International Journal of Clinical Pediatrics最新文献

{"title":"Nutritional Management of Gastroesophageal Reflux Among Infants in the Philippines: Insights From Real-World Evidence","authors":"F. Gatcheco, M. V. Sales, Grace R. Battad, Marilou Tan, Mazzali Gloria, U. Kudla, L. Muhardi","doi":"10.14740/IJCP338","DOIUrl":"https://doi.org/10.14740/IJCP338","url":null,"abstract":"Background: The objective of the study was to describe the clinical course of infants with pediatrician-diagnosed gastroesophageal regurgitation (GER), after changing to an infant anti-regurgitation formula. Methods: Information on frequency and volume of regurgitation, and disease progression were collected from mothers of 0- to 12-month-old Filipino infants with GER at baseline and 1 month after a pediatrician prescribed-formula containing carob bean gum, galacto-oligosaccharides and partially hydrolyzed whey protein for 14 days. Results: Eighty-nine infants aged ≤ 6 months and 40 aged 7 - 12 months old were enrolled. The most frequently reported amount of baseline regurgitation was half of the total feed (29 (33%) younger infants and 17 (43%) older infants). Baseline regurgitation frequency ranged from 1 - 3 times/day (45 (51%) and 21 (52%)) to 4 - 6 times/day (33 (37%) and 14 (35%)) and 7 - 9 times/day (11 (12%) and five (13%)). Regurgitation after 1-day consumption was resolved in 16 (18%) and 8 (20%) and in 57 (64%) and 31 (78%) younger and older infants at 14 days. Forty-one (32%) infants still had regurgitation episodes after a 14-day trial with decreased frequency and volume; three (7%) infants did not show any improvement, while one (1%) infant had increased amount of regurgitation. No medicine was given to study participants. Parent-reported sleep disturbance decreased in three (37%) younger infants and 25 (63%) older infants. Conclusion: Nutrition intervention has effectively improved symptom and quality of life among infants with GER within 14 days. Information on underlying conditions among those with unresolved symptoms are needed. Int J Clin Pediatr. 2019;8(1):1-7 doi: https://doi.org/10.14740/ijcp338","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76346620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Preterm Infant With Mild Abdominal Distension and Rising C-Reactive Protein","authors":"A. Alshafei, Mahmoud Ahmed","doi":"10.14740/IJCP326","DOIUrl":"https://doi.org/10.14740/IJCP326","url":null,"abstract":"Abdominal distension is a common clinical presentation in neonates admitted to neonatal intensive care units (NICUs), especially preterm infants. The underlying causes are multiple and range from simple transient etiologies to life-threatening events with significant morbidities. Neonatal sepsis is the most common diagnosis encountered; however, other differential diagnoses should be thought. Premature neonates are particularly susceptible to abdominal distension because of gut immaturity, relative immune deficiency and frequent exposure to invasive procedures. Herein, we report a preterm infant who developed abdominal distension and hepatomegaly on day 4 of life. This was associated with progressively rising C-reactive protein (CRP) levels and normal abdominal X-ray. Bed side abdominal ultrasonography revealed the diagnosis. Int J Clin Pediatr. 2019;8(1):22-25 doi: https://doi.org/10.14740/ijcp326","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88390236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Peeling of Skin Following Post-Streptococcal Atypical Kawasaki Disease: A Case Report and Literature Review","authors":"Sam Hassan","doi":"10.14740/IJCP319","DOIUrl":"https://doi.org/10.14740/IJCP319","url":null,"abstract":"Kawasaki disease (KD) is a systemic vasculitis occurring due to collective immune mechanisms in a genetically susceptible individual, triggered by infections, though the actual cause is yet to be determined. KD is the most common cause of coronary heart disease in children. Typical diagnostic criteria are fever more than 4 days plus four of clinical criteria of cervical lymphadenopathy, skin rashes, mucus membrane redness and lip changes, non-purulent conjunctivitis, peripheral changes in palms and feet. In atypical cases three criteria with fever are enough to commence treatment and echocardiograph early. An often-reported association with KD is streptococcal infections. Skin peeling occurs in both conditions, however in streptococcal infections it occurs early while late during convalescence stage in KD except peeling of the genitocrural area that may occurs early. Skin peeling in the streptococcal infection is related to exotoxin while the cause of the peeling in KD is not well known; but it is likely related to the immunological pathogenesis. Another type of skin peeling that occurs recurrently following the initial attack of KD in many months is of an unknown reason. The presentation in this report is exceptional; it is for the first time reporting association of atypical KD presented with post streptococcal complications and vitamin D deficiency followed by the skin re-peeling 6 months after the patients fully resolved. Moreover, it is for the first time reporting nail changes, painful micturition due to urethral involvement and mucus membrane erythema that all resolved without treatment. The cause possibly is related to innate immune mechanism post infections and possible role for vitamin D deficiency paving the way for the post-group A streptococcal (GAS) vasculitis which is an immune response that later acted to trigger the skin peeling. Patient initially presented with significant peeling of streptococcal infections and features of KD responding to monoclonal antibody. This case highlights that clinicians need to know about recurrent peeling following KD in many months and to make the parents aware about its harmless course. It is the first report of association of post streptococcal atypical KD vasculitis, vitamin D deficiency, skin harmless post-KD skin peeling, nail changes, mucus membrane erythema and painful micturition due to urethral involvement. Int J Clin Pediatr. 2019;8(1):12-18 doi: https://doi.org/10.14740/ijcp319","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84852710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Response to Low-Dose Rituximab Following Development of Severe Hemophagocytic Lymphohistiocytosis Due to Epstein-Barr Virus Infection","authors":"Namiki Hidemasa, Yagasaki Hiroshi, Hiraide Maiko, Morioka Ichiro","doi":"10.14740/IJCP325","DOIUrl":"https://doi.org/10.14740/IJCP325","url":null,"abstract":"Viral infection-associated hemophagocytic lymphohistiocytosis is often observed in children. When Epstein-Barr virus is the pathogen, patients can develop serious coagulopathy and pancytopenia. Usually such patients respond to standard steroid therapy, but alternative therapy for steroid-refractory cases is limited. Here we present the clinical observation of a Japanese girl who was successfully treated with rituximab after she failed to respond to standard steroid therapy. Int J Clin Pediatr. 2019;8(1):8-11 doi: https://doi.org/10.14740/ijcp325","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78747753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Molecular Study of Solid Pseudopapillary Neoplasm of the Pancreas in a Pediatric Patient","authors":"V. Chagas, Marlon D. M. Santos, J. Fischer, B. Ribeiro, F. Rosman, P. Carvalho, Danielle FornyForny, M. Carvalho","doi":"10.14740/IJCP320","DOIUrl":"https://doi.org/10.14740/IJCP320","url":null,"abstract":"Solid pseudopapillary neoplasm of the pancreas (SPNP) is considered as a tumor with low malignant potential. Little is known about how its molecular heterogeneity is involved in its pathogenesis. We aim to evaluate tumor heterogeneity by immunohistochemistry (IH) and proteomics in three macroscopically distinct areas. Tumor fragments were obtained from a 12-year-old female patient. We identified by mass spectrometry (MS) 1,427, 5,786, and 4,298 proteins for each sample, 1,337 being common to all fragments. Several MS results were immunohistochemically validated. Our results demonstrate unique intra-tumor protein profiles based on its heterogeneity. Int J Clin Pediatr. 2018;7(4):63-68 doi: https://doi.org/10.14740/ijcp320","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"2 1","pages":"63-68"},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72800615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Withdrawal Following in Utero Exposure to Kratom","authors":"Emma M. Nellhaus, L. Andrews, J. Haas, D. Miskell, Kenneth Kurek, Zachary Hansen, T. Davies","doi":"10.14740/IJCP317W","DOIUrl":"https://doi.org/10.14740/IJCP317W","url":null,"abstract":"In recent years, the clinical definition of neonatal abstinence syndrome (NAS) has been expanded to describe neonates experiencing withdrawal due to in utero exposure to numerous neuroactive substances, not exclusively opioids. Complex NAS cases involving exposure to multiple and unusual narcotics have become widespread. Kratom is one such substance. It is extracted from tropical tree leaves, and can be used both as a recreational drug and to mitigate opioid withdrawal. Although kratom may potentially serve as a viable opioid alternative, its activity and the consequences of controlled use are largely unstudied, particularly in the pregnant population. A newborn male infant was not initially identified as being at risk for withdrawal due to no maternal admission of substance use and maternal urine drug screen was negative. On the first day of life (DOL), the neonate was observed to exhibit significant signs of withdrawal including high-pitched crying, facial grimacing, irregular respiratory pattern, mottling, and mild undisturbed tremors. Upon interview with the mother it was noted that there was heavy caffeine use, daily cigarette smoking, daily use of the “herbal alternative” (kratom) throughout the pregnancy. In this report, we present a case of NAS precipitated by  in utero exposure to kratom, discuss the present body of research regarding kratom and consider potential implications of escalating kratom use on the incidence and severity of NAS. For this prenatally exposed neonate, clonidine was successfully used to control withdrawal symptoms. Int J Clin Pediatr. 2018;7(4):55-58 doi: https://doi.org/10.14740/ijcp317w","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"15 1","pages":"55-58"},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88023396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scurvy: A Case Report on a Child With Autism","authors":"P. Lim, Bahadun Juanna","doi":"10.14740/ijcp321","DOIUrl":"https://doi.org/10.14740/ijcp321","url":null,"abstract":"Scurvy is a nutritional deficiency which has currently become uncommon. Accurate history taking, strong suspicion and good clinical correlation especially in high risk groups are important in making an early diagnosis. A 9-year-old boy with underlying autism was presented to the Pediatric Dental Clinic with gingival swelling, fever and refusal to walk. The child was subsequently referred to the Pediatric Medical team for suspicion of a hematological malignancy. After a thorough assessment, he was diagnosed of having scurvy due to his peculiar diet habit. Vitamin C supplementation was started as diagnostic and therapeutic measures. Scurvy is a disease caused by chronic vitamin C deficiency. Though it has become uncommon, it still exists in high risk populations. The clinical manifestation of scurvy could be variable and non-specific. In practice, the diagnosis of scurvy is based on history and clinical findings. In cases of suspicion, resolution of disease manifestations after vitamin C supplementation remains the best diagnostic evidence. High index of suspicion is crucial to diagnose scurvy early in modern era. Early diagnosis is important for prompt initiation of treatment and fast resolution of symptoms. Int J Clin Pediatr. 2018;7(4):59-62 doi: https://doi.org/10.14740/ijcp321","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"86 1","pages":"59-62"},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83700485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bowel Movement Patterns and Constipation Prevalence in School Children of South Jordan","authors":"E. Altamimi, M. H. Al-Safadi","doi":"10.14740/IJCP318","DOIUrl":"https://doi.org/10.14740/IJCP318","url":null,"abstract":"Background: Pediatric constipation is a common problem worldwide. Diet is one of the major determinants of bowel movement patterns, including the presence of constipation. Little is known about bowel movement pattern in Jordanian children. Parents might not recognize constipation in school children, which could lead to delayed treatment and increase rate of complication. This study aimed to investigate bowel motion pattern and constipation prevalence in Jordanian children using self-reporting. Methods: Six schools in Alkarak governorate were selected randomly. Students of grades 6 - 8 were asked to fill the Arabic version of Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III (QPGS-RIII) questionnaire. Children were diagnosed with constipation if two or more criteria on the QPGS-RIII were met. Fisher’s exact test was used to analyze categorical data, while Student’s  t -test was used for continuous data. Results: Of 429 questionnaires administered, 413 (96.3%) were completed (males: 50.8%; mean age: 12.7 years old (range: 11 - 16 years old)). A statistically significant sex difference in the presence of hard, bulky bowel movements and fecal incontinence was observed (P = 0.000, 0.041 and 0.002, respectively). In our cohort, 110 (26.6%) children met Rome III criteria for constipation, which was not statistically significant by sex (59 (28.1%) versus 51 (25.1%), male versus female participants, respectively; P = 0.491). Conclusion: Most Jordanian school children reported a daily soft bowel movement without pain or retention. Constipation affects approximately 25% of Jordanian school children between 11 and 16 years old. Int J Clin Pediatr. 2018;7(4):47-50 doi: https://doi.org/10.14740/ijcp318","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"25 1","pages":"47-50"},"PeriodicalIF":0.0,"publicationDate":"2018-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84929315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Klebsiella pneumoniae Nosocomial Infection in an African Pediatrics Health Center: Case of Campus-Teaching Hospital in Togo","authors":"Nadiedjoa Kokou Douti, M. Fiawoo, M. Salou, Kossi M Senagbe, M. Hemou, E. Sanni, D. Y. Atakouma, B. Bakondé, M. Prince-david","doi":"10.14740/IJCP313W","DOIUrl":"https://doi.org/10.14740/IJCP313W","url":null,"abstract":"Background: The target of our study was to analyze clinical, para-clinical and environmental aspects of a nosocomial infection that occurred at the pediatrics division at Campus Teaching Hospital. Methods: This was a prospective study initiated after observation of some suspicious cases of nosocomial infection amongst patients. Forty-one children from 29 days to 15 years of age admitted to the Pediatrics Division at Campus Teaching Hospital for a period of 3 months (from April 1 to June 31, 2016) were taken into account in this study. In our study, we included all sick children who showed a reappearance of severe infectious syndrome after 3 days of admission and whose blood cultures were positive. During this period of study, 20 nurses and six medical doctors were questioned as regards to hands clean during the discharge of their work. Studied parameters were: age, sex, initial treatment, bacteria found, sensibility of bacteria, swab results on medical materials in use and hands care. Results: During the study, 41 cases of blood cultures were identified, out of which 30 (73.17%) tested positive to  Klebsiella pneumoniae . The most concerned range of age was between 1 and 5 (56.09%). The initial diagnoses were dominated by 27 malaria (65.85%) and gastroenteritis fever (17.08%). All isolated cases of  Klebsiella pneumoniae in our study were multi-resistant but sensitive to colistin. Two children out of 30 infected by  Klebsiella pneumoniae died. During the period of study, health staff on duty did not regularly practise proper hands hygiene. Conclusions: The case of nosocomial infection is very common in African health centers and it should draw the attention of health officials. Int J Clin Pediatr. 2018;7(4):51-54 doi: https://doi.org/10.14740/ijcp313w","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"3 1","pages":"51-54"},"PeriodicalIF":0.0,"publicationDate":"2018-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81332723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune Pancreatitis in Two Adolescent Boys","authors":"S. Saadé, C. Yaghi, J. B. Jaoude, B. Eid","doi":"10.14740/IJCP303W","DOIUrl":"https://doi.org/10.14740/IJCP303W","url":null,"abstract":"In this current review, we report the cases of autoimmune pancreatitis in two adolescent boys. The diagnosis was made essentially on the basis of imaging result and response to steroid therapy. One of them developed ulcerative colitis 1 year later, which was in favor of the autoimmune pancreatitis diagnosis. Since the presentation of autoimmune pancreatitis can mimic other conditions, a prompt diagnosis should be made, helping the patient receive adequate treatment and avoid unnecessary surgical interventions. Int J Clin Pediatr. 2018;7(3):39-42 doi: https://doi.org/10.14740/ijcp303w","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"4 1","pages":"39-42"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85235927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}