International Archives of Occupational and Environmental Health最新文献

Exposure-response relation for vibration-induced white finger: influence of different estimates of daily exposure time. 振动诱发白指的暴露-反应关系：不同日暴露时间估计的影响。

IF 2.4 3区医学

International Archives of Occupational and Environmental Health Pub Date : 2026-05-02 DOI: 10.1007/s00420-026-02210-w

Magdalena F Scholz, Anthony J Brammer, Steffen Marburg

{"title":"Exposure-response relation for vibration-induced white finger: influence of different estimates of daily exposure time.","authors":"Magdalena F Scholz, Anthony J Brammer, Steffen Marburg","doi":"10.1007/s00420-026-02210-w","DOIUrl":"10.1007/s00420-026-02210-w","url":null,"abstract":"Purpose: It is analyzed whether differences in how the daily usage time is determined in a population exposed to hand-transmitted vibration are the cause of discrepancies between exposure-response models constructed for vibration-induced white finger (VWF). The predictions of the models are then used to evaluate the one in ISO 5349-1:2001.Methods: Pooled analyses employing data from epidemiologic studies of vibration-exposed occupations deemed the most reliable, together with published ratios between daily tool or machine usage times determined by questionnaire or interview and measured values, are used to construct exposure-response relations. These models are compared to those in which the daily usage time is not compensated.Results: Of 17 data points, for 7 the usage time ratio is greater than 1, and for the rest the ratio is equal to 1. Adjusting daily vibration exposures, expressed as A(8)-values, by means of such ratios, results in reductions of varying magnitude. However, the exposure-response models show minor changes, and the scatter in the data points previously observed remains.Conclusions: Methods for estimating 10% prevalence of VWF from the prevalence recorded in a population study are found to have more effect on the models than different methods for estimating the daily usage time. Yet, the spread and clustering in the data remain and point to issues in the constituents of the A(8)-value. The ISO relation is generally consistent with the lower 95-percentile confidence limit of the models and so provides a conservative exposure limit at least for A(8)-values greater than about 3 [Formula: see text].","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of DCBA exposure on liver fibrosis and NAFLD: a comprehensive investigation integrating NHANES data analysis, network toxicology, and molecular docking. DCBA暴露对肝纤维化和NAFLD的影响：一项综合NHANES数据分析、网络毒理学和分子对接的综合研究。

IF 2.4 3区医学

International Archives of Occupational and Environmental Health Pub Date : 2026-05-02 DOI: 10.1007/s00420-026-02212-8

Yansong Fu, Jiayun Wang, Xin Zeng, Hong Qin

{"title":"Effects of DCBA exposure on liver fibrosis and NAFLD: a comprehensive investigation integrating NHANES data analysis, network toxicology, and molecular docking.","authors":"Yansong Fu, Jiayun Wang, Xin Zeng, Hong Qin","doi":"10.1007/s00420-026-02212-8","DOIUrl":"https://doi.org/10.1007/s00420-026-02212-8","url":null,"abstract":"Purpose: This study examined associations between urinary 3-diethyl-carbamoyl benzoic acid (DCBA), the principal metabolite of the insect repellent DEET, and liver fibrosis (LF) as well as non-alcoholic fatty liver disease (NAFLD) using a nationally representative sample. Network toxicology approaches were employed to explore underlying molecular mechanisms.Methods: We analyzed 5,960 adults from NHANES with DCBA measurements obtained through liquid chromatography-tandem mass spectrometry. LF severity was determined using NAFLD Fibrosis Score (NFS ≥ 0.676), whereas NAFLD was identified via sex-specific alanine aminotransferase criteria. Weighted logistic regression models incorporated progressive adjustment for demographic, anthropometric, and clinical factors. Network toxicology identified molecular targets, with molecular docking and dynamics simulations validating mechanistic pathways.Results: DCBA exposure showed significant positive correlations with LF risk after full adjustment (OR = 1.254, 95% CI: 1.097-1.432, P < 0.001), demonstrating clear dose-response patterns (P-trend = 0.019). However, DCBA exhibited no meaningful relationship with NAFLD prevalence (OR = 1.002, 95% CI: 0.935-1.074, P = 0.954). Alcohol intake substantially modified the DCBA-LF relationship (interaction P = 0.002), showing stronger effects in drinkers (OR = 1.45, 95% CI: 1.23-1.69). Epidermal growth factor receptor emerged as the key molecular target with strongest binding capacity ( -6.9 kcal/mol).Conclusion: DCBA displays selective correlations with hepatic fibrosis independent of steatotic processes, with alcohol potentiating fibrogenic effects. These results establish new exposure-response relationships for common environmental chemicals and advance mechanistic understanding for risk assessment applications.","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement of muscle passive stiffness in vibration-exposed groundskeepers. 振动暴露的场地管理员肌肉被动刚度的测量。

IF 2.4 3区医学

International Archives of Occupational and Environmental Health Pub Date : 2026-04-30 DOI: 10.1007/s00420-026-02214-6

Nathan Chen, Seunghyeon Yang, Justin Leach, Jonghwa Oh

引用次数: 0

Autopsy reports and asbestos exposure from mesothelioma patients: a population-based study in Northeastern Italy. 尸检报告和间皮瘤患者的石棉暴露：意大利东北部一项基于人群的研究

IF 2.4 3区医学

International Archives of Occupational and Environmental Health Pub Date : 2026-04-13 DOI: 10.1007/s00420-026-02207-5

Flavia D'Agostin, Corrado Negro, Fabiano Barbiero, Paola De Michieli, Rossana Bussani, Maurizio Pinamonti, Francesca Larese Filon, Francesca Rui

引用次数: 0

Assessment of blood lead reference values for the Southern Ghanaian population against the background of international recommendations. 在国际建议的背景下评估加纳南部人口的血铅参考值。

IF 2.4 3区医学

International Archives of Occupational and Environmental Health Pub Date : 2026-04-04 DOI: 10.1007/s00420-026-02202-w

Linda Consoir, John Arko-Mensah, Jens Bertram, Julius N Fobil, Nicole Heussen, Thomas Schettgen, Margot Lakemeyer, Travis Heggie, Thomas Küpper

引用次数: 0

Occupational air pollutant exposure and seasonal variation in respiratory outcomes among brick kiln workers. 砖窑工人职业性空气污染物暴露与呼吸结果的季节性变化。

IF 2.4 3区医学

International Archives of Occupational and Environmental Health Pub Date : 2026-03-24 DOI: 10.1007/s00420-026-02208-4

Sohaib Hasnain, Nadia Akram, Asim Mansha, Toheed Asghar, Khalid Mahmood Zia

引用次数: 0

Dialkylphosphate urinary metabolites and cholinesterase activities in Mexican indigenous farmworkers. 墨西哥土著农场工人尿中二烷基磷酸代谢物和胆碱酯酶活性。

IF 2.4 3区医学

International Archives of Occupational and Environmental Health Pub Date : 2026-03-24 DOI: 10.1007/s00420-026-02206-6

Diana M Paredes-Céspedes, José F Herrera-Moreno, Aurora E Rojas-García, Irma M Medina-Díaz, Briscia S Barrón-Vivanco, Cyndia A González-Arias, Francisco A Verdín-Betancourt, Néstor Ponce-Ruíz, Yael Y Bernal-Hernández

{"title":"Dialkylphosphate urinary metabolites and cholinesterase activities in Mexican indigenous farmworkers.","authors":"Diana M Paredes-Céspedes, José F Herrera-Moreno, Aurora E Rojas-García, Irma M Medina-Díaz, Briscia S Barrón-Vivanco, Cyndia A González-Arias, Francisco A Verdín-Betancourt, Néstor Ponce-Ruíz, Yael Y Bernal-Hernández","doi":"10.1007/s00420-026-02206-6","DOIUrl":"10.1007/s00420-026-02206-6","url":null,"abstract":"Purpose: Organophosphate (OP) pesticides are widely used in agriculture, vector control, and represent a global public health concern, particularly for occupationally exposed farmers and applicators. This study aimed to evaluate the associations among urinary dialkylphosphate (DAP) metabolites, cholinesterase activities, and butyrylcholinesterase (BuChE) polymorphisms in an indigenous population in Mexico.Methods: A cross-sectional study was conducted among 191 farmworkers. Data were collected using a structured questionnaire addressing sociodemographic characteristics, lifestyle factors, pesticide exposure, and dietary intake. Venous blood and urine samples were obtained to determine cholinesterase activities and urinary DAP concentrations, respectively.Results: Detectable urinary DAP levels were identified, with dimethylthiophosphate (DMTP) as the predominant metabolite. BuChE activity was significantly associated with dietary lipid and carbohydrate intake. A high prevalence of ancestral genotypes was observed in the BuChE gene. Age-stratified analyses demonstrated differences in cholinesterase activities, and males with low BuChE activity exhibited higher urinary DAP metabolite concentrations.Conclusion: These findings highlight variability in OP pesticide metabolite levels and their relationships with dietary factors and genetic background among indigenous agricultural workers. Improved understanding of these interactions is essential for mitigating exposure-related health risks in vulnerable populations.","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":"99 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between psychosocial working conditions and sickness absence days among employees reporting symptoms of common mental disorders in Germany. 德国报告常见精神障碍症状的雇员的社会心理工作条件与病假天数之间的关系。

IF 2.4 3区医学

International Archives of Occupational and Environmental Health Pub Date : 2026-03-11 DOI: 10.1007/s00420-026-02205-7

Meike Heming, Florian Angerer, Christoph Kröger, Gianni Lidolt, Nicole R Hander, Eva Rothermund, Harald Gündel, Nadine Mulfinger, Ute Schröder, Uta Wegewitz, Regina Herold, Peter Angerer

引用次数: 0

DNA methylation as an epigenetic marker of children's exposure to traffic-related air pollution in the Klang Valley, Malaysia. DNA甲基化作为马来西亚巴生谷儿童暴露于交通相关空气污染的表观遗传标记。

IF 2.4 3区医学

International Archives of Occupational and Environmental Health Pub Date : 2026-03-03 DOI: 10.1007/s00420-026-02204-8

Juliana Jalaludin, Nur Faseeha Suhaimi, Suhaili Abubakar

引用次数: 0

Maternal occupational physical activity during pregnancy and childhood cancers in Denmark 1968-2013. 1968-2013年丹麦孕妇职业体力活动与儿童癌症

IF 2.4 3区医学

International Archives of Occupational and Environmental Health Pub Date : 2026-03-03 DOI: 10.1007/s00420-026-02203-9

Xiwen Huang, Garikayi Chemhaka, Johnni Hansen, Chuanjie Deng, Niklas Krause, Beate Ritz, Julia E Heck

引用次数: 0