Infection and Drug Resistance最新文献

{"title":"Acute Necrotizing Fasciitis Caused by <i>Rhizopus</i> Infection in a Patient with Diabetes and Pulmonary Tuberculosis: A Case Report.","authors":"Xiaoqing Huang, Junke Qiu, Lei Pan, Caihong Wang, Chuanfeng Tang","doi":"10.2147/IDR.S503791","DOIUrl":"10.2147/IDR.S503791","url":null,"abstract":"<p><strong>Background: </strong>Zygomycosis, also termed mucormycosis, is a rare yet highly fatal fungal infection caused by Mucorales species, notably <i>Rhizopus</i> spp.</p><p><strong>Case presentation: </strong>This case study details a 72-year-old man with diabetes, pulmonary tuberculosis, and nephrotic syndrome who developed acute necrotizing fasciitis attributable to <i>R. oryzae</i>. Despite initial empirical antibiotic therapy, the infection progressed rapidly. Metagenomic next-generation sequencing (mNGS) facilitated a swift diagnosis, identifying <i>R. oryzae</i> in blood and drainage samples. The treatment included amphotericin B and isavuconazole, along with aggressive surgical debridement. The patient exhibited substantial improvement, and he was discharged after stabilization.</p><p><strong>Conclusion: </strong>This case highlights the critical role of early diagnosis through mNGS and the need for a multidisciplinary approach to manage severe mucormycosis in immunocompromised patients.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"775-782"},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance Surveillance of Skin and Soft Tissue Infections: Hospital-Wide Bacterial Species and Antibiograms to Inform Management at a Zonal Tertiary Hospital in Mwanza, Tanzania.","authors":"Baraka N Justine, Martha F Mushi, Vitus Silago, Zechariah Igembe, John Muyombe, Peter Peter Kishengena, Nyanda Shango Michael, Mathew Gabriel Maganga, Alicia Massenga, Francis Tegete, Fabian A Massaga, Jeremiah Seni","doi":"10.2147/IDR.S483953","DOIUrl":"10.2147/IDR.S483953","url":null,"abstract":"<p><strong>Purpose: </strong>The National Action Plan on antimicrobial resistance (NAP-AMR) in Tanzania is focused on blood stream infections and urinary tract infections despite skin and soft tissue infections (SSTIs) being common. This study assessed the proportion of laboratory-confirmed SSTIs, identify bacterial species involved, analyze AMR phenotypes, and investigate the risk factors associated with multidrug-resistant (MDR) SSTIs.</p><p><strong>Patients and methods: </strong>Analytical cross-sectional study was conducted between January and June 2023, involving 614 patients with SSTIs. Patients' information was collected using standard AMR surveillance tools, and either pus swabs or pus aspirate or necrotic tissues were collected and analyzed using standard microbiological procedures, WHONET and STATA software programs.</p><p><strong>Results: </strong>The median age (interquartile range) of patients was 34 (14-54) years with males accounting for 54.4%. Laboratory-confirmed SSTIs was 72.5% (445/614), yielding 586 bacterial isolates. The most frequent SSTIs types were surgical site infections (30.0%), chronic wounds (27.9%), and traumatic wounds (19.7%). The commonest pathogens were <i>Staphylococcus aureus</i> (17.1%), <i>Escherichia coli</i> (17.1%), and <i>K. pneumoniae</i> (16.0%). The AMR phenotypes identified were methicillin resistant <i>Staphylococcus aureus</i>, 29.0%; Extended-spectrum beta lactamase producing Gram-negative bacteria, 47.3%; and carbapenem resistant Gram-negative bacteria, 12.9%. The overall MDR SSTIs was 40.9% (251/614) and was significantly higher among inpatients compared to outpatients [OR (95% CI); p-value: 1.86 (1.33-2.59); p-value<0.001].</p><p><strong>Conclusion: </strong>Approximately three-quarter of patients have laboratory-confirmed SSTIs caused predominantly by MDR pathogens. Revisiting SSTIs treatment guidelines at BMC and inclusion of SSTIs in the on-going AMR surveillance in Tanzania are recommended.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"791-802"},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 <i>Klebsiella pneumoniae</i> Infections.","authors":"Tao Yan, Qiuyan Wang, Chengcheng Ma, Xuan Teng, Zhen Gong, Wenwen Chu, Qiang Zhou, Zhou Liu","doi":"10.2147/IDR.S501921","DOIUrl":"10.2147/IDR.S501921","url":null,"abstract":"<p><strong>Purpose: </strong><i>Klebsiella pneumoniae</i> is a globally prevalent pathogen responsible for severe hospital- and community-acquired infections, and presents significant challenges for clinical management. Current therapeutic strategies are no longer able to meet the clinical needs; therefore, there is an urgent need to develop novel therapeutic strategies. This study aimed to evaluate the efficacy of phage therapy in treating bacterial infections.</p><p><strong>Methods: </strong>Isolated phage vB_Kpn_HF0522 and phage morphology were observed using transmission electron microscopy. Analysis of vB_Kpn_HF0522 characteristics, including optimal multiplicity of infection (MOI), one-step growth curve, host range, stability in different environments, and adsorption capacity. The phage genomic sequence was analyzed to explore evolutionary relationships. The effect of phage vB_Kpn_HF0522 on biofilms was assessed using crystal violet staining assay. The <i>Galleria mellonella</i> (<i>G. mellonella</i>) infection model and mouse infection models were established to evaluate the practical application potential of the phage and the fitness cost of phage-resistant bacteria.</p><p><strong>Results: </strong>Phage was isolated from hospital sewage for experimental studies. Genome analysis revealed that vB_Kpn_HF0522 is a double-stranded linear DNA virus. Biological characterization demonstrated that this phage specifically targets serotype K1 <i>K. pneumoniae</i> with an optimal multiplicity of infection (MOI) of 0.01, effectively disrupting biofilms and inhibiting bacterial growth. The bacterial growth rate remained largely unchanged after the phage resistance mutation, but mice infected with the mutant strain showed significantly higher survival rates than those infected with the wild-type strain. vB_Kpn_HF0522 increased the survival rate of infected <i>G. mellonella</i> from 12.5% to 75%, inhibited incisional surgical site infections and alleviated inflammatory response in mice.</p><p><strong>Conclusion: </strong>These findings indicate that vB_Kpn_HF0522 has significant potential for treating specific bacterial infections, and may serve as an antimicrobial agent for research and clinical anti-infective therapy.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"803-818"},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Optimization of Empirical Antimicrobial Therapy for Febrile Neutropenia in Patients With Hematologic Malignancies.","authors":"Yuqing Cui, Xin Liu, Sizhou Feng","doi":"10.2147/IDR.S493670","DOIUrl":"10.2147/IDR.S493670","url":null,"abstract":"<p><strong>Purpose: </strong>Since the publication of the 2011 Infectious Diseases Society of America (IDSA) guidelines for empirical treatment of febrile neutropenia (FN), there have been significant shifts in pathogen profiles and emerging challenges in treatment. These include increased prevalence of multidrug-resistant (MDR) bacteria and changes in the distribution of Gram-negative or Gram-positive bacteria (GPB). The study aims to update and optimize empirical treatment strategies for hematological malignancy (HM) patients, a population particularly vulnerable to these evolving threats.</p><p><strong>Methods: </strong>A literature review was conducted on studies published between January 2010 and December 2023 regarding empirical treatment of FN in HM patients, focusing on pathogen characteristics, treatment regimens, and duration of therapy.</p><p><strong>Results: </strong>Approximately one-third of HM patients with FN experience fever of unknown origin (FUO), while 40-50% have clinically documented infections (CDI), and 10-30% present with microbiologically documented infections (MDI), with a predominance of Gram-negative bacteria (GNB). Factors such as prolonged neutropenia, prior broad-spectrum antibiotic use, and previous infections with drug-resistant bacteria are associated with MDR infections. Cefepime, piperacillin/tazobactam (PTZ), and carbapenem are viable empirical treatments for high-risk HM patients, though cefepime monotherapy's advantage remains uncertain. In cases of pneumonia, shock, or suspected carbapenem-resistant infections, combination therapy, tigecycline, and newer antibiotics like ceftazidime/avibactam (CAZ/AVI) are often used. Empirical broad-spectrum antibiotics can be safely discontinued in FUO patients after 48 hours of clinical stability and apyrexia.</p><p><strong>Conclusion: </strong>Proper selection of empirical antibiotics and determining optimal treatment duration are essential for reducing antibiotic resistance and improving outcomes in HM patients with FN. These findings underscore the need for updated clinical guidelines that address evolving pathogen profiles and the growing challenge of MDR infections.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"715-729"},"PeriodicalIF":2.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Influencing Factors and Construction of a Column Chart Model for Postoperative Pulmonary Infection in Patients With Severe Traumatic Brain Injury.","authors":"Gaoyi Wu, Xiwen Zhong, Jing Chen","doi":"10.2147/IDR.S488933","DOIUrl":"10.2147/IDR.S488933","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the influencing factors of postoperative pulmonary infection in patients with severe traumatic brain injury, and establish and validate a column chart prediction model.</p><p><strong>Methods: </strong>A retrospective study was conducted on 314 patients with severe traumatic brain injury in our hospital from January 2022 to March 2024. They were separated into an internal validation group of 235 cases and an external validation group of 79 cases randomly. The internal validation group was grouped into an infection group of 73 cases and an non-infection group of 162 cases. All patients underwent pathogen detection and identification.</p><p><strong>Results: </strong>A total of 96 strains of pathogens were isolated from 73 patients with concurrent pulmonary infections. Independent risk factors for postoperative pulmonary infection in patients with severe TBI included age ≥ 60 years, diabetes, tracheotomy, operation time ≥ 4 hours, sputum excretion in the supine position, mechanical ventilation duration ≥ 7 days, and GCS score < 8 points mechanical ventilation duration (P<0.05). The constructed column chart prediction model had high discrimination, calibration, and clinical practical value.</p><p><strong>Conclusion: </strong>The column chart model, incorporating age, diabetes, tracheotomy, operation time, sputum excretion position, mechanical ventilation duration and GCS score, can effectively predict pulmonary infections in severe traumatic brain injury patients.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"745-755"},"PeriodicalIF":2.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Activity and Metabolomic Analysis of Linalool Against Pathogenic Bacteria Methicillin-Resistant <i>Staphylococcus aureus</i>.","authors":"Nana Long, Min Qiu, Youwei Zuo, Hongping Deng","doi":"10.2147/IDR.S491358","DOIUrl":"10.2147/IDR.S491358","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to evaluate the antibacterial activity and mechanism of linalool against Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA).</p><p><strong>Methods: </strong>The determination of the antibacterial activity of linalool against clinically isolated MRSA strains was based on the minimum inhibitory concentration (MIC) and growth curve analysis. Finally, the inhibition mechanism of linalool was elucidated through metabolomic analysis and molecular docking.</p><p><strong>Results: </strong>Among the isolated strains, penicillin resistance was found to be the highest, while resistance to daptomycin/quinupristin-dalfopristin, linezolid, vancomycin, tetracycline, telithromycin, and levofloxacin was not observed. The MIC range of linalool was 211.24-1.65 μg/mL, with MIC₅₀ and MIC₉₀ values of 13.2 μg/mL and 105.62 μg/mL, respectively. Metabolomic analysis revealed that linalool interferes with various substance metabolisms and energy metabolism in MRSA, with the glutathione pathway potentially being a key pathway affected by linalool. Molecular docking revealed that linalool exhibited good binding potential to the target glutathione.</p><p><strong>Conclusion: </strong>This study suggests that linalool could be developed as a drug or preservative to inhibit MRSA growth.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"731-744"},"PeriodicalIF":2.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome Characteristic of NDM-5-Producing <i>Klebsiella Quasipneumoniae</i> and <i>Klebsiella Pneumoniae</i> in China.","authors":"Lifeng Chen, Ruishan Liu, Haowei Ye, Jiajie Qian, Danfeng Lou","doi":"10.2147/IDR.S492203","DOIUrl":"10.2147/IDR.S492203","url":null,"abstract":"<p><p>The global dissemination of carbapenem-resistant Enterobacteriaceae poses a significant threat to public health. In this study, we identified two clinical <i>Klebsiella</i> isolates, <i>K. quasipneumoniae</i> ACESH02628 and <i>K. pneumoniae</i> ACESH02857, harboring the <i>bla</i> _NDM-5 gene in China. Both strains exhibited multidrug resistance, including reduced susceptibility to carbapenems, and carried transferable NDM-5-bearing plasmids. Specifically, S1-pulsed-field gel electrophoresis (PFGE), southern blotting, and whole-genome sequencing revealed that ACESH02628 contained an IncHI2/IncHI2A-type plasmid, while ACESH02857 carried an IncX3-type plasmid, both associated with the regional spread of NDM-5. Comparative analyses showed high genetic similarity with previously reported NDM-5 plasmids from <i>Salmonella enterica</i> and <i>Escherichia coli</i> in China, underscoring the ease of horizontal transfer and potential for broader dissemination. Our findings highlight the emergence of NDM-5-producing <i>K. quasipneumoniae</i> of clinical origin and reinforce the need for vigilant surveillance and infection control measures to curb the proliferation of these highly resistant pathogens.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"769-774"},"PeriodicalIF":2.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multidisciplinary-Based and Bundle Intervention for Controlling Carbapenem-Resistant Organisms in Neurosurgery.","authors":"Wen Zhu, Yi Liang, Jie Xu, Chao Weng","doi":"10.2147/IDR.S506658","DOIUrl":"10.2147/IDR.S506658","url":null,"abstract":"<p><strong>Purpose: </strong>Carbapenem-resistant organisms (CROs) have been listed as the primary risk resistance bacteria due to their high detection rates and extensive drug resistance. Research on the effectiveness of CRO intervention programs in secondary hospitals is limited. This study aims to observe the effect of multidisciplinary-based and bundle interventions under PDCA (plan-do-check-act) cycle management on the control of CROs in neurosurgery.</p><p><strong>Patients and methods: </strong>We conducted a before-after study from January 2021 to December 2023, which was divided into pre-intervention phase and intervention phase. The surveillance analysis and event analysis were used to identify the key links and targeted pathogens of the intervention. PDCA cycle management tool was used to strengthen the bundle management of multidisciplinary collaboration. After one year of PDCA intervention, the process surveillance and outcome surveillance indicators of prevention and control measures from January 2023 to December 2023 were collected and compared with the pre-intervention phase (January 2021-December 2022).</p><p><strong>Results: </strong>A total of 1809 patients were involved in our study. The 11 prevention and control measures were evaluated. After the implementation of PDCA cycle management, the measures including timely completion of multi-drug resistance prevention and control registration, and issuance of contact precaution orders, were significantly improved (<i>p</i> < 0.05). The total detection rate of CRO strains was 52.25%, which was significantly lower than 66.45% before intervention (RR = 0.786; 95% CI, 0.678-0.912; <i>p</i> < 0.05), and the incidence density of patients infected or colonized with CROs showed significant decrease from 18.75 per 1000 patient-days to 15.09 per 1000 patient-days (IRR = 0.563; 95% CI, 0.449-0.707; <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The multidisciplinary and bundle interventions based on PDCA cycle management tool had a good effect on the prevention and control of CROs in neurosurgery.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"757-768"},"PeriodicalIF":2.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Escherichia coli</i> in the T11-12 Thoracic Vertebrae: A Case Report.","authors":"Dandan Weng, Hongyuan Zhou, Guancheng Huang, Qingren Cao, Huafeng Wang, Zhujun Cao, Qing Xie","doi":"10.2147/IDR.S506265","DOIUrl":"10.2147/IDR.S506265","url":null,"abstract":"<p><strong>Background: </strong>Pyogenic thoracic spondylitis is a rare but severe infection, particularly when complicated by sepsis and acute kidney injury (AKI). Early diagnosis and precise management are essential for improving outcomes, given the limitations of traditional microbiology detection methods in identifying the causative pathogens.</p><p><strong>Case presentation: </strong>A 68-year-old immunocompetent male presented with recurrent fever, fatigue, loss of appetite and initial evidence of sepsis and AKI upon admission. With the prompt computed tomography (CT)-guided percutaneous biopsy of the thoracic vertebrae, <i>Escherichia coli</i> was identified as the causative pathogen using metagenomic next-generation sequencing (mNGS). A diagnosis of pyogenic thoracic spondylitis was then made followed by the treatment of antibiotics optimized by therapeutic drug monitoring (TDM) techniques. With a total effective antibiotic treatment period of 7 weeks, the patient recovered without resorting to surgical interventions.</p><p><strong>Conclusion: </strong>This is a rare case of acute thoracic spondylitis caused by <i>E. coli</i>, successfully treated without surgery. This case highlights the significant challenges in diagnosis and treatment. It underscores the value of mNGS in identifying rare infections and emphasizes the role of TDM in optimizing antibiotic therapy, providing a reference for future cases of rare and critical infections with fever of unknown origin.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"693-702"},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicenter Surveillance of <i>Pseudomonas aeruginosa</i> Isolates From Blood: Clinical Distribution Characteristics and Antibiotic Resistance Trends in Hebei Province, China (2016-2021).","authors":"Cuixin Qiang, Xiaoxuan Liu, Pu Qin, Hainan Wen, Zhirong Li, Jing Yang, Yanan Niu, Weigang Wang, Zirou Ouyang, Min Zhao, Jiayiren Li, Yulian Zhang, Jianhong Zhao","doi":"10.2147/IDR.S489527","DOIUrl":"10.2147/IDR.S489527","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the clinical distribution and antimicrobial resistance of <i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>) isolated from blood specimens in 75 hospitals in Hebei Province from 2016 to 2021 to aid in the rational selection of antimicrobial drugs.</p><p><strong>Patients and methods: </strong>WHONET 5.6 and SPSS 24.0 were used to retrospectively analyze clinical distribution characteristics and variations in drug-resistance.</p><p><strong>Results: </strong>Between 2016 and 2021, 2208 <i>P. aeruginosa</i> strains were detected in blood specimens from Hebei Province. The median age of the patients with isolated <i>P. aeruginosa</i> was 63 years, with a male-to-female ratio of 2.1:1. Predominantly, patients were in the hematology (20.7%) and critical care medicine (18.4%) departments. During the monitoring period, the resistance rate of <i>P. aeruginosa</i> to various antibacterial drugs, such as aminoglycosides, fluoroquinolones, and carbapenems, decreased to varying degrees, with an average resistance rate of less than 20.0% over six years. Resistance rates were notably higher in pediatric and intensive care medicine, particularly in neonatal patients, where resistance to antimicrobial drugs, such as piperacillin/tazobactam, gentamicin, ciprofloxacin, and levofloxacin, exceeded 75%.</p><p><strong>Conclusion: </strong>The main isolates of <i>P. aeruginosa</i> were from elderly and intensive care patients, with a male predominance. From 2016 to 2021, the resistance rate of <i>P. aeruginosa</i> isolated from blood specimens in Hebei Province to various antibiotics such as aminoglycosides, fluoroquinolones, and carbapenems decreased to varying degrees. The resistance rates are high in pediatric and intensive care medicine, especially among neonatal patients. However, resistance to antibiotics varies with age and department, necessitating tailored antimicrobial administration. The issue of antibacterial drug resistance in newborn patients is concerning, and special attention is needed when during treatment.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"703-713"},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}