Intensive Care Medicine最新文献

{"title":"Hypernatremia in the critically Ill: beyond free water replacement.","authors":"Themistoklis Paraskevas, Marlies Ostermann, Michael Joannidis","doi":"10.1007/s00134-026-08566-4","DOIUrl":"10.1007/s00134-026-08566-4","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2236-2239"},"PeriodicalIF":22.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical metagenomics: a call to action.","authors":"Andrew Conway Morris, Jonathan D Edgeworth, Pedro Povoa","doi":"10.1007/s00134-026-08577-1","DOIUrl":"10.1007/s00134-026-08577-1","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2224-2227"},"PeriodicalIF":22.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics must be part of end-of-life decisions: a necessary evil?","authors":"Iuri Correia, João Gonçalves Pereira, Victoria Metaxa","doi":"10.1007/s00134-026-08561-9","DOIUrl":"10.1007/s00134-026-08561-9","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2204-2206"},"PeriodicalIF":22.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial pressure physiology, monitoring and individualized management in the acute brain injured patient.","authors":"Fabio Silvio Taccone, Yaseen Arabi, Marta Baggiani, Sergio Brasil, Anthony Figaji, Elisa Gouvea Bogossian, Gregory Hawryluk, Victoria Mccredie, Kirsten Moller, Corina Puppo, Chiara Robba, Gentle Sunder Shrestha, Fadime Tokmak, Andrew Udy, Yu Lin Wong, Geert Meyfroidt","doi":"10.1007/s00134-026-08558-4","DOIUrl":"10.1007/s00134-026-08558-4","url":null,"abstract":"<p><p>Acute brain injury (ABI), including traumatic brain injury, ischemic and hemorrhagic stroke, is associated with high morbidity and mortality, which is driven not only by the primary brain injury, but also by the development of secondary cerebral insults. Among these, raised intracranial pressure (ICP) plays a central pathophysiological role, acting both as a consequence and a driver of ongoing brain injury through mechanical deformation and cerebral ischemia. Although invasive intracranial pressure (ICP) monitoring has a longstanding and ongoing role in neurocritical care management, the interpretation and clinical use of ICP remain controversial. Traditional management strategies rely on fixed ICP thresholds (e.g., > 22 mmHg) to trigger a standardized stepwise escalation of therapy; however, growing clinical evidence indicates that tolerance to ICP elevation varies widely across patients, disease entities, and physiological contexts. This review summarizes the physiological determinants of ICP, including intracranial compliance, cerebrospinal fluid dynamics, cerebral blood volume, and systemic factors, and describes the mechanisms underlying intracranial hypertension. We discuss limitations of using fixed ICP thresholds and highlight emerging concepts, such as ICP burden, waveform morphology, cerebral autoregulation, and functional brain monitoring, as tools to individualize ICP interpretation. The role of invasive and noninvasive ICP monitoring (nICP) modalities is reviewed, emphasizing the complementary value of nICP in guiding decision-making when invasive monitoring is unavailable or contraindicated. Particular attention is given to the integration of ICP within multimodal neuromonitoring frameworks assessing cerebral perfusion, oxygenation, and metabolism. Finally, we explore future perspectives, including the potential of artificial intelligence-based approaches to analyse complex neuromonitoring data, predict secondary insults, and move toward actionable, patientspecific therapeutic strategies. Collectively, these advances support a shift from a uniform, threshold-driven approach toward individualized, physiology-informed management of intracranial hypertension.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2108-2128"},"PeriodicalIF":22.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148619830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond technology: the case for a family-focused ICU as disruptive innovation. Authors' reply.","authors":"Massimiliano Greco, Maurizio Cecconi","doi":"10.1007/s00134-026-08586-0","DOIUrl":"10.1007/s00134-026-08586-0","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2261-2262"},"PeriodicalIF":22.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic errors in critically ill patients: challenges, contributing factors, and improvement strategies through the SEIPS framework.","authors":"María Cruz Martín Delgado, Bertrand Guidet, Arzu Topeli","doi":"10.1007/s00134-026-08565-5","DOIUrl":"10.1007/s00134-026-08565-5","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2220-2223"},"PeriodicalIF":22.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher Correction: Lung- and diaphragm-protective mechanical ventilation in acute respiratory distress syndrome.","authors":"Glauco M Plens, Idunn S Morris, Richard Greendyk, Andrea Castellví-Font, Annemijn H Jonkman, Domenico L Grieco, Glasiele C Alcala, Jose Dianti, Marcelo Britto Passos Amato, Martin Dres, Shailesh Bihari, Robinder G Khemani, Laurent Brochard, Taiga Itagaki, Ewan C Goligher","doi":"10.1007/s00134-026-08557-5","DOIUrl":"10.1007/s00134-026-08557-5","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":"2264-2266"},"PeriodicalIF":22.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe obesity and chest wall elastance in ARDS.","authors":"Damien Barrau, Sami Hraiech, Christophe Guervilly","doi":"10.1007/s00134-026-08624-x","DOIUrl":"https://doi.org/10.1007/s00134-026-08624-x","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":" ","pages":""},"PeriodicalIF":22.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volatile anesthetic sedation in acute respiratory distress syndrome","authors":"Brian O’Gara, Christina Boncyk, Lukas M. Müller Wirtz, Daniel Molano Franco, Yuki Kotani, Giovanni Landoni, Angela Jerath, Erwan L’Her, Martin Bellgardt, Tobias Becher, Beatrice Beck-Schimmer, Jeremy R. Beitler, Jean Michel Constantin, Christopher G. Hughes, Andreas Meiser, Matthieu Jabaudon","doi":"10.1007/s00134-026-08613-0","DOIUrl":"https://doi.org/10.1007/s00134-026-08613-0","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"9 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149067435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of neurologic causes and systemic causes of death in severe meningitis and encephalitis: insights from the international prospective multicenter EURECA study","authors":"Lysander Grospeaud,Romain Sonneville,Etienne de Montmollin,on behalf of the EURECA Investigator Study Group,Nadia Aissaoui,Laurent Argaud,Juliette Audibert,Pierre Bailly,Barabara Balandín Moreno,François Barbier,Omar Ben Hadj Salem,Pascal Beuret,Patricia Boronat,Jeremy Bourenne,Cédric Bruel,Fabrice Bruneel,Italo Calamai,Alain Cariou,Russel Chabanne,Frank Chemouni,Patrick Chillet,Giuseppe Citerio,Damien Contou,Daniel da Silva,Gennaro De Pascale,Jan J. De Waele,Sophie Demeret,Thibault Ducrocq,Etienne Escudier,Ricard Ferrer,Aurélien Frerou,Hugues Georges,Guillaume Geri,Bikram Kumar Gupta,Mohan Gurjar,Raimund Helbok,Janneke Horn,Sami Hraiech,Kada Klouche,Jean-Claude Lacherade,Mickael Landais,Romaric Larcher,Loic Le Guennec,Guillaume Louis,Antoine Marchalot,Eric Mariotte,Maelle Martin,Ignacio Martin-Loeches,Alexandre Massri,Philippe Mateu,Shakti Bedanta Mishra,Gregory Papin,Mathilde Perrin,Jesus Priego,Aguila Radjou,Keyvan Razazi,M. K. Renuka,Danielle Reuter,Thomas Ritzenthaler,Damien Roux,Stéphane Ruckly,Manuel Santafe,Benjamine Sarton,Sulekha Saxena,David Schnell,Carole Schwebel,Shidasp Siami,Roland Smonig,Xavier Souloy,Bertrand Souweine,Quentin Staiquly,Benjamin Sztrympf,Fabio Silvio Taccone,Martial Thyrault,Jean-François Timsit,Estela Val-Jordán,Paula Vera,Guillaume Voiriot","doi":"10.1007/s00134-026-08603-2","DOIUrl":"https://doi.org/10.1007/s00134-026-08603-2","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"33 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}