{"title":"Rapid Response to Low-Dose Rituximab Following Development of Severe Hemophagocytic Lymphohistiocytosis Due to Epstein-Barr Virus Infection","authors":"Namiki Hidemasa, Yagasaki Hiroshi, Hiraide Maiko, Morioka Ichiro","doi":"10.14740/IJCP325","DOIUrl":null,"url":null,"abstract":"Viral infection-associated hemophagocytic lymphohistiocytosis is often observed in children. When Epstein-Barr virus is the pathogen, patients can develop serious coagulopathy and pancytopenia. Usually such patients respond to standard steroid therapy, but alternative therapy for steroid-refractory cases is limited. Here we present the clinical observation of a Japanese girl who was successfully treated with rituximab after she failed to respond to standard steroid therapy. Int J Clin Pediatr. 2019;8(1):8-11 doi: https://doi.org/10.14740/ijcp325","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"33 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Clinical Pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14740/IJCP325","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Viral infection-associated hemophagocytic lymphohistiocytosis is often observed in children. When Epstein-Barr virus is the pathogen, patients can develop serious coagulopathy and pancytopenia. Usually such patients respond to standard steroid therapy, but alternative therapy for steroid-refractory cases is limited. Here we present the clinical observation of a Japanese girl who was successfully treated with rituximab after she failed to respond to standard steroid therapy. Int J Clin Pediatr. 2019;8(1):8-11 doi: https://doi.org/10.14740/ijcp325