Javier Cespedes-Suarez, Yanisley Martin-Serrano, María Rosa Carballosa-Peña, Diana Rosa Dager-Carballosa
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引用次数: 8
摘要
乙型肝炎(HVB)是世界上最常见的传染病之一,其广泛的地理分布是一个健康问题,特别是在非洲大陆,成人人口的患病率为6.1%。目前的治疗需要延长治疗时间(大多数病例需要终生治疗),目的是阻止病毒复制,维持免疫稳定性,预防肝病的进展以及肝硬化和肝癌等最可怕的并发症。由于臭氧具有已知和已证实的抗菌和免疫调节特性,因此有多篇文献指出臭氧疗法是治疗乙型肝炎的一种替代方法。在这些前提下,我们进行了本临床研究,包括28例慢性乙型肝炎阳性诊断,表面抗原(HVBs Ag)阳性,抗表面抗原(HVBs)抗体阴性,病毒载量(HVB DNA)和转氨酶升高的患者。这些患者经过1年的进化和抗病毒治疗,接受Major autohemattherapy治疗,每15天进行15次治疗,维持浓度为50微克,初始剂量为4,000微克/毫升至12,000微克/毫升。我们在完成治疗前15天开始治疗前显示Ag HVBs, Ac HVBs, HVB病毒载量和转氨酶。结果显示,表面抗原阴性,表面抗原抗体阳性,病毒载量显著下降至检测不到的值,转氨酶正常,表明疾病的功能恢复与良好的免疫反应有关,为患者提供了更好的生活质量。关键词:乙型肝炎,转氨酶,臭氧治疗,自体血液治疗,表面抗原,表面抗原抗体。
Response of patients with chronic Hepatitis B in one year of treatment with Major Autohemotherapy.
The Hepatitis B (HVB) is one of the most common infectious diseases in the world, it’s wide geographical distribution is a health problem, especially on the African continent, with prevalence rate of 6.1% in the adult population. Current treatment requires prolonged therapy (most cases for the rest of life) with the aim of stopping viral replication, maintaining immunological stability, preventing progression of liver disease and the most feared complications such as cirrhosis and hepatic cancer
There are multiple references that point to ozone therapy as an alternative in the treatment of Hepatitis B, because of the known and demonstrated antimicrobial and immunomodulatory properties. With these premises, we performed the present clinical study that included 28 patients with positive diagnosis of chronic Hepatitis B, surface antigen (HVBs Ag) positive, antibodies against surface antigen (HVBs) negative, viral load (HVB DNA ) and transaminaseselevated. These patients with 1 year of evolution and antiviral treatment were treated with Major Autohemotherapy with protocol of 15 sessions and maintenance every 15 days to 50 mcg of concentration, initial dose of 4,000 mcg / ml up to 12,000 mcg /ml
We indicate Ag HVBs, Ac HVBs, HVB Viral Loading and transaminases before starting treatment at 15 days of completion and quarterly until the year. The results showed negativization of the surface antigen, antibody positivity against the surface antigen, significant decrease of viral load to undetectable values and normal values of the transaminases demonstrating the functional recovery of the disease associated with favorable immunological response providing a better quality of patients' lives.
Key words: Hepatitis B, Transaminases, Ozone therapy, Major Autohemotherapy, Surface antigen, Surface Antigen Antibody.