International Archives of Occupational and Environmental Health最新文献

{"title":"Association of coexposure to indoor solid fuels, outdoor air pollution, and heatwave with the risk of Cardiometabolic Multimorbidity among middle-aged and older Chinese adults.","authors":"Wei Kong, Honglin Zheng, Mingye Zhu, Mingqi Zhang, Jialin Wang, Wen Zhong, Fang Wang","doi":"10.1007/s00420-026-02232-4","DOIUrl":"10.1007/s00420-026-02232-4","url":null,"abstract":"<p><strong>Background: </strong>Indoor solid fuels, outdoor air pollution (PM₁, PM_2.5, and PM₁₀), and heatwave are all modifiable environmental factors. However, their mixed effects on Cardiometabolic Multimorbidity (CMM) and its core component diseases (diabetes, heart disease, and stroke) remain unclear.</p><p><strong>Methods: </strong>In this study, four diseases analysis cohorts (CMM: n = 10,273; diabetes: n = 9,893; heart disease: n = 9,536; and stroke: n = 10,466) were constructed using data from the five waves (2011, 2013, 2015, 2018, and 2020) of the CHARLS. A time-varying Cox proportional hazards model was used to estimate the hazard ratio (HR) for environmental factor exposure. The Cumulative Risk Index (CRI) and the Quantile g-computation (Qgcomp) model were employed to assess the cumulative effect and component weights of coexposure to multiple environmental factors.</p><p><strong>Results: </strong>The single-exposure analysis indicated that indoor solid fuels use significantly increased heart disease (HR = 1.118, 95% CI 1.016-1.231) and stroke (HR = 1.149, 95% CI 1.007-1.310) risks. PM₁, PM_2.5, and PM₁₀ were the most consistent risk factors for CMM, diabetes, and heart disease (all HRs > 1, P < 0.001), and heatwave was sometimes associated with higher risks of CMM, diabetes, and heart disease. The CRI analysis demonstrated that coexposure to multiple environmental factors increased the CMM, diabetes, and heart disease risks. The Qgcomp model further showed that these coexposure increased the risk of four diseases, with ORs (95% CIs) (CMM:1.650, 1.375-1.979; diabetes: 1.675, 1.475-1.903; heart disease: 1.228, 1.080-1.397; stroke: 1.205, 1.011-1.437), with indoor solid fuels use as the primary contributor.</p><p><strong>Conclusions: </strong>In conclusion, long-term coexposure to indoor solid fuels, outdoor air pollution, and heatwave increased the risk of CMM and its core component diseases. Indoor solid fuels play a main role in these effects.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are younger workers more at risk? a study on age differences in occupational exposure to carcinogens.","authors":"Alberto Scarselli, Marisa Corfiati, Alessandro Marinaccio","doi":"10.1007/s00420-026-02238-y","DOIUrl":"10.1007/s00420-026-02238-y","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to describe the levels of occupational exposure to the most common cancer-causing agents in the Italian industrial context, with a particular focus on age differences to identify high-risk groups of young workers.</p><p><strong>Methods: </strong>Data on exposure to carcinogens were extracted from the national occupational exposures database (SIREP), covering exposure measurements collected between 1996 and 2024. Thirteen carcinogenic agents with over 10,000 recorded measurements were analysed. Exposure intensity was categorised as low, medium, or high according to European regulatory standards. Multinomial logistic and linear mixed-effects regression models, adjusted for gender and calendar period, were used to assess the association between age and exposure level.</p><p><strong>Results: </strong>A total of 457,291 exposure measurements were selected for the main carcinogens registered in SIREP. Exposed workers (159,582) were only in a small proportion women (9%) and mostly aged between 20 and 44 years in both genders (63% in women, 57% in men). Young people (i.e., under 30) constituted a considerable portion of the total exposed workers (25%) and compared to older workers (≥ 30) had 17.6% higher exposure levels overall, 18.4% in men and 11.2% in women. Age differences in exposure persisted mainly across industries and job categories, but also by gender and nationality.</p><p><strong>Conclusion: </strong>This study underscores the necessity for targeted preventive strategies, including tailored training programmes, enhanced supervision, and rigorous enforcement of safety protocols for young workers. Improved monitoring and age-specific interventions are essential to reduce occupational cancer risks and safeguard the health of the younger workforce.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term cancer trends among male Taiwanese farmers: an age-period-cohort analysis (2000-2023).","authors":"Lynn M Francis, Amr S Soliman, Liang-You Wu, Chi-Jung Chung","doi":"10.1007/s00420-026-02235-1","DOIUrl":"10.1007/s00420-026-02235-1","url":null,"abstract":"<p><strong>Purpose: </strong>Male farmers are frequently exposed to various environmental and occupational hazards that may be related to cancer risk. Long-term cancer incidence trends in male farmers in Taiwan remain unclear. This study examined temporal trends in cancer incidence among male farmers over a 24-year period.</p><p><strong>Methods: </strong>Using Taiwan's Longitudinal Health Insurance Database of Patients with Catastrophic Illnesses (2000-2023), we conducted a nationwide cohort study of agricultural workers whose aged 15-84 (N= 2,426,531). ICD-O-3 and the corresponding ICD-9-CM and ICD-10-CM codes from the Taiwan Cancer Registry Annual Report were used to identify annually incident cancer cases. Age-standardized incidence rates, age-standardized rate ratios, and age-standardized incidence ratios were calculated. A Joinpoint regression and age-period-cohort model were used to identify and examine temporal trends across the study period.</p><p><strong>Results: </strong>Overall cancer incidence was higher among male farmers compared to the male general population, with an increasing temporal trend from 2000 to 2023. Lip and lung cancers showed a significantly increased annual average percentage change (AAPC) value, age effect, period effect, and cohort effect for the study period, while liver cancer showed a decreasing AAPC, period effect, and cohort effect, with an increasing age effect over the entire study period.</p><p><strong>Conclusion: </strong>This study provides evidence that lung and lip cancer incidence among male farmers increased significantly over the study period, while liver cancer decreased. As exposure varies by agricultural activity and farm type, further research is needed to identify specific exposures that are related to the higher risk of cancer in this population.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shift work, accelerated biological aging and mortality risk in US adults: a national prospective cohort study.","authors":"Ruhan Wang, Keyu Yuan, Tingting Li, Buyun Liu, Wei Bao, Shuang Rong","doi":"10.1007/s00420-026-02233-3","DOIUrl":"10.1007/s00420-026-02233-3","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association between shift work and all-cause and cause-specific mortality in the U.S. population and assess whether biological age acceleration mediates this relationship.</p><p><strong>Design, setting, and participants: </strong>A prospective cohort study included 7548 adults from the National Health and Nutrition Examination Survey (NHANES) 2005-2010, with mortality follow-up through 2019.</p><p><strong>Exposure: </strong>Shift work included regular night, evening, or rotating shifts versus daytime schedules.</p><p><strong>Main outcomes and measures: </strong>Primary outcomes were all-cause, cardiovascular (CVD), and cancer mortality.</p><p><strong>Results: </strong>Among 7548 participants (mean follow-up 11.6 years), 358 deaths occurred. Shift work was associated with significantly increased all-cause mortality after full adjustment (HR = 1.52; 95% CI 1.09-2.13). CVD and cancer mortality associations were non-significant. No statistically significant interactions were observed in subgroup analyses of all-cause mortality. Shift workers showed greater PhenoAge acceleration (β = 0.39 years), which statistically accounted for 6.18% of the association between shift work and all-cause mortality.</p><p><strong>Conclusions and relevance: </strong>Shift work was associated with higher all-cause mortality and greater PhenoAge acceleration. PhenoAge acceleration may statistically account for a small proportion of this association, although causal mediation cannot be inferred.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal changes in short-term PM_2.5-cardiorespiratory mortality associations and implications for the health benefits of the clean air action in the Sichuan Basin, 2014-2022.","authors":"Jiayi Chen, Yue Ou, Jian Qian, Jing Zeng, Sheng Li, Junyu Wang, Na Yang, Tao Zhang, Fei Yin, Chenglin Tao, Xinyin Xu, Nan Wang, Menglu Jiang, Ying Deng, Yue Ma","doi":"10.1007/s00420-026-02237-z","DOIUrl":"10.1007/s00420-026-02237-z","url":null,"abstract":"<p><strong>Background: </strong>Evidence remains limited on how PM_2.5-related mortality risk has evolved under sustained air-quality improvement following the implementation of the Clean Air Action (CAA), and how such changes have influenced related health benefits. This study aimed to investigate temporal changes in short-term PM_2.5-related cardiorespiratory mortality associations and to quantify the respective contributions of PM_2.5 concentration reductions and risk changes to mortality outcomes.</p><p><strong>Methods: </strong>We conducted a multi-county time-series study in the Sichuan Basin, China, covering the period from 2014 to 2022. An extended two-stage analytical framework was applied to estimate county -specific PM_2.5-mortality associations, followed by pooled analyses. Longitudinal meta-regression was used to assess annual trends in excess risk (ER), and period-specific analyses were performed across different stages of the CAA. Scenario analyses were conducted to quantify mortality changes attributable to PM_2.5 concentration reductions and to temporal changes in the exposure-response relationship.</p><p><strong>Results: </strong>A significant nonlinear temporal pattern in ER per 10 μg/m³ increase in PM_2.5 was observed (P < 0.001), characterized by an increase during 2014-2016, a decline during 2017-2019, and an increase again during 2020-2022. Corresponding ERs for the three periods were 0.7% (95% CI: 0.6%-0.9%), 0.4% (95% CI: 0.3%-0.6%), and 1.4% (95% CI: 1.2%-1.6%), respectively. Declining PM_2.5 concentrations were associated with 52,831 fewer cardiorespiratory deaths, whereas changes in ER increased mortality by 10,041 deaths. The later period increase in risk was consistently observed across sexes and was more pronounced among individuals aged 65 years and older.</p><p><strong>Conclusions: </strong>Temporal increases in short-term PM_2.5-related mortality risk partially offset the health benefits achieved through reductions in PM_2.5 concentrations during the later CAA period. These findings highlight the importance of incorporating time-varying health risk and population vulnerability into evaluations of air quality policies.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific basis and applicability of the ISO 2631-1 health guidance caution zone.","authors":"Marco Tarabini, Genevieve Williams, Suzanne Smith, Setsuo Maeda, Massimo Bovenzi","doi":"10.1007/s00420-026-02236-0","DOIUrl":"10.1007/s00420-026-02236-0","url":null,"abstract":"<p><strong>Purpose: </strong>This work evaluates the scientific foundation and practical applicability of the Health Guidance Caution Zone (HGCZ) defined in the ISO 2631-1 standard for assessing health risks from whole-body vibration. The primary objective is to investigate the HGCZ's derivation process, its underlying data sources, and its effectiveness in predicting adverse health outcomes across various occupational environments.</p><p><strong>Methods: </strong>This study examines the relationship between vibration metrics-such as frequency-weighted acceleration and vibration dose value-and reported musculoskeletal, neurological, and vascular outcomes, while also considering the role of individual confounding factors, including posture, age, and body mass index, in shaping exposure-response relationships.</p><p><strong>Results: </strong>HGCZ boundaries were identified as pragmatic expert compromises rather than being derived from quantitative dose-response relationships. While the zone is a reasonable predictor for low back pain in seated operators, it lacks empirical support for neck, shoulder, or vascular outcomes. Analysis of aviation data showed that most flight scenarios reached caution thresholds significantly faster than traditional land-based driving, while individual factors such as posture and body mass index were found to modify actual health outcomes.</p><p><strong>Conclusion: </strong>We suggest the evolution of the HGCZ toward a probabilistic framework, where fixed thresholds are complemented by models linking exposure magnitude and duration to the likelihood of specific health outcomes (not only low back pain). Supported by biomechanical modelling and segment-specific frequency weightings, this approach would enable a more accurate assessment of WBV risk, extending rather than replacing the current framework.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leisure-time and commuting physical activity and subsequent sickness absence among young and early midlife employees: a register-linked follow-up study 2017-2020.","authors":"Ville Päivärinne, Pi Fagerlund, Jouni Lahti, Ossi Rahkonen, Tea Lallukka","doi":"10.1007/s00420-026-02234-2","DOIUrl":"10.1007/s00420-026-02234-2","url":null,"abstract":"<p><strong>Purpose: </strong>We examined leisure-time physical activity (LTPA) and active commuting (AC) and their associations with subsequent sickness absence (SA) among young and early midlife employees.</p><p><strong>Methods: </strong>The 2017 Helsinki Health Study survey among employees of the City of Helsinki aged 19-39 was prospectively linked to register-based data on total, short- and long-term SA spells (2017-2020). LTPA (n=3618) and AC (n=3513) were assessed as weekly metabolic equivalent (MET) hours in 2017. LTPA was categorized into five groups based on intensity and weekly volume (inactivity, moderate, moderate-to-vigorous, vigorous and high vigorous) and AC into four groups (inactive, low moderate, moderate-to-vigorous, vigorous). Analyses were stratified by sex and adjusted for sociodemographic and lifestyle factors using negative binomial regression to estimate incidence rate ratios (IRRs) and their 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Women had more SA than men (135 vs 97 days per 10 person-years; p<0.001). Women with moderate-to-vigorous LTPA had, compared to the inactive, lower rates of total SA (IRR 0.69, 95% CI 0.60-0.80) short SA and long SA after full adjustments for covariates. Men with vigorous LTPA remained protective in total SA days (IRR 0.60, 95% CI 0.44-0.81) and short SA spells after adjustment. For AC, protective associations were observed only among women.</p><p><strong>Conclusion: </strong>LTPA including vigorous-intensity activity was associated with lower SA over the follow-up, although patterns differed by sex and activity level. Associations for AC were weaker and confirmed for women only. Vigorous-intensity physical activity may be beneficial for reducing SA already in early working life.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effort-reward imbalance model in policing: associations with mental health and work functioning among sworn and civilian employees.","authors":"Bjørn Lau, Knut Inge Fostervold, Brita Bjørkelo","doi":"10.1007/s00420-026-02231-5","DOIUrl":"10.1007/s00420-026-02231-5","url":null,"abstract":"<p><strong>Objective: </strong>The Effort-Reward Imbalance (ERI) model is widely used to explain work-related stress and its health consequences. In policing, ERI research has primarily focused on sworn officers, while civilian employees have received limited attention. The purpose of this study was to examine whether ERI variables are associated with mental health and occupational functioning among police employees, and whether these associations differ between sworn officers and civilian personnel.</p><p><strong>Methods: </strong>This cross-sectional study included sworn police officers and civilian employees in the Norwegian police. A random sample of 4000 employees was invited to complete an online survey, and 560 employees participated. Effort, reward, and overcommitment were measured with the 16-item short ERI questionnaire, and the ERI ratio was calculated from the effort and reward scales. Anxiety symptoms, depressive symptoms, work engagement, and job-related self-efficacy were assessed using separate questionnaires. Group differences were examined using analyses of covariance, and associations between ERI predictors and outcome variables were tested using hierarchical regression analyses with interaction terms for occupational role.</p><p><strong>Results: </strong>In the covariate-adjusted analytic sample (N = 558), no significant differences were observed between sworn officers and civilian employees in ERI variables, mental health outcomes, or occupational functioning. Higher ERI ratio was associated with higher anxiety symptoms (β = 0.28) and depressive symptoms (β = 0.33) and with lower work engagement (β = - 0.27) and job-related self-efficacy (β = - 0.16). Overcommitment showed stronger associations with anxiety symptoms (β = 0.50) and depressive symptoms (β = 0.46) and was inversely associated with job-related self-efficacy (β = - 0.28) and work engagement (β = - 0.14). Occupational role did not moderate these associations.</p><p><strong>Conclusions: </strong>The findings support the ERI model by demonstrating consistent associations between effort-reward imbalance, overcommitment, mental health, and occupational functioning in policing. Neither the levels of the ERI variables nor their associations with the outcomes differed by occupational role, suggesting that ERI processes operate similarly across occupational categories within a highly regulated welfare-state context.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reciprocal longitudinal associations between job insecurity and depressive symptoms in young working women: the SLOSH study 2010-2020.","authors":"Ylva Lindberg, Kristiina Rajaleid, Göran Kecklund, Paraskevi Peristera, Anna Nyberg","doi":"10.1007/s00420-026-02230-6","DOIUrl":"10.1007/s00420-026-02230-6","url":null,"abstract":"<p><strong>Objective: </strong>To investigate job insecurity and symptoms of depression in different labour market groups, with a specific focus on young women.</p><p><strong>Methods: </strong>Data were drawn from six waves of the Swedish Longitudinal Occupational Survey of Health (n = 14,827) in 2010-2020. Differences in job insecurity between young (≤ 35) working women and other gender and age (> 35) groups, and between labour market industries with different gender composition, were estimated. Longitudinal multilevel structural equation models were fitted to estimate reciprocal associations between job insecurity and depressive symptoms two years later, while adjusting for demographic and employment factors.</p><p><strong>Results: </strong>Younger workers reported significantly higher job insecurity compared with older. For older workers job insecurity was significantly lower in female dominated industries, whereas this pattern was not observed among younger workers. There was a medium strong path between job insecurity and depressive symptoms in young working women (0.106, p = 0.001), and men (0.111, p = 0.011). The reverse associations were not statistically significant. For older women and men, the effect sizes for associations between job insecurity and depression were small (0.044, p = 0.000 and 0.047, p = 0.000, respectively) whereas reverse paths estimates were of medium strength (0.077, p = 0.000 and 0.109, p = 0.000).</p><p><strong>Conclusion: </strong>The results indicated a clear age-related pattern. Higher levels of job insecurity and a stronger association between job insecurity and depressive symptoms were found among younger compared with older workers. No gender differences were observed. The results highlight the importance of addressing job insecurity as a concern in early working life.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longer-term neurological and endocrine/metabolic conditions in the deepwater horizon oil spill coast guard cohort study: A principal component analysis.","authors":"Hristina Denic-Roberts, Jordan McAdam, Lawrence S Engel, Jeanine M Buchanich, Rachel G Miller, Evelyn O Talbott, Dana L Thomas, Glen A Cook, Blake Hansen, Jill E Emerick, Tina Costacou, Jennifer A Rusiecki","doi":"10.1007/s00420-026-02228-0","DOIUrl":"10.1007/s00420-026-02228-0","url":null,"abstract":"<p><strong>Purpose: </strong>Deepwater Horizon oil spill (DWHOS) responders potentially experienced multiple stressors. We examined associations between DWHOS deployment-related stressor patterns and neurological and endocrine/metabolic conditions among U.S. Coast Guard active duty responders who completed post-deployment surveys (n = 3102).</p><p><strong>Methods: </strong>Deployment-related stressor patterns were identified using principal component analysis of self-reported stressors. Neurological and endocrine/metabolic outcomes were classified from military health encounter records. Associations between principal components (PCs) and incident outcomes (2010-2015) were estimated through Cox proportional hazards regression.</p><p><strong>Results: </strong>A five-component solution explained 79.2% of the variance. PC1 (high physical/moderate chemical stressor pattern) was associated with migraine [adjusted hazard ratio (aHR): 1.25, 95% confidence interval (CI): 1.01-1.56]. PC2 (high crude oil/dispersant stressor pattern) was associated with several migraine/headache conditions including migraine with aura (1.54, 1.14-2.07), mononeuritis of upper limb and mononeuritis multiplex (1.36, 1.11-1.68), disorders of lipid metabolism (1.11, 1.01-1.23) and its subcategory other and unspecified hyperlipidemia (1.11, 1.01-1.24), and dysmetabolic syndrome X (1.74, 1.19-2.54). PC3 (high fatigue/moderate chemical inhalation stressor pattern) was associated with several migraine/headache conditions (aHR range: 1.18-1.60), disorders of lipid metabolism (1.11, 1.00-1.23) including other and unspecified hyperlipidemia (1.13, 1.01-1.26), and overweight and obesity (1.13, 1.00-1.27). PC4 (high anxiety/modest fatigue stressor pattern) was associated with abnormality of gait (1.34, 1.03-1.73). PC5 (high back pain) was associated with mononeuritis of lower limb, several balance and gait-related conditions, thyroid disorders, and obesity (aHRs range: 1.16-1.67).</p><p><strong>Conclusion: </strong>Oil spill response stressor patterns were associated with increased risks of multiple longer-term neurological and endocrine/metabolic conditions, with associations varying by PC.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13469484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}