Haematology Journal of Bangladesh最新文献

{"title":"Spectrum of Bone Complications in Newly diagnosed Multiple Myeloma patients","authors":"Salina Haque, Zulfia Zinat Chowdhury, K. Ahmed, A. Islam, Mohammad Ali, J. Ferdouse, T. Ara, Md. Mahbubur Rahman","doi":"10.37545/haematoljbd202290","DOIUrl":"https://doi.org/10.37545/haematoljbd202290","url":null,"abstract":"Abstract \u0000Multiple myeloma is a malignant disorder of plasma cells that seed throughout the bone marrow and usually produce a monoclonal immunoglobulin in the blood, urine, or both, cause lytic bone lesions. A total of 159 newly diagnosed multiple myeloma patients aged 24 to 85 were included in this study. The median age of 159 patients was 56 years. Highest incidence of multiple myeloma was found in 50-59 years age group and P value was statistically significant. Male patient was 103 (65%) and female patient was 56 (35%). The median age of male patients was 56 years and the female patients was 57 years. There was no statistically significant age difference between male and female patients. 76.1% patients had bone involvement. Lytic bone lesions were found in 45.9% cases. Among them 15.1% patient had single lytic lesion and 30.8% patient had multiple lytic lesions. Most common site of lytic lesion was skull (33.3%).Pelvis was the second most common site of lytic lesion (15.7%).The prevalence of fracture was 44.7%, among them vertebral fracture was in 37.1% cases, rib fracture was in 9.4% cases, humerus fracture was in 3.1%, femur fracture was in 3.8%, fracture of neck of femur in 0.6%. Nerve root compression found in 12.6% cases. Lytic lesion and fracture are most common features of bone involvement in multiple myeloma patients. MRI study instead of radiographic study may increase the detection of bone lesion especially in the thoraco-lumber spine, pelvis and proximal femurs. Further studies incorporating MRI study are necessary to determine skeletal changes of MM patients.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123632863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Soluble Transferrin Receptor in Diagnostic Work Up for The Assessment of Iron Status and Iron Deficiency","authors":"Mohammed Nuruzzaman Bhuiyan, S. Giti, Mahbuba Akhter, Md. Mizanur Rahman, L. Naznin, M. Hossen, Md Moshiur Rahman, Tasnim Tabassum Tory","doi":"10.37545/haematoljbd202294","DOIUrl":"https://doi.org/10.37545/haematoljbd202294","url":null,"abstract":"Background: Iron deficiency anaemia (IDA) is the most frequent form of anaemia in human population. For diagnosing IDA usually conventional laboratory tests such as serum iron, serum ferritin and transferrin saturation are used. However, both ferritin and transferrin proteins are markedly influenced by inflammation, behaving as acute-phase reactants and making it difficult to diagnosis iron-deficiency anemia (IDA) when it is combined with any inflammatory condition. Soluble transferrin receptor (sTfR) is a truncated extracellular form of the membrane transferrin receptor produced by proteolysis. Concentrations of serum sTfR are related to iron status and erythropoiesis in the body. Serum transferrin receptor (sTfR) levels are raised in iron deficiency but are not influenced by inflammatory changes. \u0000Aim: The aim of this study is to evaluate the significance of soluble transferrin receptors in diagnostic work up of iron deficiency. \u0000Materials and Methods: It was a prospective observational study carried out from June 2021 to November 2021 at the Department of Haematology and Biochemistry of Armed Forces Institute of Pathology (AFIP), Dhaka Cantonment. A total of 50 blood sample were collected and subjected to diagnose as microcytic hypochromic anaemia through complete blood count (CBC) and peripheral blood film (PBF). Then serum iron profile and serum sTfR was done by automated analyzer to evaluate differentials of microcytic hypochromic anaemia. \u0000Results: Among 50 cases 5 (10%) were male and 45 (90%) were female. Most of the patients were between 31-40 years age group (34%). Out of 50 patients 42 (84%) showed mild anaemia,6 (12%) showed moderately anaemia and 2(4%) showed severely anaemia according to reference range. Then serum iron profile was done. Among 50 samples 37 (74 %) had low serum iron, 18 (36 %) had high TIBC and 45 (90%) had low serum ferritin in comparison with reference range. Also this study revealed high serum sTfR than normal in 48 (96%) patients. While evaluating the frequency of sTfR level in perspective of both male and female anaemic patients, p-value was found < 0.0001 which was statistically significant. \u0000Conclusion: This study demonstrates that sTfR level in conjunction with other biochemical markers of iron deficiency anaemia is very useful in evaluating iron status. Serum sTfR is a new diagnostic tool for evaluating of iron deficiency anemia when it is associated with other inflammatory condition.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115349222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukocyte Adhesion Deficiency: First Case Report from Bangladesh","authors":"Md Sazzad Zayed Chowdhury, F. Khatun, QuaziMohammadImranul Haq, M. Chowdhury, Muhammad Shahidul Islam Sikder Rumi","doi":"10.37545/haematoljbd202288","DOIUrl":"https://doi.org/10.37545/haematoljbd202288","url":null,"abstract":"Leukocyte Adhesion Deficiency (LAD) is an autosomal recessive immunodeficiency disorder characterized by failure of leukocyte to adhere to endothelium resulting in recurrent overwhelming infection from childhood. Deficiency of CD18 expression due to mutation of beta-2 integrin results in LAD. Persistent neutrophilia without infection and leukemoid reaction during infection is hallmark for LAD. Based on percentage of CD18 expression it can be divided into three types (mild, moderate and severe). Diagnosis requires flow cytometric measurement of CD 18, CD11a, CD11b and CD15a or mutation analysis. We are presenting a 4-year female baby with recurrent skin and soft tissue infection. Diagnosis was suspected by history, physical examination and blood reports and confirmed by flow cytometric measurement of CD18 expression. It reveals LAD type-I severe variety. Allogenic stem cell transplant is the only recommended option for LAD. In other cases, antibiotic and antifungals are the mainstay of conservative management. \u0000 ","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132504356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrospinal Fluid Analysis of Acute Lymphoblastic Leukaemia Patients Attending at a Tertiary Care Hospital","authors":"M. Rubel, Muhammad Nurul Farhad, Dilsad Jahan, Gazi Yeasinul Islam, M. Kamruzzaman","doi":"10.37545/haematoljbd202284","DOIUrl":"https://doi.org/10.37545/haematoljbd202284","url":null,"abstract":"Background: Acute lymphoblastic leukaemia (ALL) is a malignant disease of the bone marrow in which lymphoid precursors undergoes a sequence of somatic mutations leading to excessive proliferation and replaces the normal hematopoietic cells of the bone marrow. CNS involvement with lymphoblast is associated with a very poor prognosis and reduced overall survival. CNS may be   involved at diagnosis or relapse. In this study we used conventional biochemical and cytological analysis of CSF along with Flow cytometry to detect lymphoblast in CSF. Methods: This is an observational study conducted in department of haematology, Dhaka Medical College Hospital (DMCH) from July 2017 to December 2017. Purposive sampling was done. After taking informed written consent properly CSF was taken from lumber puncture for cytology, biochemistry and for flow cytometry. After proper data collection sample was analyse using SPSS 20 for Windows 7 program version. Results: Total 50 patients of ALL were included in this study. Flow cytometry (FCM) of CSF fluid showed 10 patients (20%) have CNS involvement. Median age CNS disease vs without CNS disease were 29 vs 21 years (p>0.05). Among the 50 participants 30 were male and 20 were female. Among the 10 patients with CNS diseases 6 were male and 4 were female. 46 cases were newly diagnosed ALL (92%). Among new cases 6 (13%) had CNS involvement. Among 4 relapsed cases 100% had CNS involvement (p<0.001). Patients with or without CNS involvement had median haemoglobin, WBC, and blasts respectively 7.2g/dl and 7.15g/dl, 21x103/µl and 26 x103/µl, and 65% and 45% (p>0.05). Among patients who had CNS involvement 50% had T cell involvement and another 50 had B cell involvement. The most common translocation was t(12;21) found in 24 (48%) patients. t(9:22) was present in 9 (18%) cases (5 with CNS involvement and 4 without CNS involvement). Conclusion: Although acute lymphoblastic leukaemia is a common malignancy of childhood, but it can also affect adults. This study revealed that median age of the ALL in our country is second decade with slight male preponderance. About one fifth of the patients had CNS involvement with equal sharing of B and T cell origin.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125831853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of a Rare Case of Hereditary Angioedema in Bangladesh","authors":"Mahfuzer Rahman, Golam Rabbani, A. Banu, Mohsina Akter, Asm Shafiujjaman, M. Anwar, M. Kabir, M. Azad, Md. Kamrul Hasan","doi":"10.37545/haematoljbd202292","DOIUrl":"https://doi.org/10.37545/haematoljbd202292","url":null,"abstract":"Hereditary angioedema (HAE) is a rare disease that is characterised by recurrent episodes of angioedema in absence of urticaria or pruritus. It usually affects skin and the mucosa of the upper respiratory tract and the gastrointestinal tracts. It is usually a self-limited disease and resolves without treatment in a few days, although fatal asphyxiation may occur due to laryngeal involvement. The rarity, severity of the presentation and the need for appropriate treatment made a special interest to the clinicians for the disease. Early diagnosis can enable the attending physicians to administer an appropriate treatment to rescue the life of the patient. Our case is a 21-year medical student presented with several occasions of attack of angioedema involving lips, eyelids, and face since her 12 years of age. Lack of appropriate diagnostic facilities made the diagnosis of her disease delayed.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133915775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should we choose fresher blood unit for transfusion?","authors":"M. Doha, S. Miah, Md. Ashadul Islam, Atiar Rahman, Mahbuba Sharmin","doi":"10.37545/haematoljbd202295","DOIUrl":"https://doi.org/10.37545/haematoljbd202295","url":null,"abstract":"Though refrigeration of whole blood and packed red blood cell (PRBC) in 1o-6o c provide longer shelf life up to 35-42 days, question remain about their efficacy at the end of storage time. Moreover, storing whole blood and PRBC for such a long time is reportedly associated with various changes in the red cell and plasma which collectively is called ‘storage lesion’. It was a matter of debate in the scientific community whether transfusion of older blood unit carries any risk to the recipient. This review tries to focus on the various effect of storage on red cell and their potential involvement in the clinical outcome of recipient in the view of recent exploration in this field. ","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116375237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of efficacy of oral iron versus parenteral iron in the treatment of iron deficiency anaemia","authors":"M. E. Hossain, H. Mahfuz, M. Uddin, Mostafil Karim","doi":"10.37545/haematoljbd202281","DOIUrl":"https://doi.org/10.37545/haematoljbd202281","url":null,"abstract":"Background: Iron deficiency anaemia (IDA) is one of the most widespread nutritional deficiency and common medical conditions seen in everyday clinical practice. IDA has a substantial haematological complication with potentially serious clinical consequences that often may require iron therapy. In most patients, body stores of iron can be restored by oral iron therapy but parenteral iron therapy results rapid correction of haemoglobin levels, faster and higher replenishment of iron stores with better compliance. The study was to compare the efficacy of oral iron (ferrous sulphate) with parenteral iron (iron sucrose) to treat iron deficiency anaemia. Methods: 221 patients were included in the study. 101 patients were given oral iron in the form of ferrous sulphate containing 67 mg of elemental iron three times daily. 120 patients were treated with iron sucrose.  After a 25 mg test dose on the first infusion only, this was given at a dose of 300 mg by intravenous infusion diluted in 250 ml of normal saline, every alternate day. Haemoglobin level and serum ferritin of both groups were done before iron therapy, 3 weeks and 12 weeks after iron therapy. Results: The mean±SD rise of haemoglobin concentration 3 weeks after iron therapy in iron sucrose group was 11.2±0.60 g/dL, while in ferrous sulphate group was 9.0±0.58 g/dL. The mean±SD ferritin 3 weeks after iron therapy in iron sucrose group was 81.0±15.18 ng/mL, while in ferrous sulphate group was 27.0±12.22 ng/mL. The mean±SD haemoglobin concentration 12 weeks after iron therapy in iron sucrose group was 12.2±0.60 g/dL, while in ferrous sulphate group was 11.0±0.58 g/dL. The mean±SD ferritin 12 weeks after iron therapy in iron sucrose group was 82.0±16.17 ng/mL, while in ferrous sulphate group was 52.0±12.22 ng/mL. No serious adverse events were reported in either the ferrous sulphate group or iron sucrose group. Conclusion: Iron sucrose causes higher rise in haemoglobin level and serum ferritin as compared to oral iron therapy.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114809782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of A2 Blood Group among A Blood Group","authors":"M. Rahman, S. Giti, M. Rahman, Mohammed Nuruzzaman Bhuiyan, Mohammed Shameem Montasir Hossen, Mohammed Elias Hossain","doi":"10.37545/haematoljbd202287","DOIUrl":"https://doi.org/10.37545/haematoljbd202287","url":null,"abstract":"Background: Transfusion medicine is an important branch in the field of medicine and patient care. Prior knowledge and identification of subgroups of ABO blood group system is important in blood transfusion, inheritance pattern, genetics and disease susceptibility. Getting right donor in right time in right place is sometime a challenge in patient care. So proper blood typing is mandatory. Still now there is no data on frequency of rare A2 blood group in Bangladesh Armed Forces as well as in Bangladesh. Aim: To see the frequency of A2 blood group among ABO blood groups in Bangladesh Armed forces and Bangladesh. Materials and Methods: A total of 200 patients with blood group A irrespective of age and sex were included in this retrospective study and the study was carried out in the Department of Transfusion Medicine Armed Forces Institute of Pathology (AFIP), Dhaka Cantonment, Dhaka, Bangladesh from 01 June 2021 to 30 June 2021. Blood grouping was performed by slide method and Anti-A1 reagent is used to differentiate blood group A1  from blood group A2. Results: Among 200 A blood group individual 198 were typed as A1 (99%) and 02 were typed as A2 (01%). Among those two one had anti A1 antibody while other didn’t have. Conclusion: A2 is a rare subtype of A blood group.  Care should be taken during routine ABO grouping especially in cases of discrepancies or mix-field or weak positive reactions in A blood group.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122729889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Minor ABO Incompatibility in Allogeneic Stem Cell Transplant by Plasma Reduction: Case Report from A Tertiary Care Private Hospital in Dhaka","authors":"Tamanna Afroz","doi":"10.37545/haematoljbd202285","DOIUrl":"https://doi.org/10.37545/haematoljbd202285","url":null,"abstract":"Human Leukocyte Antigen (HLA) matching plays a crucial role in allogeneic SCT outcome and remains the single most important factor for donor selection.  ABO blood group barrier is often crossed between patient and donor. ABO incompatibility may cause acute haemolysis due to transfer of high titter donor isohaemagglutinins contained in the graft or in paediatric patients with small blood volume. To overcome this obstacle, some amount of plasma present in progenitor cell product can be reduced. Plasma reduction can be done in many ways. For a financial constrain set up, we did the plasma reduction manually to overcome the complications and cost. Here we are presenting a case report from Bangladesh.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116213012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of Immunophenotypic Aberrant Expression in De-Novo Acute Leukaemia","authors":"K. Islam, I. Jahan, Md. Adnan Hasan Masud, M. Hossain, Nishat Mahzabin, Md. Arif-Ur- Rahman, M. Ahmed, Mujahida Rahman, Md Salahuddin Shah, Md. Abdul Aziz, M. Begum, A. Yunus","doi":"10.37545/haematoljbd202283","DOIUrl":"https://doi.org/10.37545/haematoljbd202283","url":null,"abstract":"Background: Aberrant expression (AE) of Acute Leukaemia (AL) is essential to confirm the diagnosis of AL patients whether it is biphenotypic/mix phenotypic AL or it is AL with AE. Objectives:  This study is conducted to observe the diversity of aberrant immunophenotypic expressions among the patients of acute leukaemia with varying frequencies, to find out the correlation between aberrantly expressed immunophenotypic markers with different variety of French American British (FAB) sub classification of acute leukaemia and any correlation of clinical presentation of AL patients with aberrantly expressed immunophenotypic markers. Methodology: This cross-sectional observational study was carried out in the department of Haematology, BSMMU, Bangladesh on 50 patients from 14 to 65 years of age of both sex of newly diagnosed de- novo untreated AL patients from January 2017 to June 2018. Informed written consent & clinical history is taken and physical examinations were done in a predesigned data collection sheet. Then Bone marrow (BM) with peripheral blood sample for morphology and immunophenotyping were done in the laboratory of the Haematology department of BSMMU. After collection of data, these data were analysed for the final result. Result: In this study, 24 (48%) patients of de-novo Acute Leukaemia have Immunophenotypic aberrant expressions. Among them 12 (24%) patients were AML with AE, 9 (18%) patients were B ALL with AE, 3 (6%) patients were T ALL with AE and 2 (4%) patients were MPAL. In case of AML the most frequent Lymphoid aberrant marker is CD7 (12%), In B ALL the most frequent aberrant marker is CD5 (10%) and in T ALL the most frequent aberrant marker is CD10 (4%). Conclusion: In de-novo acute leukaemia, there is significant number of patients have aberrant expression which should be differentiated from biphenotypic/mix phenotypic AL for therapeutic and prognostic implications.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"73 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132948648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}