Journal of Ozone Therapy最新文献

{"title":"Treatment of Degenerative Disc Disease associated with Modic changes, with ozone therapy. A new therapeutic proposal.","authors":"A. Grangeat, Angeles Erario","doi":"10.7203/JO3T.4.5.2020.14739","DOIUrl":"https://doi.org/10.7203/JO3T.4.5.2020.14739","url":null,"abstract":"Introduction. \u0000Modic Changes (MCs) represent signal changes in the vertebral endplate and subchondral bone region visualized on T1 and T2 weighted magnetic resonance images (MRI). Three types of MCs It have been identified (Types 1 to 3). Modic changes are commonly associated with low-back pain (LBP). \u0000In the last few years scientific papers have shown that one of the causes of MCs (fundamentally, the MCs type 1) is the infection caused by an anaerobic bacterium of very low virulence: Propionibacterium acnes (P. acnes). This bacterium resides on the human skin, oral cavity, intestinal tract, and external ear canal as normal flora. As a consequence of tooth brushing and endodontic-therapy, could invade the blood stream leading to transient bacteremia. The authors propose a treatment which consists of Amoxicillin-clavulanate (500 mg/125 mg) three times a day, at 8-hour intervals, for 90 days/100 days. \u0000Objectives. \u0000Ozone therapy could be the gold standard therapy for MC1 because ozone is a powerful anti-microbial, anti-inflammatory and analgesic agent, which regulates oxidative stress, immune system and oxygen metabolism. \u0000Materials and Methods \u0000Patients with LBP lasting 6 months or more and MC1 confirmed by MRI of lumbar spine L3/L4 or L4/L5 or L5/S1 and who responded with 5 or more points on the VAS scale were treated with three intradiscal sessions of ozone therapy and ten paravertebral sessions. \u0000Results. \u0000Patients who were treated with ozone therapy according to our treatment proposal showed a substantial improvement on VAS comparing the beginning and the end of the treatment. They show a significant difference in pain, and general condition. However, these results were not reflected on ODI scale, neither on the MRI but we could notice certain improvements.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127632581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone therapy as complementary treatment for surgical infection: case report.","authors":"J. Buric, M. Damilano, P. Berjano","doi":"10.7203/JO3T.4.5.2020.18022","DOIUrl":"https://doi.org/10.7203/JO3T.4.5.2020.18022","url":null,"abstract":"Background: Infection is a serious surgical complication that increases significantly morbidity and mortality rates as well as health care expenses. Bacterial ever-growing resistance to antibiotics makes the treatment of such events even more troublesome. \u0000Objective: Report on a surgical infection case treated with ozone as a complementary therapy. \u0000Methods and Materials: Female, 65 years old, submitted to a complex surgical procedure for adult kyphotic deformity correction that presented with early post-surgical infection. The patient was treated with revision surgery and antibiotics that improved the condition but were unable to delete the infection. Ozone, in its gaseous form, was injected subcutaneously and paravertebraly twice weekly for three weeks. \u0000Results: After 3 weeks of treatment the wound healed completely and repeated visits and blood exams up to one year after the surgery did not show recurrence of infection. \u0000Conclusions: Although not a definite indication on validity of ozone therapy for surgical infections, the results of this case report indicate a new way that merits to be explored.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128346941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role and the effects of the ozone paravertebral injections, in lumbar disc herniation patients.","authors":"G. Calle, Lucio Huayhua, A. Martínez","doi":"10.7203/JO3T.4.5.2020.18023","DOIUrl":"https://doi.org/10.7203/JO3T.4.5.2020.18023","url":null,"abstract":"The results obtained from a group of patients suffering from discoradicular conflict syndrome treated with paravertebral oxygen-ozone injections were analyzed. From a total number of 8500 patients treated with ozone during the period 2002/2015, 880 patients underwent intradiscal injection and 7620 patients were treated with paravertebral ozone injections. This paper analyses a subgroup of 1850 patients (24.28% of the patients who were treated with paravertebral injections), including those patients who underwent the total 10-session treatment, complied with a 5-year follow-up and with the sample homogeneity parameters following a predictability therapeutic effectiveness (PET) index devised for such purpose (PET index O3) by us in 2009. The outcomes were assessed based on the VAS score and modified Mac Nab criteria. Definite results determined positive post-treatment outcomes considered excellent and good in 81% of the cases. Such effectiveness percentage resulted lower than the one achieved with the intradiscal injection technique (89%), and higher than the percentage seen in papers on the selective nerve root block technique.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114831204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Not just herniated disc” back pain: Outcome of oxygen-ozone treatment in selected applications.","authors":"M. Bonetti, A. Zambello, M. Leonardi, C. Princiotta","doi":"10.7203/JO3T.4.5.2020.10811","DOIUrl":"https://doi.org/10.7203/JO3T.4.5.2020.10811","url":null,"abstract":"Low back pain and sciatica are highly debilitating conditions affecting all socioeconomic groups at an increasingly early age. They are caused by different often concomitant spinal disorders: disc or facet joint disease, spondylolisthesis (with or without listhesis), vertebral body and interapophyseal arthrosis, spinal stenosis, radicular and synovial cysts and, more rarely, infections and primary or metastatic cancer.Treatment of low back pain and/or sciatica requires an accurate diagnosis based on thorough history-taking and physical examination followed by appropriate imaging tests, namely computed tomography and/or magnetic resonance scans in addition to standard X-rays of the spine.In recent years, several reports have demonstrated the utility of oxygen-ozone therapy in reducing the size of herniated discs. The present study reports on the outcome of oxygen-ozone treatment in 416 patients with non-discogenic low back pain caused by degenerative disease of the posterior vertebral compartment (facet synovitis, Baastrup syndrome, spondylolysis and spondylolisthesis, facet degeneration).","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":"539 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123460035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diamod tip.","authors":"José Baeza Noci","doi":"10.7203/JO3T.4.5.2020.21363","DOIUrl":"https://doi.org/10.7203/JO3T.4.5.2020.21363","url":null,"abstract":"This issue 5 is devoted to spine diseases that can be treated or improved by using medical ozone. Dr. Alberto Alexandre compiled during 2015 and 2016 a number of papers from experienced authors in order to prepare a monographic issue but found a lot of difficulty in publishing it. I offered him our Journal to publish these scientific works and he agreed. \u0000 \u0000COVID-19 pandemic has produce a huge increase in publishing time for all journals but we finally have been able to produce this issue. Due to the delay in its publication, some papers have been published by their authors in other journals. \u0000 \u0000We are hardly working in issue 6 that will be opened for different topics and we are preparing issue 7 that we expect to be a monographic on dental applications. \u0000 \u0000All papers are welcomed!","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121023370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone injections therapies for temporo-mandibular joint disorders/disfunctions [abstract]","authors":"Robert Harris","doi":"10.7203/jo3t.3.4.2019.15505","DOIUrl":"https://doi.org/10.7203/jo3t.3.4.2019.15505","url":null,"abstract":"INTRODUCTION: Temporomandibular Joint Disorders/Dysfunctions (TMJD) were first described in ancient Egyptian literature. The condition has been reported in the medical/dental literature under a variety terms and syndromes. TMJD is the currently accepted term for a variety of conditions in the head, neck and temporomandibular joint areas. \u0000 \u0000MATERIALS AND METHODS: A systematic review and search of the literature produced the following results: \u00001. TMJ Infection 2,080,000 Google \u00002. TMJ Injections 32,900 Google \u00003. TM Joint 24,839 PubMed \u00004. TMJ Disorders 16,511 PubMed \u00005. TMJ Dysfunction 6,439 PubMed \u0000The information obtained from these sources in conjunction with clinical training was the basis for the development of the currently described protocols. \u0000 \u0000RESULTS: The current treatment protocols for TM Joint injections utilize homeopathic solutions, B vitamins, procaine and gaseous ozone. These protocols have been used and modified since 2001. The results have demonstrated a significant reduction in the pain levels and improved function of the TM Joint. \u0000 \u0000CONCLUSIONS: Using gaseous ozone in therapeutic combinations of anesthetics, homeopathics and B vitamins have produced positive outcomes in the management of the majority of the very difficult to treat population of head, neck and TMJD patients","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128456838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone Therapy in Idiopathic Carpal Tunnel Syndrome. Biochemical, Neurophysiological and Clinical Aspects [abstract]","authors":"M. Rascaroli, B. Borghi","doi":"10.7203/jo3t.3.4.2019.15530","DOIUrl":"https://doi.org/10.7203/jo3t.3.4.2019.15530","url":null,"abstract":"PURPOSE: Idiopathic Carpal Tunnel Syndrome (CTS) is the most common entrapment neuropathy. \u0000The aim of the paper was to design a prospective study to evaluate clinical and neurophysiological outcome following Ozone Therapy . \u0000We also focusing the attention on the evidences concerning the role of Subsynovial Connective Tissue (SSCT )in the pathogenesis of CTS and the ozone pre-conditioning effects linked to pain pathways and to fibrosis induced by Ischemia-Reperfusion Injury. \u0000 \u0000MATERIALS and METHODS: Thirty-one patients, aged between 36 and 86 23 women and 8 men), were stratified clinically by Boston Carpal Tunnel Questionnaire (B.C.T.Q.) and Neurophysiologically by Padua’s Gravity Scale classifying patients into five Electro-myographic categories (Minimal, Slight, Moderate, Severe and Extreme) . The mean symptom duration was also recorded. \u0000The patients included in the B.C.T.Q. underwent diagnostic neurophysiological tests, strictly standardized in stimulation parameters, electrodes distances and skin temperature, before and after treatment. \u0000The Ozone Therapy was performed by injecting 4 ml of O3-O2 mixture at 10 mcrg/mL concentration under the transverse carpal ligament twice a week for eight sessions. \u0000 \u0000RESULTS: We compared the B.C.T.Q. scores and the neurophysiological parameters obtained before and after O2-O3 treatment: the improvement of symptoms was significantly greater than the improvement of motor and sensory nerve conduction. \u0000The highest clinical improvement degree was found in patients classified in Slight and Moderate Groups. \u0000 \u0000DISCUSSION: Chemical mediators, neo-angiogenesis and Ischemia-Reperfusion Injury lead to oxidative stress and non-inflammatory fibrosis that play a central role at various stages in CTS pathogenesis that can be recognized by clinical and neuro-physiological tests. \u0000Further studies have to be carried out to better understand these relationships and optimize timing of Ozone Therapy.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124733341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain reliefe in viral infections. What role does ozone play? [abstract]","authors":"C. Imperiale, F. Araimo, P. Tordiglione","doi":"10.7203/jo3t.3.4.2019.15509","DOIUrl":"https://doi.org/10.7203/jo3t.3.4.2019.15509","url":null,"abstract":"PURPOSE: This preliminary study aim to investigate the role of ozone in ameliorating quality of life in patient affected by herpes infections thus reducing post herpetic neuralgia. \u0000 \u0000BACKGROUND: Zoster-associated pain is experienced by approximately 90% of patients. Post-herpetic neuralgia (PHN) is a common consequence of an HSV infection. It is a chronic neuropathic pain condition that persists 3 months or more following an outbreak of shingles. Current interventions for PHN, such as lidocaine patches, opioids, antidepressants, anti-epileptics, electric stimulating catheters, are palliative and often fail to treat the underlying disease. Because multiple contributing factors seem to determine the severity of PHN, the management of chronic pain requires an integrated approach. \u0000 \u0000MATERIAL and METHODS: twelve patients (8 men/ 4 women) suffering for a burning pain in correlation with herpetic infection were electively treated with a Systemic Ozone Therapy on a blood volume of 120 ml mixed with equal volume of ozone/oxygen mixture at 25 mcgr/mL twice a week, following once a week for 2nd and 3rd week. VAS and health questionnaire were measured. \u0000 \u0000RESULTS: the majority of patients showed a VAS reduction in burning pain between 6 (T1) and 12 hr (T2) . At 48 hr (T3) every patient showed an amelioration in quality of sleep. Results at 3 months were comparable. \u0000 \u0000CONCLUSIONS: clarifying the mechanism of action triggered by ozone in reducing pain during viral infection is under investigation. We hypothesize that the moderate oxidative stress induced by Ozone enhances the antioxidant elements giving a final protection of damaged cells, renewing of neural system. \u0000Being easy to perform, giving an improvement of night rest with no side effect and well accepted by patients.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132607773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment for radicular compression experience of 926 cases in Bolivia [abstract]","authors":"R. Alvarado-Reyes","doi":"10.7203/jo3t.3.4.2019.15392","DOIUrl":"https://doi.org/10.7203/jo3t.3.4.2019.15392","url":null,"abstract":"PURPOSE: The present study aims to demonstrate the advantage of treating the radicular compression with the minimally invasive approach such as the discolysis with Ozone Therapy, rather than the surgical approach that we know has complications such as the spine fail back syndrome. This study shows the experience in Bolivia shows from August 2004 to August 2016. \u0000 \u0000MATERIAL AND METHODS: Were treated 926 patients with radicular compression at cervical, thoracic and lumbar level 569 males and 357 females First were performed intra discal injections, the discolysis, of ozone at 30 mcgr/mL followed by 15 or 20 paravertebral injections at 20 mcgr/mL. \u0000 \u0000RESULTS: Among the 926 patients with radicular compression were observed that sensory and motor dysfunction were completely abolished in 611 patients (66%) improved in 176 patients (19%) and with poor results and the dysfunction remained unchanged in 139 patients 15% some of them underwent surgical treatment. \u0000 \u0000DISCUSSION: The discolysis with Ozone is a minimally invasive approach is atraumatic and safety and with this method avoids complications such as spine fail back syndrome, which in USA statistics are reported in 15% to 20%. \u0000 \u0000CONCLUSION: With the treatment of ozone therapy is possible to obtain excellent and good results in 85 % of the cases. Ozone is a useful alternative the effectiveness using this minimal invasive method can avoid complications like spine fail back syndrome.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114082890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of intra-articular PRP, Ozone and Ozone+PRP injections in patients with osteoarthritis.","authors":"Lale Yeprem, Aysegul Ellialtioglu, J. Baeza-Noci","doi":"10.7203/JO3T.2.3.2018.10904","DOIUrl":"https://doi.org/10.7203/JO3T.2.3.2018.10904","url":null,"abstract":"Osteoarthritis (OA) is the most common form of arthritis and some joints are effected more than others. The prevalence of OA increases with age and it represents the major problem for functional impairment in older patients. Non-surgical treatment with oral drugs is not suitable for many patients suffering from gastric disorders, high blood pressure or different heart diseases. Intra-articular injections are a promising solution in these cases. \u0000This study was performed to compare the efficacy and safety of ozone injections, PRP (platelet rich plasma) injections and combined ozone plus PRP injections in patients with symptomatic knee OA. \u0000120 patients were diagnosed of OA according to the criteria of the American College of Rheumatology and included into this study. Patients were randomly divided into three equal groups (40 patients each group). We include patients whose VAS score was 5 or above. Patients with inflammatory, endocrine and metabolic disturbances, and patients who had meniscectomy within the past 10 years, extra articular surgery within the last year, arthrocentesis in last 6 months or any drug given intra-articular were not included. We did not include either patients with misalignment. \u0000Patients in the first group were treated with intra-articular injections of ozone/oxygen gas mixture 2 times/week, at 10 µg/mL concentration and a volume of 5 mL for a total of 12 injections. \u0000Patients in the second group were treated only with PRP injections once a week for a total of 3 times. \u0000Patients in the third group were treated with intra-articular injections of Ozone+PRP (10 µg/ml concentration, 5 ml volume) once a week for a total of 3 times. \u0000The pain levels of patients were measured with Visual Analog Scale (VAS). Side effects were collected using an open list record. \u0000All the groups improved their baseline VAS in a significant way, although the group with the best results was group 3 with the combination of ozone and PRP in the same injection. \u0000We are planning further studies including systemic ozone in order to improve more the pain in our patients.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":"08 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115393724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}