Convenient Approach to Access Octa-Glycosylated Porphyrins via “Click Chemistry”

Abstract

Easy, quantitative, and one-pot introduction of eight -lactoside-modules onto a porphyrin-core was achieved through -catalyzed chemoselective coupling (click chemistry) between a porphyrin carrying eight alkyne-terminals and -lactosyl azides. The obtained porphyrin-based glycocluster shows not only good water-solubility but also strong/specific lectin-affinity.