International Journal of Clinical Pediatrics最新文献

{"title":"Kawasaki Disease Complicated by Peripheral Gangrene in a Case of Inherited Thrombophilia","authors":"Faten Al Tasseh, H. Khatib, Rodaina Kordab, S. Ghanem, Z. Naja, A. Naja, Georges Haber, M. Rajab, Malek J Baassiri, R. Haidar","doi":"10.14740/IJCP306W","DOIUrl":"https://doi.org/10.14740/IJCP306W","url":null,"abstract":"Kawasaki disease is a febrile vasculitis targeting medium sized arteries, causing coronary artery aneurysm without appropriate treatment. Many children do not fulfill the criteria and due to its serious complications, the American Heart Association (AHA) published an algorithm for atypical Kawasaki disease based on laboratory tests and echocardiography. Peripheral ischemia is a rare complication with harmful sequalae. Here we reports a case of a 14-month-old patient, who was diagnosed of atypical Kawasaki disease, developed peripheral ischemia and gangrene of the second and third right hand fingers, and was found to have factor V Leiden heterozygous mutation. Int J Clin Pediatr. 2018;7(3):43-45 doi: https://doi.org/10.14740/ijcp306w","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"14 1","pages":"43-45"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84023590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Infectious Parotitis in Infants with Severe Bronchopulmonary Dysplasia: A Case Series","authors":"J. Sharma, C. Lachica, W. Manimtim","doi":"10.14740/IJCP302W","DOIUrl":"https://doi.org/10.14740/IJCP302W","url":null,"abstract":"We report four former extremely premature infants with severe bronchopulmonary dysplasia (BPD) who had tracheostomy for prolonged mechanical ventilation and presented with non-infectious parotitis while still in the neonatal intensive care unit. A retrospective chart review of patients with BPD who developed parotitis was conducted over a 5-year period at a level IV neonatal intensive care unit with a BPD home ventilator program. During this 5-year period, there were 409 patients with BPD, and 48 (11.7%) of these patients had a tracheostomy (severe BPD). Four patients with severe BPD with tracheostomy and on mechanical ventilation developed non-infectious parotitis. All four patients initially underwent an infectious work-up, which were negative. Non-infectious parotitis can complicate the clinical course of tracheostomized and ventilator-dependent infants with severe BPD. Awareness of this condition in infants with chronic illness will prevent unnecessary investigations since the clinical course is self-limited. Int J Clin Pediatr. 2018;7(3):36-38 doi: https://doi.org/10.14740/ijcp302w","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"16 1","pages":"36-38"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90846279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speech and Feeding Improvements in Children After Posterior Tongue-Tie Release: A Case Series","authors":"R. Baxter, Lauren Hughes","doi":"10.14740/IJCP295W","DOIUrl":"https://doi.org/10.14740/IJCP295W","url":null,"abstract":"Ankyloglossia, commonly referred to as “tongue-tie,” has recently seen a surge in cases and awareness with a corresponding increase in diagnosis and treatment. The evidence linking tongue-tie release and breastfeeding improvement has been published previously. However, due to a lack of published evidence for children, many medical professionals still believe that a restricted tongue does not contribute to feeding or speech issues in older children. The condition of tongue-tie exists on a continuum with variable visibility and symptoms. Some restrictions, mainly anterior or “classic” tongue-tie, are highly visible and easier to detect. However, “posterior” or submucosal tongue-ties are often more challenging to diagnose. Recently, an increase in awareness and education has led to improved detection of these posterior tongue-ties. The data presented in these case studies will demonstrate that even posterior ties restrict movement and affect oral structures that are required for speech and feeding. In this case series, five patients with posterior tongue restrictions underwent CO 2 laser frenectomy without any general anesthesia or sedation. After a quick in-office procedure, all five patients demonstrated increased lingual mobility evidenced by improved speech and feeding skills. Some improvements were observed immediately after the procedure by clinical staff and the child’s family. While these patients required continued intervention from a speech-language pathologist, their improved lingual mobility allowed for more significant and faster improvement in speech and feeding skills. These cases challenge the status quo that speech and feeding are not affected by posterior tongue-tie. Continued research is warranted to determine the impact that all classes of lingual restrictions can have on speech and feeding development. Int J Clin Pediatr. 2018;7(3):29-35 doi: https://doi.org/10.14740/ijcp295w","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"18 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86153231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study for Probiotics and Symbiotics Versus Placebo in Pediatrics Acute Diarrhea: Randomized Controlled Trial","authors":"Pamela Houeiss, A. Farah, P. Noun, M. AlOjaimi, G. AbiFares, M. Amm, H. Feghali, G. Nicolas, G. Nader, M. Samarani, P. Makhoul, M. Khalife","doi":"10.14740/IJCP288E","DOIUrl":"https://doi.org/10.14740/IJCP288E","url":null,"abstract":"Background: Acute diarrhea is a major cause of morbidity and mortality in children, particularly in developing countries (the second cause of death). Probiotics and symbiotics are recent treatments for this disease, especially in the acute phase. Our objective is to compare probiotic or symbiotic treatment against placebo in acute diarrhea by following the evolution of diarrhea in terms of hours, number of bowel movements, volume of stools and their consistency. On a larger scale, we want to find a cost-effective intervention that reduces the morbidity and mortality of diarrhea. Methods: Eighty-three children aged 6 months to 5 years, from three different regions of Mount Lebanon, were randomized to receive a probiotic, a symbiotic or a placebo once daily for 5 days. Patients were excluded from the study if they had any history of a chronic disease. The statistical analysis was carried out on SPSS v22.00 Results: Out of 120 surveys distributed to parents, 84 were completed: 43 patients received probiotics (nine received Lactobacillus , 21 received spores, and 13 patients received yeast), 24 received symbiotics and 17 were controls. Stool consistency normalized on day 4 in the probiotics and symbiotics groups (P = 0.009). Less number of days with fever (P = 0.018) were observed in the probiotic and symbiotic groups (1 day) compared to placebo (4 days). No difference in the symptoms associated with diarrhea was observed in the different groups. Conclusions: Probiotics and symbiotics normalized stool consistency in pediatric diarrhea by day 4 and decreased the number of days with fever compared to control. Our study did not show a statistically significant difference between the different probiotics and symbiotics for the treatment of diarrhea. Int J Clin Pediatr. 2018;7(3):21-28 doi: https://doi.org/10.14740/ijcp288e","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"108 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2018-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87642850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Renal Ultrasound in Children With Febrile Urinary Tract Infection","authors":"Dr. Shabbeer, M. Nizamuddin","doi":"10.26326/2281-9649.28.3.1869","DOIUrl":"https://doi.org/10.26326/2281-9649.28.3.1869","url":null,"abstract":"Background: This study was designed to examine the capability of renal ultrasonography (US) for predicting vesicoureteral reflux (VUR) and renal scarring (RS), and to assess, using initial US, the significant urologic abnormalities that impact on management of children hospitalized with the first febrile urinary tract infection (UTI). Methods: Hospitalized children aged ≤ 2 years with the first febrile UTI were prospectively evaluated using imaging studies, including 99mTc dimercaptosuccinic acid (DMSA) scan, US, and voiding cystourethrography. Results: Of the 310 children analyzed (195 boys and 115 girls), 105 (33.9%) had abnormal US. Acute DMSA scans were abnormal in 194 children (62.6%), including 89 (45.9%) with concomitant abnormal US. There was VUR in 107 children (34.5%), including 79 (25.5%) with grades III-V VUR. The sensitivity and negative predictive values of US were 52.3% and 75.1%, respectively, for grades I-V VUR; and 68.4% and 87.8%, respectively, for grades III-V VUR. Eighty-five children (27.4%) had RS, including 55 (64.7%) with abnormal US. Of the 105 children with abnormal US, 33 (31.4%) needed subsequent management (surgical intervention, parental counseling, or follow-up of renal function). Nephromegaly on initial US and grades III-V VUR were risk factors of RS. Conclusions: Abnormal US may carry a higher probability of grades III-V VUR and RS, and can affect subsequent management in a significant number of children. Nephromegaly on initial US and grades III-V VUR are strongly associated with an increased risk for RS. Thus, US should be performed on children after the first febrile UTI and children with normal US may not require voiding cystourethrography. Int J Clin Pediatr. 2018;7(1-2):6-12 doi: https://doi.org/10.14740/ijcp295e","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"75 1","pages":"6-12"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81240704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fulminant Hepatic Failure in Measles in a 6-Month-Old Child","authors":"S. Sati, Shreshtha Banga, Swadesh Singh Bhadouria","doi":"10.14740/ijcp294w","DOIUrl":"https://doi.org/10.14740/ijcp294w","url":null,"abstract":"Measles is known to cause self-limiting illness, mostly in children. Measles is a systemic infection with known complications but information regarding the consequences of liver involvement is limited. Fulminant hepatic failure has been reported rarely in very young children. We present here a case of fulminant hepatitis in a 6-month-old child with measles from central India. Int J Clin Pediatr. 2018;7(1-2):17-18 doi: https://doi.org/10.14740/ijcp294w","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"25 1","pages":"17-18"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75125726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Transfusion: Uncross-Matched “O” Negative Blood From Unrelated Donors in Emergency","authors":"Sanjay G Gokhale, S. Gokhale","doi":"10.14740/IJCP291W","DOIUrl":"https://doi.org/10.14740/IJCP291W","url":null,"abstract":"","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"118 1","pages":"19-20"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75467886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acrocyanosis Presentation in Postural Orthostatic Tachycardia Syndrome","authors":"J. Abou-Diab, Dina Moubayed, D. Taddeo, O. Jamoulle, C. Stheneur","doi":"10.14740/IJCP293W","DOIUrl":"https://doi.org/10.14740/IJCP293W","url":null,"abstract":"Postural orthostatic tachycardia syndrome (POTS) is a clinical chronic condition characterized by chronic fatigue and orthostatic symptoms associated with postural tachycardia. Early diagnosis and intervention can prevent significant functional consequences, although it can be very difficult to recognize. Two cases of POTS were presented in this article to help clinicians identify POTS more easily. Firstly, we present a 16-year-old adolescent female who was hospitalized for daily headaches, chronic fatigue, bilateral lower limbs discoloration and edema on standing position associated with orthostatic symptoms. All investigations were negative except for tilt table test, which showed heart rate increase of 80 beats per min, hypotension and discoloration of lower limbs, confirming POTS diagnosis. Non-pharmacological treatment showed no improvement. Midodrine was started because of β-blockers intolerance with only moderate response. Secondly, we present a 17-year-old patient diagnosed with benign hypermobility syndrome who was referred for recurring episodes of palpitations associated with heat, nausea, headache and vertigo for the past year. She also reported dizziness and lower limbs discoloration on standing position. Previous investigations were negative. A clinical diagnosis of POTS was made based on history. Non-pharmacologic treatments with hydration, increase of salt intake and regular exercise were tested. However, no improvement was shown. Symptoms were controlled by a propranolol trial. These cases relate a clinical sign that can be easily identified by a clinician attempting to diagnose POTS. Acrocyanosis can be unquestioned or ignored. Clinicians should be attentive to this condition, and attempt to diagnose its underlying causes. This can result in lowering unnecessary testing and interventions. Patients with dependent acrocyanosis should be closely evaluated for the diagnosis of POTS. Int J Clin Pediatr. 2018;7(1-2):13-16 doi: https://doi.org/10.14740/ijcp293w","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"20 1","pages":"13-16"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85908493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear Growth and Nutritional Status of Young Gabonese Sickle Cell Patients, and Associated Factors","authors":"E. K. Kamgaing, S. M. Rogombe, J. Minko, Carine Eyi Zang, U. Bisvigou, J. Koko, S. Ategbo","doi":"10.14740/IJCP290W","DOIUrl":"https://doi.org/10.14740/IJCP290W","url":null,"abstract":"Background: Stunting and undernutrition mark the nutritional status of the sickle cell patient, but some surveys show trends to overweight in some countries. The primary objective of this study was to compare the growth of children with sickle cell, with non-sickle cell children in Gabon. Methods: It was a prospective case-control study, conducted from April to June 2016 in Libreville and Lambarene in Gabon. Cases were homozygous (SS) sickle cell children aged from 0 to 15 years; controls were normal hemoglobin-AA documented, matched by sex and age. We compared their weight, height, arm and head circumferences measured according to conventional techniques. Results: We compared 118 cases to 118 controls, mean age was 85 ± 7.2 months, and the sex ratio was 1.07. Before 59 months, there was no significant difference in the comparison of the averages of the anthropometric indices except for the z-score of the brachial perimeter for age which was smaller in the cases (-0.85 versus -0.19, P = 0.04). The risk of stunting in cases was greater (odds ratio (OR) = 6.9, 95% confidence interval (CI): 5.4 - 8.3), the growth retardation increased with age, correlated factors with growth retardation were male gender (relative risk (RR) = 2.04, 95% CI: 1.2 - 2.7), a mother with no remunerative activity (r = 0.11, P 3 (r = 0.2, P = 0.003), and mean hematocrit of 9.6-15.9% (r = 0.4, P < 0.004). There were no obese subjects in cases. Conclusions: Growth retardation of children suffering from sickle cell in Gabon appears and increases with age. Male gender, low socioeconomic conditions and signs of severity or non-controlled disease are correlated with this retardation. Int J Clin Pediatr. 2018;7(1-2):1-5 doi: https://doi.org/10.14740/ijcp290w","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"44 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79126758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lebanese Registry in the Management of Antibiotic Associated Diarrhea in Children: Observational Study in Daily Practice","authors":"E. Choueiry, R. Kamel, H. Chacar, P. Mouawad, R. Sacy","doi":"10.14740/ijcp269w","DOIUrl":"https://doi.org/10.14740/ijcp269w","url":null,"abstract":"Background: Antibiotic-associated diarrhea (AAD) is a common complication in patients prescribed antibiotics, and represents an economic and health burden. Evidence that probiotics may be beneficial for the prevention of AAD is increasing. The aims of this registry were to assess the prevalence of probiotic prescriptions in pediatric patients for whom an antibiotic treatment regimen was prescribed, and to explore the potential health benefits that such an administration may provide. Methods: This longitudinal, multicenter, observational study enrolled 249 pediatric patients prescribed an antibiotic treatment for 5 - 14 days, with or without a concomitant probiotic. The number of probiotic-administered patients, and AAD incidence rates throughout the 15-day follow-up period, were assessed. Results: Of the 246 patients who met inclusion/exclusion criteria in Lebanon, the investigators had prescribed an additional probiotic treatment to 118 (48%) of them, while, the other 128 (52%) did not receive such additional treatment. A significantly higher number of patients in the probiotic group were at high risk of developing diarrhea (probiotic: 27.1% vs. no probiotic: 6.3%; P < 0.001). Among high risk patients, the frequency of diarrhea was doubled in the group with no probiotics (probiotic: 21.9% (n = 7) vs. no probiotic: 50.0% (n = 4); P = 0.182). Despite the significantly larger number of probiotic-administered patients that were at high risk of developing diarrhea, the proportion of patients who reported developing diarrhea was not statistically different between the two groups (probiotic: n = 22 (18.6%) vs. no probiotic: n = 24 (18.8%); P = 0.983). Conclusions: In conclusion, this Lebanese disease registry demonstrated that almost half of pediatric patients with mild to moderate infections were prescribed probiotics in combination with antibiotics to decrease the risk of AAD. This observation was particularly significant in the high risk population as per the treating physician’s judgment. Int J Clin Pediatr. 2017;6(1-2):8-19 doi: https://doi.org/10.14740/ijcp269w","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"16 1","pages":"8-19"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72636235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}