Infection and Drug Resistance最新文献

{"title":"Methicillin-Resistant <i>Staphylococcus aureus</i>-Induced Discitis Following Acupuncture: A Case Report.","authors":"Weihang Yang, Shuang Xia, Liang Li, Jiahao Xu, Hongjian Ji, Wanglin Yao, Fengchao Shi","doi":"10.2147/IDR.S500762","DOIUrl":"10.2147/IDR.S500762","url":null,"abstract":"<p><p>This report describes a case of lumbar disc infection potentially induced by acupuncture in a 43-year-old male with a history of back pain. After acupuncture treatment at another hospital, the patient experienced worsened pain. Physical examination revealed tenderness at the upper lumbar intervertebral space and paravertebral percussion pain. Laboratory tests showed no bacterial growth in both aerobic and anaerobic blood cultures after 5 days, but C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were significantly elevated. CT and MRI scans revealed osteolysis of the L2/3 vertebral body and a paraspinal abscess in the left psoas muscle. The patient was treated with intravenous vancomycin (1 g every 12 hours for 4 weeks). After two weeks, CRP normalized, but ESR remained elevated. By week three, CRP increased to 61.19 mg/L, and severe anemia developed. Follow-up MRI indicated worsening of the lumbar infection. A transfusion was performed, and surgery was conducted in the fourth week. Intraoperative findings confirmed methicillin-resistant Staphylococcus aureus (MRSA) as the causative pathogen. Postoperatively, symptoms improved, and inflammatory markers normalized. This case highlights the need for standardized acupuncture practices and prompt surgical intervention in cases of infectious discitis unresponsive to conservative treatment.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"17 ","pages":"5839-5846"},"PeriodicalIF":2.9,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bloodstream Infection Combined with Thoracic Infection Caused by <i>Mycoplasma hominis</i>: A Case Report and Review of the Literature.","authors":"Xuehong Duan, Le Wang, Ning Fan, Teng Li, Jian Guo","doi":"10.2147/IDR.S478555","DOIUrl":"10.2147/IDR.S478555","url":null,"abstract":"<p><strong>Objective: </strong><i>Mycoplasma hominis</i> is usually found in urogenital tract infections and is associated with several extra-genitourinary infections, including septic arthritis, bacteremia, and meningitis. Here, we report a rare case of <i>M. hominis</i> induced bloodstream infection with thoracic inflammation in a surgical patient.</p><p><strong>Methods: </strong>A 56-year-old male who underwent surgery for multiple pelvic and rib fractures developed fever, pleural effusion, and wound exudation despite receiving prophylactic anti-infection treatment with cefotiam. Then, replacing the broad-spectrum antimicrobial drugs such as biapenem, imipenem, linezolid still had no obvious curative effect. Meanwhile, a total of 4 groups of blood cultures were collected from patients, of which 2 groups reported positive results 2 to 3 days after specimen collection. At the same time, the patient's pleural effusion and wound pus were also cultured, and transparent needle-like small colonies grew on Columbia blood agar plates within 2 to 3 days after inoculation.</p><p><strong>Results: </strong>The cultured transparent pinpoint-like small colonies were identified as <i>M. hominis</i> by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 16SrRNA sequencing. The results of antibiotic susceptibility testing (AST) showed that <i>M. hominis</i> was susceptible to doxycycline, minocycline, josamycin, sparfloxacin, and spectinomycin but resistant to azithromycin, clarithromycin, norfloxacin, roxithromycin, and ofloxacin. According to the AST results and clinical symptoms, moxifloxacin was selected as targeted therapy for <i>M. hominis</i> infection, and cefoperazone/sulbactam was combined to prevent the infection of other gram-negative bacteria. Finally, the patient was cured successfully.</p><p><strong>Conclusion: </strong>Although <i>M. hominis</i> bloodstream and thoracic infections are rare, they cannot be ignored. <i>M. hominis</i> is intrinsically resistant to agents that work on bacterial cell wall synthesis used. Fluoroquinolones could be kept as potential active and thus a likely curative factor. When routine empirical anti-infection treatment is ineffective, the pathogen should be identified as early as possible. If necessary, gene sequencing technology should be used for diagnosis and sensitive anti-infection drug treatment should be promptly administered to reduce the risk of bloodstream infections.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"17 ","pages":"5795-5801"},"PeriodicalIF":2.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Documented Successful Treatment of Chronic Postoperative Fungal Endophthalmitis Induced by <i>Trichosporon Inkin</i> with Fluconazole.","authors":"Ning Fan, Xuehong Duan, Xuan Liu, Ping Fan, Ningning Chen, Jihong Sun","doi":"10.2147/IDR.S485152","DOIUrl":"10.2147/IDR.S485152","url":null,"abstract":"<p><p>This report details an uncommon occurrence of chronic endophthalmitis following cataract surgery attributed to an infection by Trichosporon inkin (T. inkin). The infection was identified through MALDI-TOF mass spectrometry along with sequencing analysis. Although the patient exhibited a robust immune response, the infection escalated quickly from the right eye to the left. Treatment involved vitrectomy and peeling surgery on the right eye, paired with systemic fluconazole antifungal therapy and intravitreal injection, resulting in significant recovery. The visual acuity of the right eye enhanced from finger counting to 20/63. This account represents the inaugural documented instance of endophthalmitis caused by <i>T. inkin</i> that was effectively managed with fluconazole. This underscores the critical role of vitreous humor enrichment culture and antifungal susceptibility testing of <i>T. inkin</i> in the treatment of endophthalmitis.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"17 ","pages":"5803-5813"},"PeriodicalIF":2.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The in vitro Activity of Omadacycline Alone and in Combination Against Carbapenem-Resistant <i>Klebsiella pneumoniae</i>.","authors":"Yingying Du, Yan Liu, Tong Liu, Fen Pan, Shikui Mu, Yunlou Zhu, Hanlu Gao, Xin Jing, Xing Wang, Yuhao Liu, Sheng Wang","doi":"10.2147/IDR.S473546","DOIUrl":"10.2147/IDR.S473546","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the in vitro activity of omadacycline (OMC) and OMC-based combination therapy against carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP).</p><p><strong>Methods: </strong>The broth microdilution assay assessed the in vitro susceptibility of CRKP to OMC. The checkerboard assay was performed to evaluate the activity of OMC combined with polymyxin B (PB), amikacin (AN), or meropenem (MEM) against KPC-producing (class A) CRKP strains, and OMC combined with PB, aztreonam (ATM), MEM, or AN against class B and class A plus class B CRKP strains. Synergistic effects of OMC and PB were further evaluated by time-kill assays in the KPC-producing CRKP strains.</p><p><strong>Results: </strong>Broth microdilution assays revealed a notable variation in susceptibility between KPC-producing and class B CRKP strains, with MIC50/90 of 32/32 mg/L and 0.5/8 mg/L, respectively. Although KPC-producing CRKP strains were resistant to OMC, a synergistic effect was observed in 37.5% of KPC-producing CRKP strains when OMC was combined with PB. In the nine KPC-producing CRKP strains, time-kill assays found that cell densities of six strains (66.7%) decreased by 3.61 ± 0.23 log₁₀ CFU/mL compared to the initial inoculum after 2 hours of PB exposure. The cell densities further decreased by an average of 2.38 ± 0.23 log₁₀ CFU/mL when the six strains were exposed to OMC plus PB, confirming their potent synergism.</p><p><strong>Conclusion: </strong>OMC monotherapy is ineffective against KPC-producing CRKP strains, but OMC plus PB has a potent synergistic effect on them, suggesting that OMC plus PB is the preferred combination therapy against KPC-producing CRKP in vitro.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"17 ","pages":"5785-5794"},"PeriodicalIF":2.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11675304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Biology, Virulence, and General Aspects of <i>Candida dubliniensis</i>.","authors":"Manuela Gómez-Gaviria, Dario A Baruch-Martínez, Héctor M Mora-Montes","doi":"10.2147/IDR.S497862","DOIUrl":"10.2147/IDR.S497862","url":null,"abstract":"<p><p>Fungal infections have become a growing public health concern, aggravated by the emergence of new pathogenic species and increasing resistance to antifungal drugs. The most common candidiasis is caused by <i>Candida albicans</i>; however, <i>Candida dubliniensis</i> has become an emerging opportunistic pathogen, and although less prevalent, it can cause superficial and systemic infections, especially in immunocompromised individuals. This yeast can colonize the oral cavity, skin, and other tissues, and has been associated with oral infections in patients with human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS), making it difficult to treat. The special interest in the study of this species lies in its ability to evade commonly used antifungal drugs, such as fluconazole, under different concentrations. In addition, it is difficult to identify because it can be confused with the species <i>C. albicans</i>, which could interfere with adequate treatment. Although the study of virulence factors in <i>C. dubliniensis</i> is limited, proteomic comparisons with <i>C. albicans</i> indicate that these virulence factors could be similar between the two species. However, differences could exist considering the evolutionary processes and lifestyle of each species. In this study, a detailed review of the current literature on <i>C. dubliniensis</i> was conducted, considering aspects such as biology, possible virulence factors, immune response, pathogen-host interaction, diagnosis, and treatment.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"17 ","pages":"5755-5773"},"PeriodicalIF":2.9,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features of 50 Cases of <i>Chlamydia psittaci</i> Pneumonia Identified Through Metagenomic Next-Generation Sequencing.","authors":"Jiamei Chen, Jin Wang, Ziwei Deng, Yongzhong Li, Yuni Liu, Jianliang Zhou","doi":"10.2147/IDR.S493927","DOIUrl":"10.2147/IDR.S493927","url":null,"abstract":"<p><strong>Background: </strong>Our objective was to analyze the clinical and imaging features of <i>Chlamydia psittaci</i> pneumonia to enhance its diagnostic accuracy.</p><p><strong>Methods: </strong>We systematically reviewed the cases of Chlamydia psittaci diagnosed by next-generation sequencing at the Hunan University of Medicine General Hospital between March 2019 and June 2024, summarizing and analyzing their clinical characteristics and imaging features.</p><p><strong>Results: </strong>A total of 50 cases that met the inclusion criteria were ultimately included in the study analysis. The median age of the patients was 62.96±11.08 years. Notably, 46 patients (92%) had potential exposure to birds or poultry. Forty-six patients (92%) temperature ≥39.0 °C, 37 patients (74%) had cough, 34 patients (68%) had moist rale, and 39 patients (78%) had a relatively slow pulse. Laboratory tests indicated that over 70% of patients exhibited elevated infection markers, accompanied by abnormalities in liver and renal function, electrolyte levels, and cardiac enzymes. Meanwhile, the patient's white blood cell count was normal. Chest CT (Computed Tomography) frequently revealed flaky shadows (94%), thoracic effusions (68%), and thickened pleura (54%). Bronchoscopy revealed significant bronchial mucosal hyperemia, swelling (93.478%), and reduced secretion (56.522%). A total of 44 patients (88%) showed a gradual improvement over 12 days. Forty patients (80%) were treated with doxycycline. Fifty patients were classified into two groups according to whether severe pneumonia occurred after admission. WBC (white blood cell), N% (percentage of neutrophils), NLR (Neutrophil-to-lymphocyte ratio), PLR (platelet/lymphocyte ratio), SII (platelet*Neutrophil/lymphocyte ratio), and PCT (procalcitonin) are indicators that suggest severe cases.</p><p><strong>Conclusion: </strong>The combination of the following indicators is expected to aid in diagnosis of <i>Chlamydia psittaci</i> pneumonia: opportunities to come into contact with birds or poultry, high fever, relatively slow pulse, and elevated infection indicators accompanied by organ injury. Treatment with doxycycline was effective and resulted in favorable prognosis.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"17 ","pages":"5775-5784"},"PeriodicalIF":2.9,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Different Sampling Methods Combined with Metagenomic Next-Generation Sequencing of Respiratory Specimens in Etiological Diagnosis of Patients with Severe Pneumonia.","authors":"Peng Zhou, Dehua Zhang, Jianjian Fu, Dongling Zhu, Shixiao Li","doi":"10.2147/IDR.S504173","DOIUrl":"10.2147/IDR.S504173","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the value of respiratory specimens collected via different sampling methods combined with metagenomic next-generation sequencing (mNGS) in the etiological diagnosis of severe pneumonia.</p><p><strong>Methods: </strong>A total of 117 patients with severe pneumonia between 2019 and 2024 were included in this study, with 60 patients undergoing endotracheal aspiration (ETA) and 57 undergoing bronchoalveolar lavage (BAL), respectively. Patient records were retrospectively reviewed. Both ETA and BAL samples were tested using mNGS and conventional microbiological tests (CMT) to compare the detection rates, microbial profiles and their effects on clinical outcomes.</p><p><strong>Results: </strong>The positive rates of mNGS for ETA and BAL samples were 96.7% and 80.7%, respectively, which were higher than CMT. A total of 39 pathogenic microorganisms were detected, of which <i>Klebsiella pneumoniae, Candida albicans</i> and <i>herpes simplex virus</i>-4 (HSV-4), and <i>cytomegalovirus</i> (CMV) were the most commonly detected as bacteria, fungi and viruses, respectively. The percentages of <i>Pseudomonas aeruginosa</i> (30.0% vs 12.3%, <i>p</i> = 0.019) and <i>Stenotrophomonas maltophilia</i> (25.0% vs 8.8%, <i>p</i> = 0.020) were significantly higher in the ETA group compared to the BALF group. The detection rate of three or more microorganisms was notably higher in the ETA group. No significant differences existed in antibiotics adjustment between the groups. The ETA group experienced a higher frequency of continuous renal replacement therapy (CRRT), mechanical ventilation and complications. There was no significant difference in the hospital length of stay, duration of mechanical ventilation and mortality between both groups.</p><p><strong>Conclusion: </strong>Respiratory specimens collected by different sampling methods yield different microbial findings. ETA and BAL combined with mNGS play a role in guiding the pathogenetic diagnosis of patients with severe pneumonia. However, it is recommended that their sampling methods be determined by clinical symptoms and patient conditions.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"17 ","pages":"5729-5738"},"PeriodicalIF":2.9,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ARIMA and Bayesian Structural Time Series Models for Predicting the Trend of Syphilis Epidemic in Jiangsu Province.","authors":"Fengquan Zhang, Yanyan Li, Xinxiao Li, Bingjie Zhang, Chenlu Xue, Yongbin Wang","doi":"10.2147/IDR.S462998","DOIUrl":"10.2147/IDR.S462998","url":null,"abstract":"<p><strong>Purpose: </strong>This study sets out to explore the forecasting value in syphilis incidence of the Bayesian structural time series (BSTS) model in Jiangsu Province.</p><p><strong>Methods: </strong>The seasonal autoregressive integrated moving average (ARIMA) and BSTS models were constructed using the series from January 2017 to December 2021, and the prediction accuracy of both models was tested using the series from January 2022 to November 2022.</p><p><strong>Results: </strong>From January 2017 to November 2022, the total number of syphilis cases in Jiangsu Province was 170629, with an average monthly notification cases of 2403. The optimal model was ARIMA (1,0,0) (0,1,1) 12 (AIC = 663.12, AICc = 664.05, and BIC = 670.60). The model coefficients were further tested: AR1 = 0.48 (t = 3.46, P < 0.001), and SMA1 =-0.48 (t =-2.32, P = 0.01). The mean absolute deviation, mean absolute percentage error, root mean square error, and root mean square percentage error from the BSTS model were smaller than those from the ARIMA model. The total number of syphilis cases predicted by the BSTS model from December 2022 to December 2023 in Jiangsu Province was 29902 (95% CI: 16553 ~ 42,401), with a monthly average of 2300 (95% CI: 1273 ~ 3262) cases.</p><p><strong>Conclusion: </strong>Syphilis is a seasonal disease in Jiangsu Province, and its incidence is still at a high level. The BSTS model is superior to the ARIMA model in dynamically predicting the incidence trend of syphilis in Jiangsu Province and has better application value.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"17 ","pages":"5745-5754"},"PeriodicalIF":2.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic <i>Scedosporium apiospermum</i> Infection Affecting Multiple Sites After Near-Drowning: A Case Report.","authors":"Aiping Zhang, Zijian Wang, Haoyu Sheng, Jianghua Yang","doi":"10.2147/IDR.S483524","DOIUrl":"10.2147/IDR.S483524","url":null,"abstract":"<p><p><i>Scedosporium apiospermum</i> (<i>S. apiospermum</i>) can cause fungal infections in near-drowning victims, and an increasing number of cases have been reported. However, cases of bone and joint infections caused by <i>S. apiospermum</i> are rare. In this case, a 35-year-old otherwise healthy Chinese female presented with aspiration pneumonia and knee arthritis after accidentally falling into sewage and near-drowning and underwent macrogenomic second-generation sequencing of arthrocentesis fluid, which showed <i>S. apiospermum</i>. However, new lesions involving the hip joint and spine continued to develop under voriconazole monotherapy. The patient was treated with voriconazole combined with amphotericin B cholesterol sulfate lipid complex for 30 consecutive days. The patient's symptoms improved significantly. This case highlights the robust invasiveness of <i>S. apiospermum</i> and the extensive spread of infection, underscoring the importance of prompt diagnosis and treatment. A combined therapeutic approach may offer a safe and efficacious option for managing <i>S. apiospermum</i> infection.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"17 ","pages":"5739-5744"},"PeriodicalIF":2.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosisand Its Role in the Treatment of Sepsis-Related Organ Injury: Mechanisms and Potential Therapeutic Approaches.","authors":"Pengyu Zhang, Wendi Liu, Shu Wang, Yuan Wang, Han Han","doi":"10.2147/IDR.S496568","DOIUrl":"10.2147/IDR.S496568","url":null,"abstract":"<p><p>Sepsis is a complicated clinical disease caused by a defective host response to infection, leading to elevated morbidity and fatality globally. Sepsis patients have a significant risk of life-threatening organ damage, including hearts, brains, lungs, kidneys, and livers. Nevertheless, the molecular pathways driving organ injury in sepsis are not well known. Ferroptosis, a non-apoptotic cell death, occurs due to iron metabolism disturbance and lipid peroxide buildup. Multiple studies indicate that ferroptosis has a significant role in decreasing inflammation and lipid peroxidation during sepsis. Ferroptosis inhibitors and medications, aimed at the most studied ferroptosis process, including Xc-system, Nrf2/GPX4 axis, and NCOA4-FTH1-mediated ferritinophagy, alleviating sepsis effectively. However, few clinical trials demonstrated ferroptosis-targeted drugs's effectiveness in sepsis. Our study examines ferroptosis-targeted medicinal agents and their potential benefits for treating sepsis-associated organ impairment. This review indicates that ferroptosis suppression by pharmaceutical means may be a useful therapy for sepsis-associated organ injury.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"17 ","pages":"5715-5727"},"PeriodicalIF":2.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}