Amanda Y. Leong, Stefan Edginton, Laurie A. Lee, Natalia Jaworska, Lisa Burry, Kirsten M. Fiest, Christopher J. Doig, Daniel J. Niven
{"title":"The association between pain, analgesia, and delirium among critically ill adults: a systematic review and meta-analysis","authors":"Amanda Y. Leong, Stefan Edginton, Laurie A. Lee, Natalia Jaworska, Lisa Burry, Kirsten M. Fiest, Christopher J. Doig, Daniel J. Niven","doi":"10.1007/s00134-025-07784-6","DOIUrl":"https://doi.org/10.1007/s00134-025-07784-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>We performed a systematic review with meta-analysis examining the relationship between pain or pain medications and delirium occurence, duration, and severity.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We searched MEDLINE, EMBASE, CINAHL and the Cochrane Central Register of Controlled Trials from inception to May 15, 2023. We included randomised or observational studies among critically ill adults, that reported data on pain or exposure to analgesics, and reported delirium presence, duration, or severity with no language or region restrictions. PROSPERO ID: CRD42022367715. Two authors independently screened records and extracted data. Risk of bias was evaluated using Risk of Bias 2 or the Risk of Bias In Non-randomized Studies of Interventions. We pooled data using the Hartung-Knapp Sidik-Jonkmann random effects model. PRISMA was followed.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>From 8,054 citations, 90 studies (119,230 patients) published between 2001 and 2023 were included in the systematic review. 41 studies were included in the primary meta-analysis examining prevalent delirium: seven studies evaluated pain; 12 studies evaluated fentanyl; and five studies evaluated morphine. There was a trend to association between pain and delirium occurrence (OR 2.49, 95% CI 0.98–6.30), and a significant association between pain and incident delirium (OR 3.70, 95% CI 1.73–7.93). Fentanyl (OR 2.49, 95% CI 1.45–4.27) and morphine (OR 2.13, 95% CI 1.21–3.75) were associated with delirium occurrence. Risk of bias was critical for many studies.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>We observed an association between pain and incident delirium among critically ill adults. Exposure to morphine or fentanyl (but no other pain medications) was associated with increased risk of delirium occurrence.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"32 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Romain Sonneville, Etienne de Montmollin, Damien Contou, Ricard Ferrer, Mohan Gurjar, Kada Klouche, Benjamine Sarton, Sophie Demeret, Pierre Bailly, Daniel da Silva, Etienne Escudier, Loic Le Guennec, Russel Chabanne, Laurent Argaud, Omar Ben Hadj Salem, Martial Thyrault, Aurélien Frerou, Guillaume Louis, Gennaro De Pascale, Janneke Horn, Raimund Helbok, Guillaume Geri, Fabrice Bruneel, Ignacio Martin-Loeches, Fabio Silvio Taccone, Jan J De Waele, Stéphane Ruckly, Quentin Staiquly, Giuseppe Citerio, Jean-François Timsit
{"title":"Correction: Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study.","authors":"Romain Sonneville, Etienne de Montmollin, Damien Contou, Ricard Ferrer, Mohan Gurjar, Kada Klouche, Benjamine Sarton, Sophie Demeret, Pierre Bailly, Daniel da Silva, Etienne Escudier, Loic Le Guennec, Russel Chabanne, Laurent Argaud, Omar Ben Hadj Salem, Martial Thyrault, Aurélien Frerou, Guillaume Louis, Gennaro De Pascale, Janneke Horn, Raimund Helbok, Guillaume Geri, Fabrice Bruneel, Ignacio Martin-Loeches, Fabio Silvio Taccone, Jan J De Waele, Stéphane Ruckly, Quentin Staiquly, Giuseppe Citerio, Jean-François Timsit","doi":"10.1007/s00134-025-07792-6","DOIUrl":"https://doi.org/10.1007/s00134-025-07792-6","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":27.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed Aabdi, Hicham Nassik, Youssef Motiaa, Brahim Boukatta, Hicham Sbai
{"title":"End-of-life practices in intensive care units in Morocco: challenges and unmet educational needs","authors":"Mohammed Aabdi, Hicham Nassik, Youssef Motiaa, Brahim Boukatta, Hicham Sbai","doi":"10.1007/s00134-025-07800-9","DOIUrl":"https://doi.org/10.1007/s00134-025-07800-9","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"22 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new chapter in intensive care medicine","authors":"Samir Jaber","doi":"10.1007/s00134-025-07799-z","DOIUrl":"https://doi.org/10.1007/s00134-025-07799-z","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"15 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yoshihiro Nagai, Shigehiko Uchino, Ken Tonai, Shinshu Katayama
{"title":"“Tracheal ballooning” during positive-pressure ventilation in a patient with status asthmaticus and acquired tracheomegaly","authors":"Yoshihiro Nagai, Shigehiko Uchino, Ken Tonai, Shinshu Katayama","doi":"10.1007/s00134-025-07798-0","DOIUrl":"https://doi.org/10.1007/s00134-025-07798-0","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"10 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katrina Augustin,Zachary M Shinar,Dinis Dos Reis Miranda
{"title":"Correspondence by Augustin et al. regarding the article \"Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation\".","authors":"Katrina Augustin,Zachary M Shinar,Dinis Dos Reis Miranda","doi":"10.1007/s00134-025-07791-7","DOIUrl":"https://doi.org/10.1007/s00134-025-07791-7","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"13 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamad F El-Khatib,Cynthia J Karam,Carine A Zeeni,Ahmad W Husari,Pierre K Bou-Khalil
{"title":"Oxygenation indexes for classification of severity of ARDS.","authors":"Mohamad F El-Khatib,Cynthia J Karam,Carine A Zeeni,Ahmad W Husari,Pierre K Bou-Khalil","doi":"10.1007/s00134-025-07786-4","DOIUrl":"https://doi.org/10.1007/s00134-025-07786-4","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"107 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Setting the ventilator with AI support: challenges and perspectives.","authors":"Sebastian Johannes Fritsch,Maurizio Cecconi","doi":"10.1007/s00134-024-07778-w","DOIUrl":"https://doi.org/10.1007/s00134-024-07778-w","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"37 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andres Giglio Jiménez, Weimar Tovar, Cesar Pedreros, Andrés Ferre
{"title":"Should we move beyond the concept of fluid responsiveness?","authors":"Andres Giglio Jiménez, Weimar Tovar, Cesar Pedreros, Andrés Ferre","doi":"10.1007/s00134-025-07787-3","DOIUrl":"https://doi.org/10.1007/s00134-025-07787-3","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"27 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Covert consciousness in critical care","authors":"Jan Claassen, Daniel Kondziella, Michael J. Young","doi":"10.1007/s00134-024-07722-y","DOIUrl":"https://doi.org/10.1007/s00134-024-07722-y","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"51 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}