Inflammopharmacology最新文献

{"title":"Molecular mechanisms and treatment strategies for estrogen deficiency-related and glucocorticoid-induced osteoporosis: a comprehensive review.","authors":"Satyajit Mohanty, Anwesha Sahu, Tuhin Mukherjee, Sneha Kispotta, Payel Mal, Muskan Gupta, Jeet Kumar Ghosh, Pranav Kumar Prabhakar","doi":"10.1007/s10787-025-01749-3","DOIUrl":"10.1007/s10787-025-01749-3","url":null,"abstract":"<p><p>Osteoporosis, a debilitating condition characterized by reduced bone mass and increased fracture risk, is notably influenced by estrogen deficiency and glucocorticoid treatment. This comprehensive review elucidates the molecular mechanisms underpinning estrogen deficiency-related osteoporosis (EDOP) and glucocorticoid-induced osteoporosis (GIOP). The role of estrogen in bone metabolism is critically examined, highlighting its regulatory effects on bone turnover and formation through various signaling pathways. Conversely, this review explores how glucocorticoids disrupt bone homeostasis, focusing on their impact on osteoclast and osteoblast function and the subsequent alteration of bone remodeling processes. The pathogenesis of both conditions is intertwined, with estrogen receptor signaling pathways and the role of inflammatory cytokines being pivotal in driving bone loss. A detailed analysis of pathogenetic and risk factors associated with EDOP and GIOP is presented, including lifestyle and genetic factors contributing to disease progression. Modern therapeutic approaches emphasize pharmacologic, non-pharmacologic, and herbal treatments for managing EDOP and GIOP. In summary, current therapeutic strategies highlight the efficacy and the safety of various interventions. This review concludes with future directions for research, suggesting a need for novel treatment modalities and a deeper understanding of the underlying mechanisms of osteoporosis. By addressing the multifaceted nature of EDOP and GIOP, this work aims to provide insights into developing targeted therapeutic strategies and improving patient outcomes in osteoporosis management.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"2409-2445"},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of TRPM3 channels in the medial prefrontal cortex mitigates OCD symptoms following traumatic brain injury.","authors":"Gajendra N Pardeshi, Noor Ali, Kamini R Shirasath, Sameer N Goyal, Kartik T Nakhate, Sanjay N Awathale","doi":"10.1007/s10787-025-01763-5","DOIUrl":"10.1007/s10787-025-01763-5","url":null,"abstract":"<p><p>Although tumor necrosis factor-alpha (TNF-α) plays an important role in the development of obsessive-compulsive disorder (OCD), the pathogenesis remains unclear. Since transient receptor potential melastatin 3 (TRPM3) channels are activated during inflammatory conditions, crosstalk with TNF-α in the progression of OCD has not been investigated yet. We hypothesize that mild traumatic brain injury (mTBI) stimulates TRPM3 channels, thereby enhancing the level of TNF-α in the medial prefrontal cortex (mPFC), a key brain region implicated in OCD pathogenesis. The closed-head weight-drop method was used for mTBI-induced OCD in mice, and neurological assessment was carried out using rotarod and beam-walk tests. Marble-burying test, open-field test, dark-light emergence test, and nest-building behavior test were performed to examine OCD-like symptoms. The mPFC was isolated, and the TNF-α level and TRPM3 immunoreactivity were estimated using ELISA and immunohistochemistry techniques. Additionally, Golgi-Cox staining and HPLC were performed to quantify dendritic arbor and serotonin content. To validate our hypothesis, mTBI mice were treated with a selective TRPM3 inhibitor naringenin (50 mg/kg) via intraperitoneal route, and all the above parameters were screened. Marble-burying and nest-building behaviors were increased in mTBI mice. However, exploratory behavior and time spend in the light chamber were significantly reduced. Moreover, mTBI increases TNF-α concentration and TRPM3 immunoreactivity, while decreasing dendritic arbor and serotonin content. Notably, naringenin treatment reversed these behavioral, biochemical, and molecular abnormalities. Naringenin may inhibit TRPM3-mediated TNF-α production and serotonin transmission, thereby suppressing OCD symptoms. Thus, we propose a novel therapeutic approach for treating OCD associated with traumatic brain injury.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"2849-2868"},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on anti-inflammatory plants: a mechanistic insight through preclinical and clinical studies.","authors":"Deepti Chaudhary, Saraswati Patel, Ritika Gururani, Pooja Chak, Sonika Jain, Jaya Dwivedi, Swapnil Sharma","doi":"10.1007/s10787-025-01764-4","DOIUrl":"10.1007/s10787-025-01764-4","url":null,"abstract":"<p><p>Inflammatory diseases are a leading cause of morbidity and mortality worldwide, necessitating the exploration of novel therapeutic agents. Natural products, particularly plant-derived compounds, have emerged as promising candidates for managing inflammation due to their diverse bioactive constituents and significant safety. The present review provides a comprehensive analysis of the anti-inflammatory potential of medicinal plants, their mechanisms of action, and their therapeutic relevance in preclinical and clinical studies. A total of 94 medicinal plants and isolated compounds with reported anti-inflammatory activities have been discussed, with their mode of action including different signaling pathways, viz., inhibition of COX, LOX, cytokine modulation, and oxidative stress reduction. Despite substantial preclinical validation, the translation of these findings into clinical applications remains limited. Further research focusing on bioactive compound isolation, molecular pharmacology, and clinical trials is essential to establish plant-based therapeutics as viable alternatives to conventional anti-inflammatory drugs.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"2447-2476"},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the anti-anaphylaxis potential of natural products: A Review.","authors":"Aya H Eid, Eman S Zaki, Miral O Sabry, Riham A El-Shiekh, Samar S Khalaf","doi":"10.1007/s10787-025-01685-2","DOIUrl":"10.1007/s10787-025-01685-2","url":null,"abstract":"<p><p>Allergies are a common health issue affecting many people around the world, especially in developed countries. They occur when the immune system overreacts to substances that are usually harmless. Some common allergic conditions include asthma, sinus infections, skin rashes, food allergies, hay fever, severe allergic reactions, eczema, swelling, and reactions to medications or insect stings. The causes of these allergies are complex and often linked to genetics, which can lead to heightened immune responses known as atopy. Throughout history, plant extracts have been used for various purposes, including medicine and food. In addition, their bioactive compounds show a wide range of beneficial effects, such as reducing allergic reactions, fighting oxidative stress, mast cell stabilizers, and lowering inflammation, highlighting their potential for treating various health conditions. Flavonoids and phenolic compounds are commonly used in anaphylaxis for their potent anti-inflammatory action. This review aims to promote the use of natural products as potential treatments for anaphylaxis. In addition, the discovery of new drugs derived from natural sources holds significant promise for the management of anaphylaxis.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"2589-2622"},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic potential of NLRP3 inhibitors in Parkinson's Disease: a systematic review of in-vivo studies.","authors":"Najwane Said Sadier, Inaam Ali Hazimeh, Walaa Khazaal, Amani Al Khayat Al Sabouri, Abdulmajeed G Almutary, Abdullah M Alnuqaydan, Linda Abou-Abbas","doi":"10.1007/s10787-025-01733-x","DOIUrl":"10.1007/s10787-025-01733-x","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease is a progressive neurodegenerative disorder characterized by motor symptoms such as tremors, rigidity, and bradykinesia. Although the exact etiology is unknown, the nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome-induced inflammation, plays a crucial role in the pathogenesis of Parkinson's disease. Many NLRP3 inhibitors are recognized for their role as potential therapeutic interventions for Parkinson's disease.</p><p><strong>Methods: </strong>A systematic literature search was performed in PubMed, Embase, and Science Direct databases for papers published during the 10 years prior to May 2023. All animal interventional studies assessing the effects of NLRP3 inhibitors on Parkinson's disease animal models were included. Primary outcomes included NLRP3 inflammasome inhibition, microglial activation reduction, oxidative stress, and anti-inflammatory marker reduction. The secondary outcomes included dopaminergic neuron loss alleviation and behavioral motor function attenuation. Quality assessment and narrative synthesis of the studies were performed.</p><p><strong>Results: </strong>Twenty-four studies out of 796 papers initially identified met the inclusion criteria. All the included studies, except one, found a reduction in NLRP3 inflammasome activation and anti-inflammatory markers in Parkinson's disease animal models after treatment with various NLRP3 inhibitors compared to control groups without inhibitors. Additionally, eighteen out of twenty-four inhibitors decreased microglial activation and behavioral deficits. Moreover, ten inhibitors attenuated oxidative stress, and twenty-two out of twenty-four alleviated dopaminergic neuron loss. The inhibitors utilized different mechanisms and pathways to exert their effects, including the NLRP3/Caspase-1 pathway, the NF-κB/NLRP3 pathway, inhibition of ROS and/or pyroptosis, as well as autophagy and mitophagy.</p><p><strong>Conclusion: </strong>NLRP3 inhibitors represent a prospective therapy for Parkinson's disease, demonstrating efficacy in lowering neuroinflammation and protecting against dopaminergic loss. However, constraints, such as a male animal focus, apparent regional bias from China-centric studies, and diversity in induction models, entail the results presented herein require cautious interpretation. Further research, including preclinical and clinical studies, is required to thoroughly examine the safety, effectiveness, and generalizability of NLRP3 inhibitors in Parkinson's disease.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"2657-2677"},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review.","authors":"Nurfarah Hazwani Takhor, Chia Wei Phan","doi":"10.1007/s10787-025-01746-6","DOIUrl":"10.1007/s10787-025-01746-6","url":null,"abstract":"<p><p>Ergothioneine (ET) is an under recognised diet-derived compound which has the potential to be a \"longevity vitamin\". It was found to be beneficial for cognitive function and age-related neurodegenerative disorder (ARND). Thus, this study was conducted to synthesise the existing evidence of ET's effects on cognition and ARND, emphasizing its potential as a micronutrient for healthy aging. This study also highlights the future prospects of the research regarding ET's effects on cognition and ARND that are suggested in existing literature. Three databases (Pubmed, Scopus, and Web of Science) were used to search for the studies that meet the inclusion and exclusion criteria. A total of 19 studies were included after screening in this review. The risk of bias of each study was assessed using the Office of Health Assessment and Translation (OHAT) risk of bias rating tool. All studies' characteristics and main findings were tabulated according to their type of study. Mechanisms of ET in improving cognitive function and preventing ARND were found to be through its antioxidative, anti-inflammatory and antisenescence properties. Its role in neurotransmission and neuroprotection also contributed to improving cognition and preventing ARND. In conclusion, ET is a potential compound to be explored as its role in cognition and ARND have been discovered through several studies.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"2351-2375"},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Ropivacaine effect on hemostasis and pain level in patients undergoing orthognathic surgery: a triple-blinded, randomized, clinical trial.","authors":"Majid Hosseini-Abrishami, Mozhgan Kazemian, Mohammad Javad Sedaghati, Mohammad Alipour, Melika Hoseinzade, Alireza Ghaffarian-Hosseini, Vahid Reza Askari","doi":"10.1007/s10787-025-01728-8","DOIUrl":"10.1007/s10787-025-01728-8","url":null,"abstract":"","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"2697"},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of TRPV1⁺ and TRPA1⁺ nociceptive neurons in delayed-onset muscle soreness: inhibition by hesperidin methyl chalcone.","authors":"Giovana B Cortez, Mariana M Bertozzi, Amanda M Dionisio, Maiara Piva, Nayara R Morelli, Thacyana T Carvalho, Rubia Casagrande, Waldiceu A Verri, Sergio M Borghi","doi":"10.1007/s10787-025-01762-6","DOIUrl":"10.1007/s10787-025-01762-6","url":null,"abstract":"<p><strong>Objective: </strong>Delayed-onset muscle soreness (DOMS) is a type of pain caused by muscle injury provoked by eccentric, high intensity, or long-duration exercise. Hesperidin methyl chalcone (HMC) is a flavonoid with analgesic and anti-inflammatory actions. We investigated the effects of HMC against DOMS.</p><p><strong>Methods: </strong>Mice received AMG9810 (100 nmol) or HC-030031 (10 μg) once intrathecally, or HMC twice (12 h plus 30 min before) intraperitoneally (1, 3, or 10 mg/kg) and were subjected to a single uninterrupted acute swimming session of 120 min to induce DOMS. Sham animals were subjected to swimming just for 30 s, and naïve mice were not exposed to water. Calcium imaging of dorsal root ganglia (DRG) neurons was used to assess nociceptive neuron activation. Muscle mechanical hyperalgesia was assessed 12-48 h later. Oxidative parameters (superoxide anion, lipid peroxidation, and antioxidant activity) and leukocyte recruitment (macrophages and neutrophils) were evaluated 2 and 24 h later, respectively.</p><p><strong>Results: </strong>DRG neurons from mice that underwent intense acute swimming showed higher levels of calcium at 24 h post-session relative to naïve mice. Capsaicin [transient receptor potential vanilloid 1 (TRPV1 agonist)] or AITC [transient receptor potential ankyrin 1 (TRPA1 agonist)] were used as agonists controls to identify the populations of responsive neurons positive for TRPV1/A1. KCl was used as a cell viability control. Counterproof pharmacologic functional tests targeting TRPV1 or TRPA1 with receptor antagonists reduce muscle mechanical hyperalgesia and DRG neuron increased activity. HMC (3 mg/kg) reduced muscle mechanical hyperalgesia, activation of DRG nociceptive neurons at 24 h post-swimming session and upon TRPV1 or TRPA1 agonists and inhibited oxidative stress and the recruitment of neutrophils and macrophages to muscle in DOMS mice.</p><p><strong>Conclusions: </strong>Thus, HMC prevented DOMS in mice caused by unaccustomed exercise. The underlying mechanisms of HMC involve targeting oxidative stress, inflammation, and reduced activity of TRPV1⁺ and TRPA1⁺ nociceptive neurons.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"2815-2832"},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of polyphenolics in the management of rheumatoid arthritis through intracellular signaling pathways: a mechanistic review.","authors":"Uzma Saleem, Maryam Farrukh, Malik Saadullah, Rida Siddique, Humaira Gul, Aqsa Ahmad, Bushra Shaukat, Muhammad Ajmal Shah","doi":"10.1007/s10787-025-01731-z","DOIUrl":"10.1007/s10787-025-01731-z","url":null,"abstract":"<p><p>Inflammation of the joints, bone erosion, and cartilage destruction are the main characteristics of rheumatoid arthritis (RA) which causes joint malfunction, structural distortion, and long-term impairment of function. According to various studies, RA affects 0.1-2.0% of people globally. It is unclear what causes RA, but multiple pathways have been associated with its pathophysiology. Non-steroidal anti-inflammatory drugs; NSAIDs (diclofenac, celecoxib, and ibuprofen), disease-modifying antirheumatic drugs; DMARDs (methotrexate, azathioprine, and cyclosporine), immunological compounds (rituximab, anakinra, and infliximab), and immune suppressants are the currently available options. However, they are associated with major side effects, like hypertension, hepatotoxicity, gastric ulcers, and kidney dysfunction which results in their limited use. To treat RA effectively, there is an urgent need for treatment options that offer minimal side effects. The dietary polyphenols have therapeutic effects on RA based on their antioxidant, apoptotic, anti-inflammatory, immunosuppressive, and immunomodulatory characteristics. At the molecular level, interleukin (IL)-6, mitogen-activated protein kinase (MAPK), tumor necrosis factor-alpha (TNF-alpha), interleukin 1b, c-Jun N-terminal kinase (JNK), and nuclear factor k light-chain-enhancer of activated B-cell (NF-kB) pathways play a critical role in modulation. Various polyphenolic compounds have been studied for their potential efficacy against RA, including genistein, resveratrol, carnosol, curcumin, epigallocatechin gallate, kaempferol, and hydroxyl tyrosol. However, it is noted that most of the studies are investigated on animal models of RA. The present review article discusses the underlying mechanisms that lead to RA and explores the promising role of polyphenols as potential therapeutic agents.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"2263-2275"},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-dependent effects of omega-3 polyunsaturated fatty acids on C-reactive protein concentrations in cardiometabolic disorders: a dose-response meta-analysis of randomized clinical trials.","authors":"Manoochehr Amin Amlashi, Atefeh Payahoo, Saber Jafari Maskouni, Elaheh Dehghani, Mahtab Karami Talandashti, Yeganeh Ghelichi, Mahya Nikoumanesh, Soroush Rezvani, Hossein Shahinfar, Farzad Shidfar","doi":"10.1007/s10787-025-01744-8","DOIUrl":"10.1007/s10787-025-01744-8","url":null,"abstract":"<p><strong>Background: </strong>Based on current knowledge, omega-3 fatty acids help to reduce the concentration of C-reactive protein (CRP). However, the dose-response effect and the strength of this effect are not entirely clear.</p><p><strong>Methods: </strong>We systematically searched and screened databases to include eligible studies. This study incorporates a random effect, as well as dose-response meta-analyses using a restricted cubic spline model.</p><p><strong>Results: </strong>Forty randomized clinical trials were analyzed. Results demonstrated significant non-linear dose-response efficacy in the reduction of CRP concentration in patients with cardiovascular disease, metabolic syndrome, and hypertension up to 1200 mg/day of EPA and DHA. In addition, there was a linear decrease in CRP concentration in the dyslipidemia population. The meta-analysis results did not show any significant reduction of CRP in overweight and obese participants, and the dose-response analysis failed to show any apparent reduction. In type 2 diabetes, pooling the results revealed a significant reduction in CRP; however, the combination of EPA and DHA failed to show significant dose-response efficacy in changing CRP concentration.</p><p><strong>Conclusion: </strong>1200 mg/day of EPA and DHA may help to reduce CRP concentration in patients with cardiometabolic disorders. This reduction is clinically significant, and thus intervention with omega-3 fatty acids should be considered for this population.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"2325-2339"},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}