Jean-Pierre Frat, Domenico L Grieco, Audrey De Jong, Kevin Gibbs, Guillaume Carteaux, Oriol Roca, Virginie Lemiale, Lise Piquilloud, Nuttapol Rittayamai, Lara Pisani, Gonzalo Hernandez, Arnaud W Thille
{"title":"Noninvasive respiratory supports in ICU.","authors":"Jean-Pierre Frat, Domenico L Grieco, Audrey De Jong, Kevin Gibbs, Guillaume Carteaux, Oriol Roca, Virginie Lemiale, Lise Piquilloud, Nuttapol Rittayamai, Lara Pisani, Gonzalo Hernandez, Arnaud W Thille","doi":"10.1007/s00134-025-08036-3","DOIUrl":"https://doi.org/10.1007/s00134-025-08036-3","url":null,"abstract":"<p><strong>Background: </strong>Noninvasive respiratory supports are routinely applied in critically ill patients with acute respiratory failure to avoid intubation and invasive mechanical ventilation, thereby reducing the risk of related complications, and to facilitate successful weaning from mechanical ventilation after extubation. They are also applied during the intubation procedure for preoxygenation with the aim of enhancing oxygenation and ensuring the safety of the procedure.</p><p><strong>Main body: </strong>High-flow nasal oxygen decreases airway dead space, provides a stable concentration of inspired oxygen, generates low level of flow-dependent positive airway pressure, and optimizes comfort. Positive-pressure noninvasive supports include continuous positive-airway pressure and noninvasive ventilation and enable providing higher end-expiratory pressure, thereby further improving oxygenation. Noninvasive ventilation, but not continuous positive-airway pressure, better decreases inspiratory effort, and increases tidal volume and transpulmonary driving pressure.</p><p><strong>Conclusion: </strong>High-flow nasal oxygen has become the first-line therapy in acute hypoxemic respiratory failure, while noninvasive ventilation remains the reference treatment during exacerbations of chronic obstructive pulmonary disease, in patients with respiratory acidosis. In patients requiring intubation, noninvasive ventilation is the optimal technique for preoxygenation to decrease the risk of hypoxemia, while high-flow nasal oxygen is an alternative option for non-hypoxemic patients or those with contraindications to noninvasive ventilation. After extubation in patients at high risk of reintubation, prophylactic noninvasive ventilation, eventually alternating with high-flow nasal oxygen, improves weaning outcome compared to other strategies; high-flow nasal oxygen alone outperforms conventional oxygen in low-risk patients.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":27.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurotoxicity of sedative drugs: a matter of concern in adults?","authors":"Giovanni Landoni,Yuki Kotani,Vladimir Lomivorotov","doi":"10.1007/s00134-025-08030-9","DOIUrl":"https://doi.org/10.1007/s00134-025-08030-9","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"18 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Melatonin for ICU Delirium Prevention: Optimal Pharmacokinetics but No Clinical Benefit in the DEMEL Trial.","authors":"Bin Liu,Peng Huang,Yanchao Liang,Bo Xie","doi":"10.1007/s00134-025-08037-2","DOIUrl":"https://doi.org/10.1007/s00134-025-08037-2","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"115 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Post-sepsis recovery: perspectives on measuring what matters.","authors":"Lukasz Szarpak,Bernard Rybczynski,Andrzej Krupa,Michal Pruc","doi":"10.1007/s00134-025-08055-0","DOIUrl":"https://doi.org/10.1007/s00134-025-08055-0","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"98 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Djillali Annane,Josef Briegel,Christopher W Seymour
{"title":"Corticosteroids in sepsis: certainties and shadows.","authors":"Djillali Annane,Josef Briegel,Christopher W Seymour","doi":"10.1007/s00134-025-08044-3","DOIUrl":"https://doi.org/10.1007/s00134-025-08044-3","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"111 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Boudhabhay,R Lopez,E Azoulay,M Darmon,E Mariotte
{"title":"Longitudinal analysis of arterial pressure and its impact on outcomes in patients with thrombotic thrombocytopenic purpura.","authors":"I Boudhabhay,R Lopez,E Azoulay,M Darmon,E Mariotte","doi":"10.1007/s00134-025-08038-1","DOIUrl":"https://doi.org/10.1007/s00134-025-08038-1","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"14 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elie Azoulay, Agnès Veyradier, Spero Cataland, Berangere S Joly, Paul Knoebl, Lara Zafrani, Jules Wendon, Fadi Fakhouri, Bernhard Lämmle, Katerina Pavenski, Nathalie Biebuyck, Karen Vanhoorelbeke, Shruti Chaturvedi, Allyson M Pishko, Katia Donadello, Marie Scully, Masanuri Matsumoto, Flora Peyvandi, María Eva Mingot-Castellano, X Long Zheng, Eric Mariotte, Ygal Benhamou, Paul Coppo
{"title":"Correction: Thrombotic thrombocytopenic purpura: early diagnosis and effective treatment in 2025.","authors":"Elie Azoulay, Agnès Veyradier, Spero Cataland, Berangere S Joly, Paul Knoebl, Lara Zafrani, Jules Wendon, Fadi Fakhouri, Bernhard Lämmle, Katerina Pavenski, Nathalie Biebuyck, Karen Vanhoorelbeke, Shruti Chaturvedi, Allyson M Pishko, Katia Donadello, Marie Scully, Masanuri Matsumoto, Flora Peyvandi, María Eva Mingot-Castellano, X Long Zheng, Eric Mariotte, Ygal Benhamou, Paul Coppo","doi":"10.1007/s00134-025-08041-6","DOIUrl":"https://doi.org/10.1007/s00134-025-08041-6","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":27.1,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Let PEEP do the talking?","authors":"Andrea Bellone, Andrew Bersten","doi":"10.1007/s00134-025-08042-5","DOIUrl":"https://doi.org/10.1007/s00134-025-08042-5","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":27.1,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas Heming, Lindsay Berry, Elizabeth Lorenzi, Scott Berry, Derek C Angus
{"title":"Correspondence about the article \"Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia: the REMAP-CAP corticosteroid domain randomized clinical trial\": author's reply.","authors":"Nicholas Heming, Lindsay Berry, Elizabeth Lorenzi, Scott Berry, Derek C Angus","doi":"10.1007/s00134-025-08046-1","DOIUrl":"https://doi.org/10.1007/s00134-025-08046-1","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":27.1,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The invisible weight of knowledge: epistemic inequity in global critical care research.","authors":"Jorge Iván Alvarado-Sánchez","doi":"10.1007/s00134-025-08039-0","DOIUrl":"https://doi.org/10.1007/s00134-025-08039-0","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"109 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}