Rapid Response to Low-Dose Rituximab Following Development of Severe Hemophagocytic Lymphohistiocytosis Due to Epstein-Barr Virus Infection

Namiki Hidemasa, Yagasaki Hiroshi, Hiraide Maiko, Morioka Ichiro
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引用次数: 2

Abstract

Viral infection-associated hemophagocytic lymphohistiocytosis is often observed in children. When Epstein-Barr virus is the pathogen, patients can develop serious coagulopathy and pancytopenia. Usually such patients respond to standard steroid therapy, but alternative therapy for steroid-refractory cases is limited. Here we present the clinical observation of a Japanese girl who was successfully treated with rituximab after she failed to respond to standard steroid therapy. Int J Clin Pediatr. 2019;8(1):8-11 doi: https://doi.org/10.14740/ijcp325
爱泼斯坦-巴尔病毒感染引起的严重噬血细胞淋巴组织细胞增多症后低剂量利妥昔单抗的快速反应
病毒性感染相关的噬血细胞性淋巴组织细胞增多症常见于儿童。当爱泼斯坦-巴尔病毒为病原体时,患者可出现严重的凝血功能障碍和全血细胞减少症。通常这类患者对标准类固醇治疗有反应,但对类固醇难治性病例的替代治疗是有限的。在这里,我们提出的临床观察,一个日本女孩谁是成功的治疗利妥昔单抗后,她未能响应标准类固醇治疗。中华临床儿科杂志,2019;8(1):8-11 doi: https://doi.org/10.14740/ijcp325
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