{"title":"爱泼斯坦-巴尔病毒感染引起的严重噬血细胞淋巴组织细胞增多症后低剂量利妥昔单抗的快速反应","authors":"Namiki Hidemasa, Yagasaki Hiroshi, Hiraide Maiko, Morioka Ichiro","doi":"10.14740/IJCP325","DOIUrl":null,"url":null,"abstract":"Viral infection-associated hemophagocytic lymphohistiocytosis is often observed in children. When Epstein-Barr virus is the pathogen, patients can develop serious coagulopathy and pancytopenia. Usually such patients respond to standard steroid therapy, but alternative therapy for steroid-refractory cases is limited. Here we present the clinical observation of a Japanese girl who was successfully treated with rituximab after she failed to respond to standard steroid therapy. Int J Clin Pediatr. 2019;8(1):8-11 doi: https://doi.org/10.14740/ijcp325","PeriodicalId":13773,"journal":{"name":"International Journal of Clinical Pediatrics","volume":"33 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Rapid Response to Low-Dose Rituximab Following Development of Severe Hemophagocytic Lymphohistiocytosis Due to Epstein-Barr Virus Infection\",\"authors\":\"Namiki Hidemasa, Yagasaki Hiroshi, Hiraide Maiko, Morioka Ichiro\",\"doi\":\"10.14740/IJCP325\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Viral infection-associated hemophagocytic lymphohistiocytosis is often observed in children. When Epstein-Barr virus is the pathogen, patients can develop serious coagulopathy and pancytopenia. Usually such patients respond to standard steroid therapy, but alternative therapy for steroid-refractory cases is limited. Here we present the clinical observation of a Japanese girl who was successfully treated with rituximab after she failed to respond to standard steroid therapy. Int J Clin Pediatr. 2019;8(1):8-11 doi: https://doi.org/10.14740/ijcp325\",\"PeriodicalId\":13773,\"journal\":{\"name\":\"International Journal of Clinical Pediatrics\",\"volume\":\"33 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Clinical Pediatrics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14740/IJCP325\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Clinical Pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14740/IJCP325","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Rapid Response to Low-Dose Rituximab Following Development of Severe Hemophagocytic Lymphohistiocytosis Due to Epstein-Barr Virus Infection
Viral infection-associated hemophagocytic lymphohistiocytosis is often observed in children. When Epstein-Barr virus is the pathogen, patients can develop serious coagulopathy and pancytopenia. Usually such patients respond to standard steroid therapy, but alternative therapy for steroid-refractory cases is limited. Here we present the clinical observation of a Japanese girl who was successfully treated with rituximab after she failed to respond to standard steroid therapy. Int J Clin Pediatr. 2019;8(1):8-11 doi: https://doi.org/10.14740/ijcp325