International Hepatology Communications最新文献_第8页

Interferon-α plus indomethacin combined therapy in HBeAg positive chronic hepatitis B non-responder to a previous IFNα course: results of a pilot study 干扰素α +吲哚美辛联合治疗对先前IFNα疗程无反应的HBeAg阳性慢性乙型肝炎:一项初步研究的结果

International Hepatology Communications Pub Date : 1996-07-01 DOI: 10.1016/0928-4346(96)00286-1

Pietro Andreone , Carmela Cursaro , Annagiulia Gramenzi , Rita Miniero , Mauro Bernardi , Giovanni Gasbarrini

{"title":"Interferon-α plus indomethacin combined therapy in HBeAg positive chronic hepatitis B non-responder to a previous IFNα course: results of a pilot study","authors":"Pietro Andreone , Carmela Cursaro , Annagiulia Gramenzi , Rita Miniero , Mauro Bernardi , Giovanni Gasbarrini","doi":"10.1016/0928-4346(96)00286-1","DOIUrl":"https://doi.org/10.1016/0928-4346(96)00286-1","url":null,"abstract":"<div><p><em>Background</em>: interferon-α is able to induce a sustained inhibition of hepatitis B virus replication in about 30–40% of patients with chronic hepatitis B. There is evidence that non-steroidal antiinflammatory drugs can enhance the synthesis of antiviral proteins induced by interferon-α, <em>Aim</em>: to evaluate the efficacy and tolerability of combined therapy with interferon-α plus indomethacin in HBeAg and HBV-DNA positive patients affected by chronic active hepatitis non-responders to a previous interferon-α treatment. <em>Methods</em>: after six months of retreatment with interferon-α (6 MU thrice weekly) six patients were enrolled, without stopping the therapy, to receive interferon-α (with the same schedule) plus indomethacin (25 mg orally twice daily) for an additional six month course. <em>Results</em>: at the end of treatment and after six months of follow-up alanine transaminase normalization was seen in three (50%) and four (66.7%) patients, HBV-DNA loss in one (17%) and three (50%), <span><math><mtext>HBeAg</mtext><mtext>HBeAb</mtext></math></span> serum conversion in one (17%) and two (33%), respectively. The combined therapy was well tolerated and no indomethacin side-effects were observed. The treatment was stopped in one patient after 4 months because of a remarkable increase of alanine transaminase levels, and in another after five months because of hyperthyroidism occurrence. <em>Conclusions</em>: the results of this study, even if obtained in a small number of patients, are encouraging and suggest a randomized controlled trial to be confirmed.</p></div>","PeriodicalId":13746,"journal":{"name":"International Hepatology Communications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0928-4346(96)00286-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89995867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Impaired biliary excretion of organic anions and cations in bile duct-ligated rat 胆管结扎大鼠胆道有机阴离子和阳离子排泄受损

International Hepatology Communications Pub Date : 1996-07-01 DOI: 10.1016/0928-4346(96)00299-X

Hajime Takikawa, Naoyo Sano, Satoko Fukumura, Satoko Uegaki, Masami Yamanaka

引用次数: 5

Electromagnetic determination of portal venous flow in rats during exercise 运动时大鼠门静脉流量的电磁测定

International Hepatology Communications Pub Date : 1996-07-01 DOI: 10.1016/0928-4346(96)00296-4

Lisa Yano , Hiromi Yano , Kazuhisa Taketa

{"title":"Electromagnetic determination of portal venous flow in rats during exercise","authors":"Lisa Yano , Hiromi Yano , Kazuhisa Taketa","doi":"10.1016/0928-4346(96)00296-4","DOIUrl":"10.1016/0928-4346(96)00296-4","url":null,"abstract":"<div><p>We investigated the response of portal venous blood flow in rats to different exercise intensities by long term implantation of an electromagnetic flowprobe around the portal vein. The coefficients of variation for five determinations of portal venous flow for 5 consecutive days before exercise were 9.7 ± 2.0%. The portal venous flow and oxygen consumption (V̇O<sub>2</sub>) were simultaneously measured during and after treadmill exercise of five intensities (5–25 m/min). Portal venous flow remained unchanged at the moderate exercise levels of 5, 10 and 15 m/min at a 15% grade for 20 min. The portal flow demonstrated a significant decrease at the 20 m/min with a 60 ml/kg/min of V̇O<sub>2</sub>, but the decreased portal venous flow returned to the pre-exercise level during the recovery period. At the highest intensity of exercise, 25 m/min, the decreased portal venous flow remained unchanged throughout the recovery period. We concluded that the continuous measurement of portal venous flow during exercise offers a clear advantage over other methods, and that there was an evoking point during the high intensity exercise though portal venous flow was unaltered at a moderate intensity of exercise.</p></div>","PeriodicalId":13746,"journal":{"name":"International Hepatology Communications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0928-4346(96)00296-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85720315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Application of neural network to the interpretation of laboratory data for the diagnosis of two forms of chronic active hepatitis 应用神经网络对两种慢性活动性肝炎诊断的实验室数据进行解释

International Hepatology Communications Pub Date : 1996-07-01 DOI: 10.1016/0928-4346(96)00292-7

Hiroshi Nakano, Yasuyuki Okamoto, Hitomi Nakabayashi, Seigo Takamatsu, Hiroyuki Tsujii, Hiroki Matsuoka

{"title":"Application of neural network to the interpretation of laboratory data for the diagnosis of two forms of chronic active hepatitis","authors":"Hiroshi Nakano, Yasuyuki Okamoto, Hitomi Nakabayashi, Seigo Takamatsu, Hiroyuki Tsujii, Hiroki Matsuoka","doi":"10.1016/0928-4346(96)00292-7","DOIUrl":"https://doi.org/10.1016/0928-4346(96)00292-7","url":null,"abstract":"<div><p>The purpose of this study is to investigate the ability of neural network to discriminate the two subtypes, mild and severe form, of chronic active hepatitis, on the basis of the patterns of the five blood biochemical parameters. Serum levels of cholinesterase, albumin, alkaline phosphatase, type IV collagen and hyaluronate were used as variables. The neural network trained with the data from 31 patients: 11 of mild form and 20 of severe form of chronic active hepatitis. The ability of the network to predict the diagnosis of the patients who were additionally recruited was tested with a separate group (cross-validation group) of 9 patients with chronic active hepatitis. A neural network with 5 input neurons, 10 hidden neurons and 2 output neurons correctly classified all 31 patients. This network correctly predicted the diagnoses for 78% of the cross-validation group. These results suggested that neural network are useful for the differentiation of two forms of chronic active hepatitis by a less invasive blood biochemical analysis.</p></div>","PeriodicalId":13746,"journal":{"name":"International Hepatology Communications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0928-4346(96)00292-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91611969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Application of neural network to the interpretation of laboratory data for the diagnosis of two forms of chronic active hepatitis 应用神经网络对两种慢性活动性肝炎诊断的实验室数据进行解释

International Hepatology Communications Pub Date : 1996-07-01 DOI: 10.1016/0928-4346(96)00292-7

H. Nakano, Y. Okamoto, H. Nakabayashi, S. Takamatsu, H. Tsujii, H. Matsuoka

引用次数: 8

Impaired biliary excretion of organic anions and cations in bile duct-ligated rat 胆管结扎大鼠胆道有机阴离子和阳离子排泄受损

International Hepatology Communications Pub Date : 1996-07-01 DOI: 10.1016/0928-4346(96)00299-X

H. Takikawa, N. Sano, Satoko Fukumura, S. Uegaki, M. Yamanaka

引用次数: 5

Suppressive effects of all-trans retinoic acid on the lipopolysaccharide-stimulated release of tumor necrosis factor-α and nitric oxide by rat Kupffer cells in vitro 全反式维甲酸对体外大鼠Kupffer细胞脂多糖刺激释放肿瘤坏死因子-α和一氧化氮的抑制作用

International Hepatology Communications Pub Date : 1996-07-01 DOI: 10.1016/0928-4346(96)00295-2

Kenta Motomura, Hidehiko Isobe, Hironori Sakai, Hajime Nawata

引用次数: 11

Suppressive effects of all-trans retinoic acid on the lipopolysaccharide-stimulated release of tumor necrosis factor-α and nitric oxide by rat Kupffer cells in vitro 全反式维甲酸对体外大鼠Kupffer细胞脂多糖刺激释放肿瘤坏死因子-α和一氧化氮的抑制作用

International Hepatology Communications Pub Date : 1996-07-01 DOI: 10.1016/0928-4346(96)00295-2

K. Motomura, H. Isobe, H. Sakai, H. Nawata

引用次数: 11

Alterations in some hepatic biochemical variables following repeated gallium arsenide administration in rats 反复给药砷化镓对大鼠肝脏生化指标的影响

International Hepatology Communications Pub Date : 1996-06-01 DOI: 10.1016/0928-4346(96)00285-X

S. Flora

引用次数: 8

Concomitant findings of anti-HBc as a sole marker for hepatitis B virus infection and elevated serum transaminases are associated with a high prevalence of hepatitis C virus infection 同时发现抗hbc作为乙型肝炎病毒感染的唯一标志和血清转氨酶升高与丙型肝炎病毒感染的高流行率有关

International Hepatology Communications Pub Date : 1996-06-01 DOI: 10.1016/0928-4346(96)00288-5

Suwandhi Widjaja , Sumanto Simon , Sugianto Ali , Inggriani Listiawan , Anna Widyastuti , Swa Kurniawati , Erik Depla , Sing-Hiem Yap

{"title":"Concomitant findings of anti-HBc as a sole marker for hepatitis B virus infection and elevated serum transaminases are associated with a high prevalence of hepatitis C virus infection","authors":"Suwandhi Widjaja , Sumanto Simon , Sugianto Ali , Inggriani Listiawan , Anna Widyastuti , Swa Kurniawati , Erik Depla , Sing-Hiem Yap","doi":"10.1016/0928-4346(96)00288-5","DOIUrl":"10.1016/0928-4346(96)00288-5","url":null,"abstract":"<div><p>From two hundred sixty five patients with liver disease and elevated serum transaminases who were admitted or referred to Atmajaya academic hospital in Jakarta, 37 patients were found to be anti-HBc positive as a sole marker of HBV infection. Nineteen out of these 37 patients were also anti-HCV positive, HCV-RNA was detected in 16 patients. From 1656 individuals with normal serum transaminases who underwent serological examination and consisted of 489 subjects from population based study in Kalianyar (an urban area in Jakarta), 258 students of Atmajaya Medical School, 541 women and 162 children from maternity-child clinic and 206 patients admitted to hospital without evidence of liver disease, anti-HBc as a sole marker for HBV infection was found in 213. However, HCV-RNA was detected only in 2 subjects. We conclude that concomitant findings of anti-HBc as a sole marker for HBV infection and elevated ALT are associated with a relative high prevalence of HCV infection. In a group of individuals without evidence of liver disease, HCV infection was uncommon, even when anti-HBc is present as a sole marker of HBV infection.</p></div>","PeriodicalId":13746,"journal":{"name":"International Hepatology Communications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0928-4346(96)00288-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91470551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0