Innate Immunity最新文献_第8页

Pyroptosis, inflammasome, and gasdermins in tumor immunity. 肿瘤免疫中的焦亡、炎性体和气真皮。

IF 3.2 4区医学

Innate Immunity Pub Date : 2023-01-01 DOI: 10.1177/17534259221143216

Xiaohu Ouyang, Junfen Zhou, Lan Lin, Zili Zhang, Shanshan Luo, Desheng Hu

引用次数: 6

SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury. 在脂多糖诱导的急性肺损伤中，SENP3通过HIF-1α/PKM2轴促进M1巨噬细胞极化。

IF 3.2 4区医学

Innate Immunity Pub Date : 2023-01-01 DOI: 10.1177/17534259231166212

Shuangjun He, Chenyu Fan, Yiming Ji, Qian Su, Feng Zhao, Cuiying Xie, Xuelian Chen, Yang Zhang, Yi Chen

{"title":"SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury.","authors":"Shuangjun He, Chenyu Fan, Yiming Ji, Qian Su, Feng Zhao, Cuiying Xie, Xuelian Chen, Yang Zhang, Yi Chen","doi":"10.1177/17534259231166212","DOIUrl":"https://doi.org/10.1177/17534259231166212","url":null,"abstract":"M1/M2 macrophage polarization plays a pivotal role in the development of acute lung injury (ALI). The hypoxia-inducible factor-1α/pyruvate kinase M2 (HIF-1α/PKM2) axis, which functions upstream of macrophage polarization, has been implicated in this process. The function of HIF-1α is known to be tightly regulated by SUMOylation. Upregulation of SUMO-specific peptidase 3 (SENP3), a deSUMOylation enzyme, is induced by reactive oxygen species (ROS), which are abundantly produced during ALI. To explore the links between SENP3, macrophage polarization, and lung injury, we used mice with Senp3 conditional knockout in myeloid cells. In the lipopolysaccharide (LPS)-induced ALI model, we found that in vitro and in vivo SENP3 deficiency markedly inhibited M1 polarization and production of pro-inflammatory cytokines and alleviated lung injury. Further, we demonstrated that SENP3 deficiency suppressed the LPS-induced inflammatory response through PKM2 in a HIF-1α-dependent manner. Moreover, mice injected with LPS after PKM2 inhibitor (shikonin) treatment displayed inhibition of M1 macrophage polarization and reduced lung injury. In summary, this work revealed that SENP3 promotes M1 macrophage polarization and production of proinflammatory cytokines via the HIF-1α/PKM2 axis, contributing to lung injury; thus, SENP3 may represent a potential therapeutic target for ALI treatment.","PeriodicalId":13676,"journal":{"name":"Innate Immunity","volume":"29 1-2","pages":"25-34"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/03/fd/10.1177_17534259231166212.PMC10164277.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9429638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

1103 Lupus clinical flares in patients with gut pathobiont blooms share a novel peripheral blood transcriptomic immune activation profile 1103 肠道病理性水华患者的狼疮临床发作具有一个新的外周血转录组免疫激活谱

IF 3.2 4区医学

Innate Immunity Pub Date : 2022-12-01 DOI: 10.1136/lupus-2022-lupus21century.68

G. Silverman, MacIntosh G. Cornwell, P. Izmirly, J. Buyon, Doua F. Azzouz, Kelly V. Ruggles

引用次数: 1

1005 Characterization of regulatory receptors on plasmacytoid dendritic cells in lupus 1005狼疮患者浆细胞样树突状细胞调节受体的研究

IF 3.2 4区医学

Innate Immunity Pub Date : 2022-12-01 DOI: 10.1136/lupus-2022-lupus21century.65

M. Jensen, Ilona Nln, T. Iwamoto, Jessica M. Dorschner, D. Vsetecka, Gabrielle A McCoy, J. L. Paredes, T. Niewold

引用次数: 0

1101 Urine complement activation products in lupus nephritis 尿补体激活产品在狼疮肾炎中的应用

IF 3.2 4区医学

Innate Immunity Pub Date : 2022-12-01 DOI: 10.1136/lupus-2022-lupus21century.66

Nicholas L. Li, D. Birmingham, L. Biederman, T. Nadasdy, B. Rovin

引用次数: 0

1102 The trajectory of glomerular and tubulointerstitial lesions after treatment of lupus nephritis 狼疮性肾炎治疗后肾小球和小管间质病变的发展轨迹

IF 3.2 4区医学

Innate Immunity Pub Date : 2022-12-01 DOI: 10.1136/lupus-2022-lupus21century.67

A. Malvar, V. Alberton, Bruno J Lococo, M. C. Lourenço, Joaquín Martínez, Mauro Elencwajg, H. Nagaraja, B. Rovin

引用次数: 0

1004 Altered ERα localization differentially modulates immune cell subsets 1004改变的ERα定位差异调节免疫细胞亚群

IF 3.2 4区医学

Innate Immunity Pub Date : 2022-12-01 DOI: 10.1136/lupus-2022-lupus21century.64

Cameron Leyers, Jena R. Wirth, M. Cunningham

引用次数: 0

1105 Response Gene to Complement-32 expression is upregulated in the kidney and promotes renal fibrosis in lupus nephritis 1105 补体32表达应答基因在肾脏中上调并促进狼疮性肾炎的肾纤维化

IF 3.2 4区医学

Innate Immunity Pub Date : 2022-12-01 DOI: 10.1136/lupus-2022-lupus21century.70

Vinh Phu Nguyen, A. Tatomir, C. Drachenberg, H. Rus, V. Rus

引用次数: 0

Surfactant proteins and innate immunity of otitis media. 表面活性剂蛋白与中耳炎先天免疫。

IF 3.5 4区医学

Innate Immunity Pub Date : 2022-10-01 Epub Date: 2022-09-07 DOI: 10.1177/17534259221123309

Osama Abdel-Razek, Jason Audlin, Dennis S Poe, Guirong Wang

{"title":"Surfactant proteins and innate immunity of otitis media.","authors":"Osama Abdel-Razek, Jason Audlin, Dennis S Poe, Guirong Wang","doi":"10.1177/17534259221123309","DOIUrl":"10.1177/17534259221123309","url":null,"abstract":"Otitis media (OM) is the most common disease among young children and one of the most frequent reasons to visit the pediatrician. Development of OM requires nasopharyngeal colonization by a pathogen which must gain access to the tympanic cavity through the eustachian tube (ET) along with being able to overcome the defense mechanisms of the immune system and middle ear mucosa. OM can be caused by viral or bacterial infection. The three main bacterial pathogens are Streptococcus pneumoniae, nontypeable Haemophilus influenzae (NTHi), and Moraxella catarrhalis. Innate immunity is important in OM resolution as the disease occurs in very young children before the development of specific immunity. Elements of innate immunity include natural barriers and pattern recognition receptors such as Toll like receptors (TLRs), and Nod like receptors (NLRs). Surfactant proteins A (SP-A) and D (SP-D) act as pattern recognition receptors and are found in the lung and many other tissues including the ET and the middle ear where they probably function in host defense. Surfactant has a potential for use in the treatment of OM due to surface tension lowering function in the ET, and the possible immune functions of SP-D and SP-A in the middle ear and ET.","PeriodicalId":13676,"journal":{"name":"Innate Immunity","volume":"28 7-8","pages":"213-223"},"PeriodicalIF":3.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/23/6a/10.1177_17534259221123309.PMC9900255.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9218295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous anti-P. aeruginosa IgY-antibodies do not decrease pulmonary bacterial concentrations in a porcine model of ventilator-associated pneumonia. 静脉注射抗P。在呼吸机相关肺炎的猪模型中，铜绿假单胞菌IgY抗体不会降低肺部细菌浓度。

IF 3.2 4区医学

Innate Immunity Pub Date : 2022-10-01 Epub Date: 2022-11-13 DOI: 10.1177/17534259221114217

A Otterbeck, P Skorup, K Hanslin, A Larsson, J Stålberg, H Hjelmqvist, M Lipcsey

{"title":"Intravenous anti-P. aeruginosa IgY-antibodies do not decrease pulmonary bacterial concentrations in a porcine model of ventilator-associated pneumonia.","authors":"A Otterbeck, P Skorup, K Hanslin, A Larsson, J Stålberg, H Hjelmqvist, M Lipcsey","doi":"10.1177/17534259221114217","DOIUrl":"10.1177/17534259221114217","url":null,"abstract":"Ventilator associated pneumonia (VAP) caused by P. aeruginosa is a cause of morbidity and mortality in critically ill patients. The spread of pathogens with anti-microbial resistance mandates the investigation of novel therapies. Specific polyclonal anti-P. aeruginosa IgY-antibodies (Pa-IgY) might be effective for VAP caused by P. aeruginosa. The objective of this study was to investigate if intravenous Pa-IgY decreases the lower airway concentration of P. aeruginosa in VAP. We used a double blind randomized placebo controlled porcine model of VAP caused by P. aeruginosa. Eighteen pigs were randomized to either receive intravenous Pa-IgY or placebo. Repeated registration of physiological parameters and sampling was performed for 27 h. Concentration of P. aeruginosa in BAL-cultures was similar in both groups with 104.97 ± 102.09 CFU/mL in the intervention group vs 104.37 ± 102.62 CFU/mL in the control group at the end of the experiment. The intervention group had higher heart rate, cardiac index, oxygen delivery and arterial oxygen tension/fraction of inspired oxygen-ratio, but lower plasma lactate and blood hemoglobin levels than the control group. In summary, in an anesthetized and mechanically ventilated porcine model of VAP, Pa-IgY at the dose used did not decrease concentrations of P. aeruginosa in the lower airways.","PeriodicalId":13676,"journal":{"name":"Innate Immunity","volume":"28 7-8","pages":"224-234"},"PeriodicalIF":3.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9234861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2