Infection最新文献

{"title":"Model-informed identification of optimised dosing strategies for meropenem in critically ill patients receiving SLEDD: an observational study.","authors":"Franz Weber, Christina Scharf, Linda B S Aulin, Ferdinand Weinelt, Michael Paal, Gerd Mikus, Michael Vogeser, Katharina Habler, Wilhelm Huisinga, Michael Zoller, Robin Michelet, Charlotte Kloft, Uwe Liebchen","doi":"10.1007/s15010-025-02504-0","DOIUrl":"10.1007/s15010-025-02504-0","url":null,"abstract":"<p><strong>Purpose: </strong>An increasing number of critically ill patients receive slow extended daily dialysis (SLEDD) due to their pathophysiology while suffering from sepsis, necessitating effective and safe antibiotic therapy. Although SLEDD reduces meropenem exposure and increases treatment failure risk, effective and safe dosing regimens are unclear. We aimed to identify optimised meropenem dosing strategies for critically ill SLEDD patients through population pharmacokinetic (PK) modelling and PK/pharmacodynamic (PD)-based probability of target attainment (PTA) analysis.</p><p><strong>Methods: </strong>Clinical data from a prospective study involving critically ill SLEDD patients receiving meropenem were monitored through routine therapeutic drug monitoring. A total of 178 blood samples from 13 patients (median 14 samples per patient) were analysed. A PK model was developed and utilised to evaluate 24 clinically relevant dosing regimens during SLEDD therapy (7-h on-SLEDD periods q24h) in PTA analyses. The PK/PD target window of minimum meropenem concentration between 8 mg/L (P. aeruginosa; R-breakpoint) and 44.45 mg/L (toxicity threshold) was used.</p><p><strong>Results: </strong>A one-compartment PK model with linear elimination and total clearance (CL) split into renal (CL_REN; 45%) and SLEDD-associated (55%) CL well characterised the SLEDD data. Creatinine clearance (urine-collected; CLCR_urine) was identified as significant factor on CL_REN. Continuous infusions, specifically 2 g q24h for CLCR_urine 0-25 mL/min and 3 g q24h for CLCR_urine 25-40 mL/min, showed the highest PTA being effective and safe during SLEDD therapy. A comprehensive dosing nomogram was developed.</p><p><strong>Conclusion: </strong>Our easy-to-use dosing nomogram presents a promising tool in optimising meropenem dosing regimens for critically ill SLEDD patients considering their kidney function in clinical practice.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov NCT03985605. Registered 14 June 2019. https://classic.</p><p><strong>Clinicaltrials: </strong>gov/ct2/show/study/NCT03985605.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"1819-1831"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When oral health affects overall health: biofilms, dental infections, and emerging antimicrobial strategies.","authors":"Ahmed Adel Abdelaziz, Ahmed S Doghish, Akram N Salah, Reda M Mansour, Yasser M Moustafa, Sherif S Abdel Mageed, Hebatallah Ahmed Mohamed Moustafa, Walaa A El-Dakroury, Sama A Doghish, Osama A Mohammed, Mustafa Ahmed Abdel-Reheim, Shaimaa O Abbass, Sara O Abbass, Mariam O Abbass, Amira Mohamed Samy, Mahmoud A Elrebehy, Youssef A Doghish","doi":"10.1007/s15010-025-02533-9","DOIUrl":"10.1007/s15010-025-02533-9","url":null,"abstract":"<p><p>Dental health is a crucial component of overall health, yet it is frequently overlooked in discussions about well-being. This article explores the multifaceted aspects of dental infections, primarily focusing on biofilms formed by pathogenic bacteria such as Streptococcus mutans and Porphyromonas gingivalis. These biofilms contribute to dental caries and periodontal disease, conditions that affect oral health and have systemic consequences. Recent advancements in understanding biofilm formation and interactions have led to novel strategies for prevention and treatment, including using nanoparticles and smart hydrogels designed to disrupt biofilm integrity while promoting biocompatibility with human tissues. Furthermore, the article highlights the potential of natural remedies, including herbal extracts, as adjuncts in maintaining oral hygiene and combating microbial infections. A comprehensive overview of biofilm dynamics, including adhesion, maturation, and dispersion, is presented, alongside discussions on innovative therapeutic approaches addressing the limitations of conventional treatments. Ultimately, this article emphasizes the importance of maintaining dental health in preventing a wide spectrum of health issues, reinforcing that the mouth is a gateway to the body.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"1603-1624"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple clinical tool for effective screening of haemophagocytic lymphohistiocytosis in dengue.","authors":"Jeco Jacob Kuttykandathil, Arfath Ahmed, Gauri Malavalli Girish, Chyavan Trisule Reddy Tummaluru, Vivek Kothandaraman Koushik, Tapendu Patoary, Chakrapani Mahabala","doi":"10.1007/s15010-025-02542-8","DOIUrl":"10.1007/s15010-025-02542-8","url":null,"abstract":"<p><strong>Purpose: </strong>Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder. Dengue fever is a common trigger for HLH in the tropics. We aimed to develop a simplified clinical tool to detect HLH in dengue patients.</p><p><strong>Methods: </strong>A cross-sectional observational study was carried out at Kasturba Medical College Mangalore. Patients between 18 and 60 years of age, with dengue fever for more than five days with suspected HLH symptoms were selected. Hepatosplenomegaly, temperature, haemoglobin levels, total leucocyte count, platelet count, ferritin, triglyceride, and liver function tests were assessed. HLH-2004 criteria were used to confirm the diagnosis. A simple clinical tool was developed via decision tree analysis using clinical and laboratory parameters.</p><p><strong>Results: </strong>Patients with HLH had marked leucopenia, thrombocytopenia, hyperferritinaemia and elevated aspartate aminotransferase levels, and a greater incidence of hepatosplenomegaly than those without HLH. Decision tree analysis was used to generate a clinical diagnostic tool, which demonstrated an accuracy of 94%, at a confidence interval of 95% (90-98%). The model's ability to predict HLH was 79%, while its specificity was 96%. It had a positive predictive value of 68% and a negative predictive value of 97%. The kappa value of the predicted model was 0.70, indicating an agreement with the diagnosis using HLH-2004 criteria, with a significant p-value (< 0.001).</p><p><strong>Conclusions: </strong>Splenomegaly can be used as a screening method to diagnose HLH in patients with dengue. By using an algorithmic approach, combining splenomegaly with leucopenia and thrombocytopenia, this clinical tool accurately detects HLH in patients with dengue.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2037-2044"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral antibiotics demonstrate similar rates of success and complications compared to parenteral antibiotics for bone and joint infections: a systematic review and meta-analysis.","authors":"Gabriella Schreiner, Stephen Fucaloro, Jesus Meija, Laura Krivicich, Matthew Salzler","doi":"10.1007/s15010-025-02517-9","DOIUrl":"10.1007/s15010-025-02517-9","url":null,"abstract":"<p><strong>Purpose: </strong>Bone and joint infections (BJIs) cause significant morbidity, and current guidelines suggest treatment with parenteral antibiotics for 4-6 weeks. However, utility of oral antibiotics as a potential alternative has yet to be thoroughly investigated. To provide a statistical appraisal of literature comparing treatment success and complication rates of oral antibiotics to parenteral antibiotics for BJIs.</p><p><strong>Methods: </strong>PubMed, Embase, Cochrane, and Web of Science databases were queried for studies published by November 12, 2024. Randomized controlled trials (RCTs) comparing parenteral to oral regimens for the entire treatment duration were included, as well as comparative studies evaluating \"early switch\" therapy, defined as switching from parenteral to oral antibiotics within 28 days. Data was pooled and sub-analyzed according to design (RCTs or early switch cohorts). Treatment successes and complications for parenteral and oral groups were assessed via DerSimonian-Laird binary random-effects modeling with a p-value < 0.05 indicating significance.</p><p><strong>Results: </strong>Six RCTs (1,310 patients) compared treatment success of parenteral or oral regimens for the duration of the infection treatment, and six retrospective cohort studies (1,106 patients) compared parenteral therapy to early switch therapy. Meta-analysis of RCTs demonstrated no significant difference for treatment success rates for oral versus parenteral antibiotics (OR 1.09 [0.79-1.51], p = 0.93, I² = 0.00%). Six early switch cohort studies demonstrated that oral antibiotics had significantly higher success (OR = 1.70 [1.13-2.54], p = 0.01, I² = 0.00%). Meta-data of both RCTs and early switch cohort studies demonstrated no significant difference in complication rates.</p><p><strong>Conclusion: </strong>No difference in treatment success rates or complication rates was found when comparing oral and parenteral antibiotics. Oral antibiotics are a possible option for treatment of BJIs.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"1899-1909"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual case of non-sexual Mpox transmission in a heterosexual woman.","authors":"Marc Biller, Julia Lais, Stefan Esser, Stefanie Sammet","doi":"10.1007/s15010-025-02550-8","DOIUrl":"10.1007/s15010-025-02550-8","url":null,"abstract":"<p><p>Monkeypox (MPOX) is becoming an important differential diagnosis in non-endemic regions, particularly in patients with atypical dermatologic lesions and systemic symptoms. Although it is more commonly associated with males, it is important to consider MPOX in females, as its presentation may be misattributed to more common infections. This article describes a 28-year-old heterosexual female with cutaneous lesions and systemic symptoms that were initially thought to be a localized infection. Further evaluation confirmed MPOX with a bacterial superinfection. The patient had no sexual but close contact with a confirmed case of MPOX. Clinicians must remain vigilant to recognize the broad spectrum of MPOX presentations and ensure timely diagnosis, isolation, and preventive measures to limit transmission.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2257-2259"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible link between steatotic liver diseases, severe COVID-19 and cognitive impairment in post-COVID-19 syndrome.","authors":"Philipp A Reuken, Freya Wagner, Kathrin Finke, Christina Lemhöfer, Christian Puta, Sven Stengel, André Scherag, Jan-Christoph Lewejohann, Andreas Stallmach, Stefanie Quickert","doi":"10.1007/s15010-025-02531-x","DOIUrl":"10.1007/s15010-025-02531-x","url":null,"abstract":"<p><strong>Purpose: </strong>Steatotic liver diseases (SLD) have become more prevalent over the last decade and are associated not only with cardiometabolic diseases but also with psychological symptoms (depression, fatigue). These symptoms are also common in post-COVID syndrome (PCS). Therefore, the aim of the study was to analyze the burden of SLD in PCS patients.</p><p><strong>Methods: </strong>We systematically screened all PCS patients from our post-COVID outpatient clinic using transient elastography, structured questionnaires for neurocognitive evaluation and blood sample analysis. Controls without PCS and without known liver diseases were also recruited and assessed with the same approach.</p><p><strong>Results: </strong>560 PCS patients and 103 healthy controls were included. The overall prevalence of SLD was high in both cohorts (57 vs. 53%). PCS patients with SLD were more frequently male (41 vs. 24%), older (52 vs. 44 years) and had more cardiometabolic diseases (87.0 vs. 46.4%). Cognitive impairment was more related to SLD in PCS patients than in the no-SLD group (OR: 1.68, CI: 1.14-2.46, p = 0.008). The presence of SLD was related to severe COVID-19 with hospitalization (OR: 2.91, CI: 1.85-4.56, p < 0.001). Within 1 year of the follow-up, 152 of 289 patients described a resolution in PCS irrespective of the presence or absence of SLD (log-rank p = 0.96).</p><p><strong>Conclusions: </strong>SLD is associated with severe COVID-19 and cognitive dysfunction in PCS. Longitudinal studies are needed to assess the role of hepatic steatosis, development of post-acute infection regulation (e.g., SARS-CoV-2) and to differentiate between SLD-associated symptoms and PCS.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"1979-1992"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infection prevention and control measures for multidrug-resistant organisms: a systematic review and network meta-analysis.","authors":"Yuhui Geng, Zhuo Liu, Xiaojuan Ma, Ting Pan, Mingbo Chen, Jingxia Dang, Ping Zhang, Chen Chen, Yuan Zhao, Dongfeng Pan, Peifeng Liang","doi":"10.1007/s15010-025-02498-9","DOIUrl":"10.1007/s15010-025-02498-9","url":null,"abstract":"<p><strong>Background: </strong>The effectiveness of infection prevention and control measures combating multidrug-resistant organisms (MDROs) in healthcare settings remains controversial.</p><p><strong>Methods: </strong>PubMed, Embase, MEDLINE, Cochrane Library, and CINAHL were searched from inception to June 1, 2024. The interventions encompassed standard precautions (SP), contact precautions (CP), hand hygiene (HH), environmental cleaning (ENV), antimicrobial stewardship programs (ASP), decolonization (DCL), and chlorhexidine baths (CHG). The primary outcome were the acquisition, infection, and colonization of MDROs. Secondary outcomes were all-cause mortality and MDROs-associated bacteraemia. Effect indicators were expressed as rate ratios (RRs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>The study included a total of 97 articles, comprising 19 RCTs and 78 non-RCTs. The results showed that the most effective combination interventions for the acquisition, infection, and colonization of MDROs compared to SP varied as follows: CP + CHG (RR, 0.38 [0.18, 0.79]), SP + CP + ENV (RR, 0.04 [0.02, 0.08]), and SP + CHG (RR, 0.28 [0.14, 0.56]). In subgroup analyses, CP + CHG (RR, 0.36 [0.20,0.64]) was the most effective intervention for the acquisition of MDROs in the ICU setting, whereas SP + CP + ASP (RR, 0.35 [0.14,0.92]) was the most effective hospital-wide. Across subgroups, SP + CP + ENV (RR, 0.04 to 0.09 [95% CI, 0.01 to 0.99]) was identified as the most effective intervention for MDROs infections. In the ICU setting, SP + CHG (RR, 0.28 [0.14,0.56]) demonstrated the highest effectiveness in reducing the colonization of MDROs, whereas SP + CP + ENV + CHG (RR, 0.15 [0.06,0.38]) was the most effective on a hospital-wide scale. SP + CP + DCL (RR, 0.28 [0.24, 0.32]) was associated with reduced CRE colonization. The results of this study were robust according to the sensitivity analysis. None of the analyses related to secondary outcomes were statistically significant. In terms of article quality assessment, 94.7% of the RCTs were medium to high risk, while 92.31% of the non-RCTs. The primary limitation of the RCTs were related to the randomization process, whereas the non-RCTs were primarily affected by confounding bias.</p><p><strong>Conclusions: </strong>Effective interventions differ based on carriage status, intervention setting, and the resistant strain. Additionally, contact precautions is a crucial component of these combinations. Consequently, healthcare organizations can select appropriate interventions based on their unique resistance profiles to optimize precision and resource efficiency.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"1789-1800"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and patient-reported outcomes of self-administered outpatient parenteral antimicrobial treatment (S-OPAT): a scoping review.","authors":"Jolanda M Maaskant, Tessa de Vries, Laura Volle, Faridi S Jamaludin, Suzanne E Geerlings, Kim C E Sigaloff","doi":"10.1007/s15010-025-02549-1","DOIUrl":"10.1007/s15010-025-02549-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to provide a comprehensive overview of the existing literature on Self-administered Outpatient Parenteral Antimicrobial Therapy (S-OPAT), focusing on safety and clinical outcomes, factors influencing these outcomes, and the experiences of patients and caregivers.</p><p><strong>Methods: </strong>We searched the databases MEDLINE, CINAHL, Embase and Cochrane library. Publications were included if they reported on the clinical outcomes, safety, and/or experiences of patients and caregivers with S-OPAT. Study selection and data extraction were performed independently by two reviewers. Quantitative and qualitative data were summarized in data charting forms.</p><p><strong>Results: </strong>Forty-four studies were included: 41 primary studies, 2 systematic reviews and 1 clinical guideline. Clinical outcomes were reported in 17 and safety in 23 primary studies. Eleven studies compared S-OPAT to other OPAT delivery models. These studies showed that all models were generally comparable regarding clinical outcomes, but two studies reported an increased number of adverse events with S-OPAT. Nine studies, exploring a total of 7 potential risk factors, identified older age, comorbidities and Staphylococcus aureus infections as contributors to adverse events. The results of 14 studies on patient-centred outcomes showed that patients and caregivers considered S-OPAT a suitable alternative to other OPAT delivery models.</p><p><strong>Conclusion: </strong>We conclude that S-OPAT is a viable model of care, demonstrating favourable clinical outcomes, although some safety concerns have been reported. The growing care demand now and in the future urges further development of S-OPAT care. Gaps of knowledge still exist, and we provide recommendations for future research.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2083-2102"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro- and nanoplastics reduce the phagocytosis and intracellular killing of E. coli by THP1-Blue™ NFκB monocytes.","authors":"Florian Edbauer, Hans-Christoph Ludwig, Marie Julia Moritz, Roland Nau, Jana Seele","doi":"10.1007/s15010-025-02565-1","DOIUrl":"10.1007/s15010-025-02565-1","url":null,"abstract":"<p><strong>Purpose: </strong>Micro- and nanoplastic particles occur ubiquitously in the environment and have been detected in various organs in animals and humans. We studied, how micro- and nanoplastic influence phagocytosis and intracellular killing of live bacteria in human monocytes.</p><p><strong>Methods: </strong>Cells of the human reporter cell line THP1-Blue™ NFκB were pre-treated with different concentrations of micro- and nanoplastic (diameter 1 μm and 100 nm) and then incubated with Escherichia coli DH5α. Phagocytosis and intracellular killing was studied using an antibiotic protection assay. The activation of the NFκB promoter was quantified by measuring the production of alkaline phosphatase. Cytokines were measured by enzyme immunoassay. Cell viability was determined by trypan blue staining and lactate dehydrogenase measurement. Electron microscopic images were taken to localize micro- and nanoplastic.</p><p><strong>Results: </strong>Micro- and nanoplastic particles were rapidly internalized by monocytes. They reduced phagocytosis of E. coli in a concentration- and time-dependent manner. Exposure to micro- and nanoplastic also reduced the intracellular killing of bacteria in a concentration-dependent manner. Plain plastic particles did not induce NFκB synthesis and IL1β and IL6 release. At concentrations inhibiting phagocytosis, micro- and nanoplastic was not cytotoxic. Endotoxin stimulated phagocytosis of bacteria. High concentrations of plastic particles reduced the stimulatory effect of endotoxin on phagocytosis of bacteria, but not the effect on NFκB synthesis.</p><p><strong>Conclusion: </strong>Exposure to micro- and nanoplastic reduced the ability of phagocytes to internalize and kill bacteria. High plastic concentrations decreased the endotoxin-stimulated phagocytosis of bacteria. Hence, exposure to plastic particles may reduce the host`s immune defence against bacterial pathogens.</p>","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2179-2189"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A very rare case of osseous involvement of the dens axis in a 52-year-old HIV positive patient as part of secondary syphilis.","authors":"K Lange, C Helbig, N Eckardt, M Baier, J Guse, S Hagel, A Stallmach, B T Schleenvoigt","doi":"10.1007/s15010-025-02552-6","DOIUrl":"10.1007/s15010-025-02552-6","url":null,"abstract":"","PeriodicalId":13600,"journal":{"name":"Infection","volume":" ","pages":"2261-2263"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}