Thyrotoxic effects of organophosphate insecticides in adults: a bibliometric and meta-analysis.

IF 2.4 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Archives of Occupational and Environmental Health Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI:10.1007/s00420-025-02159-2

Massira Ousseni Diawara, Gaoju Pan, Xu Yang, Mohammed Alqudaimi, Mahamadou Fofana, Solim Essomandan Clémence Bafei, Di Wu, Hein Min Tun, Qianqi Liu, Mingzhi Zhang, Yankai Xia

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引用次数: 0

Abstract

Objective: Organophosphate insecticides (OPIs) are widely used worldwide, raising growing concerns over their potential thyrotoxic effects. Despite mounting evidence, inconsistencies persist regarding their impact on thyroid hormone (TH) regulation in humans. This study aimed to clarify the relationship between OPI exposure and TH levels in adults, addressing a critical gap in environmental health research.

Methods: A systematic literature search was conducted on Pubmed, Cochrane Library, Web of Science, and Google Scholar before 15th May 2025. After extraction, a bibliometric analysis was applied to synthetize the associations between OPIs and TH in adults; while a meta-analysis was performed to summarize epidemiological investigations with THs, including thyroid-stimulating hormone (TSH), total and free triiodothyronine (T3 and FT3), and total and free thyroxine (T4 and FT4).

Results: From an initial pool of 852 articles, thirteen studies met the inclusion criteria for bibliometric analysis. Most were published between 1999 and 2024, with a peak in 2010, and originated primarily from the USA and Spain. Of these, seven studies, encompassing data from 6308 adults were included in the meta-analysis and grouped by five THs. The meta-analysis revealed significant negative associations in serum levels of T3 [β = - 0.02 (95% CI - 0.03, - 0.01)], and FT3 [β = - 0.02 (95% CI - 0.03, - 0.01)].

Conclusion: These findings highlight the potential endocrine-disrupting effects of OPI exposure in adults, particularly on the hypothalamic-pituitary-thyroid axis (HPT), and emphasize the need for continued investigation into the public health implications of such environmental exposures.

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有机磷杀虫剂对成人甲状腺毒性的影响：文献计量学和荟萃分析。

目的：有机磷杀虫剂（OPIs）在世界范围内广泛使用，其潜在的甲状腺毒性引起了越来越多的关注。尽管有越来越多的证据，但它们对人类甲状腺激素（TH）调节的影响仍然不一致。本研究旨在阐明成人OPI暴露与TH水平之间的关系，解决环境健康研究中的一个关键空白。方法：在2025年5月15日前，系统检索Pubmed、Cochrane Library、Web of Science、谷歌Scholar等网站的文献。提取后，应用文献计量学分析综合成人OPIs与TH之间的关系；采用荟萃分析，总结THs的流行病学调查，包括促甲状腺激素（TSH）、总三碘甲状腺原氨酸（T3和FT3）、总甲状腺素（T4和FT4）和游离甲状腺素（T3和FT4）。结果：在最初的852篇文献中，13篇研究符合文献计量学分析的纳入标准。大多数论文发表于1999年至2024年之间，在2010年达到高峰，主要来自美国和西班牙。其中，包含6308名成年人数据的7项研究被纳入荟萃分析，并按5个THs分组。meta分析显示血清T3 [β = - 0.02 (95% CI - 0.03, - 0.01)]和FT3 [β = - 0.02 (95% CI - 0.03, - 0.01)]水平呈显著负相关。结论：这些发现强调了OPI暴露对成人的潜在内分泌干扰作用，特别是对下丘脑-垂体-甲状腺轴（HPT）的影响，并强调有必要继续调查这种环境暴露对公共卫生的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.