Indian journal of cancer最新文献_第3页

ALL induction outcome: Real-world data from a pediatric oncology center in an LMIC setup with rural predominance. ALL 诱导结果：来自一个以农村为主的低收入国家儿科肿瘤中心的真实数据。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-01-12 DOI: 10.4103/ijc.ijc_355_21

Abhilasha Sampagar, Neha G Patil, Nalla A Reddy, Merle Dias

{"title":"ALL induction outcome: Real-world data from a pediatric oncology center in an LMIC setup with rural predominance.","authors":"Abhilasha Sampagar, Neha G Patil, Nalla A Reddy, Merle Dias","doi":"10.4103/ijc.ijc_355_21","DOIUrl":"10.4103/ijc.ijc_355_21","url":null,"abstract":"Background: Acute lymphoblastic leukemia (ALL) has survival rates of greater than 90% in developed nations. However, various sociodemographic factors adversely affect outcome rates in low- and middle-income countries (LMICs).Objective: To study induction outcome of ALL and various factors affecting it.Methods: This was a prospective cohort study which enrolled 86 children up to the age of 18 years with newly diagnosed ALL registered in newly established pediatric hematology and oncology division over the duration of 3 years. Sociodemographic and clinical data was collected. Outcome was assessed using morphological remission, minimal residual disease (MRD) and mortality rate.Results: Of the 170 children with malignancies registered, 86 were ALL. Mean age was 7.09 ± 4.07 years and the M: F ratio of 1.32:1. Sixteen (38.09%) of them had severe acute malnutrition and another 16 (38.09%) had moderate acute malnutrition. Thirty (68.18%) children over 5 years were undernourished. Seventy-four (86.05%) were B-ALL and 12 (13.95%) T-ALL. In total, 28.77% had WBC counts greater than 50 × 10 9 /L. t (12;21) was the most common cytogenetic abnormality. Majority (60.46%) of the patients belonged to lower socioeconomic status. Seventy-one (93.42%) patients completed induction of which 100% attained morphological remission and 64 (90.14%) were MRD negative. There were five mortalities, three (60%) due to sepsis and 2 (40%) due to hemophagocytic lymphohistiocytosis. Fifty (65.78%) children had morbidities during induction, febrile neutropenia being the commonest.Conclusions: Successful induction outcome rates at par with high-income countries can be achieved even in resource-limited settings of LMIC with support from government and NGOs. Decentralized cancer care centers can eﬀectively pave the way in reducing cancer mortality in children of lower socioeconomic status residing in rural areas.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"215-223"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139465808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial commentary. 编辑评论。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-09-11 DOI: 10.4103/ijc.ijc_582_24

Hasmukh Jain

引用次数: 0

Ocular relapse of acute lymphoblastic leukemia - A clinicopathological correlation. 急性淋巴细胞白血病眼部复发--临床病理学相关性。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-07-13 DOI: 10.4103/ijc.ijc_1258_21

Sashwanthi Mohan, Jyotirmay Biswas

引用次数: 0

The effect of the social support perceived by the women receiving chemotherapy on functional and psychosocial conditions: A cross-sectional, descriptive and correlational study. 接受化疗的妇女所感受到的社会支持对其功能和社会心理状况的影响：一项横断面、描述性和相关性研究。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2023-12-07 DOI: 10.4103/ijc.IJC_94_21

Hacer Ataman, Rujnan Tuna

{"title":"The effect of the social support perceived by the women receiving chemotherapy on functional and psychosocial conditions: A cross-sectional, descriptive and correlational study.","authors":"Hacer Ataman, Rujnan Tuna","doi":"10.4103/ijc.IJC_94_21","DOIUrl":"10.4103/ijc.IJC_94_21","url":null,"abstract":"Background: Today, cancer is one of the most important health problems with fatal results. Individuals with cancer have to cope with many functional and psychosocial problems in the course of the disease besides physical impairments. The effect of social support of women receiving chemotherapy on their functional and psychosocial conditions was determined.Methods: This study had a cross-sectional, descriptive, and correlational design. The study was conducted with 330 women patients in a state hospital located in Istanbul, Turkey, which has an outpatient chemotherapy unit and is one of the hospitals where outpatient chemotherapy is applied most.Results: In the study, it was determined that there was a very high positive correlation between the social support perceived by the women with cancer and self-esteem and a very high negative correlation of self-esteem with fatigue and depression ( P < 0.001). In contrast, there was a very high negative correlation between social support and self-esteem with many of the functional symptoms and a very high positive correlation between social support and self-esteem with fatigue and depression ( P < 0.001). Education, number of children, economic situation, family structure, self-esteem, fatigue, and depression variables explained 33% of cancer patients' social support.Conclusion: The management of the functional and psychosocial symptoms of women with cancer is closely related to the perceived social support. In the management of the functional and psychosocial symptoms of women with cancer, it is important to provide and maintain psychological support by involving the patients' families in the treatment process.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"253-261"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of concurrent intrahepatic splenosis and pancreatic adenocarcinoma following splenectomy. 脾切除术后并发肝内脾肿大和胰腺癌的罕见病例。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2023-05-02 DOI: 10.4103/ijc.IJC_70_21

Jiangbin Li, Li He, Nianan Luo, Rui Dong

引用次数: 0

Pancreatic neuroendocrine tumor with abundant mitochondria. 线粒体丰富的胰腺神经内分泌肿瘤。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-07-16 DOI: 10.4103/ijc.ijc_679_21

Divya Shetty, Aditi Raj, Anjali Amarapurkar

引用次数: 0

Efficacy and safety of apatinib for elderly patients with previously treated extensive-stage colorectal cancer patients and the prognostic significance of common adverse reactions. 阿帕替尼对曾接受过广泛期结直肠癌治疗的老年患者的疗效和安全性以及常见不良反应的预后意义。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-09-11 DOI: 10.4103/ijc.IJC_1368_20

Yongjun Yu, Yuwei Li, Chen Xu, Weihua Zhang

{"title":"Efficacy and safety of apatinib for elderly patients with previously treated extensive-stage colorectal cancer patients and the prognostic significance of common adverse reactions.","authors":"Yongjun Yu, Yuwei Li, Chen Xu, Weihua Zhang","doi":"10.4103/ijc.IJC_1368_20","DOIUrl":"10.4103/ijc.IJC_1368_20","url":null,"abstract":"Background: This study was designed to investigate the efficacy and safety of apatinib monotherapy in the treatment of elderly patients with advanced colorectal cancer (CRC) who have progressed on the standard regimens.Methods: The data of 106 elderly patients with advanced CRC who have progressed on standard treatment were analyzed. The primary endpoint of this study was progression-free survival (PFS), the secondary endpoints were objective response rate (ORR), disease control rate (DCR), and overall survival (OS). The safety outcomes were assessed by the proportion and severity of adverse events.Results: Efficacy was assessed using the best overall response of patients during treatment with apatinib, including 0 patients with complete response, 9 patients with partial response, 68 patients with stable disease, and 29 patients with progressive disease. ORR and DCR were 8.5 and 72.6%, respectively. The median PFS of 106 patients was 3.6 months, and the median OS was 10.1 months. The most frequent adverse reactions of elderly patients with advanced CRC receiving apatinib treatment were hypertension (59.4%) and hand-foot syndrome (HFS) (48.1%). The median PFS of patients with and without hypertension was 5.0 and 3.0 months, respectively ( P = 0.008). The median PFS of patients with and without HFS was 5.4 and 3.0 months, respectively ( P = 0.013).Conclusions: The clinical benefit of apatinib monotherapy was observed in elderly patients with advanced CRC who have progressed on the standard regimens. The adverse reactions of hypertension and HFS were positively related to treatment efficacy.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"317-323"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10805745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bartholin's gland adenoid cystic carcinoma: Report of three cases and the review of literature. 巴氏腺腺样囊性癌：三例病例报告及文献综述。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-07-16 DOI: 10.4103/ijc.ijc_359_21

Zeynep Güral, Serap Yücel, Fulya Agaoglu

引用次数: 0

Misconducts in research and methods to uphold research integrity. 研究中的不当行为和维护研究诚信的方法。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-07-16 DOI: 10.4103/ijc.ijc_4_23

Karthik N Rao, Manish Mair, Ripu D Arora, Prajwal Dange, Nitin M Nagarkar

{"title":"Misconducts in research and methods to uphold research integrity.","authors":"Karthik N Rao, Manish Mair, Ripu D Arora, Prajwal Dange, Nitin M Nagarkar","doi":"10.4103/ijc.ijc_4_23","DOIUrl":"10.4103/ijc.ijc_4_23","url":null,"abstract":"Research misconduct refers to deliberate or accidental manipulation or misrepresentation of research data, findings, or processes. It can take many forms, such as fabricating data, plagiarism, or failing to disclose conflicts of interest. Data falsification is a serious problem in the field of medical research, as it can lead to the promotion of false or misleading information. Researchers might engage in p-hacking - the practice of using someone else's research results or ideas without giving them proper attribution. Conflict of interest (COI) occurs when an individual's personal, financial, or professional interests could potentially influence their judgment or actions in relation to their research. Nondisclosure of COI can be considered research misconduct and can damage the reputation of the authors and institutions. Hypothesis after results are known can lead to the promotion of false or misleading information. Cherry-picking data is the practice of focusing attention on certain data points or results that support a particular hypothesis, while ignoring or downplaying results that do not. Researchers should be transparent about their methods and report their findings honestly and accurately. Research institutions should have clear and stringent policies in place to address scientific misconduct. This knowledge must become widespread, so that researchers and readers understand what approaches to statistical analysis and reporting amount to scientific misconduct. It is imperative that readers and researchers alike are aware of the methods of statistical analysis and reporting that constitute scientific misconduct.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"354-359"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An ominous cause of hirsutism: Adrenocortical carcinoma. 多毛症的不祥之因：肾上腺皮质癌

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-07-13 DOI: 10.4103/ijc.ijc_86_22

Pankaj Singhania, Rana Bhattacharjee, Subhankar Chowdhury

引用次数: 0