发布求助
文献互助 智能选刊 最新文献

International Journal of Carbohydrate Chemistry最新文献

筛选
英文 中文
Selective Modification of Chitosan to Enable the Formation of Chitosan-DNA Condensates by Electron Donator Stabilization 电子供体稳定修饰壳聚糖使壳聚糖- dna缩合物形成
International Journal of Carbohydrate Chemistry Pub Date : 2011-09-05 DOI: 10.1155/2011/146419
K. E. Kador, A. Subramanian
{"title":"Selective Modification of Chitosan to Enable the Formation of Chitosan-DNA Condensates by Electron Donator Stabilization","authors":"K. E. Kador, A. Subramanian","doi":"10.1155/2011/146419","DOIUrl":"https://doi.org/10.1155/2011/146419","url":null,"abstract":"Chitosan, a polyaminosaccharide, has been investigated for its use in the field of drug-delivery and biomaterial applications because of its natural biocompatibility and polycationic properties. Chemical modifications of chitosan have been attempted in an effort to increase the transfection efficiency with respect to gene delivery applications; however, it is unknown how these modifications affect the formation of the condensates. This study attempts to determine the effects of modification of the cationic center of chitosan on the ability to condense DNA. Specifically, electron-donating or -withdrawing groups were used as modifiers of the cationic charge on the chitosan backbone to stabilize the protonated form of chitosan, which is necessary to form condensates and increase the efficiency of the polymer to condense DNA by yielding condensates at a lower nitrogen to phosphorous (N : P) ratio. While an N : P ratio of 7 is needed to condense DNA with unmodified chitosan, phthalate-modified chitosan yielded condensates were obtained at an N : P ratio of 1.0.","PeriodicalId":13788,"journal":{"name":"International Journal of Carbohydrate Chemistry","volume":"42 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2011-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74479237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Quaternary Salts of Chitosan: History, Antimicrobial Features, and Prospects 壳聚糖季铵盐:历史、抗菌特性及展望
International Journal of Carbohydrate Chemistry Pub Date : 2011-07-26 DOI: 10.1155/2011/312539
D. Britto, R. Goy, S. Filho, O. Assis
{"title":"Quaternary Salts of Chitosan: History, Antimicrobial Features, and Prospects","authors":"D. Britto, R. Goy, S. Filho, O. Assis","doi":"10.1155/2011/312539","DOIUrl":"https://doi.org/10.1155/2011/312539","url":null,"abstract":"Recently, increasing attention has been paid to water-soluble derivatives of chitosan at its applications. The chemical characteristics and the antimicrobial properties of these salts can play significant role in pharmacological and food areas mainly as carriers for drug delivery systems and as antimicrobial packaging materials. In the current paper, a historical sequence of the main preparative methods, physical chemistry aspects, and antimicrobial activity of chitosan quaternized derivatives are presented and briefly discussed. In general, the results indicated that the quaternary derivatives had better inhibitory effects than the unmodified chitosan.","PeriodicalId":13788,"journal":{"name":"International Journal of Carbohydrate Chemistry","volume":"24 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2011-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76910944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 55
Chitosan-Based Macromolecular Biomaterials for the Regeneration of Chondroskeletal and Nerve Tissue 基于壳聚糖的大分子生物材料用于软骨骨骼和神经组织再生
International Journal of Carbohydrate Chemistry Pub Date : 2011-07-26 DOI: 10.1155/2011/303708
G. D. Guerra, N. Barbani, M. Gagliardi, E. Rosellini, C. Cristallini
{"title":"Chitosan-Based Macromolecular Biomaterials for the Regeneration of Chondroskeletal and Nerve Tissue","authors":"G. D. Guerra, N. Barbani, M. Gagliardi, E. Rosellini, C. Cristallini","doi":"10.1155/2011/303708","DOIUrl":"https://doi.org/10.1155/2011/303708","url":null,"abstract":"The use of materials, containing the biocompatible and bioresorbable biopolymer poly()-2-amino-2-deoxy--D-glucan, containing some N-acetyl-glucosamine units (chitosan, CHI) and/or its derivatives, to fabricate devices for the regeneration of bone, cartilage and nerve tissue, was reviewed. The CHI-containing devices, to be used for bone and cartilage regeneration and healing, were tested mainly for in vitro cell adhesion and proliferation and for insertion into animals; only the use of CHI in dental surgery has reached the clinical application. Regarding the nerve tissue, only a surgical repair of a 35 mm-long nerve defect in the median nerve of the right arm at elbow level with an artificial nerve graft, comprising an outer microporous conduit of CHI and internal oriented filaments of poly(glycolic acid), was reported. As a consequence, although many positive results have been obtained, much work must still be made, especially for the passage from the experimentation of the CHI-based devices, in vitro and in animals, to their clinical application.","PeriodicalId":13788,"journal":{"name":"International Journal of Carbohydrate Chemistry","volume":"249 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2011-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77167729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
A Biopolymer Chitosan and Its Derivatives as Promising Antimicrobial Agents against Plant Pathogens and Their Applications in Crop Protection 生物聚合物壳聚糖及其衍生物在植物病原体抗菌方面的应用前景
International Journal of Carbohydrate Chemistry Pub Date : 2011-06-19 DOI: 10.1155/2011/460381
M. Badawy, E. Rabea
{"title":"A Biopolymer Chitosan and Its Derivatives as Promising Antimicrobial Agents against Plant Pathogens and Their Applications in Crop Protection","authors":"M. Badawy, E. Rabea","doi":"10.1155/2011/460381","DOIUrl":"https://doi.org/10.1155/2011/460381","url":null,"abstract":"Recently, much attention has been paid to chitosan as a potential polysaccharide resource. Although several efforts have been reported to prepare functional derivatives of chitosan by chemical modifications, few attained their antimicrobial activity against plant pathogens. The present paper aims to present an overview of the antimicrobial effects, mechanisms, and applications of a biopolymer chitosan and its derivatives in crop protection. In addition, this paper takes a closer look at the physiochemical properties and chemical modifications of chitosan molecule. The recent growth in this field and the latest research papers published will be introduced and discussed.","PeriodicalId":13788,"journal":{"name":"International Journal of Carbohydrate Chemistry","volume":"20 1","pages":"1-29"},"PeriodicalIF":0.0,"publicationDate":"2011-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85100150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 330
Structure and Dynamics of Glycosphingolipids in Lipid Bilayers: Insights from Molecular Dynamics Simulations 脂质双层中鞘糖脂的结构和动力学:来自分子动力学模拟的见解
International Journal of Carbohydrate Chemistry Pub Date : 2011-04-10 DOI: 10.1155/2011/950256
Ronak Y. Patel, P. V. Balaji
{"title":"Structure and Dynamics of Glycosphingolipids in Lipid Bilayers: Insights from Molecular Dynamics Simulations","authors":"Ronak Y. Patel, P. V. Balaji","doi":"10.1155/2011/950256","DOIUrl":"https://doi.org/10.1155/2011/950256","url":null,"abstract":"Glycolipids are important constituents of biological membranes, and understanding their structure and dynamics in lipid bilayers provides insights into their physiological and pathological roles. Experimental techniques have provided details into their behavior at model and biological membranes; however, computer simulations are needed to gain atomic level insights. This paper summarizes the insights obtained from MD simulations into the conformational and orientational dynamics of glycosphingolipids and their exposure, hydration, and hydrogen-bonding interactions in membrane environment. The organization of glycosphingolipids in raft-like membranes and their modulation of lipid membrane structure are also reviewed.","PeriodicalId":13788,"journal":{"name":"International Journal of Carbohydrate Chemistry","volume":"40 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2011-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80055836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Endogenous and Exogenous CD1-Binding Glycolipids 内源性和外源性cd1结合糖脂
International Journal of Carbohydrate Chemistry Pub Date : 2011-04-05 DOI: 10.1155/2011/749591
Janice M. H. Cheng, A. A. Khan, Mattie S. M. Timmer, B. L. Stocker
{"title":"Endogenous and Exogenous CD1-Binding Glycolipids","authors":"Janice M. H. Cheng, A. A. Khan, Mattie S. M. Timmer, B. L. Stocker","doi":"10.1155/2011/749591","DOIUrl":"https://doi.org/10.1155/2011/749591","url":null,"abstract":"In the same way that peptide antigens are presented by major histocompatibility complex (MHC) molecules, glycolipid antigens can also activate the immune response via binding to CD1 proteins on antigen-presenting cells (APCs) and stimulate CD1-restricted T cells. In humans, there are five members of the CD1 family, termed CD1a–e, of which CD1a–d are involved in glycolipid presentation at the cell surface, while CD1e is involved in the intracellular trafficking of glycolipid antigens. Both endogenous (self-derived) and exogenous (non-self-derived) glycolipids have been shown to bind to members of the CD1 family with varying degrees of specificity. In this paper we focus on the key glycolipids that bind to the different members of the CD1 family.","PeriodicalId":13788,"journal":{"name":"International Journal of Carbohydrate Chemistry","volume":"93 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2011-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90697936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Thiolactosides: Scaffolds for the Synthesis of Glycolipids in Animal Cells 硫代乳糖苷:动物细胞中糖脂合成的支架
International Journal of Carbohydrate Chemistry Pub Date : 2011-03-03 DOI: 10.1155/2011/267208
Masako Mori, M. Kasuya, M. Mizuno, K. Hatanaka
{"title":"Thiolactosides: Scaffolds for the Synthesis of Glycolipids in Animal Cells","authors":"Masako Mori, M. Kasuya, M. Mizuno, K. Hatanaka","doi":"10.1155/2011/267208","DOIUrl":"https://doi.org/10.1155/2011/267208","url":null,"abstract":"Various glycolipids were synthesized using thiolactosides as scaffolds for glycosylation in animal cells. The basic building blocks, n-dodecyl β-D-thiolactoside (β-LacSC12) and n-dodecyl α-D-thiolactoside (α-LacSC12), were chemically synthesized in 2 steps: glycosylation followed by deacylation. The thiolactosides were administered to animal cells in culture and served as substrates for cellular enzyme-catalyzed glycosylation. Incubation of mouse melanoma B16 cells in the presence of β-LacSC12 or α-LacSC12 resulted in sialylation of the terminal galactose residue and gave a GM3-type ganglioside. Administration of β-Lac SC12 in Madin-Darby canine kidney (MDCK) cells likewise gave a GM3-type ganglioside. On the other hand, introduction of β-LacSC12 in African green monkey kidney (Vero) cells gave Gb3- and Gb4-type glycolipids aside from GM3-type ganglioside. In the course of the study, significant changes in B16 cell morphology and elevated secretion of melanin were also observed.","PeriodicalId":13788,"journal":{"name":"International Journal of Carbohydrate Chemistry","volume":"46 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2011-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73585448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Study of Antibacterial Efficacy of Hybrid Chitosan-Silver Nanoparticles for Prevention of Specific Biofilm and Water Purification 壳聚糖-银纳米颗粒对特定生物膜的防治及水净化效果的研究
International Journal of Carbohydrate Chemistry Pub Date : 2011-01-01 DOI: 10.1155/2011/693759
Somnath Ghosh, Tasneem Kausar Ranebennur, H. Vasan
{"title":"Study of Antibacterial Efficacy of Hybrid Chitosan-Silver Nanoparticles for Prevention of Specific Biofilm and Water Purification","authors":"Somnath Ghosh, Tasneem Kausar Ranebennur, H. Vasan","doi":"10.1155/2011/693759","DOIUrl":"https://doi.org/10.1155/2011/693759","url":null,"abstract":"Antibacterial efficacy of silver nanoparticles (Ag NPs) deposited alternatively layer by layer (LBL) on chitosan polymer in the form of a thin film over a quartz plate and stainless steel strip has been studied. An eight-bilayer chitosan/silver (Cs/Ag)8 hybrid was prepared having a known concentration of silver. Techniques such as UV-visible spectroscopy, inductively coupled plasma optical emission spectroscopy (ICP-OES), and atomic force microscopy (AFM) were carried out to understand and elucidate the physical nature of the film. Gram-negative bacteria, Escherichia coli (E. coli), were used as a test sample in saline solution for antibacterial studies. The growth inhibition at different intervals of contact time and, more importantly, the antibacterial properties of the hybrid film on repeated cycling in saline solution have been demonstrated. AFM studies are carried out for the first time on the microbe to know the morphological changes affected by the hybrid film. The hybrid films on aging (3 months) are found to be as bioactive as before. Cytotoxicity experiments indicated good biocompatibility. The hybrid can be a promising bioactive material for the prevention of biofilms specific to E. coli and in purification of water for safe drinking.","PeriodicalId":13788,"journal":{"name":"International Journal of Carbohydrate Chemistry","volume":"6 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81131769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Koenigs-Knorr Glycosylation with Neuraminic Acid Derivatives 神经氨酸衍生物的Koenigs-Knorr糖基化
International Journal of Carbohydrate Chemistry Pub Date : 2010-12-02 DOI: 10.1155/2010/594247
G. Pazynina, V. Nasonov, I. Belyanchikov, R. Brossmer, Maxim Maisel, A. Tuzikov, N. Bovin
{"title":"Koenigs-Knorr Glycosylation with Neuraminic Acid Derivatives","authors":"G. Pazynina, V. Nasonov, I. Belyanchikov, R. Brossmer, Maxim Maisel, A. Tuzikov, N. Bovin","doi":"10.1155/2010/594247","DOIUrl":"https://doi.org/10.1155/2010/594247","url":null,"abstract":"Earlier we reported a convenient and efficient method of preparing α2-6 sialooligosaccharides in conditions of Koenigs-Knorr reaction. The use of Ag2CO3 allowed carrying out α2-6 sialylation of galacto-4,6-diol of mono- and disaccharides with chloride of acetylated N-acetylneuraminic acid methyl ester as glycosyl donor. In this study we applied this approach to other derivatives of neuraminic acid, namely, Neu5Gc, 9-deoxy-9-NAc-Neu5Ac, Neu5Acα2-8Neu5Ac, and Neu5Acα2-8Neu5Acα2-8Neu5Ac as glycosyl donors; eight compounds were synthesized: Neu5Gcα-O(CH2)3NH2 (8), Neu5Gcα2-6Galβ1-4GlcNAcβ-O(CH2)3NH2 (10), 9-deoxy-9-NAc-Neu5Ac-O(CH2)3NH2 (15), 9-deoxy-9-NAc-Neu5Acα2-6Galβ1-4GlcNAcβ-O(CH2)3NH2 (17), Neu5Acα2-8Neu5Acα-O(CH2)3NH2(23) Neu5Acα2-8Neu5Acα-OCH3 (24), Neu5Acα2-8Neu5Acα-OCH2(p-C6H4)NHCOCH2NH2 (25), and Neu5Acα2-8Neu5Acα2-8Neu5Acα-O(CH2)3NH2 (32). These sialosides were used for characterization of siglecs and other carbohydrate-binding proteins.","PeriodicalId":13788,"journal":{"name":"International Journal of Carbohydrate Chemistry","volume":"11 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2010-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74339018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Convenient Approach to Access Octa-Glycosylated Porphyrins via “Click Chemistry” 通过“点击化学”获取八糖基化卟啉的便捷方法
International Journal of Carbohydrate Chemistry Pub Date : 2009-12-09 DOI: 10.1155/2009/305276
Misako Okada, Yuko Kishibe, Kanako Ide, Toshiyuki Takahashi, Teruaki Hasegawa
{"title":"Convenient Approach to Access Octa-Glycosylated Porphyrins via “Click Chemistry”","authors":"Misako Okada, Yuko Kishibe, Kanako Ide, Toshiyuki Takahashi, Teruaki Hasegawa","doi":"10.1155/2009/305276","DOIUrl":"https://doi.org/10.1155/2009/305276","url":null,"abstract":"Easy, quantitative, and one-pot introduction of eight -lactoside-modules onto a porphyrin-core was achieved through -catalyzed chemoselective coupling (click chemistry) between a porphyrin carrying eight alkyne-terminals and -lactosyl azides. The obtained porphyrin-based glycocluster shows not only good water-solubility but also strong/specific lectin-affinity.","PeriodicalId":13788,"journal":{"name":"International Journal of Carbohydrate Chemistry","volume":"116 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2009-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87773307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信