脂质双层中鞘糖脂的结构和动力学:来自分子动力学模拟的见解

Ronak Y. Patel, P. V. Balaji
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引用次数: 5

摘要

糖脂是生物膜的重要组成部分,了解其在脂质双分子层中的结构和动力学有助于了解其生理和病理作用。实验技术提供了它们在模型膜和生物膜上行为的细节;然而,需要计算机模拟来获得原子水平的洞察力。本文综述了在膜环境下鞘糖脂的构象和取向动力学及其暴露、水合作用和氢键相互作用等方面的研究进展。本文还综述了鞘糖脂在筏状膜中的组织及其对脂膜结构的调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structure and Dynamics of Glycosphingolipids in Lipid Bilayers: Insights from Molecular Dynamics Simulations
Glycolipids are important constituents of biological membranes, and understanding their structure and dynamics in lipid bilayers provides insights into their physiological and pathological roles. Experimental techniques have provided details into their behavior at model and biological membranes; however, computer simulations are needed to gain atomic level insights. This paper summarizes the insights obtained from MD simulations into the conformational and orientational dynamics of glycosphingolipids and their exposure, hydration, and hydrogen-bonding interactions in membrane environment. The organization of glycosphingolipids in raft-like membranes and their modulation of lipid membrane structure are also reviewed.
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