Journal of Ozone Therapy最新文献

{"title":"The efficacy of intra-articular PRP, Ozone and Ozone+PRP injections in patients with osteoarthritis.","authors":"Lale Yeprem, Aysegul Ellialtioglu, J. Baeza-Noci","doi":"10.7203/JO3T.2.3.2018.10904","DOIUrl":"https://doi.org/10.7203/JO3T.2.3.2018.10904","url":null,"abstract":"Osteoarthritis (OA) is the most common form of arthritis and some joints are effected more than others. The prevalence of OA increases with age and it represents the major problem for functional impairment in older patients. Non-surgical treatment with oral drugs is not suitable for many patients suffering from gastric disorders, high blood pressure or different heart diseases. Intra-articular injections are a promising solution in these cases. \u0000This study was performed to compare the efficacy and safety of ozone injections, PRP (platelet rich plasma) injections and combined ozone plus PRP injections in patients with symptomatic knee OA. \u0000120 patients were diagnosed of OA according to the criteria of the American College of Rheumatology and included into this study. Patients were randomly divided into three equal groups (40 patients each group). We include patients whose VAS score was 5 or above. Patients with inflammatory, endocrine and metabolic disturbances, and patients who had meniscectomy within the past 10 years, extra articular surgery within the last year, arthrocentesis in last 6 months or any drug given intra-articular were not included. We did not include either patients with misalignment. \u0000Patients in the first group were treated with intra-articular injections of ozone/oxygen gas mixture 2 times/week, at 10 µg/mL concentration and a volume of 5 mL for a total of 12 injections. \u0000Patients in the second group were treated only with PRP injections once a week for a total of 3 times. \u0000Patients in the third group were treated with intra-articular injections of Ozone+PRP (10 µg/ml concentration, 5 ml volume) once a week for a total of 3 times. \u0000The pain levels of patients were measured with Visual Analog Scale (VAS). Side effects were collected using an open list record. \u0000All the groups improved their baseline VAS in a significant way, although the group with the best results was group 3 with the combination of ozone and PRP in the same injection. \u0000We are planning further studies including systemic ozone in order to improve more the pain in our patients.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115393724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good prospects.","authors":"José Baeza Noci","doi":"10.7203/jo3t.2.3.2018.15390","DOIUrl":"https://doi.org/10.7203/jo3t.2.3.2018.15390","url":null,"abstract":"This third issue compiles the papers sent during 2017 and some others sent in 2018, so I apologise all the authors for the delay and thank them for their patience. The 4th issue will be devoted to be the proceeding of the World Congress organized by Dr Lamberto Re in Ancona - Italy in 2017 and will be published by Summer-19. Issue number 5 will be devoted to spine diseases thanks to the wonderful effort done by Dr. Alberto Alexandre from Treviso - Italy. The rest of the papers already sent and new to come will be published on 2020. \u0000 \u0000The indexation of this journal is so fantastic, thanks to the University of Valencia’s Publication Service, that it is quickly compiled in all open journals search indexes. We will be included in other search engines as soon as we fulfil their requirements. By the moment, the only thing we need is papers. \u0000 \u0000This issue has scientific articles devoted to basic investigation, toxicity and security topics, AIDS, cardiology, hepatitis, neurology, odontology and osteoarthritis. All of them are very interesting and try to clarify some basic and clinical aspects of ozone therapy. I want to express my most sincere gratitude to all the reviewers - members of the editorial board - that have collaborated and really helped to increase the quality of all of them. Peer review process is our corner stone in order to publish a good quality journal, as I believe this is. \u0000 \u0000For the readers, I thank them for reading our journal so much and download our papers so many times; you can read in the STATISTIC section (still on testing) the great impact our journal is having in the scientific community. I also encourage them to publish their experience. I know that many of them have never published and are afraid of doing it, but I promise I will help anybody that wants to write a paper to do it. Some of you have already checked this. \u0000 \u0000I wait for your papers meanwhile we prepare the next issues! \u0000 \u0000Prof. Jose Baeza-Noci \u0000WFOT Past-President \u0000JO3T Editor-in-chief","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114848582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of the Toxicological Tests in the Application and Safety of Ozone Therapy","authors":"Silvia Menéndez-Cepero, Z. Zamora, F. Hernández","doi":"10.7203/JO3T.2.3.2018.10009","DOIUrl":"https://doi.org/10.7203/JO3T.2.3.2018.10009","url":null,"abstract":"Until today, there is not any official registry of the different routes of systemic ozone therapy. With the aim to prove the safety of this therapy, several ways of ozone (O3) applications were evaluated, such as rectal insufflation (RI), major autohemotherapy (M-AHT) and intraperitoneal application (IP). For RI, some toxicological tests were performed such as: acute, sub-chronic, mutagenic (bone marrow chromosomic aberrations and micronucleus), teratogenic  and irritation studies (at 40 mg/L and 10 mL during 15 days). For M-AHT, acute toxicological (in rats with 21, 47 and 64 mg/L and a volume of 2 mL with daily evaluation up to 15 days) and mutagenic (chromosomal aberration analysis, micronucleus assay and sister chromatid exchange test) studies were performed. For IP application, subchronic (O3 was administered during 15 days in mice at concentrations of 11, 29 and 35 mg/L and volumes of 80 mL/kg) and genotoxic (cytotoxic and clastogenic activity) studies were evaluated. All the toxicological studies performed for the O3 RI fulfilled the requirements established for an official registry (no deleterious effects were observed). However, more toxicological studies must be done with respect to M-AHT and IP O3 applications in order to prove the complete safety of these ways.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126994787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major Autohemotherapy as a treatment modality for alveolar osteitis","authors":"M. Khalifah","doi":"10.7203/JO3T.2.3.2018.11292","DOIUrl":"https://doi.org/10.7203/JO3T.2.3.2018.11292","url":null,"abstract":"Purpose. \u0000Alveolar osteitis is the most common post-odontectomy complication. Although blood clot disintegration is known to be the cause of the condition, an agreement is lacking regarding a treatment of choice. The aim of the current study therefore was to evaluate major autohemotherapy as one treatment method. \u0000 \u0000Patients and Methods. \u0000A total of 183 patients were categorized into 4 groups (I, II, III, and IV) according to pain severity (mild, moderate, severe, or agonizing, respectively). Major autohemotherapy was performed for all patients by withdrawing 225mL of patient's blood and mixing them with 225mL of Oxygen-Ozone gas (where Ozone concentration was 50µg/mL gas) \u0000 \u0000Results and Discussion. \u0000Despite AHT was a high-potency curative treatment for groups I and II, it was palliative for group IV. For group III, it oscillated between being a curative or a palliative treatment with a statistically insignificant difference. \u0000 \u0000Conclusion. \u0000AHT might be a recommended treatment for AO","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132313880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The immune response behavior in HIV-AIDS patients treated with Ozone therapy for two years.","authors":"Javier Cespedes-Suarez, Yanisley Martin-Serrano, María Rosa Carballosa-Peña, Diana Rosa Dager-Carballosa","doi":"10.7203/JO3T.2.3.2018.11458","DOIUrl":"https://doi.org/10.7203/JO3T.2.3.2018.11458","url":null,"abstract":"HIV continues to be one of the biggest problems for the global public health. The African region is one of the most affected, accounting for almost two thirds of the new infections. Many of them are retroviral medications and multi-therapies aiming to stop the viral replication and maintaining immunological stability, which fail to guarantee the quality of life or enhance the patient's immunity \u0000Ozone has biological properties, among which the antimicrobial and modulatory effect on the immune response is highlighted, which makes it possible to use it in a complementary way for the treatment of these patients. \u0000We conducted the present study in which the effect of the ozone therapy administered systemically (blood route) is analyzed. We have studied 32 patients to whom we applied Major Autohemotherapy with a protocol of 15 sessions and maintenance every 15 days at 50 µg/ml of concentration; the initial dose was 4,000 µg/mlup to 12,000 µg/ml \u0000We indicated viral load, CD4 and CD8 counts before and at the end of therapy. The results showed a significant decrease in viral load to undetectable values and an increase of CD4 and CD8 at the end of the 15 sessions, being maintained at 2 years of treatment, thus achieving a permanent activation of the immune system and improving the quality of life of these patients. \u0000Key words: Ozone therapy, HIV-AIDS, Immune Response, Major Autohemotherapy","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122621364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical behavior of children with infantile cerebral palsy after ozone therapy.","authors":"Benjamin E. Arenas, J. L. Calunga, Silvia Menéndez-Cepero, C. Vera, M. Infante, M. Herrera, O. Franco, A. Gorzelewski","doi":"10.7203/JO3T.2.3.2018.11205","DOIUrl":"https://doi.org/10.7203/JO3T.2.3.2018.11205","url":null,"abstract":"Objective. The aim of this study was to determine the usefulness of ozone therapy in the treatment of Infantile Cerebral Palsy (ICP). Patients and methods. A non-controlled clinical assay was made in the Ozone Research Center (CIO), Havana, Cuba from January 2013 to January 2014. The sample was constituted by patients remitted to pediatrics consultation of CIO, to whom inclusion and exclusion criteria were applied. The study group involved 45 patients, from 1 month of birth to 8 years, with cerebral palsy of hypoxic-ischemic cause. The evaluation criteria were: evolution of the motor disorder according to the Gross Motor Function Classification System (GMFCS) scale, modification of muscle tone (Ashworth modified scale) and response to treatment (O’Brien modified scale). The way of administration was rectal insufflation; concentrations between 15, 20, 25 and 30 mg/L were used, volumes varied according to age, making calculation of the dose of ozone according to kilograms of weight. Cycles of 20 sessions, every 3 months were indicated, until completing 4 in 16 months. Patients were clinically evaluated, according to the scales used, before and after each cycle. Results and Discussion. The best answer to treatment was obtained in the group aged ? 4 years. The variables analyzed showed a significant improvement when the ozone treatment concluded. With respect to the evolution of the motor disorder, in 65 % of cases it improved. In the group of children below 4 years, the response was better in relation to the muscle tone. Response to treatment, according to the relatives’ criteria, was of 70 % of the children with marked improvement in the tone and muscle function. Conclusions. The greatest percentage of patients improved in the evolution of the motor disorder; when the Manual Ability Classification System (MACS) scale was applied, more than half the patients showed an improvement. A high percentage of children get a satisfactory result regarding muscle tone and motor function. No side effects were present in any of the cases during the study.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125227082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone therapy in idiopathic carpal tunnel syndrome. Biochemical, neurophysiological and clinical aspects.","authors":"M. Rascaroli, B. Borghi, Alessandro Rascaroli, V. Travagli","doi":"10.7203/JO3T.2.3.2018.11286","DOIUrl":"https://doi.org/10.7203/JO3T.2.3.2018.11286","url":null,"abstract":"Purpose. \u0000Idiopathic Carpal Tunnel Syndrome (CTS) is the most common entrapment neuropathy; however few and only retrospective studies have been found in search engines about Ozone Therapy. \u0000The aim of this paper was to evaluate clinical and neurophysiological outcome following Ozone Therapy in CTS. \u0000We focused the attention on the evidences concerning the role of Subsynovial Connective Tissue (SSCT) in the pathogenesis of CTS and the ozone pre-conditioning effects linked to pain and inflammatory pathways and to fibrosis induced by Ischemia-Reperfusion Injury. \u0000 \u0000Materials and methods. \u0000Thirty-five patients, aged between 21 and 80, were stratified clinically by Boston Carpal Tunnel Questionnaire (B.C.T.Q.) and Neurophysiologically by Padua’s Gravity Scale classifying patients into five Electro-myographic categories. The mean symptom duration was also recorded. \u0000The patients filled in the B.C.T.Q. before and after treatment as well underwent diagnostic neurophysiological tests, strictly standardized in stimulation parameters, electrodes placement and skin temperature. \u0000The Ozone Therapy was performed by injecting 4 ml of O2-O3 mixture at 10 ug/ml concentration under the transverse carpal ligament twice a week for eight sessions. \u0000 \u0000Results. \u0000We compared the B.C.T.Q. scores and the neurophysiological parameters obtained before and after O2-O3 treatment: the improvement of symptoms was significantly greater than the improvement of motor and sensory nerve conduction. \u0000The highest clinical improvement degree was found in patients classified in Mild and Moderate Groups. \u0000 \u0000Discussion and Conclusion. \u0000Ischemia-Reperfusion Injury triggers oxidative stress in SSCT with activation of chemical mediators and neo-angiogenesis leading to non-inflammatory fibrosis that represent the allmark of CTS. \u0000Previous and retrospective studies based O2-O3 treatment on the main mechanisms of action shared by the treatment of herniated disc in the spine; our study focused the attention on pathophysiology of the SSCT trying to recognize the various stages of CTS pathogenesis by correlating with clinical and neuro-physiological tests. \u0000Further studies have to be carried out to better understand these relationships and optimize timing of Ozone Therapy.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128413195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of patients with chronic Hepatitis B in one year of treatment with Major Autohemotherapy.","authors":"Javier Cespedes-Suarez, Yanisley Martin-Serrano, María Rosa Carballosa-Peña, Diana Rosa Dager-Carballosa","doi":"10.7203/JO3T.2.3.2018.11459","DOIUrl":"https://doi.org/10.7203/JO3T.2.3.2018.11459","url":null,"abstract":"The Hepatitis B (HVB) is one of the most common infectious diseases in the world, it’s wide geographical distribution is a health problem, especially on the African continent, with prevalence rate of 6.1% in the adult population. Current treatment requires prolonged therapy (most cases for the rest of life) with the aim of stopping viral replication, maintaining immunological stability, preventing progression of liver disease and the most feared complications such as cirrhosis and hepatic cancer \u0000There are multiple references that point to ozone therapy as an alternative in the treatment of Hepatitis B, because of the known and demonstrated antimicrobial and immunomodulatory properties. With these premises, we performed the present clinical study that included 28 patients with positive diagnosis of chronic Hepatitis B, surface antigen (HVBs Ag) positive, antibodies against surface antigen (HVBs) negative, viral load (HVB DNA ) and transaminaseselevated. These patients with 1 year of evolution and antiviral treatment were treated with Major Autohemotherapy with protocol of 15 sessions and maintenance every 15 days to 50 mcg of concentration, initial dose of 4,000 mcg / ml up to 12,000 mcg /ml \u0000We indicate Ag HVBs, Ac HVBs, HVB Viral Loading and transaminases before starting treatment at 15 days of completion and quarterly until the year. The results showed negativization of the surface antigen, antibody positivity against the surface antigen, significant decrease of viral load to undetectable values and normal values of the transaminases demonstrating the functional recovery of the disease associated with favorable immunological response providing a better quality of patients' lives. \u0000Key words: Hepatitis B, Transaminases, Ozone therapy, Major Autohemotherapy, Surface antigen, Surface Antigen Antibody.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127968673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific approach for ozone absorption in blood during systemic indirect endovenous ozonetherapy","authors":"J. Baeza-Noci, Rosa Pinto-Bonilla, Leonor Contreras-Velasco, Manuel Gomez-Moraleda","doi":"10.7203/JO3T.2.3.2018.9611","DOIUrl":"https://doi.org/10.7203/JO3T.2.3.2018.9611","url":null,"abstract":"Introduction. \u0000Reading reference ozone books from Dra. Menendez, Dra. Viebhan, Dra. Borrelli and Dr. Bocci, proper timing for mixing ozone in blood during autohemotherapy is not calculated in a scientific way, having only an estimation of it based on changes in the blood color, more related to oxygen absorption than on ozone itself. \u0000 \u0000Material and methods. \u0000We decided to reproduce a reduced model of great autohemotherapy or recently renamed as systemic indirect endovenous ozonotherapy (SIEVO) by the World Federation of Ozone Therapy – WFOT, using syringes to simplify the experiment. Our model consisted of a 20 mL syringe filled with 10 mL of blood withdrawn from healthy volunteers and mixed it gently but in controlled way with 10 mL medical ozone at different concentrations; after 5 and 8 seconds, the remaining gas was analyzed by an spectrophotometer based ozone detector to check the amount of ozone. Data were analyzed using a linear regression model. \u0000 \u0000Results. \u0000Results show that even for 60 mcgr/mL ozone concentration, 8 seconds is enough to let all ozone absorbed in blood. \u0000 \u0000Discussion and Conclusions. \u0000The experiment shows how quick ozone reacts with blood and claims for a trial with real SIEVO devices to achieve a real timing.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129420597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible errors in pain treatment with ozone [abstract]","authors":"S. Tiron","doi":"10.7203/jo3t.2.2.2018.11135","DOIUrl":"https://doi.org/10.7203/jo3t.2.2.2018.11135","url":null,"abstract":"This presentation is made based on (more than) 3000 patient’s experience. \u0000The pain treatment with ozone is an excellent one. So … why don’t we have 100% results? \u0000 \u0000- WRONG DIAGNOSIS : \u0000 \u0000a. Treatment of an irradiate pain like a local one: every pain in \u0000- Upper limb (with no evident cause): must be treated like an irradiate cervical problem, and treated in cervical region. \u0000- Lower limb ( with no evident cause ): must be treated like an irradiate lumbar problem and treated in lumbar region. \u0000b. Traumatical or surgical scars in cervical or abdominal region can explain cervical or lombar pain. The treatment must begin with subcutaneous ozone injections in the pericicatricial region. \u0000c. Pain given by chronic fatigue syndrome \u0000- Treatment in diseases when the ozone treatment is inefficient ( lumbar stenosis, wryneck … ) \u0000 \u0000- TECHNICAL ERRORS: \u0000 \u0000a. Position of the needle ( paravertebral ) \u0000b. Wrong concentration of ozone","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121076385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}