Journal of Ozone Therapy最新文献

{"title":"Ozone therapy, applications in surgical pathology.","authors":"G. Mogoş","doi":"10.7203/jo3t.6.7.2022.25993","DOIUrl":"https://doi.org/10.7203/jo3t.6.7.2022.25993","url":null,"abstract":"The paper deals with a series of cases in the field of surgical pathology, surgically and non-surgically solved in the first private clinic with continuous hospitalisation in Oltenia region. \u0000 \u0000THE RELATIONSHIP BETWEEN SURGERY AND OZONE THERAPY. \u0000The benefits are particularly seen in the postoperative period. A special category is wounds, as follows: \u0000A) Chronic, non-healing, refractory to conventional treatments or special dressings. \u0000- Local causes: resistant germs, circulatory disorders. \u0000- General causes: diabetes, neoplasia, immunosuppressed patients. \u0000B) Infected ulcerated mammary neoplasms \u0000C) Postoperative infiltration, before reaching the stage of suppuration \u0000D) Speeding up wound healing with high substance deficiency \u0000E) Post-operative wounds defectively healed \u0000A retrospective study conducted on 55 patients with various surgical pathologies treated with ozone for 20-40 days demonstrates the positive effect of the treatment, with an obvious improvement of symptoms and accelerated healing of postoperative wounds. \u0000The paper will detail cases with certain particularities: age, patient’s medical background, lesion itself, evolution under treatment. \u0000This work should awaken and propel medical specialists to reconsider ozone therapy more carefully.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133731206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone therapy in brazil: achievements and challenges for the future.","authors":"L. Philippi","doi":"10.7203/jo3t.6.7.2022.25994","DOIUrl":"https://doi.org/10.7203/jo3t.6.7.2022.25994","url":null,"abstract":"The practice of Ozone Therapy in Brazil began in 1975, with Doctor Heinz Konrad. In the 90’s, other professionals started to practice it in a precursory and unregulated way, with imported equipment. The work of physician Edison de Cezar Philippi stands out, who was a great disseminator and together with other physicians such as Dr. Glacus Brito, Dr. Maria Emília Serra, Dr. Ana Cristina Barreira, among others, founded the first association of Ozone Therapy in Brazil, which in 2006 became Brazilian Association of Ozone Therapy (ABOZ), with Dr. Maria Emília Gadelha Serra as its first president. In the state and regulatory scope, Ozone Therapy was an unknown technique. Numerous scientific articles were presented to the Ministry of Health, the Federal Council of \u0000Medicine, and ANVISA (equipment regulatory agency in Brazil). The first regulatory framework for Ozone Therapy in Brazil took place in 2015, with the publication of Resolution CFO 166/2015, which regulated Ozone Therapy in Dentistry. \u0000In 2018, Ozone Therapy was included as an integrative practice by the Ministry of Health of Brazil, with the publication of ORDINANCE N° 702 (21/03/2018) which included new practices in the National Policy on Integrative and Complementary Practices (PNPIC), of the Brazilian Unified Health System (SUS). From this milestone, the Professional Class Councils began to understand and regulate Ozone Therapy within the scope of each profession. \u0000Currently, dentistry, physiotherapy, pharmacy, nursing, veterinary medicine, and biomedicine councils have an official understanding of Ozone Therapy, each within its scope of action and with a specific definition of training. These resolutions collaborate to improve the scenario of Ozone Therapy in the country, bringing more possibilities for treatment, and health care for the entire population. \u0000Although there are numerous qualified studies for the practice to be regulated for medicine, the Federal Council of Medicine is still waiting for more scientific evidence, so it only authorizes activities in the experimental scope (registered clinical research). \u0000In the meantime, faced with the difficulties of understanding from the Federal Council of Medicine, the national congress approved a bill proposing that ozone therapy be authorized throughout the national territory. This bill is currently under review by the Senate and the next step is presidential sanction. \u0000Even with all the regulatory achievements in these 15 years of work, we still have many challenges to overcome. The main one is the regulation for use by doctors, so Ozone Therapy becomes an official technique. In addition, for Ozone Therapy to be carried out more ethically and scientifically, it is necessary to understand the scenario and some challenges: \u0000• How to establish boundaries between professional categories, since ozone has many application routes - not all professionals are prepared to perform more invasive routes. \u0000• The established model based on the diagnos","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117319499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sinergies between ozone and nutrition against inflammation and degeneration.","authors":"Vincezo Simonetti","doi":"10.7203/jo3t.6.7.2022.25979","DOIUrl":"https://doi.org/10.7203/jo3t.6.7.2022.25979","url":null,"abstract":"We understood that all chronic, degenerative and infectious diseases, except congenital genetic ones, develop in an acidic cellular environment, derive their origin from intestinal dysbiosis, a chronic inflammatory state, endothelitis and reduced tissue oxygen. \u0000Common basis for the various pathologies are: chronic inflammation, intestinal dysbiosis and increase of the same inflammatory markers TNF?, IL 1?, IL 6, IL8, IL 17, CPR. \u0000According to our experience , in serious diseases such as tumors, MS and other autoimmune diseases, the rapid improvement of symptoms and the reduction of cytokines is not possible only with low doses. We can reduce inflammation and hypoxia with ozone therapy, which when used in association with other epigenetic factors can give us results that we did not believe possible.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125409464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The low-dose ozone concept and its pharmacology in prevention and convalescence.","authors":"Renate Viebahn-Haensler","doi":"10.7203/jo3t.6.7.2022.25974","DOIUrl":"https://doi.org/10.7203/jo3t.6.7.2022.25974","url":null,"abstract":"Systemically administered ozone with its mild oxidative eustress, able to upregulate antioxidative enzymes and to modulate the immune response e.g. \u0000“cytokine storm” is recommended as part of a complementary treatment concept in chronic inflammatory, long lasting processes with high oxidative stress and in diseases which are accompanied by an redox imbalance, rather than in the acute stages. To restore the glutathione equilibrium GSH/ GSSG the low-dose ozone concept offers a strategy in redox medicine as shown here in primary and secondary prevention and convalescence. \u0000To illustrate the main pharmacological effects and to follow the treatment success we focus to the following refence substances: GSH (reduced glutathione), GGT (gamma glutamyl transferase) or SOD (superoxide dismutase) as protection markers and one or two parameters of stress markers: MDA (malondialdehyde). \u0000Especially liver and kidneys are prevented from oxidative stress, regularly GSH increases, MDA decreases. In post acute inflammations (convalescence) we find the same biochemical mechanisms, summarized in virus diseases and diabetic angiopathy.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127346982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone applications in veterinary oncology","authors":"S. Gayon-Amaro","doi":"10.7203/jo3t.6.7.2022.25996","DOIUrl":"https://doi.org/10.7203/jo3t.6.7.2022.25996","url":null,"abstract":"PURPOSE. \u0000To evaluate the clinical improvement of 6 patients –three dogs, two cats and a Panthera leo krugerii diagnosed with neoplasic patologies treated with ozonetherapy under adjusted protocols for each patient. \u0000 \u0000CASE PRESENTATION \u0000Six patients were presented to veterinary consultation for the diagnose of different injuries using citology, blood examination and imagenology in some cases. According to the diagnose (a female dog with an ulcerated mammary adenocarcinoma, another with vaginal adenocarcinoma, a male dog with basal cells tumour in the scrotum, a male cat with low grade linfoma and hepatic injury, another male cat with squamous cells carcinoma (SCC) and a male white lion with a melanoma in the lower eyelid) the ozone protocol was established using combinations of local infiltration, topic instillation of ozonized oil, major and minor autohemotherapy, ozonized drinking water, rectal insuflations and bagging technicque. The results showed an improvement of general state of the patients: increase of appetite and activity in all of them, decrease size of tumour in two patients, healing of ulcers, total remission of the basal cells tumour. Ozone therapy is the elective linfoma treatment due to the hepatic injury in this patient, who remains stable in terms of linfoma but his hepatic injury presents evidence of improving. In patient 6 –the lion with melanoma- zookeepers report absence of exudate and pruritus. \u0000 \u0000DISCUSSION. \u0000There are not enough reports of the use of ozone in oncological veterinary patients (1) but there are many preclinical papers and human case reports about ozone for cancer treament (2,3,4,5). \u0000 \u0000CONCLUSION. \u0000Based on that, it is posible to conclude that established protocols were capable of improve quality of life of the patients avoiding methastasic process and tumoral growth.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128257139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The remedy ozone for prevention and as effective method for treatment of sars.Cov-2-infection.","authors":"Renate Thiele","doi":"10.7203/jo3t.6.7.2022.25988","DOIUrl":"https://doi.org/10.7203/jo3t.6.7.2022.25988","url":null,"abstract":"Due to the oxidation-sensitive cysteine groups in spikes and proteases, reactions with ozone occur which make it difficult for the spikes to enter the cell and for the protease to be activated. \u0000There are 3 key positions where ozone therapy becomes effective: \u0000• Virus spikes \u0000• ACE2 cell receptor and Nrf2 (Nuclear Factor 2) \u0000• Nf?B (Nuclear Factor Kappa B) \u0000The earlier ozone is used the lower the viral load will be. \u0000Other supporting effects of ozone therapy: \u0000• Hypocoagulation \u0000• Activation and modulation of the immune system \u0000• Prevention and treatment of bacterial superinfections \u0000• Increasing the depleted antioxidant potential \u0000• Increase of blood circulation and oxygen supply \u0000• Analgesia in case of muscle pain or joint pain \u0000• Increase of serotonin, helpful against depressions \u0000• Application as a “dead vaccine” \u0000Ozone is a very important part of the therapy of SARS-Cov-2, but we should never forget of the necessary orthomolecular supplement, only in combination the maximum effect can be achieved.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131913389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone: A surprising gas with multiple action for health, beauty and longevity.","authors":"L. Re","doi":"10.7203/jo3t.6.7.2022.25975","DOIUrl":"https://doi.org/10.7203/jo3t.6.7.2022.25975","url":null,"abstract":"Notwithstanding the use of ozone in medicine has become widespread in many countries of the world, its real pharmacological action remains not completely clarified. \u0000We know that other than its uses as disinfectant, well documented by the literature since the beginning of the past century, the more recent medical use of ozone in several pathologies as described by the international literature is still poor investigated. Furthermore, following its clinical uses with excellent clinical responses on several heterogeneous diseases and pain, it is now clear that the biological activity of this gas is mediated by graded responses to the mild oxidative stress induced after its application. Thus, the ancestral environment of our cells, whose energy production is strictly bind to oxygen burn, may be mediated by common defenses probably linked to the ubiquitous signaling pathway mediated by Nrf2. \u0000Moreover, after the first description of the oxidative stress in the 1970s and the discovery of Nrf2 as transcription factor in 1994, we could observe a rapid growth of the literatures regarding its function as master regulator of a myriad of cellular processes and its association to a multiple pattern of diseases including aging. \u0000In conclusion, to my opinion, the Systems Medicine approach could finally represents the real key to better understand the wide reported efficacy of ozone treatment.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134603941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical behavioral outcomes related to osteoporotic patients during ozone treatment.","authors":"Eulalia Recio del Pino, Iraida Cuesta Guerra, Cristina Harris Ramírez, Yadira Betancourt Camargo, Maritza Palma López, Yolanda Mapolon Arcendor","doi":"10.7203/jo3t.5.6.2021.24982","DOIUrl":"https://doi.org/10.7203/jo3t.5.6.2021.24982","url":null,"abstract":"Bio-oxidative therapies accelerate oxygen metabolism, stimulate the antioxidant defense system, having analgesic, anti-inflammatory and immunomodulatory properties, among others. \u0000 \u0000A quasi-experimental study was carried out with the objective of knowing the clinical behavior of osteoporosis during ozone treatment at the Provincial Center for retinitis pigmentosa, Camagüey (Cuba) from January - June 2006. \u0000 \u0000The universe: 53 patients, 50 cases that met the inclusion criteria: patients with osteoporosis, those who agreed to participate in the study with prior informed consent and who decided to join the study by suspending or eliminating previously used therapies. \u0000Ozone was rectally applied, 20 sessions in 2 cycles per year. \u0000 \u0000It was registered the following variables: age groups and sex, evaluation of signs and symptoms, distribution according to occupation, clinical evolution according to cycles, variation of drug treatment and social and economic impact. \u0000 \u0000The predominant ages: 31-40 and +41 years with 16 (32%) and 21 (42%) respectively, the main symptom pain 50 (100%), occupation: workers: 42 (84%). After 20 sessions of ozone, the results were: improved 38 (76%), 50 (100%) decreased the dose of medications. \u0000 \u0000Patients were incorporated into society in less time, improving their bio-psycho-social state with a cost five times lower than the standard treatment.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123523509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To blind or not to blind","authors":"José Baeza Noci","doi":"10.7203/jo3t.5.6.2021.25088","DOIUrl":"https://doi.org/10.7203/jo3t.5.6.2021.25088","url":null,"abstract":"During this COVID-19 pandemic, I was invited to review several papers from well-reputed and high-impact factor journals. Surprisingly, the review of these papers was not blind, allowing me to know the authors and their institutions. \u0000 \u0000Not blinding the reviews allows reviewers to decide whether accept or not the task and can predispose the reviewer's final decision. What was more striking for me was to know that some authors do not accept blind reviews. \u0000 \u0000In our journal, all papers are blindly reviewed by two well-reputed reviewers with expertise in the topic. BLINDLY. Even our copyeditor, who checks and corrects English language mistakes, is blind to the paper's authorship. \u0000 \u0000Although the time for publishing is sometimes long, the edition process is systematic and thoughtful, even changing or adding some reviewers when necessary. All the process but creating the PDF files is voluntary and free, done by different WFOT members. \u0000 \u0000In issue 6, we have collected different topic papers; the paper from Recio deserves special mention, as it has belonged to grey literature since 2007. I read this paper in 2008, but I have not been able to contact ANY of the authors till recently Dr. Javier Cespedes found Dr. Marizta Palma that authorized its publication in our journal. \u0000 \u0000Issue 7 will be the Proceedings of the 7th Meeting of the WFOT that will take place in Bucharest in 2022. \u0000 \u0000We are now collecting papers for issue 8.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131440945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of left ventricle ejection fraction and natriuretic peptides in patients with heart failure treated with systemic medical ozone.","authors":"Javier Cespedes-Suarez, Pedro Conde-Perez, José Luis Calunga-Fernandez, Yanisley Martin-Serrano, María Rosa Carballosa-Peña, Benjamin Arenas-Falcon, Carmen Luisa Rodriguez-Parrellada","doi":"10.7203/jo3t.5.6.2021.24989","DOIUrl":"https://doi.org/10.7203/jo3t.5.6.2021.24989","url":null,"abstract":"Heart Failure (HF) is a prevalent disease and is a frequent reason for consultation. It is a complex entity that presents multiple pathophysiological aspects, and it is sometimes difficult to establish an adequate diagnosis, since its signs and symptoms may overlap with those of other diseases. For a better diagnosis and control of this pathology, it is currently essential to follow up through echocardiography and the determination of natriuretic peptides, since this increase significantly in patients with heart failure, having a negative predictive value for these patients. For this reason, we set out to study the effects of rectal ozone treatment on cardiac contractility and natriuretic peptides in patients with heart failure. \u0000We conducted a study with two groups of 6 patients each, who had a diagnosis of Class II-III Chronic HF according to the functional classification of the New York Heart Association (NYHA) and the American Cardiology College / American Heart Association (ACC/AHA), Echocardiogram with a Left Ventricular Ejection Fraction (LVEF) less than 50% and dosage of Elevated Natriuretic Peptides. We administer ozone rectally through insufflation, with a 20-session protocol (increasing concentration and volume every 5 sessions until reaching 300 ml), performing the following treatment scheme: 5 sessions with 25 ?g/ml concentration and 200 ml volume, 5 sessions with 30 ?g/ml and 250 ml, 5 sessions with 35 ?g/ml and 300 ml and the last 5 sessions with 40 ?g/ml and 300 ml volume. \u0000As a result, it was obtained that ozone treatment through rectal insufflation, through its anti-inflammatory and immunomodulatory effects, was able to improve the clinical status of the study group, significantly reducing below 50% the values of the natriuretic peptide that was elevated at the beginning and the ejection fraction of the left ventricle was significantly increased. Concluding in this way that ozone administration by rectal route as a complement to conventional treatment significantly increased the ejection fraction of the left ventricle, and decreased the values of natriuretic peptide, significantly improving the quality of life of these patients.","PeriodicalId":137241,"journal":{"name":"Journal of Ozone Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125887433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}