International Archives of Otorhinolaryngology最新文献_第2页

TSLP Production Induced by Poly(I:C) Stimulation Increased in the Presence of Th2 Cytokines in Patients with Severe ECRS. 在Th2细胞因子存在的情况下，Poly（I:C）刺激诱导的TSLP产生增加。

IF 1.1

International Archives of Otorhinolaryngology Pub Date : 2025-09-10 eCollection Date: 2025-07-01 DOI: 10.1055/s-0045-1809159

Akiko Inoue, Yuriko Tanaka, Hidehito Matsui, Akira Fukuo, Motonari Kondo, Kota Wada

{"title":"TSLP Production Induced by Poly(I:C) Stimulation Increased in the Presence of Th2 Cytokines in Patients with Severe ECRS.","authors":"Akiko Inoue, Yuriko Tanaka, Hidehito Matsui, Akira Fukuo, Motonari Kondo, Kota Wada","doi":"10.1055/s-0045-1809159","DOIUrl":"10.1055/s-0045-1809159","url":null,"abstract":"Introduction: In patients with eosinophilic chronic rhinosinusitis (ECRS), viral infection of the upper respiratory tract tends to exacerbate the symptoms.Objective: To clarify the effect of the cytokines during viral infection in ECRS patients, we investigated the production of thymic stromal lymphopoietin (TSLP) in the sinus mucosa of ECRS patients in the presence of polyinosinic: polycytidylic acid, or poly(I:C), which mimics viral infection, with or without interleukin-4 (IL-4) or IL-13.Methods: The ECRS patients were classified into mild, moderate, and severe groups based on the scoring system of the Japanese Epidemiological Study of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC). We obtained paranasal sinus mucosa from patients with ECRS through endoscopic sinus surgery, as well as nasal epithelial cells. The cells were stimulated with poly(I:C) in the presence or absence of IL-4 or IL-13. The TSLP concentrations in the culture supernatants were measured using enzyme-linked immunosorbent assay (ELISA) after 24 hours of stimulation.Results: Nasal epithelial cells from patients with ECRS or healthy controls produced TSLP upon stimulation with poly(I:C) alone, and the addition of IL-4 or IL-13 increased TSLP production. Notably, the increase in poly(I:C)-induced TSLP production from nasal epithelial cells in the presence of IL-4 or IL-13 was greater among the severe group compared to the other groups.Conclusion: In the sinus mucosa of patients with severe ECRS, TSLP production was enhanced more when poly(I:C) stimulation was combined with IL-4 or IL-13 stimulation. Thus, the Th2-skewed condition of the sinus mucosa during viral infection in patients with more severe ECRS may accelerate disease exacerbation.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 3","pages":"1-7"},"PeriodicalIF":1.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasal Foam Packing for Epistaxis: What are the Ideal Characteristics? 鼻出血的鼻泡沫填料：理想的特性是什么？

IF 1.1

International Archives of Otorhinolaryngology Pub Date : 2025-09-10 eCollection Date: 2025-07-01 DOI: 10.1055/s-0045-1809999

Flavio Serafini, Isabele Campos Araújo, Flavia Minhoto, Ana Luiza Figueira Santos

{"title":"Nasal Foam Packing for Epistaxis: What are the Ideal Characteristics?","authors":"Flavio Serafini, Isabele Campos Araújo, Flavia Minhoto, Ana Luiza Figueira Santos","doi":"10.1055/s-0045-1809999","DOIUrl":"10.1055/s-0045-1809999","url":null,"abstract":"Introduction: Epistaxis is a common otorhinolaryngological emergency, usually caused by digital trauma in children, and hypertension in the elderly. General practitioners in emergency rooms assist most of the cases without specific management.Objectives: Describe suitable properties for efficient nasal packing in adult epistaxis.Methods: Two cadaver heads, preserved by freezing process, were thawed for this research. When the room temperature was reached, the nasal cavities were evaluated by a nasal endoscope, which showed a length of 4.0 × 11.0 cm for the male and 4.0 × 8.5 cm for the female head. Through an orifice made in the left maxillary bone to access the maxillary sinus, a blue-dyed saline solution was applied using a sphygmomanometer (Premium) to control and mimic blood pressure. The nasal cavity was first packed with two foams with different thicknesses and densities evolved by a condom, then packed by the Merocel packing (Medtronicent Surgical Products Inc.). The pressure was administered and gradually increased until a saline leak was observed in the oropharynx. The best way to insert tampons was also evaluated to avoid extensive trauma.Results: Despite the difficulty of the application being similar in both nasal packings made with the condom and foam, t33-densityity foam, 2.0 cm thick and 11.0 cm lon resisted to a higher pressure (250mmHg) than the commercial packing Merocel (220mmHg).Conclusion: The most suitable foam for packaging wrapped with condoms is 2.0 cm thick, as it supported the blood pressure commonly found in epistaxis.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 3","pages":"1-5"},"PeriodicalIF":1.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin Prevents Cisplatin-Induced Cyto-Histopathological Damage in the Bone Marrow and Inner Ear. 褪黑素防止顺铂诱导的骨髓和内耳细胞组织病理学损伤。

IF 1.1

International Archives of Otorhinolaryngology Pub Date : 2025-09-10 eCollection Date: 2025-07-01 DOI: 10.1055/s-0045-1809645

Juliana Gusmão de Araujo, Lucieny Silva Martins Serra, Lucas Lauand, Selma Aparecida Souza Kückelhaus, André Luiz Lopes Sampaio

{"title":"Melatonin Prevents Cisplatin-Induced Cyto-Histopathological Damage in the Bone Marrow and Inner Ear.","authors":"Juliana Gusmão de Araujo, Lucieny Silva Martins Serra, Lucas Lauand, Selma Aparecida Souza Kückelhaus, André Luiz Lopes Sampaio","doi":"10.1055/s-0045-1809645","DOIUrl":"10.1055/s-0045-1809645","url":null,"abstract":"Introduction: Cisplatin is an effective chemotherapeutic drug. Its side effects, ototoxicity and genotoxicity, limit widespread application. Melatonin could reduce these toxic effects due to its antioxidant activity.Objective: To determine the effect of melatonin against cisplatin-induced ototoxicity and genotoxicity in rats.Methods: To assess ototoxicity, 33 rats were randomly divided into: group 1 (saline), group 2 (melatonin), group 3 (cisplatin + saline), and group 4 (cisplatin + melatonin). Groups 3 and 4 received a single dose of 10 mg/kg of cisplatin. Groups 2 and 4 received daily doses of 1 mg/kg of melatonin. The number of viable neurons and their average diameter in the spiral and vestibular ganglia were analyzed. In the stria vascularis and spiral ligament, the number of viable cells was evaluated. To assess genotoxicity, 12 animals were randomly divided into: group A (saline), group B (cisplatin + saline), and group C (cisplatin + melatonin). The rats in groups B and C received a single dose of 10 mg/kg of cisplatin. Group C received a single dose of 1 mg/kg of melatonin.Results: The micronucleus count and percentage of polychromatic erythrocytes in the bone marrow of rat femurs were analyzed. The animals in group 3 presented a greater loss of cells than the animals in other groups regarding all cochlear structures evaluated. Furthermore, the diameters of neurons were smaller in the animals in group 3. Melatonin-treated rats presented a lower micronucleus count and a higher number of polychromatic erythrocytes than animals treated with cisplatin alone.Conclusion: Melatonin reduces cisplatin-induced cyto-histopathological damage in the bone marrow and inner ear; therefore, it could be used as a tumor adjuvant treatment.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 3","pages":"1-8"},"PeriodicalIF":1.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspective of Parents of Infants and Children with Hearing Impairment about Hearing Aid Management: A Questionnaire-Based Study. 听力障碍婴幼儿家长对助听器管理的看法：一项问卷调查。

IF 1.1

International Archives of Otorhinolaryngology Pub Date : 2025-09-10 eCollection Date: 2025-07-01 DOI: 10.1055/s-0045-1810004

Anil Kumar, Rashmi J Bhat

{"title":"Perspective of Parents of Infants and Children with Hearing Impairment about Hearing Aid Management: A Questionnaire-Based Study.","authors":"Anil Kumar, Rashmi J Bhat","doi":"10.1055/s-0045-1810004","DOIUrl":"10.1055/s-0045-1810004","url":null,"abstract":"Introduction: It is important to understand the intricacies of hearing aid management early in the child's life to appreciate the full benefits of early intervention.Objective: Identifying aspects of hearing aid management that carers regard as taxing will allow hearing professionals to focus and encourage these areas, potentially leading to higher hearing aid use and better outcomes.Methods: 49 parents of children with hearing impairment participated in the study. Parent Hearing Aid Management Inventory (PHAMI) was used to explore parent access to information and experiences in three domains such as parent skills and confidence in hearing aid management, hearing aid use, and communication with the audiologist using a 4-point rating scale. The data was collected using direct interviews and through Microsoft forms.Results: The majority of the parents desired information and support in identifying hearing aid options/accessories, obtaining financial assistance for costs, and using a listening stethoscope for determining when the hearing aid was not working. The most common challenges identified by parents as influencing their child's hearing aid use were activities (for example, playing, travelling in the car), and the fear of losing and damaging the hearing aids. Although many parents were pleased with the audiologist's assistance, they desired that the audiologist be more patient and contact them more regularly after the hearing aids were fitted.Conclusion: Professionals can help with effective device management by addressing parental challenges, collaborating on specific device management goals, and helping as needed.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 3","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Tinnitus in Patients Affected by COVID-19: A Systematic Review. 新冠肺炎患者耳鸣的特点：一项系统综述

IF 1.1

International Archives of Otorhinolaryngology Pub Date : 2025-08-20 eCollection Date: 2025-07-01 DOI: 10.1055/s-0045-1802968

Daniella Wuttke Doutrelepont, Carolina Pereira Fernandes, Luiza Silva Vernier, Marcia Salgado Machado

{"title":"Characteristics of Tinnitus in Patients Affected by COVID-19: A Systematic Review.","authors":"Daniella Wuttke Doutrelepont, Carolina Pereira Fernandes, Luiza Silva Vernier, Marcia Salgado Machado","doi":"10.1055/s-0045-1802968","DOIUrl":"10.1055/s-0045-1802968","url":null,"abstract":"Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has brought up reports of an increase in new cases of tinnitus and changes in chronic and/or preexisting episodes. Nevertheless, there is no established data on the characteristics of tinnitus and its correlation with coronavirus disease 2019 (COVID-19).Objective: To analyze the characteristics of tinnitus in subjects affected by COVID-19 while detailing the correlation between these two factors.Data synthesis: We found 327 articles, 37 of which were selected: 11 cross-sectional studies, 4 case-control studies, 3 cohort studies, and 19 observational studies. The sum of the samples totaled 399,524 patients included in the present review. The prevalence of new tinnitus varied from 0.2% to 96.2%. Most articles provided incomplete information or were missing information. Systemic arterial hypertension was the most common underlying disease. Finally, we found a predominance of hearing loss and olfactory and taste disorders, followed by fever and cough.Conclusion: The prevalence of new tinnitus ranged from 0.2 to 96.2%, whereas the prevalence of preexisting tinnitus varied from 8 to 76.2%. It was not possible to satisfactorily assess the characteristics of tinnitus. Therefore, a direct correlation between tinnitus and COVID-19 could not be determined, as this symptom may be influenced by other factors.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 3","pages":"1-20"},"PeriodicalIF":1.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regionalization of Health Care in Head and Neck Cancer: Concept and Considerations. 头颈癌保健区域化：概念和考虑。

IF 1.1

International Archives of Otorhinolaryngology Pub Date : 2025-08-20 eCollection Date: 2025-07-01 DOI: 10.1055/s-0045-1802574

Sebastián Castro, Mario Tapia, Felipe Cardemil

{"title":"Regionalization of Health Care in Head and Neck Cancer: Concept and Considerations.","authors":"Sebastián Castro, Mario Tapia, Felipe Cardemil","doi":"10.1055/s-0045-1802574","DOIUrl":"10.1055/s-0045-1802574","url":null,"abstract":"Introduction: Head and neck cancer are rare and require complex medical and surgical management. Regionalization or centralization of care, defined as the concentration of patients with complex diseases from a specific area in institutions with more experienced and highly functional multidisciplinary teams, may be an alternative to achieve better oncologic outcomes.Objective: To systematize the current knowledge regarding the centralization of care in head and neck oncology and its consequences in the practice of related surgeries.Data synthesis: Currently, there is evidence that this strategy shows better oncologic outcomes in centers with greater volumes, greater adherence to evidence-based clinical guidelines and quality indicators, and a multidisciplinary team in charge of decision-making. The center in Ontario, Canada, is framed as an example of this strategy, achieving improved outcomes while maintaining a high level of quality.Conclusion: Although more high-quality studies are needed to support this strategy, we believe that the evidence already available is sufficient to consider it a valid option to improve the oncologic outcomes of patients.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 3","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Music Training on Social, Behavioral, and Academic Skills of Children with Cochlear Implants from the School Teacher's Perspective. 音乐训练对植入人工耳蜗儿童社交、行为及学业技能的影响——以学校教师为视角。

IF 1.1

International Archives of Otorhinolaryngology Pub Date : 2025-08-20 eCollection Date: 2025-07-01 DOI: 10.1055/s-0045-1809646

Paula Martins-Said, Kátia de Freitas Alvarenga, Dagma Venturini Marques Abramides

{"title":"Effects of Music Training on Social, Behavioral, and Academic Skills of Children with Cochlear Implants from the School Teacher's Perspective.","authors":"Paula Martins-Said, Kátia de Freitas Alvarenga, Dagma Venturini Marques Abramides","doi":"10.1055/s-0045-1809646","DOIUrl":"10.1055/s-0045-1809646","url":null,"abstract":"Introduction: Music has been recognized as a therapeutic tool in auditory rehabilitation, promoting essential social and behavioral development in children with cochlear implants (CIs), as identified by the World Health Organization (WHO). Additionally, there is a lack of studies on the development of these skills in this context.Objective: To investigate the effect of music training on the development of social, behavioral, and academic skills in children with CIs from the schoolteacher's perspective.Methods: The present is an experimental study involving 10 children with CIs, aged between 6 and 10 years, who composed the experimental group. They had a semester of music training and were assessed through the Social Skills Rating System (SSRS) questionnaire at 4 different moments: 2 months before the beginning of the music training, at the beginning of the music training (first week of class), during the music training (3 months after the beginning), and at the end of the music training (6 months after the beginning). To compare the multiple SSRS assessments, we used the repeated measures analysis of variance (ANOVA) test and the Tukey test ( p ≤ 0.05).Results: The results showed a statistically significant improvement in social skills in terms of assertiveness, social resourcefulness, self-control, affectivity, cooperation, externalizing behavior problems, and academic competence.Conclusion: From the schoolteacher's perspective CI-using children who had music training experienced an improvement in their social and academic skills and behavioral problems.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 3","pages":"1-10"},"PeriodicalIF":1.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Oleuropein on the Treatment of Allergic Rhinitis. 橄榄苦苷治疗变应性鼻炎的疗效观察。

IF 1.1

International Archives of Otorhinolaryngology Pub Date : 2025-08-20 eCollection Date: 2025-07-01 DOI: 10.1055/s-0045-1809644

Özge Çaglar Cil, Basak Büyük, Hüseyin Avni Eroglu, Hilal Sehitoglu

{"title":"The Effect of Oleuropein on the Treatment of Allergic Rhinitis.","authors":"Özge Çaglar Cil, Basak Büyük, Hüseyin Avni Eroglu, Hilal Sehitoglu","doi":"10.1055/s-0045-1809644","DOIUrl":"10.1055/s-0045-1809644","url":null,"abstract":"Introduction: Allergic rhinitis is a disease that negatively affects social and work life and sometimes does not respond to many treatments. Therefore, new treatments are needed. For the prevention and treatment of allergies, oleuropein has been emphasized, and positive results have been shown in the literature.Objective: To investigate the effects of general and topical oleuropein during the allergic rhinitis period and the histopathological changes in the nasal mucosa compared with steroid nasal sprays and control group in rats.Methods: We developed an experimental animal model with 44 rats divided into 6 groups. Except for the control group, the allergic rhinitis in the other five groups was created with ovalbumin. As treatment, saline was administered to group 3, steroids, to group 4, oleuropein, to group 5, and steroids and oleuropein were administered to group 6. The effects of the drugs were examined histopathologically and the levels of immunoglobulin E (IgE) in the blood were compared.Results: Considering the symptomatic findings in rats, we could observe that allergic rhinitis occurred. Based on the IgE levels and histopathological findings, we have statistically shown that oleuropein may be effective in treatment of allergy rhinitis.Conclusion: Oleuropein has been shown to be useful in the treatment of allergic rhinitis in an animal model, but further studies are needed before it is introduced into the medical practice.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 3","pages":"1-7"},"PeriodicalIF":1.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mucormycosis and Hearing: A Hospital-Based Study. 毛霉病与听力：一项基于医院的研究。

IF 1.1

International Archives of Otorhinolaryngology Pub Date : 2025-08-07 eCollection Date: 2025-07-01 DOI: 10.1055/s-0045-1802578

Monalisa Jati, Ripu Daman Arora, Ruuzeno Koutsu, Nitin M Nagarkar, Roshan Marandi, Kartik Agrawal

{"title":"Mucormycosis and Hearing: A Hospital-Based Study.","authors":"Monalisa Jati, Ripu Daman Arora, Ruuzeno Koutsu, Nitin M Nagarkar, Roshan Marandi, Kartik Agrawal","doi":"10.1055/s-0045-1802578","DOIUrl":"10.1055/s-0045-1802578","url":null,"abstract":"Introduction Mucormycosis, a fungal infection with severe consequences, gained prominence during the coronavirus disease 2019 (COVID-19) pandemic. While significant efforts were made to understand the systemic implications of mucormycosis, its effect on the auditory system remains unexplored. Objective This study aimed to investigate the auditory implications of mucormycosis through a comprehensive case-control study focusing on hearing loss and middle ear dysfunction. Methods A total of 30 mucormycosis patients without prior auditory issues, and 30 age and gender-matched controls, underwent comprehensive hearing assessment, including pure-tone and immittance audiometry. Statistical analyses, including descriptive statistics, Mann-Whitney U test, Pearson chi-square test, and multiple logistic regression were performed to analyze the data. Result Mucormycosis patients exhibited significantly higher auditory thresholds across all frequencies compared to controls ( p < 0.05). Approximately half of these patients experienced some degree of hearing loss, predominantly mild. Immittance measurement showed a higher prevalence of abnormal tympanograms in mucormycosis patients, indicating middle ear dysfunction. Acoustic reflex was absent in half of the mucormycosis patients suggesting impaired auditory function. Conclusion The present study revealed significant auditory health impacts of mucormycosis, finding a notable prevalence of hearing loss and middle ear dysfunction, which emphasizes the need for routine audiological evaluations and increased awareness of mucormycosis-related auditory issues. Despite the study's limitations, we identified potential risk factors for hearing impairment, suggesting a need for further large-scale studies to confirm these findings and understand the mechanisms. These insights aim to improve diagnosis, treatment, and prevention strategies for better clinical outcomes.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 3","pages":"1-7"},"PeriodicalIF":1.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is CPAP the Key to Reduce the Cardiovascular Risk in Patients with OSA? CPAP是降低OSA患者心血管风险的关键吗？

IF 1.1

International Archives of Otorhinolaryngology Pub Date : 2025-08-07 eCollection Date: 2025-07-01 DOI: 10.1055/s-0045-1801855

Kiran Abraham-Aggarwal, Ashutosh Kacker

{"title":"Is CPAP the Key to Reduce the Cardiovascular Risk in Patients with OSA?","authors":"Kiran Abraham-Aggarwal, Ashutosh Kacker","doi":"10.1055/s-0045-1801855","DOIUrl":"10.1055/s-0045-1801855","url":null,"abstract":"Introduction Obstructive sleep apnea (OSA) is a prevalent condition often managed with continuous positive airway pressure (CPAP) treatment. There is an ongoing debate about the link between OSA and cardiovascular disease (CVD), but the existing evidence points toward an association. Objective The present study aims to investigate whether CPAP is an effective strategy to reduce the risk of developing CVD risk among OSA patients. Methods The literature search was conducted in collaboration with Weill Cornell Medical College librarians, and we identified the five most recent papers highlighting the correlation between CPAP treatment for OSA and CVD risk reduction. Results Recent studies highlight the link between OSA and CVD, emphasizing the potential of the CPAP therapy to reduce the risks of developing CVD and the mortality associated with the condition. The analyses by Guo et al., Peker et al., Khan et al., and Wickwire et al., collectively involving thousands of patients across various study designs, including randomized clinical trials and retrospective cohort studies, consistently demonstrate that the CPAP treatment improves cardiovascular outcomes by lowering blood pressure, reducing sleepiness scores, and significantly decreasing the risk of serious CVD events, especially with consistent adherence to therapy. Conclusion Although further studies are needed to confirm these findings among patients with consistent high compliance to the CPAP treatment, it remains reasonable to continue to prescribe CPAP as the first-line therapy for OSA due to its potential cardiovascular benefits and low associated risks.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 3","pages":"1-3"},"PeriodicalIF":1.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0