Association between SLICC/ACR damage index and outcomes for lupus patients after cardiac valve surgery.

IF 2.1 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Szu-Yen Hu, Chiao-Feng Cheng, Kelvin Jeason Yang, Chih-Hsien Wang, Nai-Hsin Chi, Ron-Bin Hsu, Yih-Sharng Chen, Hsi-Yu Yu
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引用次数: 0

Abstract

Systemic lupus erythematosus (SLE) is associated with multi-organ damage including cardiac valve, which may need valvular operation. However, methods for outcome prediction and prosthetic valve selection are unclear in SLE patients undergoing cardiac valve surgery. Twenty-five SLE patients receiving valvular operation in a single institute between 2002 and 2020 were enrolled. Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index (SLICC/ACR damage index, SDI) was applied to evaluate the damage severity. Clinical outcomes were compared between patients with different SDI. The hospital survival rate was 88%, and long-term survival rate was 59.5% and 40.2% at 5 and 10 years. The median SDI was 4 (interquartile range 3-6) in our study, patients were then grouped into higher SDI (defined as SDI ≥ 5, n = 11) and lower SDI group (defined as SDI < 5, n = 14). The in-hospital survival rate (72.2% vs 100%, P = 0.074) and 5-year survival rate (18.2% vs 92.9%, P < 0.001) were lower in higher SDI group, compared to lower SDI group. SDI score was associated with long-term outcome for SLE patients receiving cardiac valve surgery. SDI ≥ 5 was associated with very poor long-term outcomes. This finding implicates that xenograft might be a reasonable choice for SLE patients with SDI ≥ 5.

Abstract Image

Abstract Image

狼疮患者心脏瓣膜手术后SLICC/ACR损伤指数与预后的关系
系统性红斑狼疮(SLE)与包括心脏瓣膜在内的多器官损害有关,可能需要瓣膜手术。然而,对于接受心脏瓣膜手术的SLE患者,预后预测和人工瓣膜选择的方法尚不清楚。在2002年至2020年期间,在同一研究所接受瓣膜手术的25例SLE患者被纳入研究。采用系统性狼疮国际合作诊所/美国风湿病学会损伤指数(SLICC/ACR损伤指数,SDI)评价损伤严重程度。比较不同SDI患者的临床结果。住院生存率为88%,5年和10年长期生存率分别为59.5%和40.2%。在我们的研究中,中位SDI为4(四分位数范围为3-6),然后将患者分为高SDI组(定义为SDI≥5,n = 11)和低SDI组(定义为SDI)
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来源期刊
Interactive cardiovascular and thoracic surgery
Interactive cardiovascular and thoracic surgery CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.30
自引率
0.00%
发文量
292
审稿时长
2-4 weeks
期刊介绍: Interactive CardioVascular and Thoracic Surgery (ICVTS) publishes scientific contributions in the field of cardiovascular and thoracic surgery, covering all aspects of surgery of the heart, vessels and the chest. The journal publishes a range of article types including: Best Evidence Topics; Brief Communications; Case Reports; Original Articles; State-of-the-Art; Work in Progress Report.
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