Intensive Care Medicine最新文献

{"title":"Adopting Code ICH in intensive care.","authors":"J Claude Hemphill, Giuseppe Citerio","doi":"10.1007/s00134-024-07655-6","DOIUrl":"10.1007/s00134-024-07655-6","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2179-2181"},"PeriodicalIF":27.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin decontamination to prevent infections in the intensive care unit.","authors":"Marc Bonten, Bruno Martins Tomazini, Stephan Harbarth","doi":"10.1007/s00134-024-07701-3","DOIUrl":"10.1007/s00134-024-07701-3","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2144-2145"},"PeriodicalIF":27.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hermetic wisdom: unlocking the mysteries of citrate anticoagulation for continuous renal replacement therapy.","authors":"Rogério da Hora Passos, Rafaella Maria da Cunha Lyrio, Fernanda Oliveira Coelho, Bruno Zawadzki","doi":"10.1007/s00134-024-07582-6","DOIUrl":"10.1007/s00134-024-07582-6","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2211-2212"},"PeriodicalIF":27.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute cor pulmonale as a confounder in trials of ECMO or prone ventilation in ARDS.","authors":"Joseph R Riddell, Benjamin J Jones, Ifan Lewis, Matthew P Wise","doi":"10.1007/s00134-024-07620-3","DOIUrl":"10.1007/s00134-024-07620-3","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2235-2236"},"PeriodicalIF":27.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fludrocortisone dose-response relationship in septic shock: a randomised phase II trial.","authors":"James Walsham, Naomi Hammond, Antje Blumenthal, Jeremy Cohen, John Myburgh, Simon Finfer, David Evans, Sandra Peake, Peter Kruger, James McCullough, Loki Johnk, Dhaval Ghelani, Laurent Billot, Sana Shan, Jason Meyer, Dorrilyn Rajbhandari, Carolyn Koch, Rinaldo Bellomo, Louise M Burrell, Morag Young, Michael Roberts, Lorraine Mackenzie, Gregory Medley, Joshua Dalton, Balasubramanian Venkatesh","doi":"10.1007/s00134-024-07616-z","DOIUrl":"10.1007/s00134-024-07616-z","url":null,"abstract":"<p><strong>Background: </strong>The combination of intravenous hydrocortisone and enteral fludrocortisone may reduce mortality in patients with septic shock. The optimal dose and reliability of absorption of fludrocortisone in critically ill patients are unclear.</p><p><strong>Methods: </strong>In a multi-centre, open label, phase II randomized clinical trial, intravenous hydrocortisone alone or in combination with one of three doses of enteral fludrocortisone (50 µg, 100 µg or 200 µg daily) for 7 days was compared in patients with septic shock. The primary outcome was time to shock resolution. We conducted pharmacokinetic studies to assess absorption.</p><p><strong>Results: </strong>Out of 153 enrolled patients, 38 (25%) received hydrocortisone alone, 42 (27%) received additional 50 µg, 36 (24%) received 100 µg and 37 (24%) received 200 µg fludrocortisone. Plasma concentrations of fludrocortisone were detected in 97% of patients at 3 h-median (interquartile range [IQR]) 261 (156-334) ng/L. There was no significant difference in the time to shock resolution between groups with median (IQR) of 3 (2.5-4.5), 3 (2-4), 3 (2-6) and 3 (2-5.5) days in the hydrocortisone alone, 50 µg, 100 µg and 200 µg fludrocortisone groups, respectively. The corresponding 28-day mortality rates were 9/38 (24%), 7/42 (17%), 4/36 (11%) and 4/37 (11%), respectively. There were no significant differences between groups with respect to, recurrence of shock, indices of organ failure or other secondary outcomes.</p><p><strong>Conclusions: </strong>Enteral fludrocortisone resulted in detectable plasma fludrocortisone concentrations in the majority of critically ill patients with septic shock, although they varied widely indicating differing absorption and bioavailability. Its addition to hydrocortisone was not associated with shorter time to shock resolution.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2050-2060"},"PeriodicalIF":27.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards improved management of pulmonary herpes simplex virus and cytomegalovirus in COVID-19 ARDS: a future perspective.","authors":"Thanigaivel Sundaram, Kuppusamy Sathishkumar","doi":"10.1007/s00134-024-07636-9","DOIUrl":"10.1007/s00134-024-07636-9","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2195-2196"},"PeriodicalIF":27.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocolized fluid balance neutralization during continuous renal replacement therapy.","authors":"Raghavan Murugan, John Prowle, William Beaubien-Souligny","doi":"10.1007/s00134-024-07698-9","DOIUrl":"10.1007/s00134-024-07698-9","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2141-2143"},"PeriodicalIF":27.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of prolonged versus shorter awake prone positioning in managing acute respiratory failure in COVID-19 Patients. A Clinical Assessment.","authors":"Kuppusamy Sathishkumar","doi":"10.1007/s00134-024-07621-2","DOIUrl":"10.1007/s00134-024-07621-2","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2199-2200"},"PeriodicalIF":27.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A farewell as Editor-in-Chief: reflecting on the evolution of Intensive Care Medicine over the last 18 years.","authors":"Giuseppe Citerio","doi":"10.1007/s00134-024-07649-4","DOIUrl":"https://doi.org/10.1007/s00134-024-07649-4","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"50 12","pages":"1969-1970"},"PeriodicalIF":27.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fludrocortisone with hydrocortisone in sepsis: new evidence in an ongoing debate.","authors":"Otavio Ranzani, Djillali Annane, Mervyn Singer","doi":"10.1007/s00134-024-07699-8","DOIUrl":"10.1007/s00134-024-07699-8","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2138-2140"},"PeriodicalIF":27.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}