Study of left ventricle ejection fraction and natriuretic peptides in patients with heart failure treated with systemic medical ozone.

Heart Failure (HF) is a prevalent disease and is a frequent reason for consultation. It is a complex entity that presents multiple pathophysiological aspects, and it is sometimes difficult to establish an adequate diagnosis, since its signs and symptoms may overlap with those of other diseases. For a better diagnosis and control of this pathology, it is currently essential to follow up through echocardiography and the determination of natriuretic peptides, since this increase significantly in patients with heart failure, having a negative predictive value for these patients. For this reason, we set out to study the effects of rectal ozone treatment on cardiac contractility and natriuretic peptides in patients with heart failure. We conducted a study with two groups of 6 patients each, who had a diagnosis of Class II-III Chronic HF according to the functional classification of the New York Heart Association (NYHA) and the American Cardiology College / American Heart Association (ACC/AHA), Echocardiogram with a Left Ventricular Ejection Fraction (LVEF) less than 50% and dosage of Elevated Natriuretic Peptides. We administer ozone rectally through insufflation, with a 20-session protocol (increasing concentration and volume every 5 sessions until reaching 300 ml), performing the following treatment scheme: 5 sessions with 25 ?g/ml concentration and 200 ml volume, 5 sessions with 30 ?g/ml and 250 ml, 5 sessions with 35 ?g/ml and 300 ml and the last 5 sessions with 40 ?g/ml and 300 ml volume. As a result, it was obtained that ozone treatment through rectal insufflation, through its anti-inflammatory and immunomodulatory effects, was able to improve the clinical status of the study group, significantly reducing below 50% the values of the natriuretic peptide that was elevated at the beginning and the ejection fraction of the left ventricle was significantly increased. Concluding in this way that ozone administration by rectal route as a complement to conventional treatment significantly increased the ejection fraction of the left ventricle, and decreased the values of natriuretic peptide, significantly improving the quality of life of these patients.