Intensive Care Medicine最新文献

{"title":"Beyond perfection: why imperfect routinely collected intensive care data still hold value.","authors":"Niklas Rodemund, Bernhard Wernly, Ottokar Stundner, Patrick Rockenschaub, Andreas Koköfer","doi":"10.1007/s00134-025-07844-x","DOIUrl":"https://doi.org/10.1007/s00134-025-07844-x","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":27.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modernizing autopsy practices in the ICU to advance critical care diagnostics-authors' response.","authors":"Koenraad H Blot, Britt Marcoen, Dirk Vogelaers, Stijn Blot","doi":"10.1007/s00134-025-07845-w","DOIUrl":"https://doi.org/10.1007/s00134-025-07845-w","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":27.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guideline-compliant empirical antibiotic therapy for ventilator-associated pneumonia during the pandemic: a European multicenter retrospective study","authors":"Nicolas Dognon, Romain Malapelle, Maxime Leroy, Keyvan Razazi, Saad Nseir","doi":"10.1007/s00134-025-07842-z","DOIUrl":"https://doi.org/10.1007/s00134-025-07842-z","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"8 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing ICU antifungal therapy: overcoming pharmacokinetic limitations with combination strategies.","authors":"Rongqiang Liao, Xiaoyuan Zheng","doi":"10.1007/s00134-025-07846-9","DOIUrl":"https://doi.org/10.1007/s00134-025-07846-9","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":27.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence on “Implementing palliative care in the intensive care unit: a systematic review and mapping of knowledge to the implementation research logic model” Authors’ reply","authors":"S. A. Meddick-Dyson, N. A. Pattison, J. W. Boland, M. Pearson, F. E. M. Murtagh","doi":"10.1007/s00134-025-07849-6","DOIUrl":"https://doi.org/10.1007/s00134-025-07849-6","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"225 2 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: An unspoken contributor to VILI in ARDS—asymmetry of lung injury","authors":"Igor Barjaktarevic, Brooks Kuhn","doi":"10.1007/s00134-025-07810-7","DOIUrl":"https://doi.org/10.1007/s00134-025-07810-7","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"39 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subphenotypes and phenotypes to resolve sepsis heterogeneity: hype or hope?","authors":"Andre C. Kalil, Pedro Povoa, Marc Leone","doi":"10.1007/s00134-025-07828-x","DOIUrl":"https://doi.org/10.1007/s00134-025-07828-x","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"47 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation. Authors' reply.","authors":"David Pilcher, Aidan Burrell, Sze J Ng, Michael Bailey","doi":"10.1007/s00134-025-07835-y","DOIUrl":"https://doi.org/10.1007/s00134-025-07835-y","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":27.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the role of PoCUS in tailoring diuretic strategies for congestion management in critical care: authors' reply.","authors":"Marlies Ostermann, Linda Awdishu, Matthieu Legrand","doi":"10.1007/s00134-025-07831-2","DOIUrl":"https://doi.org/10.1007/s00134-025-07831-2","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":27.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of high-risk acute pulmonary embolism: an emulated target trial analysis","authors":"Andrea Stadlbauer, Tom Verbelen, Leonhard Binzenhöfer, Tomaz Goslar, Alexander Supady, Peter M. Spieth, Marko Noc, Andreas Verstraete, Sabine Hoffmann, Michael Schomaker, Julia Höpler, Marie Kraft, Esther Tautz, Daniel Hoyer, Jörn Tongers, Franz Haertel, Aschraf El-Essawi, Mostafa Salem, Rafael Henrique Rangel, Carsten Hullermann, Marvin Kriz, Benedikt Schrage, Jorge Moisés, Manel Sabate, Federico Pappalardo, Lisa Crusius, Norman Mangner, Christoph Adler, Tobias Tichelbäcker, Carsten Skurk, Christian Jung, Sebastian Kufner, Tobias Graf, Clemens Scherer, Laura Villegas Sierra, Hannah Billig, Nicolas Majunke, Walter S. Speidl, Robert Zilberszac, Luis Chiscano-Camón, Aitor Uribarri, Jordi Riera, Roberto Roncon-Albuquerque, Elizabete Terauda, Andrejs Erglis, Guido Tavazzi, Uwe Zeymer, Maike Knorr, Juliane Kilo, Sven Möbius-Winkler, Robert H. G. Schwinger, Derk Frank, Oliver Borst, Helene Häberle, Frederic De Roeck, Christiaan Vrints, Christof Schmid, Georg Nickenig, Christian Hag..","doi":"10.1007/s00134-025-07805-4","DOIUrl":"https://doi.org/10.1007/s00134-025-07805-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>High-risk acute pulmonary embolism (PE) is a life-threatening condition necessitating hemodynamic stabilization and rapid restoration of pulmonary perfusion. In this context, evidence regarding the benefit of advanced circulatory support and pulmonary recanalization strategies is still limited.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>In this observational study, we assessed data of 1060 patients treated for high-risk acute PE with 991 being included in a target trial emulation to investigate all-cause in-hospital mortality estimates with different advanced treatment strategies. The four treatment groups consisted of patients undergoing (I) veno-arterial extracorporeal membrane oxygenation (VA-ECMO) alone (<i>n</i> = 126), (II) intrahospital systemic thrombolysis (SYS) (<i>n</i> = 643), (III) surgical thrombectomy (ST) (<i>n</i> = 49), and (IV) percutaneous catheter-directed treatment (PCDT) (<i>n</i> = 173). VA-ECMO was allowed as bridging to pulmonary recanalization in groups II, III, and IV. Marginal causal contrasts were estimated using the g-formula with logistic regression models as the primary approach. Sensitivity analyses included targeted maximum likelihood estimation (TMLE) with machine learning, inverse probability of treatment weighting (IPTW), as well as variations of estimands, handling of missing values, and a complete target trial emulation excluding the VA-ECMO alone group.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>In the overall target trial population, the median age was 62.0 years, and 53.3% of patients were male. The estimated probability of in-hospital mortality from the primary target trial intention-to-treat analysis for VA-ECMO alone was 57% (95% confidence interval [CI] 47%; 67%), compared to 48% (95% CI 44%; 53%) for intrahospital SYS, 34% (95%CI 18%; 50%) for ST, and 43% (95% CI 35%; 51%) for PCDT. The mortality risk ratios were largely in favor of any advanced recanalization strategy over VA-ECMO alone. The robustness of these findings was supported by all sensitivity analyses. In the crude outcome analysis, patients surviving to discharge had a high probability of favorable neurologic outcome in all treatment groups.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Advanced recanalization by means of SYS, ST, and several promising catheter-directed systems may have a positive impact on short-term survival of patients presenting with high-risk PE compared to the use of VA-ECMO alone as a bridge to recovery.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"209 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}