Interactive cardiovascular and thoracic surgery最新文献

{"title":"Segmentectomy versus lobectomy for inner-located small-sized early non-small-cell lung cancer.","authors":"Shinya Tane,&nbsp;Yoshitaka Kitamura,&nbsp;Kenji Kimura,&nbsp;Nahoko Shimizu,&nbsp;Gaku Matsumoto,&nbsp;Kazuya Uchino,&nbsp;Wataru Nishio","doi":"10.1093/icvts/ivac218","DOIUrl":"https://doi.org/10.1093/icvts/ivac218","url":null,"abstract":"<p><strong>Objectives: </strong>Although segmentectomy is an acceptable alternative to lobectomy for peripheral small-sized non-small-cell lung cancer, the effectiveness of segmentectomy for inner lesions remains unknown. The aim of this study was to examine the feasibility of segmentectomy in comparison with lobectomy for inner lesions.</p><p><strong>Methods: </strong>We retrospectively analysed 570 patients with small (≤2 cm) cN0 non-small-cell lung cancer who underwent segmentectomy or lobectomy between January 2007 and March 2021. We focused on patients with lesions located in the inner two-thirds, which were determined using three-dimensional computed tomography (n = 227). After propensity score matching analysis based on sex, age, pulmonary function, serum carcinoembryonic antigen level, radiographic tumour findings and tumour location, we compared the surgical and oncological outcomes in patients who underwent segmentectomy (n = 66) and lobectomy (n = 66).</p><p><strong>Results: </strong>Postoperative mortality or morbidity did not differ significantly between the 2 groups. The 5-year recurrence-free and overall survival rates in the segmentectomy and lobectomy groups were 93.6% vs 84.1% and 95.8% vs 87.9%, respectively. The differences between 2 groups were not significant (P = 0.62 and P = 0.23, respectively). The 2 groups also showed no differences in loco-regional recurrence. Multivariable Cox regression analysis revealed that segmentectomy had a comparable impact on recurrence-free survival (hazard ratio, 0.61; 95% confidence interval, 0.17-2.03; P = 0.43).</p><p><strong>Conclusions: </strong>Segmentectomy for inner-located small-sized non-small-cell lung tumours could be an acceptable treatment in comparison with lobectomy.</p>","PeriodicalId":13621,"journal":{"name":"Interactive cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/51/1d/ivac218.PMC9468593.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40709628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis comparing low-flow duration of extracorporeal and conventional cardiopulmonary resuscitation.","authors":"Loes Mandigers,&nbsp;Eric Boersma,&nbsp;Corstiaan A den Uil,&nbsp;Diederik Gommers,&nbsp;Jan Bělohlávek,&nbsp;Mirko Belliato,&nbsp;Roberto Lorusso,&nbsp;Dinis Dos Reis Miranda","doi":"10.1093/icvts/ivac219","DOIUrl":"https://doi.org/10.1093/icvts/ivac219","url":null,"abstract":"<p><strong>Objectives: </strong>After cardiac arrest, a key factor determining survival outcomes is low-flow duration. Our aims were to determine the relation of survival and low-flow duration of extracorporeal cardiopulmonary resuscitation (ECPR) and conventional cardiopulmonary resuscitation (CCPR) and if these 2 therapies have different short-term survival curves in relation to low-flow duration.</p><p><strong>Methods: </strong>We searched Embase, Medline, Web of Science and Google Scholar from inception up to April 2021. A linear mixed-effect model was used to describe the course of survival over time, based on study-specific and time-specific aggregated survival data.</p><p><strong>Results: </strong>We included 42 observational studies reporting on 1689 ECPR and 375 751 CCPR procedures. Of the included studies, 25 included adults, 13 included children and 4 included both. In adults, survival curves decline rapidly over time (ECPR 37.2%, 29.8%, 23.8% and 19.1% versus CCPR-shockable 36.8%, 7.2%, 1.4% and 0.3% for 15, 30, 45 and 60 min low-flow, respectively). ECPR was associated with a statistically significant slower decline in survival than CCPR with initial shockable rhythms (CCPR-shockable). In children, survival curves decline rapidly over time (ECPR 43.6%, 41.7%, 39.8% and 38.0% versus CCPR-shockable 48.6%, 20.5%, 8.6% and 3.6% for 15, 30, 45 and 60 min low-flow, respectively). ECPR was associated with a statistically significant slower decline in survival than CCPR-shockable.</p><p><strong>Conclusions: </strong>The short-term survival of ECPR and CCPR-shockable patients both decline rapidly over time, in adults as well as in children. This decline of short-term survival in relation to low-flow duration in ECPR was slower than in conventional cardiopulmonary resuscitation.</p><p><strong>Trial registration: </strong>Prospero: CRD42020212480, 2 October 2020.</p>","PeriodicalId":13621,"journal":{"name":"Interactive cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/5f/ivac219.PMC9491846.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40633733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal timing for lung metastasectomy in patients with colorectal cancer.","authors":"Junji Ichinose,&nbsp;Kohei Hashimoto,&nbsp;Yosuke Matsuura,&nbsp;Masayuki Nakao,&nbsp;Takashi Akiyoshi,&nbsp;Yosuke Fukunaga,&nbsp;Sakae Okumura,&nbsp;Mingyon Mun","doi":"10.1093/icvts/ivac224","DOIUrl":"https://doi.org/10.1093/icvts/ivac224","url":null,"abstract":"<p><strong>Objectives: </strong>The possibility of occult metastasis remains a concern when deciding on lung metastasectomy. This study aimed to evaluate the utility of our two-step determination, which required confirmation that no new metastases had occurred over 3 months before surgery.</p><p><strong>Methods: </strong>Patients who were referred for colorectal lung metastases between 2007 and 2015 were reviewed. Immediate wedge resection was performed for cases with a single peripheral metastasis, whereas surgical indications for others were determined by the two-step determination. Early increase was defined as the emergence of new metastases within 4 months after the diagnosis of lung metastases.</p><p><strong>Results: </strong>Among 369 patients included, 92 were unresectable upon initial diagnosis, and 74 with single peripheral metastasis underwent immediate wedge resection. Surgical indications for the remaining 203 patients were ascertained based on the two-step determination. Surgery was not indicated in 48 patients (24%) due to new metastases or a favourable response to chemotherapy, with a median waiting duration of 4.8 months. Those who did not receive surgery had a worse prognosis than those who did (5-year overall survival: 21% vs 69%, P < 0.001) and were comparable to the initially unresectable group (5-year overall survival: 23%). Thirty-eight patients with early increase had lower surgical resection rates and worse prognoses than those without. Multivariable analysis identified early increase as an independent prognostic factor (hazard ratio: 4.49, P < 0.001).</p><p><strong>Conclusions: </strong>Patients with colorectal lung metastasis who developed new metastasis during the waiting period exhibited poor prognosis, suggesting the utility of the two-step determination of surgical indications.</p>","PeriodicalId":13621,"journal":{"name":"Interactive cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40647566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Midterm results of endoscopically assisted first rib resection in the zero position for thoracic outlet syndrome.","authors":"Hiroshi Satake,&nbsp;Ryusuke Honma,&nbsp;Toshiya Nito,&nbsp;Yasushi Naganuma,&nbsp;Junichiro Shibuya,&nbsp;Masahiro Maruyama,&nbsp;Tomohiro Uno,&nbsp;Michiaki Takagi","doi":"10.1093/icvts/ivac239","DOIUrl":"https://doi.org/10.1093/icvts/ivac239","url":null,"abstract":"<p><strong>Objectives: </strong>We have hypothesized that an endoscopically assisted transaxillary approach in the zero position would be able to improve visualization and allow safe surgery for thoracic outlet syndrome.</p><p><strong>Methods: </strong>We performed surgery only for patients with certain objective findings, including blood flow disruption, low blood flow and accelerated blood flow in the subclavian artery demonstrated using Doppler sonography, narrowing of the scalene interval width between the anterior and middle interscalene muscles (interscalene base) or costoclavicular space demonstrated using Duplex ultrasonography or computed tomography angiography. The present study included 45 consecutive patients (50 limbs) who underwent endoscopic transaxillary first rib resection with scalenotomy and brachial plexus neurolysis. We assessed the intraoperative parameters, including the interscalene base, blood loss, operation time, patient satisfaction, preoperative and postoperative Quick Disability of the Arm, Shoulder and Hand and complications.</p><p><strong>Results: </strong>The mean intraoperatively measured interscalene base width was 6.4 mm. All patients showed improvement after surgery. The outcome was excellent in 40% of cases, good in 48%, fair in 12% and poor in none. Pneumothorax was present in 6%. There were no other complications and no recurrences. Among patients who had been followed up for at least 2 years, the Quick Disability of the Arm, Shoulder and Hand score was significantly improved (42 before surgery vs 12 at final follow-up), especially in athletes relative to non-athletes (0.2 vs 16). The present approach achieved complete relief in 43% of cases overall (91% in athletes and 16% in non-athletes).</p><p><strong>Conclusions: </strong>Endoscopically assisted transaxillary first rib resection and brachial plexus neurolysis in the zero position are useful and safe for thoracic outlet syndrome, especially in athletes.</p>","PeriodicalId":13621,"journal":{"name":"Interactive cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a4/e1/ivac239.PMC9536291.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33462949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for early adverse outcomes after bovine jugular vein conduit implantation: influence of oversized conduit on the outcomes.","authors":"Dong-Hee Kim,&nbsp;Young Kern Kwon,&nbsp;Eun Seok Choi,&nbsp;Bo Sang Kwon,&nbsp;Chun Soo Park,&nbsp;Tae-Jin Yun","doi":"10.1093/icvts/ivac197","DOIUrl":"https://doi.org/10.1093/icvts/ivac197","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated potential risk factors for early failure of bovine jugular vein conduit (Contegra®) implantation for right ventricular outflow tract (RVOT) reconstruction.</p><p><strong>Methods: </strong>A single-centre retrospective review of 115 consecutive patients (54 males) who underwent RVOT reconstruction with Contegra between 2016 and 2019 was performed. Overall survival, explantation-free survival and freedom from significant RVOT lesions (valve regurgitation ≥ moderate or flow velocity ≥3.5 m/s) were investigated.</p><p><strong>Results: </strong>Median age, body weight and Contegra diameter were 10.3 months [interquartile range (IQR) 5.7-26.9 months], 7.8 kg (IQR 6.3-12.4 kg) and 14 mm (IQR 12-16 mm), respectively. During the median follow-up duration of 25.1 months, there were 7 deaths, 34 significant RVOT lesions, 10 endocarditis episodes and 15 explantations. Overall survival and explantation-free survival at 3 years were 94.8% and 78.4%, respectively. Significant RVOT lesions (n = 34) comprised 20 stenoses, 8 regurgitations and 6 combined lesions. Freedom from significant RVOT lesions at 3 years was 62.6%. Cox regression identified higher indexed Contegra size (Contegra diameter/body weight, mm/kg) as the only risk factor for decreased time to explantation or death (hazard ratio 2.32, P < 0.001) and time to significant RVOT lesions development (hazard ratio 2.75, P < 0.001). The cut-off value of indexed Contegra size for significant RVOT lesions at 12 months was 1.905 mm/kg (sensitivity, 0.75; specificity, 0.78; area under the curve, 0.82).</p><p><strong>Conclusions: </strong>Outcomes of RVOT reconstruction using Contegra were acceptable. However, oversized Contegra should be avoided when possible.</p><p><strong>Irb approval date: </strong>26 October 2020.</p><p><strong>Irb registration number: </strong>S2020-2505-0001.</p>","PeriodicalId":13621,"journal":{"name":"Interactive cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40635000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between SLICC/ACR damage index and outcomes for lupus patients after cardiac valve surgery.","authors":"Szu-Yen Hu,&nbsp;Chiao-Feng Cheng,&nbsp;Kelvin Jeason Yang,&nbsp;Chih-Hsien Wang,&nbsp;Nai-Hsin Chi,&nbsp;Ron-Bin Hsu,&nbsp;Yih-Sharng Chen,&nbsp;Hsi-Yu Yu","doi":"10.1093/icvts/ivac221","DOIUrl":"https://doi.org/10.1093/icvts/ivac221","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is associated with multi-organ damage including cardiac valve, which may need valvular operation. However, methods for outcome prediction and prosthetic valve selection are unclear in SLE patients undergoing cardiac valve surgery. Twenty-five SLE patients receiving valvular operation in a single institute between 2002 and 2020 were enrolled. Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index (SLICC/ACR damage index, SDI) was applied to evaluate the damage severity. Clinical outcomes were compared between patients with different SDI. The hospital survival rate was 88%, and long-term survival rate was 59.5% and 40.2% at 5 and 10 years. The median SDI was 4 (interquartile range 3-6) in our study, patients were then grouped into higher SDI (defined as SDI ≥ 5, n = 11) and lower SDI group (defined as SDI < 5, n = 14). The in-hospital survival rate (72.2% vs 100%, P = 0.074) and 5-year survival rate (18.2% vs 92.9%, P < 0.001) were lower in higher SDI group, compared to lower SDI group. SDI score was associated with long-term outcome for SLE patients receiving cardiac valve surgery. SDI ≥ 5 was associated with very poor long-term outcomes. This finding implicates that xenograft might be a reasonable choice for SLE patients with SDI ≥ 5.</p>","PeriodicalId":13621,"journal":{"name":"Interactive cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/d4/ivac221.PMC9492178.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40649596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of depression and postoperative delirium: we may need more information.","authors":"Carlos A Mestres,&nbsp;Eduard Quintana","doi":"10.1093/icvts/ivac228","DOIUrl":"https://doi.org/10.1093/icvts/ivac228","url":null,"abstract":"Cerebral complications after cardiac surgery with cardiopulmonary bypass have a substantial impact on outcomes and resource utilization. Roach et al. [1] defined 2 types of outcomes in a seminal contribution. Type I, death due to stroke/hypoxic encephalopathy, non-fatal stroke, transient ischaemic attack or stupor or coma at discharge; Type II, new deterioration in intellectual function, confusion, agitation, disorientation, memory deficit or seizure without evidence of focal injury [1]. Delirium is an acute organ dysfunction with mental status changes including alterations in level of consciousness, known to burden postoperative outcomes [2] and investigated in patients undergoing non-cardiac [3] and cardiac surgery [4]. Preoperative cognitive status and depression have been associated with postoperative delirium (POD). Assessment scores can be influenced by age, education or ethnicity [4]. Some strategies are currently being investigated aiming at predicting and treating POD after in different settings [5, 6]. In this issue of the Journal, Falk et al. [7] aimed at investigating preoperative depression as predictor of POD after cardiac surgery, analysing 1133 patients operated between 2013 and 2016. Fourteen per cent reported depressive symptoms preoperatively; the observed incidence of POD was 26%, being highest among elderly patients. One-third of patients with depression developed POD in comparison one-quarter of the non-depressed. Odds of POD were 2.19 times higher in individuals with depressive symptoms compared to controls. The onset of delirium was most common on the first 2 days after surgery. The authors concluded that in their unique population-based study, preoperative depression is associated with POD in a large proportion of patients. The corollary is that improved preoperative screening for depression and enhanced clinical surveillance in the early postoperative period for all patients is required. Although this study established the actual observed rates of POD in relation to preoperative symptoms of depression in a given population like that of the authors, there are some unclear aspects. This study was conducted between 2013 and 2016, an acute study as authors only investigated POD rates with no follow-up. It is somewhat surprising that data have been reported after a substantially long period of time, considering as said, that this looked as an acute study. Population changes of interest may have occurred during this period. One may argue that the authors’ regional population remains stable over time and that changes might be unlikely. Although population stability may be the key factor, the readership would have been keen to integrate a brief elaboration. The authors distributed the local version of the Patient Health Questionnaire (PHQ-9) 2 weeks before a scheduled operation. As confirmed by the authors in their revisions, 30% of their patients are operated as ‘urgent’ patients; however, in the final sample, urgent surgery ra","PeriodicalId":13621,"journal":{"name":"Interactive cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40336747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Descending thoracic aortic repair outcomes for chronic aortic dissection: a single-centre experience.","authors":"Yoshitaka Yamane,&nbsp;Susumu Oshima,&nbsp;Kazumasa Ishiko,&nbsp;Makoto Okiyama,&nbsp;Tomohiro Hirokami,&nbsp;Yuki Hirai,&nbsp;Shigeru Sakurai,&nbsp;Kensuke Ozaki,&nbsp;Kenichi Yoshimura,&nbsp;Shinya Takahashi,&nbsp;Shin Yamamoto","doi":"10.1093/icvts/ivac233","DOIUrl":"https://doi.org/10.1093/icvts/ivac233","url":null,"abstract":"<p><strong>Objectives: </strong>Thoracic endovascular aortic repair is a widely accepted treatment for chronic aortic dissection because of good early results compared to open surgical repair. We provide early and long-term results of descending thoracic aortic repair for chronic aortic dissection.</p><p><strong>Methods: </strong>Patients who underwent descending thoracic aortic repair for chronic aortic dissection between January 2012 and December 2020 at Kawasaki Aortic Centre were included in this analysis.</p><p><strong>Results: </strong>Four hundred ninety-two patients (median age, 64 years; interquartile range, 52-75 years) were included. The median duration of follow-up was 3.2 years (interquartile range, 1.5-5.2 years). The early mortality rate was 2.0% (n = 10); strokes occurred in 17 patients (3.5%); and spinal cord injuries occurred in 30 patients (6.1%). Early major adverse events including early death, stroke, spinal cord injury, tracheostomy and haemodialysis at the time of discharge occurred in 62 patients. Multivariable analysis indicated that age > 70 years and non-elective surgery were predictors of early major adverse events. Among patients without both risk factors (i.e. low-risk patients), 1 early death (0.4%), 3 strokes (1.5%) and 1 spinal cord injury (0.4%) were observed, 2 tracheostomies were performed (0.8%) and no patients required haemodialysis at the time of hospital discharge. The 5-year survival rate was 87.2%. The cumulative incidence of chronic aortic dissection-related aortic reintervention at 5 years was 7.9%.</p><p><strong>Conclusions: </strong>Descending thoracic aortic repair for chronic aortic dissection resulted in good early and long-term results, and it can serve as the gold standard for low-risk patients.</p>","PeriodicalId":13621,"journal":{"name":"Interactive cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/10/ivac233.PMC9519091.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40356091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porcelain aorta does not mean inoperability but needs special strategies.","authors":"Thierry Carrel,&nbsp;Paul Robert Vogt","doi":"10.1093/icvts/ivac222","DOIUrl":"https://doi.org/10.1093/icvts/ivac222","url":null,"abstract":"<p><p>Porcelain aorta is not an absolute contraindication for aortic valve and/or coronary bypass grafting but it requires a special strategy and individualized approach to minimize the risk of embolic complications and technical problems during opening and/or closing the aortotomy.</p>","PeriodicalId":13621,"journal":{"name":"Interactive cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40647565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockdown of circ_0002194 protects against oxidized low-density lipoprotein-induced cell damage via the regulation of the miR-637/PACS2 axis in human vascular endothelial cells.","authors":"Ruyang Mei,&nbsp;Mei Wu,&nbsp;Fei Ren","doi":"10.1093/icvts/ivac210","DOIUrl":"https://doi.org/10.1093/icvts/ivac210","url":null,"abstract":"<p><strong>Objectives: </strong>Atherosclerosis is one of the most common cardiovascular diseases. The functional roles of circular (circ) RNAs have been discovered in atherosclerosis. Our goal was to explore the regulation and mechanism of circ_0002194 in oxidized low-density lipoprotein-induced human vascular endothelial cells.</p><p><strong>Methods: </strong>Circ_0002194, microRNA-637 (miR-637) and phosphofurin acidic cluster sorting protein 2 (PACS2) levels were determined through the reverse transcription-quantitative polymerase chain reaction. Cell viability was detected using the Cell Counting Kit-8 assay, and angiogenetic ability was analysed via the tube formation assay. Flow cytometry was used to measure cell apoptosis. Western blot was performed to examine protein expression. Oxidative stress was assessed using commercial kits. The RNA immunoprecipitation assay and dual-luciferase reporter assay were conducted for target analysis.</p><p><strong>Results: </strong>Treatment with oxidized low-density lipoprotein induced the upregulation of circ_0002194 in endothelial cells. Cell viability and angiogenesis were promoted while cell apoptosis and oxidative stress were reduced by the downregulation of circ_0002194 in the cell model. Furthermore, miR-637 was identified as an miRNA target of circ_0002194, and the regulatory role of circ_0002194 was associated with the sponge effect on miR-637. Moreover, circ_0002194 could regulate PACS2 by affecting miR-637. Additionally, miR-637 suppressed endothelial cell damage by partly mediating the expression of PACS2.</p><p><strong>Conclusions: </strong>The results demonstrated that circ_0002194 facilitated endothelial cell dysfunction in atherosclerosis partly through upregulating PACS2 by targeting miR-637.</p>","PeriodicalId":13621,"journal":{"name":"Interactive cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40618081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}