Indian journal of cancer最新文献

{"title":"Unveiling the rare, interesting series of malignant mesenchymal tumors of the kidney in a regional cancer care institute in South India.","authors":"Narayan Hemavathi, Geeta V Patil Okaly, M N Suma, G Champaka, Nargund Ashwini, Dharmalingam Priya","doi":"10.4103/ijc.ijc_27_26","DOIUrl":"10.4103/ijc.ijc_27_26","url":null,"abstract":"<p><strong>Abstract: </strong>Malignant mesenchymal tumors of the kidney are rare, diagnostically challenging neoplasms with variable biological behaviors. Here, we present a series of five rare primary renal malignant mesenchymal tumors, comprising one case each of solitary fibrous tumor, synovial sarcoma, and pleomorphic rhabdomyosarcoma, and two cases of Ewing sarcoma. Accurate diagnosis depends on histopathological and immunohistochemical evaluation, and further confirmation is made by molecular studies. Given their aggressive nature and poor prognosis, early recognition and ongoing documentation of such cases are crucial for improving therapeutic strategies and outcomes.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"102-107"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer caregiver support system: A pilot study to assess the effect of improved caregiver support on postoperative recovery of oral cancer patients.","authors":"Meghna Kumar, Priya Kumari, Srinjeeta Garg, Soumya K Roy, Swati Srivastava, Srishti Salunke, Niranjan Agyat, Ratan Krishna, Burhanuddin Qayyumi, Ravikant Singh, Satyajit Pradhan, Pankaj Chaturvedi, Kumar Prabhash","doi":"10.4103/ijc.ijc_109_25","DOIUrl":"10.4103/ijc.ijc_109_25","url":null,"abstract":"<p><strong>Background: </strong>Postoperative recovery for patients with oral cancer is an arduous process, relying heavily on the involvement of caregivers, who often lack formal training or support. To address this gap, we developed the Cancer Caregiver Support System (CCSS)-a low-cost, mobile-accessible platform designed to empower caregivers with culturally tailored guidance.</p><p><strong>Methods: </strong>A randomized pilot study was conducted at Homi Bhabha Cancer Hospital and Research Centre (HBCH & RC), (Unit of Tata Memorial Centre, Mumbai) Muzaffarpur, by enrolling 75 postoperative oral cancer patients and their primary caregivers. Participants were randomized into two arms: Arm A received standard care plus the CCSS intervention (A Hindi-language website, printed recovery booklet, and moderated WhatsApp group); Arm B received standard care alone. Primary endpoints included 30-day morbidity and duration of nasogastric tube (NGT) dependency. Secondary endpoints included caregiver burden using the Zarit Burden Interview (ZBI) and swallowing outcomes as measured by Functional Oral Intake Scale (FOIS) scores. Tertiary endpoints included unscheduled follow-ups and readmissions.</p><p><strong>Results: </strong>While 30-day morbidity, delay in NGT weaning, and FOIS scores were comparable across arms, caregivers in the intervention arm reported significantly lower burden (mean ZBI score: 12.26 vs 17.53; P = 0.021) and fewer unplanned follow-ups (mean: 1.23 vs 2.64; P < 0.001). Readmission rates remained low in both groups.</p><p><strong>Conclusion: </strong>The CCSS intervention demonstrated feasibility and acceptability, with early signals of benefit in reducing caregiver strain and postdischarge disruptions. This pilot study underscores the potential of context-sensitive, digitally enabled caregiver support in resource-constrained oncology settings. Further scale-up and integration with AI-driven personalization are planned.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"52-75"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why our unison matters: Head and neck cancer care providers.","authors":"Shruti Venkitachalam","doi":"10.4103/ijc.ijc_850_23","DOIUrl":"10.4103/ijc.ijc_850_23","url":null,"abstract":"<p><strong>Abstract: </strong>Head and neck cancers (HNCs) form a major part of cancers affecting Indians and the Southeast Asian populations. Globally, the majority of these cancers are concentrated in these geographical locations too. These are our cancers! However, for evaluation, staging, and treatment protocols, we often depend on Western standards/data which may not be completely applicable (due to various reasons) to our patients. Some choose to formulate \"institutional guidelines\" that are more apt for our patients. There is an astounding amount of good work being done in several institutions across the country for many decades. Since the problem of head and neck cancers is largely ours, we possibly have the largest experience too. The onus to collaborate, and build a system that enables us to collect, store, access, and study every bit of information about every single patient afflicted with HNC, in any corner of our country, is on us.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"99-101"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-intensity resistance training versus manual lymphatic drainage: Effect on upper limb volume, upper limb function, and shoulder pain in subjects with post-mastectomy lymphedema.","authors":"Mohit Kumar, Sandeep Kumar, Smati Sambyal, Mitali Raj, Shivam Monga","doi":"10.4103/ijc.ijc_91_25","DOIUrl":"10.4103/ijc.ijc_91_25","url":null,"abstract":"<p><strong>Background: </strong>Lymphedema is a chronic, progressive condition affecting 90-250 million people worldwide, with women being more frequently impacted. Individuals who undergo mastectomy are at increased risk of developing upper limb lymphedema, leading to swelling, pain, discomfort, and functional limitations. Therefore, it is essential to explore effective strategies for its management.</p><p><strong>Methods: </strong>This quasi-experimental study included 20 subjects aged 40-55 years with unilateral post-mastectomy lymphedema. Demographic and clinical information was collected through interviews and verified using previous medical records. Subjects were randomly assigned to two groups: Group A (n = 10) received low-intensity resistance training with a compression garment, and Group B (n = 10) received manual lymphatic drainage with compression bandaging. Upper limb volume was measured using circumference measurements with the truncated cone formula; upper limb function was assessed using the Disability of Arm, Shoulder and Hand (DASH) questionnaire; and shoulder pain was evaluated using the Visual Analogue Scale (VAS). Both groups participated in three sessions per week for 8 weeks, after which all outcome measures were reassessed.</p><p><strong>Results: </strong>Both groups showed significant within-group improvements in upper limb volume, upper limb function, and shoulder pain. However, between-group comparisons indicated that Group A demonstrated significantly greater improvement ( P < 0.05) across all outcome measures, including circumference measurements, DASH, and VAS scores.</p><p><strong>Conclusion: </strong>Both low-intensity resistance training with compression garments and manual lymphatic drainage with compression bandaging were effective in reducing upper-limb volume, enhancing function, and decreasing shoulder pain. However, the resistance-training protocol resulted in superior overall outcomes compared to manual lymphatic drainage.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"28-34"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-year outcome of papillary thyroid carcinoma, the efficacy of risk stratification systems in predicting long-term adverse outcomes.","authors":"Gopalakrishnan C Nair, Sidhu R Sekhar, Riju R Menon, Pradeep Jacob, Misha J C Babu, Anoop V Pillai","doi":"10.4103/ijc.ijc_788_24","DOIUrl":"10.4103/ijc.ijc_788_24","url":null,"abstract":"<p><strong>Background: </strong>Papillary thyroid cancer has an established favorable outcome with a 10-year overall survival of more than 90%, but the chances of recurrences are as high as 20%. Traditionally, all intermediary-risk and high-risk category patients undergo vigorous follow-up. A sensitive risk stratification system may predict the patients requiring stringent postoperative surveillance.</p><p><strong>Methods: </strong>The present study is a retrospective cohort study of papillary thyroid cancer operated and systematically followed for a median period of 135.5 months. The outcomes at the end of the follow-up period were determined based on American Thyroid Association (ATA) guidelines (2015). We used American Joint Committee on Cancer (AJCC) risk stratification (8 th edition), ATA risk stratification (2015), and a modified dynamic risk stratification system. The disease status in the first year of the follow-up was used for reclassification.</p><p><strong>Results: </strong>The overall survival was 95.1%, but the incidence of adverse outcomes which included disease-specific mortality, structural incomplete responses, and biochemical incomplete responses was 11.2% (n: 23). The modified dynamic risk stratification had higher accuracy in predicting the outcomes.</p><p><strong>Conclusion: </strong>Patients who had excellent responses in the first year of follow-up are unlikely to develop adverse events in the future. However, those who had overt or evident distant metastases at the time of diagnosis require vigilant surveillance.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"35-40"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"News in oncology.","authors":"Santosh S Sahoo, Nisarga Bhama, Ritika H Hinduja","doi":"10.4103/ijc.ijc_315_26","DOIUrl":"10.4103/ijc.ijc_315_26","url":null,"abstract":"","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"108-111"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interinstitutional treatment outcomes comparison for oral cavity cancers from two tertiary care centers.","authors":"Manur Gururajachar Janaki, Thirukurungudi Narayanan Vijayasree, Sagarika Nithyanand, Ponnachiparambil Chandrabose Nikhila, Deepak Angamuthu, Kulangarath Chandran Jyothish","doi":"10.4103/ijc.ijc_872_23","DOIUrl":"10.4103/ijc.ijc_872_23","url":null,"abstract":"<p><strong>Background: </strong>Oral cavity cancer (OCC) patients are treated with surgery as the primary modality of treatment world over. This study is aimed to compare surgery with adjuvant radiation practiced at center A with Radical radiation practiced at center B in terms of disease control and quality of life (QOL) for OCC patients.</p><p><strong>Methods: </strong>Wide excision and neck dissection with or without reconstruction was followed by adjuvant radiation with or without chemotherapy in selected cases in center A. Radical chemoradiation was used in center B. Their disease status at 2 years of follow-up was assessed along with QOL. The results were compared between the two centers.</p><p><strong>Results: </strong>A total of 43 patients from center A and 33 patients from center B were looked at and the 2-year survival rate was 66% and 48%, respectively ( P = 0.04). Among QOL scores, pain in the mouth and shoulder was significantly higher in center A, while scores of social contact and weight losses were significantly higher in center B. Lost to follow-up was higher in center B, 52% versus 12%.</p><p><strong>Conclusion: </strong>Surgery followed by radiation with or without chemotherapy should be considered for operable OCC and provides better tumor control with a lesser QOL of subscales related to surgery. Wherever surgical expertise is not available, radical chemoradiation is preferred for a better QOL compared to palliative treatment.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"18-27"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programmed-death 1/programmed-death ligand 1 inhibitors plus chemotherapy versus chemotherapy for first-line treatment of advanced driver-gene negative non-squamous non-small cell lung cancer: An updated systematic review and meta-analysis.","authors":"Zhifei Zhao, Wenfu Shi, Meng Yu, Xuefei Cheng","doi":"10.4103/ijc.ijc_225_24","DOIUrl":"10.4103/ijc.ijc_225_24","url":null,"abstract":"<p><strong>Background: </strong>To assess the efficacy and safety of first-line programmed-death 1 (PD-1)/programmed-death ligand 1 (PD-L1) inhibitors + chemotherapy for driver-gene negative advanced non-squamous non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>Eligible literature was identified following a systematic search of four electronic databases (PubMed, Embase, Ovid, and Cochrane library databases) from their inception to June, 2023. Unpublished research was searched from the American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), and the World Conference on Lung Cancer (WCLC) meeting abstracts. Review Manager 5.3 software was used for analysis.</p><p><strong>Results: </strong>Nine randomized controlled trials (RCTs) were identified and included, involving 3443 driver-gene negative advanced non-squamous NSCLC patients. PD-1/PD-L1 inhibitors + chemotherapy had significantly longer progression-free survival (PFS) (hazard ratio [HR] = 0.57, 95% CI = 0.52-0.61, P < 0.00001), and overall survival (OS) (HR = 0.69, 95% confidence interval = 0.63-0.76, P < 0.00001) compared with chemotherapy alone. Analysis was performed based on PD-L1 expression levels; patients with any PD-L1 expression had PFS benefit ( P < 0.00001), while only patients with PD-L1 ≥50% ( P = 0.02) and PD-L1 ≤1% ( P = 0.0009) had OS benefit. Regarding liver metastases, there was no statistically significant benefit of PD-1/PD-L1 inhibitors + chemotherapy regimens for the liver metastases cohort in OS ( P = 0.08). In brain metastasis patients, PD-1/PD-L1 inhibitors + chemotherapy regimens demonstrated an improvement in PFS compared to chemotherapy ( P = 0.03).</p><p><strong>Conclusion: </strong>Our results show that PD-1/PD-L1 inhibitors + chemotherapy showed better survival benefits than chemotherapy in driver-gene negative advanced non-squamous NSCLC patients.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"9-17"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of the frequency of micronucleated cells with the severity of disease process in oral submucous fibrosis and oral squamous cell carcinoma patients: A descriptive, cross-sectional study.","authors":"Naga Bhushanam, Shaik Farha Sultana, Praveena Raman, Mohammed Thamer Alqahtani, Saeed Mohammed Alqahtani, Mohammed Abdullah Alshareef, J Suresh Babu, C Swarnalatha, Abhishek Singh Nayyar","doi":"10.4103/ijc.ijc_1006_23","DOIUrl":"10.4103/ijc.ijc_1006_23","url":null,"abstract":"<p><strong>Background: </strong>Exposure of a cell to carcinogens leads to an increase in the chromosomal aberrations, while such karyotypic anomalies and elevated deoxyribonucleic acid content have been observed in a plethora of oral precancerous lesions and conditions, and are expressed in the form of micronuclei. The aim of the present study was to correlate the frequency of these micronucleated cells (MNCs) with the severity of the disease process in oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC) patients.</p><p><strong>Methods: </strong>The present cross-sectional, hospital-based study consisted of 150 subjects in an age range from 15 to 80 years including patients who were clinically diagnosed and histopathologically proven as OSMF and OSCC patients, along with age and sex matched, normal, healthy controls. Also, cytological analysis was carried out using the oral exfoliative cytology procedure, while the frequency of MNCs was calculated using a differential counter.</p><p><strong>Results: </strong>The mean MNC% in the control group was calculated as 0.3% ± 0.35% in the present study as against the mean MNC% of 1.22% ± 0.37% in the OSMF, and 2.0% ± 0.60% in the OSCC groups, while the difference was statistically significant ( P < 0.001). Also, the mean MNC% was calculated to be 0.71% ± 0.08% in Stage I OSMF as against 1.31% ± 0.18% and 1.59% ± 0.17% in Stage II and Stage III OSMF, respectively, with the difference being statistically significant ( P < 0.001). Similarly, the difference in the mean MNC% when calculated between the different stages of OSCC was, also, statistically significant ( P < 0.001) with the mean MNC% in Stage I OSCC being 1.15% ± 0.11% as against 1.59% ± 0.25% in Stage II, and 2.23% ± 0.30% in Stage III and 2.68% ± 0.19% in Stage IV OSCC, respectively.</p><p><strong>Conclusions: </strong>Based on the results obtained in the present study, it can, thus, be concluded that the mean MNC% increased significantly in OSCC patients when compared with the control and OSMF groups, and in the OSMF group in comparison with control group, thus, suggesting micronuclei assay as a useful diagnostic adjunct for screening populations which are at high risk for developing various oral precancerous lesions and conditions, and frank oral cancers.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"41-51"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of sexual life quality and vaginal dose-volume relationship in female rectal cancer patients treated with pelvic radiotherapy.","authors":"Gul Kanyilmaz, Hatice Halis, Ozlem Ay, Oztun Temelli, Eda Yirmibesoglu Erkal, Durmus Etiz, Haldun Sukru Erkal","doi":"10.4103/ijc.ijc_764_24","DOIUrl":"10.4103/ijc.ijc_764_24","url":null,"abstract":"<p><strong>Background: </strong>There are very limited studies examining the sexual dysfunction in female rectal cancer treated with curative chemoradiotherapy (CRT). So, we aimed to evaluate the self-related sexual life quality and vaginal dose-volume relationship in female rectal cancer patients.</p><p><strong>Methods: </strong>The patients who had been treated with chemoradiotherpay between January 2012 and January 2019 were included. Vaginal contouring was performed according to the Radiation Therapy Oncology Group female pelvic normal tissue contouring atlas. Sexual functioning was evaluated by the European Organization for Research and Treatment Quality of life Questionnaire for Sexual Function Modules (EORTC QOL).</p><p><strong>Results: </strong>Fourty five disease-free female patients volunteered to participate in this study were evaluated. The mean total EORTC QOL score of patients was 19.44 points. The score was <19.44 points accepted as worse sexual functioning and ≥19.44 points accepted as better sexual functioning. We did not find any relationship between sexual functioning and radiotherapy sequence, radiotherapy technique, and total radiotherapy doses. The proximity to anal verge and older patients age were the associated factors for worse sexual functioning in female rectal cancer. Dmin, Dmean, V35, V40, V45, and V50 of vagina were the predictive factors for sexual functioning. According to multivariate regression analyses only the primary tumor distance to anal verge ( P = 0.01), and V50 ( P = 0.02) of vagina were the predictive factors for sexual functioning.</p><p><strong>Conclusions: </strong>Sexual dysfunctions in female rectal cancer were associated with tumor distance to anal verge, patients age, Dmean, Dmin, and V35-50 of vagina in female rectal cancer treated with curative radiochemotherapy.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"76-81"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}