肠内营养与充血性心力衰竭:系统综述

Laís Lopes Mascarenhas de Lacerda, D. S. Ribeiro, Valdir Cerqueira de Sant’Ana Filho, Murilo Costa Safira Andrade, Joaquim Paulo Castro de Santana
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引用次数: 0

摘要

充血性心力衰竭(CHF)是全球范围内日益严重的公共卫生问题。大约有2 300万人是这种疾病的携带者,每年诊断出200万新病例。慢性心力衰竭患者的临床发展趋向于可变营养不良,因此有必要坚持肠内营养(EN)。这种情况可能是由于摄入不足、代谢改变、促炎状态、氧化应激增加和营养物质更大损失,甚至是由于药物相互作用。目的:对充血性心力衰竭患者肠内营养重要性的主要临床结果进行系统回顾。方法:遵循PRISMA平台的系统评价规则。该研究于2022年9月至10月在Scopus、PubMed、Science Direct、Scielo和b谷歌Scholar数据库中进行。研究质量采用GRADE评分工具,偏倚风险采用Cochrane评分工具进行分析。结果与结论:共检索到122篇文献。共评估了87篇文献,其中28篇被纳入本系统综述。考虑到Cochrane工具的偏倚风险,总体评估结果为7项研究具有高偏倚风险,8项研究未达到GRADE。有适度的科学证据表明,肠内营养在提高充血性心力衰竭患者的生存率和降低发病率方面的有效性,因为很少有随机临床试验评估了这一问题,然而,肠内营养在缓解这些患者体重减轻的尝试中被高度指出。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enteral nutrition and congestive heart failure: a systematic review
Introduction: Congestive heart failure (CHF) is a serious and growing public health problem worldwide. Approximately 23 million people are carriers of this disease and two million new cases are diagnosed each year. The clinical evolution of patients with CHF is moving towards variable malnutrition, making it necessary to adhere to enteral nutrition (EN). This picture can occur due to inadequate intake, altered metabolism, proinflammatory state, increased oxidative stress, and greater loss of nutrients, even due to drug interactions. Objective: It was to carry out a systematic review of the main clinical outcomes that demonstrate the importance of enteral nutrition in patients with congestive heart failure. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to October 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 122 articles were found. A total of 87 articles were evaluated and 28 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 7 studies with a high risk of bias and 8 studies that did not meet GRADE. There is moderate scientific evidence of the effectiveness of enteral nutrition in increasing survival and reducing morbidity in patients with congestive heart failure, as there are few randomized clinical trials that have evaluated this issue, however, enteral nutrition is highly indicated in the attempt to mitigate weight loss in these patients.
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