Indian journal of cancer最新文献

{"title":"Musculoskeletal tumors presenting to an oncology multidisciplinary team in Northeast India.","authors":"Harris Caleb, Nadon Herman, Wankhar Baphiralyne, Lynser Donboklang, Lyngdoh Bifica, Toi Ruki, Borgohain Bhaskar, Agarwal Sharat, T G Khonglah, Jagtap Vikas, Devi Laishram Purnima","doi":"10.4103/ijc.ijc_405_22","DOIUrl":"10.4103/ijc.ijc_405_22","url":null,"abstract":"<p><strong>Introduction: </strong>Musculoskeletal tumors (MSTs) are a challenge to diagnose and treat. Though they are generally rare, referral bias exists in tertiary institutions. This study was performed to audit the various MST presenting to an oncology Multidisciplinary Team (MDT) in Northeast India.</p><p><strong>Materials and methods: </strong>An oncology MDT was set up in June 2016 at a tertiary hospital in Northeast India, which caters to a wide region comprising different ethnicities. In addition to patients diagnosed with MST, patients with suspected MST were also referred to the MDT. Data was collected prospectively and was analyzed up to March 2020. Our findings were also compared to those of other national and international studies.</p><p><strong>Results: </strong>During the study period, a total of 4704 cases (comprising 3426 patients) were discussed at the MDT meetings of which 174 (5%) were musculoskeletal [bone tumors {n = 110 (63.2%)}, soft tissue {n = 42 (24.2%)}] and skin lesions {n = 22 (12.6%)}]. The malignant among the bone tumors, soft tissue, and skin lesions were 59%, 88%, and 95%, respectively. After excluding secondary bone tumors and multiple myeloma, the total number of patients with primary bone tumor was found to be 88 (80%), out of which both malignant and benign were 50% each. The commonest site and diagnoses among malignant primary bone tumors were femur (15.9%) and osteosarcoma (25%), respectively. The commonest site and diagnosis among benign primary bone tumors were tibia (15.55%) and giant cell tumors (8%), respectively. The majority (56.9%) were male, with a median age of 39 years (range 3-90). The intent of treatment was curative in 71.9% of the malignant lesions.</p><p><strong>Conclusion: </strong>Osteosarcoma was found to be the most common malignancy among MSTs with male predominance. The accurate diagnosis of MST is aided by the MDT. Benign bone lesions may present to oncologists, and these differentials need to be considered.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"190-194"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of potential drug-drug interactions in cancer patients in a tertiary care hospital.","authors":"Esha Nambiar, Ananya Biswas, Prasanna R Deshpande","doi":"10.4103/ijc.ijc_24_23","DOIUrl":"10.4103/ijc.ijc_24_23","url":null,"abstract":"<p><strong>Background: </strong>Cancer patients are administered various chemotherapeutic agents along with supportive management, which increases the risk of potential drug-drug interactions (pDDIs). We aimed to assess the pDDIs in In-patient Department (IPD) patients receiving cancer chemotherapy in a tertiary care hospital.</p><p><strong>Methods: </strong>A prospective, observational study was conducted in the oncology department of a tertiary care hospital for a period of 6 months. Patient information was noted in the data collection form, and pDDIs were assessed using the Micromedex® database. Mann-Whitney U, Chi-square, and Spearman's correlation were the tests used for statistical analysis. P value of less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>In a sample size of 145 patients having a confidence interval of 95% and response distribution of 50%, the margin of error was found to be 8.11%. Male predominance (57.2%) was seen in the study. Although the adult patient population (56.5%) dominated the study, pediatric (26.9%) and geriatric (16.6%) patients were also included. A total of 115 pDDIs were found in 41% of the total patient population, out of which 56% (n = 64) were moderate and 44% (n = 51) were major in severity. The number of drug interactions was found to have correlation with the number of drugs (rho = 0.2, P = 0.01) prescribed during hospital stay.</p><p><strong>Conclusion: </strong>The present study shows that cancer patients are relatively at risk for drug-drug interactions. To avoid Adverse Drug Reaction (ADRs), harmful effects, and other undesirable clinical manifestations shown by drug-drug interactions, screening for pDDIs is required.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"213-219"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distress in cancer patients and their compliance to treatment: A prospective study.","authors":"M Lithika Lavanya, S Mukesh, Sathya Maruthavanan","doi":"10.4103/ijc.ijc_1024_22","DOIUrl":"10.4103/ijc.ijc_1024_22","url":null,"abstract":"<p><strong>Background: </strong>As per the global data 50%, of the cancer patients experience stress, whereas in India 60% -70% of cancer patients experience stress during their diagnosis, treatment and even during post-treatment follow-up period. Stress is a frequent and most commonly neglected complaint of the patient that affects the outcome of therapy. In the present study, we will assess the distress level in cancer patients and evaluate for any correlation between distress score and compliance to treatment.</p><p><strong>Methods and material: </strong>During the primary visit the patient's distress score is assessed using the National Comprehensive Cancer Network (NCCN) distress thermometer (DT) and problem list. And those patients who were illiterate or unable to read or write due to other reasons were questioned and questionnaire filled by an unbiased third party. Patients were followed up until the end of their treatment and the defaulters were noted down.</p><p><strong>Results: </strong>Forty three (19%) patients out of 224 defaulted treatment. Among this 70% had high distress risk but the difference in mean distress scores for defaulters and completed patients were statistically insignificant. (5.54 and5.37 respectively, P = 0.663).</p><p><strong>Conclusion: </strong>Patients with high distress scores have to be counseled repeatedly to prevent them from quitting the treatment therapy.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"209-212"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor structure of the brief COPE in spouses of women with gynecological cancer.","authors":"Ziye Li, Wanluan Zhang, Lihua Zhou, Weili Wang","doi":"10.4103/ijc.ijc_852_23","DOIUrl":"10.4103/ijc.ijc_852_23","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of the current study was to verify the factor structure of the Brief Coping Orientation to Problems Experienced (Brief COPE) inventory among spouses of women with gynecological cancer.</p><p><strong>Design: </strong>A descriptive study was conducted involving 351 spouses of gynecological cancer patients admitted to a hospital.</p><p><strong>Setting: </strong>Gynecological ward of a tertiary hospital of China.Main Outcome Measure: Confirmatory factor analysis and exploratory factor analysis were performed to test the factor structure of Brief COPE among participants.</p><p><strong>Results: </strong>The results showed that the soundness of data fitting three previous models of spouse caregivers were poor. A new three-factor structure was identified: avoidant coping (12 items), active coping (8 items), and seeking support (4 items), with four original items dropped.</p><p><strong>Conclusion: </strong>The findings suggest that the new three-factor structure has good construct validity, which can be used to measure the coping strategies of spouses of women with gynecological cancer.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"281-288"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guided motor imagery and deep breathing exercises on radiation therapy-induced fatigue in head and neck cancer patients.","authors":"Simmy Thomas, Purusotham Chippala","doi":"10.4103/ijc.ijc_1075_21","DOIUrl":"10.4103/ijc.ijc_1075_21","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effects of guided motor imagery and deep breathing exercises on radiation therapy-induced fatigue in head and neck cancer patients with those of conventional physiotherapy interventions.</p><p><strong>Aims: </strong>To evaluate the impact of guided motor imagery and deep breathing exercises on fatigue caused by radiation therapy in patients with head and neck cancer.</p><p><strong>Setting: </strong>Participants experiencing radiation therapy-induced fatigue were recruited from a tertiary care hospital in South India.</p><p><strong>Design: </strong>The study was conducted as a single-blinded randomized controlled trial.</p><p><strong>Methodology: </strong>A total of forty-two patients participated in the study. They were randomized using the opaque sealed envelope method and assessed by a blinded evaluator. Group A (n = 21) received guided motor imagery, deep breathing exercises, and conventional physiotherapy, while Group B (n = 21) received only conventional physiotherapy. The interventions were administered three times a week over a period of three weeks. The Cancer Fatigue Scale (CFS) was evaluated on both the first and last days of treatment.</p><p><strong>Results: </strong>An independent sample 't' test was used for between-group analysis, revealing a post-test P value of <0.05 for the physical, affective, and cognitive subscales, as well as the total score of the Cancer Fatigue Scale.</p><p><strong>Conclusion: </strong>Combining guided motor imagery and deep breathing exercises with conventional physiotherapy led to statistically significant improvements in reducing fatigue induced by radiation therapy in patients with head and neck cancer.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"289-293"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Brock model and LU-RADS in differentiating benign and malignant sub-solid pulmonary nodules.","authors":"Haolei Liu","doi":"10.4103/ijc.ijc_397_22","DOIUrl":"10.4103/ijc.ijc_397_22","url":null,"abstract":"<p><strong>Background: </strong>The Lung Imaging Reporting and Data System (LU-RADS) is one of the most widely used tools assessing pulmonary nodules in clinical practice. The Brock model is a predictive model that shows good accuracy for determining likelihood of malignancy in pulmonary nodules, but both have not been validated and compared in sub-solid pulmonary nodules (SSNs); thus, the purpose of this study was to compare the Brock model and LU-RADS in differentiating malignant from benign SSN.</p><p><strong>Methods: </strong>The clinical data of patients with SSN who underwent surgical resection and were pathologically confirmed from January 2018 to December 2021 were retrospectively analyzed. According to the pathological results, the patients were divided into two groups, the benign SSN group and the malignant SSN group. Their clinical data were then statistically analyzed. The malignant probability of SSN was calculated by the Brock model. The LU-RADS category of SSN was determined by two radiologists independently. The receiver operating characteristic curves of the Brock model and LU-RADS were drawn, and the area under curve (AUC) was compared.</p><p><strong>Results: </strong>A total of 133 patients with SSN were included in this study. LU-RADS categories 4A and 4B of the malignant SSN group were more than the benign SSN group (56 versus 4, P < 0.05); the malignant probability of the malignant SSN group was significantly higher than that of the benign SSN group (0.21 versus 0.06, P < 0.05). The Brock model has a good correlation with LU-RADS (r = 0.75, P < 0.01) and had a comparable performance in diagnosing lung cancer for the SSN (Brock versus LU-RADS, AUC: 0.83 versus 0.78, P = 0.16). Sub-group analysis showed that the Brock model had a higher performance in diagnosing malignancy for the mixed ground-glass nodules than LU-RADS (Brock versus LU-RADS, AUC: 0.92 versus 0.85, P = 0.03), but both had a similar lower performance in the detection of malignancy from the pure ground-glass nodules (Brock versus LU-RADS, AUC: 0.59 versus 0.55, P = 0.66).</p><p><strong>Conclusion: </strong>The Brock model was more suitable for distinguishing malignant from benign mixed ground-glass nodules. But both the Brock model and LU-RADS had poor performance in distinguishing malignant from benign pure ground-glass nodules.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"184-189"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An intervention based on protective factors to improve resilience for gastric cancer patients: A pilot study.","authors":"Yanan Ding, Xia Zhao, Xinqiong Zhang","doi":"10.4103/ijc.ijc_665_23","DOIUrl":"10.4103/ijc.ijc_665_23","url":null,"abstract":"<p><strong>Background: </strong>Due to the high frequency and mortality rate of gastric cancer, the mental health of patients diagnosed with this disease is particularly concerning, considering that chemotherapy, which is the primary treatment, causes both physical and emotional suffering. Therefore, we conducted a pilot trial as an initial evaluation of our constructed psychological resilience intervention program.</p><p><strong>Materials and methods: </strong>The intervention program was initially evaluated through a quasi-experimental study in which participants were grouped according to time of admission, with the control group receiving usual care and the intervention group receiving a psychological resilience intervention by the intervention team.</p><p><strong>Results: </strong>The pilot study was completed by 31 participants, with a recruitment rate of 73.3%, a completion rate of 93.9%, and a compliance rate of 60%. The intervention was well-received by all participants. Furthermore, in terms of the intervention's effectiveness, the higher hospe of the intervention group (N = 15) significantly increased (t = -3.682, P = 0.019). Although a remarkable increase in resilience (t = -2.584, P = 0.019) was observed, the difference was not obvious (t = -1.280, P = 0.211).</p><p><strong>Conclusion: </strong>The intervention program for psychological resilience in patients with stomach cancer during chemotherapy was successful. Our program offers fresh ideas for such interventions as well as new clinical care recommendations.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"265-272"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of perianal Paget's disease - Case reports.","authors":"Sourabh Mukharjee, Ayyappan Srinivasan, Vikash Mahajan, Naveen Kumar Viswanathan","doi":"10.4103/ijc.ijc_668_21","DOIUrl":"10.4103/ijc.ijc_668_21","url":null,"abstract":"<p><strong>Abstract: </strong>Perianal paget's disease is an uncommon malignant diagnosis for which surgical treatment is primarily opted for. This study presents two case reports of perianal paget's disease treated with surgery in a tertiary care oncologic center in India. Case 1: A 72 year old man presented with an itchy white patch in the perianal region, with a biopsy done in 2015 revealing extra-mammary paget's disease. The patient reported to us in November 2018, following which he was reevaluated and subsequently underwent wide local excision, diversion loop colostomy, and bilateral medial thigh perforator fasciocutaneous flaps reconstruction. Final histopathological examination confirmed diagnosis of Paget's disease. Case 2: A 69 year old man presented with recurrent perianal paget's disease after surgical excision and radiotherapy in 2016. The patient underwent wide local excision, diversion colostomy, bilateral sentinel lymph node biopsy, left ilioinguinal block dissection, and reconstruction with multiple medial thigh fasciocutaneous flaps in December 2019. Discussions: Perianal paget's disease is a rare cutaneous malignancy. Although studies regarding effective treatments are lacking, surgical excision is considered the best modality. Wide local excision with or without reconstruction remains the treatment proven to be successful, regardless of which long term follow up is crucial to identify recurrence. Larger case series are required to further comprehend the histopathology of the disease to prevent misdiagnoses and identify effective methods of treatment.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"294-296"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can preoperative 18F-fluorodeoxyglucose positron emission tomography parameters predict the molecular subtype of breast cancer?","authors":"Mehmet Esat Duymus, Abdullah Bulgurcu, Umit Ogur, Sirma Ercan, Abidin Kilincer","doi":"10.4103/ijc.ijc_1412_21","DOIUrl":"10.4103/ijc.ijc_1412_21","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the predictive value of metabolic parameters in detecting invasive breast cancer molecular subtypes.</p><p><strong>Methods: </strong>We enrolled 112 patients who had a preoperative 18F-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG PET-CT) scan and were operated on with a diagnosis of invasive breast cancer between January 2017 and August 2020. We evaluated associations among maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and clinicopathological findings by dividing the specimen into three tumor subtypes according to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER-2) expressions.</p><p><strong>Results: </strong>There was a significant difference between the three groups in the SUVmax value of axillary lymph node metastasis (P = 0.014), but no significant difference was revealed for TLG and MTV (P = 0.858 and P = 0.083, respectively). There was a significant difference between groups in SUVmax and TLG (P < 0.001 and P = 0.001, respectively) for the primary tumor, but no significant difference was observed in MTV (P = 0.051).</p><p><strong>Conclusion: </strong>We suggest that primary tumor SUVmax can be used to differentiate triple-negative patients from other subgroups, and primary tumor TLG can be used to distinguish hormone receptor positive (HR+) patients from other subgroups.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"96-103"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Streamlining the radiotherapy practice through multidisciplinary peer review rounds: An initial 4-year experience from an Indian radiotherapy department.","authors":"Vysakh Raveendran, Ganapathi Raman Rajendran, Dinesh Makuni, Niyas Puzhakkal","doi":"10.4103/ijc.ijc_1391_21","DOIUrl":"10.4103/ijc.ijc_1391_21","url":null,"abstract":"<p><strong>Aim and background: </strong>Multidisciplinary peer review is a proven and effective quality control method in radiotherapy. This study reports and analyzes the impact of the peer review rounds of a modern radiotherapy department during the first 4 years.</p><p><strong>Subjects and methods: </strong>Prospectively documented data for 183 peer review sessions consisting of 3725 patients from June 2017 to May 2021 were obtained. The proportion of cases that required major (unacceptable and requires an immediate correction before delivery) and minor plan changes (not ideal, but still allowable for delivery) were analyzed on a site-specific basis. Pareto charts were plotted for each site to demonstrate the reasons for plan changes.</p><p><strong>Results: </strong>Among the cases reviewed, 197 plans (5.29%) required any plan modifications; among these, 111 (2.98%) were major changes, while 86 (2.31%) cases required minor changes. The major changes suggested had decreased from 5.84% to 1.58% over time. The reasons for plan changes were site dependent. Frequent reasons for major plan change were modification in clinical target volume (63.06%), followed by a change in dose or fractionation (24.32%). Minor plan changes were mainly due to changes in normal tissue contour or dose (32.56%), followed by field port or MLCs (23.26%).</p><p><strong>Conclusions: </strong>Adherence to peer review practices since the establishment of the department has led to a considerable reduction in plan modifications with time as a result of consistent improvement in the radiotherapy processes.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"89-95"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}