the studies addressed, with a level of scientific evidence AI. Also, the analyzed studies showed high homogeneity in the results (high association=>50%) to studies with larger sample sizes (greater precision), presenting 98.65%. The present study showed that certain diets/probiotics can promote the improvement of GM as well as DC, especially in patients on a gluten-free diet (GFD). Therefore, patients who follow a GFD may be prone to nutritional deficiencies. Conclusion: According to the results, although some studies have a small sample size, the main randomized clinical studies showed that the modulation of nutrients/probiotics and the gut microbiota improve the inflammatory process of celiac disease, especially in patients with a gluten-free diet.","PeriodicalId":137919,"journal":{"name":"International Journal of Nutrology","volume":" 17","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114051690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}