新诊断多发性骨髓瘤患者骨并发症谱

Salina Haque, Zulfia Zinat Chowdhury, K. Ahmed, A. Islam, Mohammad Ali, J. Ferdouse, T. Ara, Md. Mahbubur Rahman
{"title":"新诊断多发性骨髓瘤患者骨并发症谱","authors":"Salina Haque, Zulfia Zinat Chowdhury, K. Ahmed, A. Islam, Mohammad Ali, J. Ferdouse, T. Ara, Md. Mahbubur Rahman","doi":"10.37545/haematoljbd202290","DOIUrl":null,"url":null,"abstract":"Abstract \nMultiple myeloma is a malignant disorder of plasma cells that seed throughout the bone marrow and usually produce a monoclonal immunoglobulin in the blood, urine, or both, cause lytic bone lesions. A total of 159 newly diagnosed multiple myeloma patients aged 24 to 85 were included in this study. The median age of 159 patients was 56 years. Highest incidence of multiple myeloma was found in 50-59 years age group and P value was statistically significant. Male patient was 103 (65%) and female patient was 56 (35%). The median age of male patients was 56 years and the female patients was 57 years. There was no statistically significant age difference between male and female patients. 76.1% patients had bone involvement. Lytic bone lesions were found in 45.9% cases. Among them 15.1% patient had single lytic lesion and 30.8% patient had multiple lytic lesions. Most common site of lytic lesion was skull (33.3%).Pelvis was the second most common site of lytic lesion (15.7%).The prevalence of fracture was 44.7%, among them vertebral fracture was in 37.1% cases, rib fracture was in 9.4% cases, humerus fracture was in 3.1%, femur fracture was in 3.8%, fracture of neck of femur in 0.6%. Nerve root compression found in 12.6% cases. Lytic lesion and fracture are most common features of bone involvement in multiple myeloma patients. MRI study instead of radiographic study may increase the detection of bone lesion especially in the thoraco-lumber spine, pelvis and proximal femurs. Further studies incorporating MRI study are necessary to determine skeletal changes of MM patients.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Spectrum of Bone Complications in Newly diagnosed Multiple Myeloma patients\",\"authors\":\"Salina Haque, Zulfia Zinat Chowdhury, K. Ahmed, A. Islam, Mohammad Ali, J. Ferdouse, T. Ara, Md. Mahbubur Rahman\",\"doi\":\"10.37545/haematoljbd202290\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract \\nMultiple myeloma is a malignant disorder of plasma cells that seed throughout the bone marrow and usually produce a monoclonal immunoglobulin in the blood, urine, or both, cause lytic bone lesions. A total of 159 newly diagnosed multiple myeloma patients aged 24 to 85 were included in this study. The median age of 159 patients was 56 years. Highest incidence of multiple myeloma was found in 50-59 years age group and P value was statistically significant. Male patient was 103 (65%) and female patient was 56 (35%). The median age of male patients was 56 years and the female patients was 57 years. There was no statistically significant age difference between male and female patients. 76.1% patients had bone involvement. Lytic bone lesions were found in 45.9% cases. Among them 15.1% patient had single lytic lesion and 30.8% patient had multiple lytic lesions. Most common site of lytic lesion was skull (33.3%).Pelvis was the second most common site of lytic lesion (15.7%).The prevalence of fracture was 44.7%, among them vertebral fracture was in 37.1% cases, rib fracture was in 9.4% cases, humerus fracture was in 3.1%, femur fracture was in 3.8%, fracture of neck of femur in 0.6%. Nerve root compression found in 12.6% cases. Lytic lesion and fracture are most common features of bone involvement in multiple myeloma patients. MRI study instead of radiographic study may increase the detection of bone lesion especially in the thoraco-lumber spine, pelvis and proximal femurs. Further studies incorporating MRI study are necessary to determine skeletal changes of MM patients.\",\"PeriodicalId\":137283,\"journal\":{\"name\":\"Haematology Journal of Bangladesh\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Haematology Journal of Bangladesh\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37545/haematoljbd202290\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Haematology Journal of Bangladesh","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37545/haematoljbd202290","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

多发性骨髓瘤是一种浆细胞的恶性疾病,它在骨髓中播散,通常在血液、尿液或两者中产生单克隆免疫球蛋白,导致溶解性骨病变。本研究共纳入159例24 ~ 85岁的新诊断多发性骨髓瘤患者。159例患者的中位年龄为56岁。多发性骨髓瘤发病率以50 ~ 59岁年龄组最高,P值有统计学意义。男性103例(65%),女性56例(35%)。男性患者中位年龄56岁,女性患者中位年龄57岁。男女患者年龄差异无统计学意义。76.1%患者有骨受累。溶解性骨病变占45.9%。其中15.1%的患者有单一溶解性病变,30.8%的患者有多发溶解性病变。溶解性病变以颅骨为最常见部位(33.3%)。骨盆是第二常见的溶解性病变部位(15.7%)。骨折发生率为44.7%,其中椎体骨折37.1%,肋骨骨折9.4%,肱骨骨折3.1%,股骨骨折3.8%,股骨颈骨折0.6%。12.6%的病例发现神经根受压。溶解性病变和骨折是多发性骨髓瘤患者骨骼受累最常见的特征。MRI检查代替x线检查可能增加骨病变的检出率,特别是在胸腰椎、骨盆和股骨近端。需要进一步的研究结合MRI研究来确定MM患者的骨骼变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Spectrum of Bone Complications in Newly diagnosed Multiple Myeloma patients
Abstract Multiple myeloma is a malignant disorder of plasma cells that seed throughout the bone marrow and usually produce a monoclonal immunoglobulin in the blood, urine, or both, cause lytic bone lesions. A total of 159 newly diagnosed multiple myeloma patients aged 24 to 85 were included in this study. The median age of 159 patients was 56 years. Highest incidence of multiple myeloma was found in 50-59 years age group and P value was statistically significant. Male patient was 103 (65%) and female patient was 56 (35%). The median age of male patients was 56 years and the female patients was 57 years. There was no statistically significant age difference between male and female patients. 76.1% patients had bone involvement. Lytic bone lesions were found in 45.9% cases. Among them 15.1% patient had single lytic lesion and 30.8% patient had multiple lytic lesions. Most common site of lytic lesion was skull (33.3%).Pelvis was the second most common site of lytic lesion (15.7%).The prevalence of fracture was 44.7%, among them vertebral fracture was in 37.1% cases, rib fracture was in 9.4% cases, humerus fracture was in 3.1%, femur fracture was in 3.8%, fracture of neck of femur in 0.6%. Nerve root compression found in 12.6% cases. Lytic lesion and fracture are most common features of bone involvement in multiple myeloma patients. MRI study instead of radiographic study may increase the detection of bone lesion especially in the thoraco-lumber spine, pelvis and proximal femurs. Further studies incorporating MRI study are necessary to determine skeletal changes of MM patients.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信