Inflammopharmacology最新文献

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Effects of aqueous extract of Waltheria indica (Sterculiaceae) leafy stems on acetic acid-induced ulcerative colitis in rats. 獐牙菜叶茎水提物对醋酸致大鼠溃疡性结肠炎的影响。
IF 4.6 2区 医学
Inflammopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1007/s10787-025-01651-y
Michel Archange Fokam Tagne, Paul Aimé Noubissi, Angèle Foyet Fondjo, Laurelle Nono Njomguep, Joseph Ngakou Mukam, Sélestin Sokeng Dongmo, René Kamgang
{"title":"Effects of aqueous extract of Waltheria indica (Sterculiaceae) leafy stems on acetic acid-induced ulcerative colitis in rats.","authors":"Michel Archange Fokam Tagne, Paul Aimé Noubissi, Angèle Foyet Fondjo, Laurelle Nono Njomguep, Joseph Ngakou Mukam, Sélestin Sokeng Dongmo, René Kamgang","doi":"10.1007/s10787-025-01651-y","DOIUrl":"10.1007/s10787-025-01651-y","url":null,"abstract":"<p><p>Ulcerative colitis is one of the inflammatory bowel diseases that manifest itself by uncontrolled inflammation of colon. The objective of this work was to evaluate the effects of aqueous extract of Waltheria indica on acetic acid-induced ulcerative colitis in rats. Six (6) groups of five (5) rats each, were anesthetized with a ketamine (50 mg/kg)/valium (10 mg/kg) mixture after eighteen (18) fasting hours. Colitis was induced by intrarectal administration of 1 mL of acetic acid (5%) in animals. Five (5) hours later, the normal control (NC) and the colitis control (CC) received distilled water (10 mL/kg bw), the positive control (Pre5) received prednisolone (5 mg/kg) and the other three test groups received the W. indica extract at 50 (Wi50), 100 (Wi100) and 200 (Wi200) mg/kg bw, orally for 7 days. At the end of the treatment, the animals were sacrificed and the blood was collected from the carotid artery, part in the ethylenediaminetetraacetate (EDTA) tube for hematological analyzes and part in dry tubes for biochemical assays. The abdomen was then opened, the colon, liver, spleen, lungs and heart were removed, drained, weighed and the indexes of each organ were determined. The extract at 200 mg/kg reduced myeloperoxidase (MPO) and inhibited the production of interleukin-1 beta (IL-1β) and interleukin-6(IL-6) in the colon and serum. The extract significantly increased the blood platelet level of the colitis rats. Thus, these results suggest that Walthera indica extract may have therapeutic potential for the treatment of inflammatory bowel diseases.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"1505-1516"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Zataria multiflora supplementation on pro- or anti-inflammatory markers: a systematic review and meta-analysis of randomized placebo-controlled trials. 多连扎伦补充剂对促抗炎或抗炎标志物的影响:随机安慰剂对照试验的系统回顾和荟萃分析。
IF 4.6 2区 医学
Inflammopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-24 DOI: 10.1007/s10787-025-01668-3
Alireza Moradi, Farzin Aslani, Mohammad Hossein Boskabady, Yasamin Pahlavan, Mohammad Reza Aslani
{"title":"Effect of Zataria multiflora supplementation on pro- or anti-inflammatory markers: a systematic review and meta-analysis of randomized placebo-controlled trials.","authors":"Alireza Moradi, Farzin Aslani, Mohammad Hossein Boskabady, Yasamin Pahlavan, Mohammad Reza Aslani","doi":"10.1007/s10787-025-01668-3","DOIUrl":"10.1007/s10787-025-01668-3","url":null,"abstract":"<p><p>The aim of this study was to investigate the effectiveness of Zataria multiflora and carvacrol supplementation on inflammatory markers (IL-2, IL-4, IL-5, IL-6, TNF-α, IL-8, IL-10, interferon gamma (IFN-γ), C-reactive protein (CRP), monocyte chemotactic protein 1 (MCP-1), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF)) by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).The exploration of literature was conducted until August 2024 on databases like PubMed/Medline, Web of Science, Scopus, Cochrane CENTRAL, and Google Scholar. The current study incorporated trial studies examining how oral supplements of Zataria multiflora and carvacrol impact concentrations of inflammatory markers. By utilizing a random effects model, the mean differences (SMD) and 95% confidence intervals (CI) were pooled for analysis of the results. The Cochrane Q and I<sup>2</sup> values were used to evaluate heterogeneity. The meta-analysis included ten cases, with 562 participants in the Zataria multiflora group and 700 in the control group. A significant decrease in the levels of various cytokines including IL-2, IL-4, IL-5, IL-6, IL-8, CRP, EGF, VEGF, and MCP-1 was observed with the consumption of Zataria multiflora along with a noteworthy increase in both IFN-γ and IL-10. However, TNF-α levels remained unaffected by the intervention involving Zataria multiflora and carvacrol. It should be noted that limitations of this study include the fact that it draws from research in Iran, encompasses a range of different diseases, and overlooks potential confounders like smoking, physical activity, and diet. In summary, the results suggested that Zataria multiflora and carvacrol can be beneficial for reducing inflammation.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"1255-1270"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long COVID has variable incidence and clinical presentations: our 6-country collaborative study. 长冠状病毒具有不同的发病率和临床表现:我们的6国合作研究。
IF 4.6 2区 医学
Inflammopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-21 DOI: 10.1007/s10787-025-01640-1
Sandor Szabo, Iryna Muzyka, Veronika Muller, Attila J Szabo, Attila Szijártó, Klara Gyires, Tamas Doczi, Jozsef Janszky, Andreas Stengel, Siri Göpel, Antonia Trichopoulou, Rafael Diaz, Nicte Camacho, George Malatinszky, Nils Lambrecht, Oksana Zayachkivska
{"title":"Long COVID has variable incidence and clinical presentations: our 6-country collaborative study.","authors":"Sandor Szabo, Iryna Muzyka, Veronika Muller, Attila J Szabo, Attila Szijártó, Klara Gyires, Tamas Doczi, Jozsef Janszky, Andreas Stengel, Siri Göpel, Antonia Trichopoulou, Rafael Diaz, Nicte Camacho, George Malatinszky, Nils Lambrecht, Oksana Zayachkivska","doi":"10.1007/s10787-025-01640-1","DOIUrl":"10.1007/s10787-025-01640-1","url":null,"abstract":"<p><p>Following the acute COVID-19 disease, many countries see long-time sequences of this infectious disease, commonly known as Long COVID. This seems to be a multi-organ inflammatory chronic condition of variable intensity and incidence, partly due to the retention of the virus or viral particles in several organs. Based on our 6-country (4 in Europe, 2 from North America) collaborative investigations, we found that the incidence of Long COVID varied from 46 (Mexico) to 17% (Ukraine), the average being 25%. In a summary evaluation of all 6 countries, we characterized as \"general\" the most frequent presenting signs and symptoms: fatigue (47%), hair loss (39.2%), and myalgia (35%), but no two countries demonstrated the same top 3 clinical signs/symptoms. Hence, we promote the following 3 key points: 1. to expand international collaborations to better understand not only the prevalence and incidence of Long COVID but also to gain insights into the pathogenesis, and identify predisposing factors and diagnostic biomarkers of Long COVID; 2. find or develop new drugs for the treatments of Long COVID and identify appropriate rehabilitation, potentially organ-specific strategies; 3. most importantly, to start long-term observational studies (e.g., for 5-10-15 years) to identify potential increased cancer incidence in any organ, especially, since we know that certain viruses are carcinogens.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"1531-1535"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of action of ethyl acetate fractions of Liparis nervosa (Thunb.) Lindl. as potential central anti-nociceptive agents. Liparis nervosa (Thunb.) Lindl.乙酸乙酯馏分作为潜在中枢抗痛觉药物的作用机制。
IF 4.6 2区 医学
Inflammopharmacology Pub Date : 2025-03-01 Epub Date: 2024-12-17 DOI: 10.1007/s10787-024-01620-x
Jiachuan Li, Hu Hu, Xin Xu, Dan Zhu, Yisheng Chen, Laiming Li
{"title":"Mechanisms of action of ethyl acetate fractions of Liparis nervosa (Thunb.) Lindl. as potential central anti-nociceptive agents.","authors":"Jiachuan Li, Hu Hu, Xin Xu, Dan Zhu, Yisheng Chen, Laiming Li","doi":"10.1007/s10787-024-01620-x","DOIUrl":"10.1007/s10787-024-01620-x","url":null,"abstract":"<p><p>Opioids/non-steroidal anti-inflammatory drugs are used to alleviate pain; however, they are expensive and can have adverse effects, especially when used over extended periods. Therefore, there is immense demand for innovative, non-addictive analgesics. Here, we report a novel plant-derived central anti-nociceptive agent, Liparis nervosa (Thunb.) Lindl. (LN), validated in animal pain models. Ethyl acetate fractions of L. nervosa (EALN) exhibited central anti-nociceptive activity in hot plate, tail immersion, formalin-induced paw oedema, and acetic acid-induced abdominal writhing tests. The chemical composition of the EALN was determined using ultra-high-performance liquid chromatography-mass spectrometry. Reserpine (monoamine transmitter-depleting agent) and naltrexone (opioid antagonist) partially suppressed the anti-nociceptive effect of EALN in both phases of the formalin test. Oral administration of EALN activated the endogenous opioid and central descending inhibitory systems by increasing β-endorphin, 5-hydroxytryptamine, and norepinephrine expression. EALN treatment increased the expression of γ-aminobutyric acid B; inhibited the expression of prostaglandin E2, substance P, calcitonin gene-related peptide, and c-Fos; and blocked the transmission of pain signals in the spinal cord. EALN treatment reduced the activity of nitric oxide and nitric oxide synthase in the central region and inhibited the nitric oxide-cyclic guanosine monophosphate signal transduction pathway, thereby attenuating the transmission of nociceptive information in the descending inhibitory pathways. The central anti-nociceptive effect of EALN was achieved by integrating these pathways. This study provides new insights into the pharmacologic action of LN and provide a therapeutic approach as a promising candidate for central anti-nociceptive agents.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"1455-1471"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating associations between JAK inhibition and venous thromboembolism by systematic mining of large-scale datasets. 通过大规模数据集的系统挖掘研究JAK抑制与静脉血栓栓塞之间的关系。
IF 4.6 2区 医学
Inflammopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-24 DOI: 10.1007/s10787-025-01677-2
Stine Rabech Haysen, Ane Langkilde-Lauesen Nielsen, Per Qvist, Tue Wenzel Kragstrup
{"title":"Investigating associations between JAK inhibition and venous thromboembolism by systematic mining of large-scale datasets.","authors":"Stine Rabech Haysen, Ane Langkilde-Lauesen Nielsen, Per Qvist, Tue Wenzel Kragstrup","doi":"10.1007/s10787-025-01677-2","DOIUrl":"10.1007/s10787-025-01677-2","url":null,"abstract":"<p><p>Janus kinase inhibitors (JAKi) have been associated with an increased risk of venous thromboembolism (VTE) limiting the use of JAKi-based therapy. To improve risk stratification and drug development, it is crucial to understand the implication of dysregulated JAK-Signal Transducers and Activators of Transcription (STAT) signaling in the pathogenesis of VTE. The objective of this study is to clarify the putative genomic vulnerability to dysregulated JAK-STAT signaling in VTE through systematic mining of large-scale datasets generated from studies comparing VTE patients with healthy controls. Particularly, we assess the representation of entities of the JAK-STAT signaling pathway including STAT target genes among sets of miRNA, mRNA, and proteins differentially abundant in VTE patients, and we explore the putative cumulative genetic association of JAK-STAT signaling gene sets to VTE. Genes related to the JAK-STAT pathway were found significantly altered in VTE patients compared to healthy controls, indicating that genes under transcriptional control of STAT may be dysregulated in VTE. In support of this notion, we find a significant overrepresentation of predicted STAT target genes among genes downregulated in VTE patients, and promoter sequences of differentially regulated genes were significantly enriched with STAT transcription factor binding site motifs. Further linking STAT signaling to the molecular signature of VTE, genes targeted by miRNAs differentially regulated in patients are significantly enriched with STAT target genes and genes acting in the JAK-STAT signaling pathway. Together, our findings indicate that disruptions in the JAK-STAT pathway contribute to the molecular profile of VTE. This offers hope for identifying ways to interact with the JAK-STAT pathway that do not carry the risk of VTE.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"1425-1434"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications of nociceptor receptors and immune modulation: emerging therapeutic targets for autoimmune diseases. 伤害感受器受体和免疫调节的意义:自身免疫性疾病的新治疗靶点。
IF 4.6 2区 医学
Inflammopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-16 DOI: 10.1007/s10787-025-01653-w
Syeda Asloob Fatima, Bushra Akhtar, Ali Sharif, Muhammad Imran Khan, Muhammad Shahid, Fozia Anjum, Fatma Hussain, Aisha Mobashar, Maham Ashraf
{"title":"Implications of nociceptor receptors and immune modulation: emerging therapeutic targets for autoimmune diseases.","authors":"Syeda Asloob Fatima, Bushra Akhtar, Ali Sharif, Muhammad Imran Khan, Muhammad Shahid, Fozia Anjum, Fatma Hussain, Aisha Mobashar, Maham Ashraf","doi":"10.1007/s10787-025-01653-w","DOIUrl":"10.1007/s10787-025-01653-w","url":null,"abstract":"<p><p>Chronic painful autoimmune disorders such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA) induce significant discomfort. They are defined by persistent inflammation and immune-mediated tissue injury. The activation and sensitisation of nociceptors, mutated in various disorders, are fundamental components contributing to the pain experienced in these conditions. Recent discoveries indicate that immunological mediators and nociceptive receptors interact functionally within peripheral and central sensitisation pathways, amplifying chronic pain. This research examines the involvement of nociceptors in rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. It explores how immune cells and pro-inflammatory cytokines induce, sensitise and regulate various nociceptive receptors (P2X, TRPA1 and TRPV1). Finally, we address possible future directions with respect to the treatment of long-lasting effects on immunity, and what new drug targets could be pursued as well, in order to counteract such either neuro-immune interactions in conditions involving the immunological system. By studying nociceptive mechanisms across autoimmune illnesses, we want to identify shared pathways and activation of nociceptors specific to individual diseases. This will shed insight on potential therapies for managing pain associated with autoimmune diseases.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"959-977"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of the NF-κB signaling pathway by Reynoutria japonica Houtt ameliorates complete Freund's adjuvant-induced arthritis in rats. 日本野鼠激活NF-κB信号通路可改善完全弗氏佐剂诱导的大鼠关节炎。
IF 4.6 2区 医学
Inflammopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-19 DOI: 10.1007/s10787-025-01662-9
Xiao-Feng Li, Xiongwu Yang, Hui Gao
{"title":"Activation of the NF-κB signaling pathway by Reynoutria japonica Houtt ameliorates complete Freund's adjuvant-induced arthritis in rats.","authors":"Xiao-Feng Li, Xiongwu Yang, Hui Gao","doi":"10.1007/s10787-025-01662-9","DOIUrl":"10.1007/s10787-025-01662-9","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) manifests through persistent synovitis and systemic inflammation, which ultimately result in the degradation of cartilage and bone. The current study was to scrutinize the anti-arthritic effect of Reynoutria japonica Houtt ameliorating complete Freund's adjuvant (CFA)-induced RA in rats and explore the underlying mechanism.</p><p><strong>Material and methods: </strong>CFA was used for the induction of RA in the rats (rats were received the oral administration of Reynoutria japonica Houtt) and estimation of body weight and organ weight. The paw volume, arthritic score, paw withdrawn threshold, and paw withdrawn latency were estimated at regular time. The RF, hematological, hepatic, non-hepatic, ATG, oxidative stress, cytokines, and inflammatory parameters were estimated. The mRNA expression of different genes was scrutinized.</p><p><strong>Results: </strong>Reynoutria japonica Houtt treatment improved the body weight and reduced the spleen and thymus index. Reynoutria japonica Houtt also suppressed the paw edema, arthritic score, paw withdrawn threshold, and paw withdrawn latency at regular time interval. Reynoutria japonica Houtt suppressed the RF and altered the hematological, hepatic, non-hepatic, cytokines and inflammatory parameters. Reynoutria japonica Houtt treatment significantly (P < 0.001) altered the expression of MMP-2, MMP-9, MMP-12, TNF-α, IL-1β, Il-6, IL-10, IL-17, COX-1, COX-2, NF-κB, iNOS, mTOR, LC3-II, AMPK, and Beclin 1.</p><p><strong>Conclusion: </strong>The result clearly stated the promising effect of Reynoutria japonica Houtt against CFA-induced RA in rats via the suppression of NF-κB signaling pathway.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"1407-1424"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in pharmacological interventions for atopic dermatitis current strategies and future directions. 特应性皮炎的药物干预研究进展:当前策略和未来方向。
IF 4.6 2区 医学
Inflammopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-15 DOI: 10.1007/s10787-025-01659-4
Yan Zhang, Shaoying Yuan, Yixing Wu, Wenkai Nie, Tianhui You, Huiwen Yang, Bing Liu
{"title":"Advancements in pharmacological interventions for atopic dermatitis current strategies and future directions.","authors":"Yan Zhang, Shaoying Yuan, Yixing Wu, Wenkai Nie, Tianhui You, Huiwen Yang, Bing Liu","doi":"10.1007/s10787-025-01659-4","DOIUrl":"10.1007/s10787-025-01659-4","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is a complex chronic inflammatory skin disorder, with its incidence significantly increasing in recent years. The pathogenesis of AD is complex, involving multiple factors such as genetic susceptibility, dysbiosis of the skin microbiome, autoimmune abnormalities, impaired epidermal barrier function, and environmental factors. These factors collectively contribute to the high incidence of the disease and its significant socio-economic burden. This article reviews the pathogenesis of AD and analyzes the current traditional treatment approaches, including topical and systemic therapies, highlighting the issues they face. It focuses on the current status and treatment strategies. Specifically, as the significant heterogeneity of AD, treatment paradigms are gradually shifting from a \"one-size-fits-all\" approach to personalized treatments. The aim is to achieve more effective management of AD and address the issues arising from individual differences. Through these discussions, this article aims to provide new perspectives and strategies for the clinical treatment of AD, in order to reduce the disease burden on patients.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"1221-1236"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular insights and efficacy of guava leaf oil emulgel in managing non diabetic as well as diabetic wound healing by reducing inflammation and oxidative stress. 番石榴叶油凝胶通过减少炎症和氧化应激在管理非糖尿病以及糖尿病伤口愈合中的分子见解和功效。
IF 4.6 2区 医学
Inflammopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-08 DOI: 10.1007/s10787-025-01648-7
Malati R Salunke, Vaibhav Shinde
{"title":"Molecular insights and efficacy of guava leaf oil emulgel in managing non diabetic as well as diabetic wound healing by reducing inflammation and oxidative stress.","authors":"Malati R Salunke, Vaibhav Shinde","doi":"10.1007/s10787-025-01648-7","DOIUrl":"10.1007/s10787-025-01648-7","url":null,"abstract":"<p><p>Wound healing in diabetic patients is often compromised due to excessive inflammation, oxidative stress, and impaired angiogenesis, leading to delayed recovery and increased susceptibility to complications. This study aimed to develop an emulgel formulation of guava leaf oil, derived from Psidium guajava (Myrtaceae), and evaluate its wound healing potential in nondiabetic and diabetic rats. Preliminary phytochemical analysis of guava leaf oil identified active compounds such as D-limonene, β-caryophyllene, and 1,8-cineole, which are known for their anti-inflammatory and antioxidant properties. The emulgel was formulated and assessed for physical attributes, including pH, viscosity, spreadability, and stability. The emulgel demonstrated potent antimicrobial activity, with the 1% concentration showing significant efficacy. In vivo studies revealed enhanced wound contraction in diabetic rats treated with the emulgel, supporting its role in promoting excision wound healing. These findings underscore the therapeutic potential of guava leaf oil emulgel as an effective agent for managing nondiabetic and diabetic wounds, providing a foundation for future clinical applications.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":"1491-1503"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Certolizumab enhances spinal cord injury recovery in rats through inhibition of the TNF-α signaling pathway and neuronal apoptosis. Certolizumab通过抑制TNF-α信号通路和神经元凋亡促进大鼠脊髓损伤恢复。
IF 4.6 2区 医学
Inflammopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-26 DOI: 10.1007/s10787-025-01674-5
Ozan Küçükatalay, Çağlar Türk, Çevik Gürel, Gökçe Ceren Kuşçu, Mustafa Eren Yüncü, İnanç Karakoyun, Murat Akşit, Onur Sarıkaya, Ali Karadağ, Mahmut Çamlar
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