{"title":"胆管结扎大鼠胆道有机阴离子和阳离子排泄受损","authors":"Hajime Takikawa, Naoyo Sano, Satoko Fukumura, Satoko Uegaki, Masami Yamanaka","doi":"10.1016/0928-4346(96)00299-X","DOIUrl":null,"url":null,"abstract":"<div><p>The effects of bile duct ligation for 3 days on biliary excretion of organic anions and cations were studied in the rat. Biliary excretion of organic anions, sulfobromophthalein, leukotriene C<sub>4</sub> and pravastatin, was markedly impaired. Biliary excretion of organic cations, vinblastine and erythromycin was also markedly impaired. These findings indicate that, in the bile duct-ligated rats, various excretory pathways from the liver are damaged, at least partly due to the impairment of canalicular carriers.</p></div>","PeriodicalId":13746,"journal":{"name":"International Hepatology Communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0928-4346(96)00299-X","citationCount":"5","resultStr":"{\"title\":\"Impaired biliary excretion of organic anions and cations in bile duct-ligated rat\",\"authors\":\"Hajime Takikawa, Naoyo Sano, Satoko Fukumura, Satoko Uegaki, Masami Yamanaka\",\"doi\":\"10.1016/0928-4346(96)00299-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effects of bile duct ligation for 3 days on biliary excretion of organic anions and cations were studied in the rat. Biliary excretion of organic anions, sulfobromophthalein, leukotriene C<sub>4</sub> and pravastatin, was markedly impaired. Biliary excretion of organic cations, vinblastine and erythromycin was also markedly impaired. These findings indicate that, in the bile duct-ligated rats, various excretory pathways from the liver are damaged, at least partly due to the impairment of canalicular carriers.</p></div>\",\"PeriodicalId\":13746,\"journal\":{\"name\":\"International Hepatology Communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0928-4346(96)00299-X\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Hepatology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/092843469600299X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Hepatology Communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/092843469600299X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Impaired biliary excretion of organic anions and cations in bile duct-ligated rat
The effects of bile duct ligation for 3 days on biliary excretion of organic anions and cations were studied in the rat. Biliary excretion of organic anions, sulfobromophthalein, leukotriene C4 and pravastatin, was markedly impaired. Biliary excretion of organic cations, vinblastine and erythromycin was also markedly impaired. These findings indicate that, in the bile duct-ligated rats, various excretory pathways from the liver are damaged, at least partly due to the impairment of canalicular carriers.
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