Infection and Drug Resistance最新文献

{"title":"<i>Clostridioides difficile</i> Bacteremia in an Elderly Female Patient After Colon Cancer Surgery.","authors":"Zhulan Yang, Kun Wang, Yi Liu, Xiaohong Xiang, Zhen Zhang","doi":"10.2147/IDR.S557503","DOIUrl":"https://doi.org/10.2147/IDR.S557503","url":null,"abstract":"<p><p><i>Clostridioides difficile</i> infection (CDI) is a major healthcare-associated concern, particularly in the elderly. While CDI typically manifests as toxin-mediated colitis, hematogenous dissemination leading to bacteremia is relatively rare and associated with high mortality. We report an unusual case of <i>C. difficile</i> bacteremia in an octogenarian female patient occurring shortly after right hemicolectomy for ascending colon adenocarcinoma. This critically ill patient presented with bloodstream infection in the ICU following surgery. Multiple risk factors converged, including advanced age, extensive colorectal surgery with mucosal disruption, malignancy, and broad-spectrum antibiotic exposure. Blood culture identification required specific anaerobic processing. Combined intravenous and high-dose oral vancomycin therapy, guided by rapid microbiological confirmation, led to successful resolution of the bacteremia. This case underscores the potential for life-threatening <i>C. difficile</i> bacteremia in vulnerable elderly patients post-colorectal cancer surgery, highlights the diagnostic challenges (necessitating anaerobic blood cultures), and emphasizes the critical importance of early suspicion, aggressive multimodal therapy, and meticulous antimicrobial stewardship in this high-risk population. It serves as a crucial reminder of this devastating complication.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"5257-5262"},"PeriodicalIF":2.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Activity of the Novel Tetracyclines Derivative, Zifanocycline Against <i>Mycobacterium abscessus</i>.","authors":"Qinlong Yu, Xiaoqin Niu, Bailong Hou, Minjie Mao, Li Zhu, Weifeng Shen, Wei Wang","doi":"10.2147/IDR.S538789","DOIUrl":"https://doi.org/10.2147/IDR.S538789","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the in vitro antibacterial activity of zifanocycline against <i>Mycobacterium abscessus</i>.</p><p><strong>Methods: </strong>From 2019 to 2024, <i>Mycobacterium abscessus</i> isolates from the respiratory tract of patients were collected at a tertiary hospital in Jiaxing City. All isolates were identified for species, subtypes, and the erm 41 gene polymorphism using whole-genome sequencing (WGS). Susceptibility to zifanocycline and 13 comparators was tested using the broth microdilution method, and the combined effects of zifanocycline and seven antibacterial drugs were evaluated.</p><p><strong>Results: </strong>A total of 67 strains of <i>Mycobacterium abscessus</i> were collected and subjected to whole-genome sequencing. Genomic analysis identified 60 strains of <i>Mycobacterium abscessus</i> subsp. <i>abscessus</i> and 7 strains of <i>Mycobacterium abscessus</i> subsp. <i>massiliense</i>. Among the <i>Mycobacterium abscessus</i> subsp. <i>abscessus</i> strains, 57 exhibited the erm41 T28 genotype, whereas the remaining three showed the erm41 C28 genotype. In our study, zifanocycline (MIC₅₀/MIC₉₀, 0.06/0.25 mg/L) demonstrated a 2-fold lower MIC₅₀ and MIC₉₀ compared to tigecycline (MIC₅₀/MIC₉₀, 0.12/0.5 mg/L), and a 4-fold and 2-fold lower MIC₅₀ and MIC₉₀, respectively, compared to omadacycline (MIC₅₀/MIC₉₀, 0.25/0.5 mg/L). In addition to amikacin and linezolid, zifanocycline demonstrated significantly superior antibacterial activity compared with ciprofloxacin, moxifloxacin, trimethoprim-sulfamethoxazole, cefoxitin, doxycycline, imipenem, and clarithromycin. The combination of zifanocycline and the seven antibacterial drugs used for the treatment of <i>Mycobacterium abscessus</i> showed no significant interactions.</p><p><strong>Conclusion: </strong>Zifanocycline exhibits positive antibacterial activity against <i>Mycobacterium abscessus</i> in vitro and has potential as an alternative agent in multidrug combination therapy regimens for the treatment of this pathogen.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"5239-5247"},"PeriodicalIF":2.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Sacrococcygeal Pilonidal Abscess Caused by Coinfection of <i>Actinomyces Turicensis</i> and <i>Actinotignum Schaalii</i>: A Case Report.","authors":"Jiayuan Ye, Shanshan Zhao, Yilian Xie, Qiuqin Mao, Lijun Chen, Bing Shen, Yuxiang Xu","doi":"10.2147/IDR.S550162","DOIUrl":"https://doi.org/10.2147/IDR.S550162","url":null,"abstract":"<p><p>Sacrococcygeal pilonidal abscesses are typically caused by <i>anaerobic</i> and Gram-negative bacteria due to their anatomical proximity to the anus; however, mixed infections involving <i>Actinomyces</i> and <i>Actinotignum</i> species are exceptionally rare, and to our knowledge, this is the first reported case of a sacrococcygeal pilonidal abscesses caused by Actinomyces turicensis and Actinotignum schaalii. The patient, an 18-year-old female, presented with one week of localized pain, redness, and swelling, which failed to respond to conventional antibiotics. Pelvic CT revealed an abscess, prompting surgical debridement and subsequent recovery. Rapid pathogen identification was achieved using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) from a single colony culture. This case underscores the importance of microbiological identification using tools like MALDI-TOF MS to recognize uncommon pathogens, which is critical for avoiding ineffective empiric antibiotics and guiding appropriate therapy. Further research is needed to optimize management strategies for such rare infections.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"5249-5256"},"PeriodicalIF":2.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Rare Dupilumab-Associated Pulmonary and Extrapulmonary Tuberculosis.","authors":"Weiyan Xu, Jianfeng Zhong","doi":"10.2147/IDR.S540790","DOIUrl":"10.2147/IDR.S540790","url":null,"abstract":"<p><p>Dupilumab, a fully human monoclonal antibody targeting the interleukin-4 receptor alpha (IL-4Rα), has revolutionized the management of moderate-to-severe atopic dermatitis (AD) by inhibiting signaling of interleukin-4 (IL-4) and interleukin-13 (IL-13). Our case report is about a 71-year-old man with a history of AD who developed pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) after treatment with dupilumab. The mechanism is unclear, but it may be related to the fact that dupilumab inhibits the expression of pro-inflammatory response-related genes and the innate immunity of macrophages, thereby aggravating TB infection. This is the first report of PTB and EPTB associated with dupilumab treatment, and it may be useful for clinicians to enhance TB vigilance in patients receiving dupilumab therapy, particularly in endemic regions.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"5219-5222"},"PeriodicalIF":2.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Genome Analysis of a Human-Derived β-Lactam-Resistant <i>Klebsiella variicola</i> Isolate from China.","authors":"Taif Shah, Jie Li, Zahir Shah, Yunlan Lu, Weihong Qin","doi":"10.2147/IDR.S544005","DOIUrl":"10.2147/IDR.S544005","url":null,"abstract":"<p><strong>Introduction: </strong><i>Klebsiella variicola</i> is an emerging bacterial pathogen commonly associated with opportunistic human infections.</p><p><strong>Methods: </strong>In this study, we characterized and analyzed the core genome of a β-lactam-resistant <i>K. variicola</i> subsp. <i>variicola</i> isolate from a human in Kunming, Yunnan, China.</p><p><strong>Results: </strong>The human-derived β-lactam-resistant <i>K. variicola</i> genome was assembled into 37 contigs, with a total genome size of 5,667,700 bp. <i>K. variicola</i> comprises multiple antimicrobial resistance (AMR) genes, including blaLEN-22, <i>fosA, OqxA</i>, and <i>OqxB</i>, as well as the virulence-associated factors <i>fimH, nlpI</i>, and <i>iutA</i>. The β-lactam-resistant <i>K. variicola</i> genome comprised K and O (KL30 and O3/O3a) serotypes. We also identified 29 SNPs from three different snpEff categories: 18 low, five moderate, and six modifiers. Subsequently, we identified five assembled replicons, including three plasmids. Plasmid pKp5-1, plasmid p15WZ-82_res, and plasmid pKP91, and two phage regions: phage region-1, which resembled Entero-phage-HK446, and phage region-2, which was questionable with phage-Erwini-vB-EhrS-59. Furthermore, secondary metabolites, such as redox-cofactor, butyrolactone, azole-containing-RiPP, terpene-precursors (two distinct clusters), NRP-metallophores, and RiPP-like gene clusters were also identified in the <i>K. variicola</i> genome.</p><p><strong>Discussion: </strong>Identifying key antibiotic resistance determinants, virulence factors, capsule serotypes, secondary metabolites, plasmids, and phage replicons emphasizes the zoonotic potential of this pathogen. Given the potential zoonotic implications, a multidisciplinary approach should be used to prevent the spread of β-lactam-resistant <i>K. variicola</i>.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"5223-5238"},"PeriodicalIF":2.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Emergence of Escape Mutations in COVID-19 Following Anti-Spike Monoclonal Antibody Treatment: How Do We Tackle It?","authors":"Daniele Focosi, Massimo Franchini, Fabrizio Maggi, Arturo Casadevall","doi":"10.2147/IDR.S540928","DOIUrl":"10.2147/IDR.S540928","url":null,"abstract":"<p><p>Treatment-emergent resistance to anti-Spike monoclonal antibody (mAb) was a largely unexpected and dramatic finding along the COVID-19 pandemic. Emergence of resistant strains was particularly common in immunocompromised patients, who often harbored very high SARS-CoV-2 loads when treated with mAb monotherapies. Concerns were raised regarding the risk for some of those resistant variants to propagate in communities. In this review, we will summarize the experience thus far and suggest recommendations to prevent and manage mAb treatment-emergent resistance such as comboing and reliance over polyclonal immunoglobulins.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"5207-5217"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic Next-Generation Sequencing Reveals <i>Tannerella forsythia</i> in Lung Abscesses: A Retrospective Case Series Linking Smoking, Oral Health, and Diagnostic Challenges.","authors":"Wen Wang, Qiongya Mo, Xuchun Ding, Junjie Pan","doi":"10.2147/IDR.S542032","DOIUrl":"10.2147/IDR.S542032","url":null,"abstract":"<p><strong>Purpose: </strong><i>Tannerella forsythia (T. forsythia)</i> is a Gram-negative anaerobic bacterium commonly found in the oral cavity of patients with periodontitis, but lung abscesses caused by this pathogen are extremely rare in the literature. This study aimed to characterize the clinical features, diagnostic challenges, and treatment outcomes of <i>T. forsythia-associated</i> lung abscesses through four case analyses.</p><p><strong>Patients and methods: </strong>We retrospectively reviewed four patients treated between April 2023 and May 2024 with lung abscesses confirmed by chest computed tomography (CT) and <i>T. forsythia</i> detection via metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF). Conventional cultures were performed but yielded negative results. Clinical data, including demographics, symptoms, imaging findings, and treatment regimens, were analyzed.</p><p><strong>Results: </strong>All patients had oral diseases, and 75% were long-term smokers. The primary clinical manifestations were nonspecific respiratory symptoms, including cough, fever, chest pain, and hemoptysis. Chest CT revealed consolidation and cavitation in the upper lobes of the lungs. <i>T. forsythia</i> was successfully detected by mNGS of BALF, while conventional cultures failed to identify pathogens in all cases. All patients received combination antibiotic therapy based on metronidazole and piperacillin-tazobactam, with some cases requiring additional antibiotics. Following treatment, significant clinical improvement was observed, and follow-up imaging demonstrated gradual resolution of the lesions.</p><p><strong>Conclusion: </strong>This study is limited by its small sample size and the lack of confirmatory tests, which warrant validation in larger prospective cohorts. Our findings highlight the advantages of mNGS in detecting fastidious pathogens (such as the anaerobic bacterium <i>T. forsythia</i>), providing new insights for the diagnosis of similar infections in the future. Additionally, the results identify smoking and poor oral health as common features that may be associated with the development of <i>T. forsythia-associated</i> lung abscesses.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"5193-5205"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Pediatric Sepsis Diagnosis: A Narrative Review of Two Decades of Evolution from SIRS to Phoenix Consensus.","authors":"Banga Mseza, Walyeldin Elfakey","doi":"10.2147/IDR.S544164","DOIUrl":"10.2147/IDR.S544164","url":null,"abstract":"<p><p>Pediatric sepsis definitions have evolved significantly from the 2005 International Pediatric Sepsis Consensus Conference (IPSCC) to the 2024 Phoenix Sepsis criteria. However, inconsistencies in previous models, including Systemic Inflammatory Response Syndrome (SIRS) and Sepsis-3, impacted diagnosis and treatment. A global task force conducted clinician surveys, meta-analysis, and validation studies, culminating in the Phoenix Sepsis Score as a refined diagnostic model. The Phoenix Sepsis Score assesses four organ systems, improving diagnostic accuracy and overcoming limitations seen in earlier models. This narrative review examines the evolution of pediatric sepsis definitions over the past two decades, from the 2005 International Pediatric Sepsis Consensus Conference (IPSCC) criteria to the recently published Phoenix Sepsis Score; providing a standardized and globally relevant approach to improving early detection and treatment outcomes.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"5187-5192"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Tuberculous Mycobacterial Infections of the Skin and Soft Tissue in a Chinese Population: A Retrospective Analysis of 15 Cases.","authors":"Hongyu Tao, Wenjun Zheng","doi":"10.2147/IDR.S540147","DOIUrl":"10.2147/IDR.S540147","url":null,"abstract":"<p><strong>Background: </strong>Non-tuberculous mycobacteria (NTM) skin and soft tissue infections (SSTIs) are increasingly recognized but underdiagnosed in China.</p><p><strong>Methods: </strong>This retrospective study analyzed 15 confirmed cases of NTM SSTIs treated at a southern Chinese hospital from 2012 to 2022. Clinical data, including demographics, clinical presentations, comorbidities, diagnostic methods, treatment regimens, and outcomes, were collected and analyzed. Diagnostic efficacy of conventional culture and metagenomic next-generation sequencing (mNGS) was compared.</p><p><strong>Results: </strong>The median age of patients was 57 years, and 66.7% were farmers. Pathogens identified included <i>Mycobacterium abscessus</i> (20.0%), <i>M. marinum</i> (13.3%), and rapidly growing mycobacteria (13.3%). Immunocompromised states, such as anti-interferon-gamma autoantibody positivity, were present in 40.0%. mNGS demonstrated superior diagnostic performance, achieving a detection rate of 86.7% (13/15 cases), compared to 26.7% for culture. Treatment regimens, including clarithromycin, rifampin, ethambutol, and moxifloxacin, lasted 1-24 months. Outcomes showed cure in 8 patients (53.3%), improvement in 6 (40.0%), and 1 lost to follow-up.</p><p><strong>Conclusion: </strong>NTM SSTIs present significant diagnostic and therapeutic challenges, with clinical variability and frequent association with immunocompromised states. <i>M. abscessus, M. marinum</i>, and <i>M. avium</i> were the predominant pathogens. mNGS improves detection but still should complement culture. Precise pathogen identification and tailored therapy are essential for achieving optimal outcomes, and further studies are needed to refine diagnostics and treatment strategies.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"5139-5147"},"PeriodicalIF":2.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonal Dynamics, Virulence Genes, Antimicrobial Resistance, and Early Diagnostic Indicators of Bloodstream Infections of <i>Vibrio vulnificus</i> in a Hospital in Eastern China from 2021 to 2024.","authors":"Huimin Chen, Qianqian Fang, Lin Zheng, Yunlin Wu, Wei Liang","doi":"10.2147/IDR.S540319","DOIUrl":"10.2147/IDR.S540319","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzes the characteristics and clonal dynamics of <i>Vibrio vulnificus</i> isolated from a Chinese hospital between 2021 and 2024.</p><p><strong>Methods: </strong>We performed whole genome sequencing (WGS) on the six collected <i>Vibrio vulnificus</i> isolates. Antibiotic susceptibility testing was conducted using the bioMérieux automated antimicrobial susceptibility testing system. The clonal dynamics were studied through phylogenetic analysis, and the clinical diagnostic value indicators for bloodstream infections (BSI) were evaluated using the receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>The six <i>Vibrio vulnificus</i> strains collected in this study were phylogenetically closely related, including two of sequence type ST678 and one each of ST696, ST675, ST607, and ST367. All strains tested positive for the <i>vcgC</i> gene; five were positive for 16S rRNA type A, and one showed type AB. Virulence gene profiling revealed that the strains universally carried exotoxins (VvhA, RTX), adhesion factors (TadZ/CpaE, IlpA, VWA), and motility-associated genes (cheW/R, motA, flgC). Notably, one strain harbored a broader array of virulence factors, including effector protein secretion systems (ompA, vipA/tssB, sciN/tssJ), biofilm formation-related genes (mrkA/B/C), and siderophores (fepA/B, entE/F, iucA/B), which may significantly enhance its pathogenicity. According to CLSI guidelines for <i>Vibrio</i> spp. all isolates were resistant to ampicillin but susceptible to third-generation cephalosporins, carbapenems, tetracyclines, quinolones, and folate pathway inhibitors. ROC curve analysis showed that high-sensitivity C-reactive protein (HS-CRP), lactate (Lac), procalcitonin (PCT), and other indicators were of good clinical value for the early diagnosis of bloodstream infection caused by <i>Vibrio vulnificus</i>.</p><p><strong>Conclusion: </strong>This study represents the inaugural whole-genome sequencing research conducted on <i>Vibrio vulnificus</i> isolates from eastern China. It comprehensively examines the current species, antibiotic resistance, virulence genes, and clinical characteristics of infected individuals, elucidating the pathogenic mechanisms and epidemiological features of <i>Vibrio vulnificus</i>. The findings offer essential references for clinical diagnosis and treatment.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"5173-5186"},"PeriodicalIF":2.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}