Inflammopharmacology最新文献_第6页

Camellia nitidissima Chi extract ameliorates dextran sulfate sodium-induced acute ulcerative colitis in mice by inhibiting TLR4/NF-κB-mediated inflammatory activation. 山茶提取物通过抑制TLR4/NF-κ b介导的炎症激活，改善硫酸葡聚糖钠诱导的小鼠急性溃疡性结肠炎。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-14 DOI: 10.1007/s10787-025-01743-9

Lirong Li, Rui Huang, Wenwen Li, Dengjie Yao, Beibei Zhang, Mengna Li, Shunan Luo, Yu Qin, Wenwen Zhang

{"title":"Camellia nitidissima Chi extract ameliorates dextran sulfate sodium-induced acute ulcerative colitis in mice by inhibiting TLR4/NF-κB-mediated inflammatory activation.","authors":"Lirong Li, Rui Huang, Wenwen Li, Dengjie Yao, Beibei Zhang, Mengna Li, Shunan Luo, Yu Qin, Wenwen Zhang","doi":"10.1007/s10787-025-01743-9","DOIUrl":"https://doi.org/10.1007/s10787-025-01743-9","url":null,"abstract":"Camellia nitidissima Chi (CNC), whose main composition was gallic acid, catechin, procyanidin-gallate, apigenin-pentosyl-glucoside, vitexin, cyanidin-3-o-glucoside, myricitrin-glucoside, gallocatechin-gallate, epicatechin and rutin, posses sound anti-inflammatory and antioxidant effects. This study aimed to explore the protective effects and mechanisms of the alcoholic extract of CNC on dextran sulfate sodium-induced ulcerative colitis. CNC effectively maintained weight and colon length, and significantly ameliorated colonic histopathological damage. Furthermore, CNC mitigated colitis-induced oxidative stress and exhibited anti-inflammatory properties in UC mice by reducing levels of myeloperoxidase (MPO) and malondialdehyde (MDA), decreasing the production of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). In addition, CNC downregulated the protein expression levels of TLR4, p-NF-κBP65, and p-IκBα of the inflammation-related TLR4/NF-κB signaling pathways. Validation of the molecular docking results also revealed that rutin, the most abundant compound in CNC, interacts with TLR4 and NF-κB protein mainly through hydrogen bonds. CNC also promoted the proliferation of Lactobacillus and Bifidobacterium while reducing the number of Enterococcus, E. coli, Bacteroides, and Peptococcus in mice to improve the intestinal environment and alleviate colitis. CNC inhibited TLR4/NF-κB signaling pathways to relieve inflammation and oxidative damage on UC, is a potential development of natural medicine for UC.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial imbalance in the gut: a new frontier in Rheumatoid arthritis research. 肠道微生物失衡：类风湿关节炎研究的新前沿。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-12 DOI: 10.1007/s10787-025-01737-7

Rufaida Wasim, Sumaiya, Asad Ahmad, Aamir Anwar, Aimen Salman

{"title":"Microbial imbalance in the gut: a new frontier in Rheumatoid arthritis research.","authors":"Rufaida Wasim, Sumaiya, Asad Ahmad, Aamir Anwar, Aimen Salman","doi":"10.1007/s10787-025-01737-7","DOIUrl":"https://doi.org/10.1007/s10787-025-01737-7","url":null,"abstract":"A chronic autoimmune illness that causes joint destruction and inflammation, rheumatoid arthritis (RA) often results in disability. Genetic, environmental, and immune system variables all have a role in the pathophysiology of RA. The complex community of bacteria that live in the gastrointestinal system, known as the gut microbiota, has been implicated in the onset and progression of RA in recent years, according to mounting data. An imbalance in the gut microbiota's composition, known as dysbiosis, has been noted in RA patients. This imbalance may impact inflammatory pathways and immunological responses, which in turn may contribute to the development and severity of the illness. Research has shown that some bacterial species, including Firmicutes, Bacteroidetes, and Proteobacteria, are either more abundant or less prevalent in RA patients than in healthy people. The gut-immune system axis may be modulated, immunological tolerance may be affected, and pro-inflammatory cytokine production may be enhanced by these microbial changes, all of which may lead to systemic inflammation linked to RA. Moreover, changes in intestinal permeability and a rise in microbial metabolite translocation may make autoimmune reactions worse. Probiotics, antibiotics, and dietary changes have also been investigated as possible treatment approaches to help RA patients regain the balance of their gut microbiota. Still up for debate, however, are the precise ways in which the gut microbiome affects RA. Comprehending the complex connection between gut microbiota and RA may give new perspectives on managing and preventing the condition, as well as future prospects for medicines that target the microbiome.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Vitamin D: a key player in COVID‑19 immunity and lessons from the pandemic to combat immune‑evasive variants. 更正：维生素D：在COVID - 19免疫和从大流行中吸取的教训中发挥关键作用，以打击免疫逃避变体。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-12 DOI: 10.1007/s10787-025-01725-x

Hussein Sabit, Shaimaa Abdel-Ghany, Mahmoud S Abdallah, Osama Abul-Maaty, Ahmed I Khoder, Nabil A Shoman, Mohamed Sameh Farrag, Pavel Martasek, Ayman M Noreddin, Mahmoud Nazih

引用次数: 0

N-Dimethyl chalcone facilitated augmentation of IL-10 and diminution of TNF-α, IL-1β, IL-6, NFκB, and COX-2 in FCA-induced arthritic rat model. n -二甲基查尔酮促进fca诱导的大鼠关节炎模型中IL-10的升高和TNF-α、IL-1β、IL-6、nf - κ b和COX-2的降低。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-12 DOI: 10.1007/s10787-025-01732-y

Faiza Waseem, Ali Sharif, Maryam Shabbir, Bushra Akhtar, Syed Wadood Ali Shah, Shahnaz, Adeel Arshad, Ejaz Basheer, Muhammad Asif Hanif, Muhammad Ali

{"title":"N-Dimethyl chalcone facilitated augmentation of IL-10 and diminution of TNF-α, IL-1β, IL-6, NFκB, and COX-2 in FCA-induced arthritic rat model.","authors":"Faiza Waseem, Ali Sharif, Maryam Shabbir, Bushra Akhtar, Syed Wadood Ali Shah, Shahnaz, Adeel Arshad, Ejaz Basheer, Muhammad Asif Hanif, Muhammad Ali","doi":"10.1007/s10787-025-01732-y","DOIUrl":"https://doi.org/10.1007/s10787-025-01732-y","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation and chronic pain due to the degradation of subchondral bone and the loss of cartilage function. The present study was designed to evaluate the activity of 1N,N-dimethyl chalcone (DGCHAL) against RA. A primary 28-day investigation was conducted on adjuvant-induced arthritic rats with DGCHAL (10 mg/kg, 20 mg/kg, and 30 mg/kg) and methotrexate (STDMTX). The therapeutic effect was estimated on the basis of measurements of paw diameter, fluctuations in body weight, oxidative stress biomarkers, and hematological parameters. In addition, the study sought to quantify the expression of key cytokines, including TNFα, IL-6, IL-10, IL-1β, and NFκβ, using qRT-PCR and ELISA techniques. Treatment with DGCHAL significantly restored the paw volume, body weight, arthritis-induced anemia, and leukocyte count. The tested compound remarkably downregulated the expression of COX-2, TNFα, IL-6, IL-1β, and NFκB and upregulated the expression of IL-10. The treatment groups increased the activities of SOD, CAT, and GSH, whereas they reduced the formation of MDA and NO as compared to the arthritic group. These findings provide an evident basis for the anti-arthritic potential of DGCHAL in a chronic arthritis rat model and should be further studied for dosage form design.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of polyphenolics in the management of rheumatoid arthritis through intracellular signaling pathways: a mechanistic review. 多酚类物质通过细胞内信号通路在类风湿关节炎治疗中的作用：一项机制综述。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-12 DOI: 10.1007/s10787-025-01731-z

Uzma Saleem, Maryam Farrukh, Malik Saadullah, Rida Siddique, Humaira Gul, Aqsa Ahmad, Bushra Shaukat, Muhammad Ajmal Shah

{"title":"Role of polyphenolics in the management of rheumatoid arthritis through intracellular signaling pathways: a mechanistic review.","authors":"Uzma Saleem, Maryam Farrukh, Malik Saadullah, Rida Siddique, Humaira Gul, Aqsa Ahmad, Bushra Shaukat, Muhammad Ajmal Shah","doi":"10.1007/s10787-025-01731-z","DOIUrl":"https://doi.org/10.1007/s10787-025-01731-z","url":null,"abstract":"Inflammation of the joints, bone erosion, and cartilage destruction are the main characteristics of rheumatoid arthritis (RA) which causes joint malfunction, structural distortion, and long-term impairment of function. According to various studies, RA affects 0.1-2.0% of people globally. It is unclear what causes RA, but multiple pathways have been associated with its pathophysiology. Non-steroidal anti-inflammatory drugs; NSAIDs (diclofenac, celecoxib, and ibuprofen), disease-modifying antirheumatic drugs; DMARDs (methotrexate, azathioprine, and cyclosporine), immunological compounds (rituximab, anakinra, and infliximab), and immune suppressants are the currently available options. However, they are associated with major side effects, like hypertension, hepatotoxicity, gastric ulcers, and kidney dysfunction which results in their limited use. To treat RA effectively, there is an urgent need for treatment options that offer minimal side effects. The dietary polyphenols have therapeutic effects on RA based on their antioxidant, apoptotic, anti-inflammatory, immunosuppressive, and immunomodulatory characteristics. At the molecular level, interleukin (IL)-6, mitogen-activated protein kinase (MAPK), tumor necrosis factor-alpha (TNF-alpha), interleukin 1b, c-Jun N-terminal kinase (JNK), and nuclear factor k light-chain-enhancer of activated B-cell (NF-kB) pathways play a critical role in modulation. Various polyphenolic compounds have been studied for their potential efficacy against RA, including genistein, resveratrol, carnosol, curcumin, epigallocatechin gallate, kaempferol, and hydroxyl tyrosol. However, it is noted that most of the studies are investigated on animal models of RA. The present review article discusses the underlying mechanisms that lead to RA and explores the promising role of polyphenols as potential therapeutic agents.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing of high-dose N-acetylcysteine as anti-inflammatory, antioxidant and neuroprotective agent in moderate to severe traumatic brain injury patients: a randomized controlled trial. 大剂量n -乙酰半胱氨酸作为抗炎、抗氧化和神经保护剂在中重度颅脑损伤患者中的应用：一项随机对照试验

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-10 DOI: 10.1007/s10787-025-01706-0

Alaa Refaat Gouda, Noha A El-Bassiouny, Ahmad Salahuddin, Emad Hamdy Hamouda, Amira B Kassem

{"title":"Repurposing of high-dose N-acetylcysteine as anti-inflammatory, antioxidant and neuroprotective agent in moderate to severe traumatic brain injury patients: a randomized controlled trial.","authors":"Alaa Refaat Gouda, Noha A El-Bassiouny, Ahmad Salahuddin, Emad Hamdy Hamouda, Amira B Kassem","doi":"10.1007/s10787-025-01706-0","DOIUrl":"https://doi.org/10.1007/s10787-025-01706-0","url":null,"abstract":"Introduction: Traumatic brain injury (TBI) refers to an impact of the brain within the skull resulting in an altered mental state. The study aim is to determine the effect of a high dose of N-acetylcysteine (NAC) on biochemical and inflammatory markers of neuronal damage and clinical outcomes in patients with moderate to severe TBI.Methods: A randomized open label-controlled trial was conducted on 40 patients with moderate to severe TBI patients presented to the emergency unit within < 24 h since the trauma occurred and randomized into NAC and control groups 20 patients each. Serum samples for evaluation of biomarkers: malondialdehyde (MDA), interleukin-6 (IL-6), neuron-specific enolase (NSE), and S100B were withdrawn at baseline and on day 7. The patients were followed for 7 days and evaluated clinically by the Glasgow Coma Scale (GCS).Results: There was a significant decrease in NSE and MDA levels on day 7 from baseline in NAC group (p < 0.001 and p < 0.001). Also, S100B and IL-6 decreased significantly in NAC group on day 7 from baseline (p = 0.003 and p < 0.001 consequently) compared to control group. Moreover, patients in NAC group showed a significantly shorter length of stay at intensive care unit (ICU) (p = 0.038). There was a significant increase in GCS in NAC group on day 7 from baseline (p = 0.001).Conclusion: Adjunctive early use of high-dose NAC significantly reduced inflammatory and oxidative markers and had neuroprotective effect which may be a novel treatment option for moderate to severe TBI patients.Trial registration: Pactr.org identifier: (PACTR202209548995270) on 14 September 2022.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavonoids regulating NLRP3 inflammasome: a promising approach in alleviating diabetic peripheral neuropathy. 黄酮类化合物调节NLRP3炎性体：缓解糖尿病周围神经病变的一种有希望的方法。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-09 DOI: 10.1007/s10787-025-01729-7

Saumya Khanna, Sachindra Kumar, Pratyasha Sharma, Rajni Daksh, Krishnadas Nandakumar, Rekha Raghuveer Shenoy

{"title":"Flavonoids regulating NLRP3 inflammasome: a promising approach in alleviating diabetic peripheral neuropathy.","authors":"Saumya Khanna, Sachindra Kumar, Pratyasha Sharma, Rajni Daksh, Krishnadas Nandakumar, Rekha Raghuveer Shenoy","doi":"10.1007/s10787-025-01729-7","DOIUrl":"https://doi.org/10.1007/s10787-025-01729-7","url":null,"abstract":"A common and serious side effect of diabetes is diabetic peripheral neuropathy (DPN), which is characterised by gradual nerve damage brought on by oxidative stress, chronic inflammation, and prolonged hyperglycemia. Studies identify NLRP3 inflammasome as a key mediator in the pathogenesis of DPN, connecting neuroinflammation and neuronal damage to metabolic failure. Because of their strong anti-inflammatory and antioxidant qualities, flavonoids, a broad class of naturally occurring polyphenols, have drawn interest as potential treatments for DPN. The various ways that flavonoids affect the NLRP3 inflammasome and their potential as a treatment for DPN are examined in this review. It has been demonstrated that flavonoids prevent NLRP3 activation, which lowers the release of pro-inflammatory cytokines including IL-1β and IL-18 and causes neuroinflammation. Flavonoids work mechanistically by reducing oxidative stress, altering important signalling pathways, and blocking the activities of NF-κB and caspase-1, which are both essential for the activation of the NLRP3 inflammasome. Preclinical research has shown that flavonoids have strong neuroprotective benefits, and few clinical evidence also points to the potential of flavonoids to improve nerve function and lessen neuropathic pain in diabetic patients. The current review emphasises how flavonoids may be used as a treatment strategy to target inflammation in DPN caused by the NLRP3 inflammasome. By targeting important inflammatory pathways, flavonoids provide a new way to slow the progression of this debilitating illness. Further investigation into the mechanisms, clinical translation, and novel drug delivery techniques could enhance the therapeutic efficacy of diabetic peripheral neuropathy.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Ropivacaine effect on hemostasis and pain level in patients undergoing orthognathic surgery: a triple-blinded, randomized, clinical trial. 更正：罗哌卡因对正颌手术患者止血和疼痛水平的影响：一项三盲、随机、临床试验。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-09 DOI: 10.1007/s10787-025-01728-8

Majid Hosseini-Abrishami, Mozhgan Kazemian, Mohammad Javad Sedaghati, Mohammad Alipour, Melika Hoseinzade, Alireza Ghaffarian-Hosseini, Vahid Reza Askari

引用次数: 0

Role of guanylate-binding protein 5 in inflammatory diseases, immune diseases, cancers, and its potential therapeutic implications. 鸟苷酸结合蛋白5在炎症性疾病、免疫性疾病、癌症中的作用及其潜在的治疗意义

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-07 DOI: 10.1007/s10787-025-01727-9

Xufan Sun, Guiyuan Jin, Huihui Zhou, Yan Wang, Fengxian Dai, Guangxi Zhou

{"title":"Role of guanylate-binding protein 5 in inflammatory diseases, immune diseases, cancers, and its potential therapeutic implications.","authors":"Xufan Sun, Guiyuan Jin, Huihui Zhou, Yan Wang, Fengxian Dai, Guangxi Zhou","doi":"10.1007/s10787-025-01727-9","DOIUrl":"https://doi.org/10.1007/s10787-025-01727-9","url":null,"abstract":"Guanylate-binding protein 5 (GBP5) is an interferon-γ (IFN-γ)-induced GTPase (Guanosine Triphosphatease) family member. It contains highly conserved guanosine triphosphate (GTP)-binding and hydrolysis domains, particularly within myeloid and T cells. Extensive research has underscored the critical role of GBP5 in various biological processes, including inflammation, cancer cell migration, and viral defence. In addition, GBP5 is involved in a range of physiological processes and is implicated in various pathological conditions, including inflammation and immune-related disorders. Recent studies have revealed the significant role of GBP5 in the initiation and progression of cancer. The impact of GBP5 on cancer varies depending on the specific cancer type and its underlying mechanisms of action. GBP5 can modulate multiple signalling pathways, including those involved in cell proliferation, cell cycle regulation, invasive metastasis, and the maintenance of homeostasis in vivo, all of which contribute to the progression of cancer. Consequently, in addition to functioning as a downstream molecule in the IFN-γ signalling pathway, GBP5 can influence the onset and progression of various diseases. This article examines the role of GBP5 in inflammation, autoimmune disorders, and malignancies while also exploring its potential therapeutic implications. We aim to deepen our understanding of GBP5 and assess its prospective applications in clinical diagnosis and treatment.","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note: Exploring the therapeutic potential of Anastatica hierochuntica essential oil in DSS-induced colitis. 摘要：探讨青脐草精油对dss性结肠炎的治疗潜力。

IF 4.6 2区医学

Inflammopharmacology Pub Date : 2025-04-04 DOI: 10.1007/s10787-025-01724-y

Abdelrahim Alqudah, Esam Qnais, Omar Gammoh, Yousra Bseiso, Mohammed Wedyan, Mohammed Alqudah, Muna Oqal, Rawan Abudalo, Shtaywy S Abdalla

引用次数: 0