International Journal of Advanced Research最新文献

{"title":"AN OBSERVATIONAL STUDY OF EFFECT ON LIPID PROFILE BY SHORT TERM USE OF LOW DOSE STEROID THERAPY IN COMMON ORTHOPAEDIC CONDITIONS","authors":"Maheshkumar Prajapati, Mohammed Sohail Siddiqui, Ravi Patel, Ronak Daglia, Abhinav Vatsa, Charchit Baurasi","doi":"10.21474/ijar01/18267","DOIUrl":"https://doi.org/10.21474/ijar01/18267","url":null,"abstract":"Introduction:Corticosteroids, potent anti-inflammatory drugs used for decades, provide symptomatic relief but carry risks like infection and chronic conditions. Despite complications, theyre prescribed for orthopedic issues. Glucocorticoids influence lipid levels, with conflicting effects. Steroids are termed a double-edged sword. This study aims to assess lipid profile effects of short-term, low-dose steroid therapy in Orthopedics and Rheumatology, evaluating glucocorticoid therapy impact and investigating other effects on musculoskeletal patients. Materials and Methods:This prospective, non-randomized observational study was conducted, focusing on patients with orthopedic and rheumatological issues. Over 150 patients were included, selected through convenient sampling. Inclusion criteria involved patients aged 18-65 without dyslipidemia or cardiovascular conditions, while exclusion criteria included those with specific medical conditions or high BMI. Patients provided written informed consent before undergoing blood tests for lipid profile and blood sugar levels, with vital signs measured. They received Medrol 4 mg thrice daily for ten days, after which outcomes including lipid levels, blood sugar, and blood pressure were assessed. Results:At baseline, 88.67% had desirable cholesterol levels and 11.33% had borderline levels. At follow-up, 20.67% had borderline levels and 79.33% had desirable levels, a statistically significant difference. Mean cholesterol levels decreased from 169.16 ± 19.70 mg/dl to 161.11 ± 27.60 mg/dl, also significant. For triglycerides, 92.67% had normal levels at baseline, decreasing to 65.33% at follow-up, with mean levels increasing from 131.33 ± 6.97 mg/dl to 139.12 ± 23.88 mg/dl. HDL levels showed improvement, with 84.67% having desirable levels at baseline compared to 43.33% at follow-up, with mean levels increasing from 41.09 ± 5.13 mg/dl to 50.71 ± 4.21 mg/dl. LDL levels decreased from 132.43 ± 16.86 mg/dl to 122.59 ± 16.93 mg/dl, with significant changes in distribution. Conclusions:Short-term steroid use for orthopedic conditions affects lipid profiles: Total cholesterol, LDL, and TG rise significantly, countered by increased HDL, offering protection. Long-term effects on lipid profiles and cardiovascular risk require further study. Risk of avascular necrosis due to subtle lipid profile changes also warrants investigation.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UNDERSTANDING MUSCLE CONTRACTION: MECHANISMS AND IMPLICATIONS","authors":"Samaira Mittal","doi":"10.21474/ijar01/18312","DOIUrl":"https://doi.org/10.21474/ijar01/18312","url":null,"abstract":"Muscle contraction is a fundamental physiological process critical for movement, stability, and various bodily functions. This research paper delves into the intricate mechanisms underlying muscle contraction, exploring the role of actin, myosin, calcium ions, and regulatory proteins in the sliding filament theory. Additionally, it discusses the physiological and biochemical aspects of muscle contraction, including the excitation-contraction coupling process and the energy requirements for muscle activity. Furthermore, the paper explores the implications of muscle contraction dysfunction in conditions such as muscular dystrophy and the potential therapeutic interventions. By comprehensively understanding muscle contraction, researchers and clinicians can advance treatments for muscle-related disorders and optimize performance in various fields.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140415064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KNOWLEDGE ATTITUDE AND AWARENESS REGARDING ZNO SUNSCREEN PROTECTION AMONG UNDERGRADUATE DENTAL STUDENTS","authors":"T. Maria Alphonsa Deepthi, K. Pratap, T. Madhavi Padma, V. Siva Kalyan, V. Srujan Kumar","doi":"10.21474/ijar01/18316","DOIUrl":"https://doi.org/10.21474/ijar01/18316","url":null,"abstract":"Background:Zincoxidenanorods were employed as the primary ultra- violet protection agent in the formulation of sunscreens. Examination of ZnO powder through FESEM and TEM micrographs revealed the predominant presence of rod-like structures with a width range between 61-70 nm. Notably, sunscreens containing 20-40% (by weight) of ZnOnanorods exhibited significantly improved UV absorbance across both UVA and UVB spectra (280-400 nm). This study mainly aims to assess the Knowledge Attitude and Awareness Regarding ZnOnanorodsinSunscreenProtectionAmongUndergraduateDentalStudents. Aim: Knowledge Attitude and Awareness Regarding ZnO Sunscreen Protection Among Undergraduate Dental Students. Objective: Analyzing and determining the Knowledge Attitude and Awareness Regarding ZnO Sunscreen Protection Among Undergraduate Dental Students. Method: A cross sectional study was conducted among the dental students (II,III, IV, interns) in a tertiary care teaching hospital,Khammam, using a web basedtool called forms pro, a semi-structural online questionnaire was designed and distributed to the students in order to fill.Descriptive statistics were calculated using SPSS verson-29..A p- value <0.05 was used to evaluate statistical significance. Result: A total of 209 students took part with females (70.8%) and males (29.2%). Age of participants ranges from 19-25 years. In this study female students have more knowledge and awareness regarding ZnO Sunscreen Protection compared to males. Among all the students Interns have more knowledge, followed by IV-BDS, III-BDS and II-BDS. Conclusion: The study result suggests that knowledge and awareness level of ZnO Sunscreen Protection is adequate.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140416071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIGH BLOOD PRESSURE IN PATIENTS WITH PRADER WILLI SYNDROME : CASE REPORT AND REVIEW OF THE LITERATURE","authors":"G. Ziani, N. Belharty, M. Cherti","doi":"10.21474/ijar01/18272","DOIUrl":"https://doi.org/10.21474/ijar01/18272","url":null,"abstract":"Prader-Willi syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbi-mortality in all ages. In this context, non-obese PWS patients showed low frequency of metabolic syndrome (MetS), while a high prevalence of hypertension was observed in obese PWS and obese controls. The aim of this report was to estimate the occurrence of high blood pressure and its components in a large group of PWS adults. An association of this syndrome with elevated cardiovascular morbi-mortality was observed, but the underlying mechanisms are not fully known.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140409024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SNIFFING VERSUS RAMPED POSITION IN THE VIDEO-LARYNGOSCOPY-GUIDED TRACHEAL INTUBATION OF MORBIDLY OBESE PATIENTS: A PROSPECTIVE RANDOMIZED OBSERVATIONAL STUDY","authors":"Adilakshmi N., Gajendra Singh, Pratima S. Kamareddy, Shilpa Wali, Anush D.S","doi":"10.21474/ijar01/18259","DOIUrl":"https://doi.org/10.21474/ijar01/18259","url":null,"abstract":"Sniffing versus Ramped position in the videolaryngoscopy-guided tracheal intubation of morbidly obese patients: a prospective randomized observational study” Introduction: Ramped positioning is recommended for intubating obese patients undergoing direct laryngoscopy. However, whether the use of the ramped position can provide any benefit in videolaryngoscopy-guided intubation remains unclear. This study assessed intubation time using videolaryngoscopy in morbidly obese patients in the ramped versus sniffing positions. Materials and Methods: This is a prospective randomized observational study in patients with morbid obesity (n = 82 body mass index [BMI] ? 35 kg/m2). Patients were randomly allocated to either the ramped or the standard sniffing position groups. During the induction of general anesthesia, difficulty in mask ventilation was assessed using the Warters scale. Tracheal intubation was performed using a C-MAC® D-Blade videolaryngoscope, and intubation difficulty was assessed using the intubation difficulty scale (IDS). The primary endpoint was the total intubation time calculated as the sum of the laryngoscopy and tube insertion times. Conclusion: Compared with the sniffing position, the ramped position reduced intubation time in morbidly obese patients and effectively facilitated both mask.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140409088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PUBLIC ADMINISTRATION: A CONCEPTUAL ANALYSIS","authors":"Kishor Kumar Dash","doi":"10.21474/ijar01/18357","DOIUrl":"https://doi.org/10.21474/ijar01/18357","url":null,"abstract":"Background/Objectives: Administration is a term that explains the ways of getting work done by others for the benefit of a certain entity. Public administration engages public servants to make better rule and regulations by understanding their interests that are able to make the life of citizens easier. Material and methods: Secondary qualitative method will be pursued in this research to acquire significant analysis. Significance of the study: However, challenges are present in the job role for which effective steps by the government need to take. Findings: The result findings symbolize the various knowledge based is on the concepts of public administration and it is explained well in this article, which explains the motive of it managing the local services and managing political influences on sectors. Conclusion: There are the crucial improvements on the growth of different public administration as per critical approach of analysis.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140410196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CASE REPORT ON ATYPICAL PRESENTATION OF CONGENITAL ADRENAL HYPERPLASIA","authors":"Karrothu Tejaswi, Y.V Siva Sankara Murty, Bonthu Sri Padma Priya Pallavi, Metta Saikiran","doi":"10.21474/ijar01/18281","DOIUrl":"https://doi.org/10.21474/ijar01/18281","url":null,"abstract":"We report a case of 52-day old infant presented to casualty with complaint of failure to gain weight,10-day history of regurgitation of feeds, poor acceptance of feed and lethargy from one day, not passed urine in last 8hours. On examination baby had tachycardia with signs of dehydration, blood gas shows metabolic acidosis with serum sodium- 124meq/l, serum potassium- 6.2meq/l. A probable diagnosis of failure to thrive with severe sepsis, inborn errors of metabolism (IEM), and CAH was considered and baby was treated with intravenous fluids, antibiotics, calcium gluconate, salbutamol nebulisation and hydrocortisone. Following the above interventions, babys hydration status and ECG changes improved. The diagnosis of CAH was considered as 17- hydroxyprogesterone levels were elevated. Genetic analysis was not done due to patients economic constraints and baby was discharged with oral Hydrocortisone, Fludrocortisone and table salt (Nacl). Currently baby is thriving well with adequate weight gain.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SADDLE PULMONARY EMBOLISM: A RARE CASE OF PROXIMAL PULMONARY EMBOLISM","authors":"Hamissou Ibrahim, Nacocan Domiciano, Amri Rachida, Cherti Mohammed","doi":"10.21474/ijar01/18332","DOIUrl":"https://doi.org/10.21474/ijar01/18332","url":null,"abstract":"Saddle pulmonary embolism is defined as the presence of a visible thrombus located at the bifurcation of the pulmonary artery trunkshowing an aspect of saddle on a chest contrasted tomography scan. This is a rare case occurring in only 5.2% of patients with pulmonary embolism. (1)We report the case of a 93-year-old female patient who had no thrombo-embolic past medical history, she had got the gall bladder operation 25 years ago. The patient was admitted for a dyspnea associated with a chest pain and desaturation related to a pulmonary embolism confirmed on a chest contrasted tomography scan that has shown a typical aspect of saddle pulmonary embolism. Our patient was stable on hemodynamic state and had a high intermediate prognostic risk score. She was managed at the cardiac intensive care unit with anticoagulation that improved her clinically.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140408530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FETO-MATERNAL COMLICATIONS IN PREGANCY WITH METABOLIC SYNDROME -A HOSPITAL BASED STUDY","authors":"Syed Bassit, Nowsheen Khan","doi":"10.21474/ijar01/18264","DOIUrl":"https://doi.org/10.21474/ijar01/18264","url":null,"abstract":"Background: Being first identified by Reaven as a syndrome in 1988,[14] metabolic syndrome (MetS) is a series of metabolic disorders, including abdominal obesity, impaired glucose tolerance and insulin metabolism, hypertension, and dyslipidaemia. [1,8,9] Prepregnancy metabolic changes are not only the determinant of complications during pregnancy, after pregnancy, during postpartum life, but the reasons for inappropriate perinatal outcomes. Overweight women before pregnancy increases the risk of pregnancy complications obesity turns out to be an independent risk factor for macrosomia,cesarean section,pregnancy-induced hypertension, preterm delivery, intrauterine growth restriction, congenital malformation, intrauterine foetal death,etc. [2,7]The emergence of MetS characteristics during pregnancy may also harm the fetus.[4]This study was conducted to study the maternal and foetal outcome in pregnant women with Metabolic Syndrome. Methods: Metabolic syndrome was diagnosed by utilizing the pregnancy adaptation of MeS criteria of NCEPATP III laboratory and clinical criteria. Cases were followed throughout pregnancy till delivery and maternal and foetal complications were recorded. Results: Sample size was 100patients less than 20 weeks of gestation with metabolic syndrome and 100 controls which were normal pregnant patients less than 20 weeks of gestation without any comorbidities. The mean age was 29-32 years. The mean gestational age was 13-16 weeks. LSCS was significantly higher in cases than controls. APH, Pregnancy Induced Hypertension, Pre-eclampsia, Gestational Diabetes Mellitus was significantly higher in cases as compared to controls. Preterm, IUGR, Macrosomia was significantly higher in cases as compared to controls. Conclusion: Metabolic syndrome and its associated complications in pregnancy have a strong effect on the maternal and the fetal well-being. A careful history and examination,proper and timely investigations and proper monitoring and follow up with required medication and optimal control of all the parameters will result in better maternal and foetal outcome.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIBACTERIAL ACTIVITY OF SMILAX CHINA AGAINST HUMAN PATHOGENIC BACTERIA","authors":"Nargish Marjhan, Md Abdul Mannan","doi":"10.21474/ijar01/18263","DOIUrl":"https://doi.org/10.21474/ijar01/18263","url":null,"abstract":"Many plant species that are employed in herbalism are considered medicinal plants and some of these species even have therapeutic properties. In third world countries, using herbs to cure and control illnesses is common. Pharmacokinetic and metabolic research in conventional medicine have produced a lot of interest among the researchers all over the world. The Plant Smilax china is regarded as a powerful resource for the synthesis and development of drugs. Smilax chinaroot extract has a good antimicrobial activity. In order to detect the antimicrobial activity of the root extract of Smilax chinaon Escherichia coli, Staphylococcus aureus and Streptococcus pyogenes, a Zone of Inhibition was observed. Smilax china root extract containing test disk inhibited growth of pathogenic bacteria. Test disk containing 250 μg, 500 μg and 1000 μg showed 10 mm, 14 mm and 18 mm zone of inhibition against Escherichia coli. 8 mm, 9 mm and 14 mm zone of inhibition against Staphylococcus aureus. 7 mm, 8 mm and 11 mm zone of inhibition against Streptococcus pyogenes. Whereas 30 μgAmikacin containing standard antibiotic disk showed 14 mm, 12 mm and 10 mm zone of inhibition against Escherichia coli, Staphylococcus aureusand Streptococcus pyogenes. This research concluded that Smilax chinaroot extract contain antimicrobial properties. Proper and systemic study of Smilax china may enlighten this formulation as natural origin for antimicrobial drug production.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}