Indian journal of cancer最新文献_第4页

The clinical efficacy and safety of TACE combined with apatinib for advanced hepatocellular carcinoma: A propensity score matching analysis. TACE联合阿帕替尼治疗晚期肝细胞癌的临床疗效和安全性：倾向评分匹配分析。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2022-11-30 DOI: 10.4103/ijc.IJC_967_20

Cheng Chen, Xiaoting Duan, Yanfeng Shen, Guiying Li

{"title":"The clinical efficacy and safety of TACE combined with apatinib for advanced hepatocellular carcinoma: A propensity score matching analysis.","authors":"Cheng Chen, Xiaoting Duan, Yanfeng Shen, Guiying Li","doi":"10.4103/ijc.IJC_967_20","DOIUrl":"10.4103/ijc.IJC_967_20","url":null,"abstract":"Background: The combined treatment of transcatheter arterial chemoembolization (TACE) and apatinib had beneficial effects on the survival of patients with advanced hepatocellular carcinoma (HCC), but the efficacy of this regimen is still controversial and needs further investigation.Materials and methods: The clinical records of advanced HCC patients between May 2015 and December 2016 were collected from our hospital. They were categorized into the TACE monotherapy group and the combination of TACE and apatinib group. After propensity score matching (PSM) analysis, the disease control rate (DCR), objective response rate (ORR), progression-free survival (PFS), and occurrence of adverse events were compared between the two treatments.Results: There were 115 HCC patients included in the study. Among them, 53 received TACE monotherapy and 62 were treated with TACE plus apatinib. After PSM analysis, 50 pairs of patients were compared. The DCR of the TACE group was significantly lower than that of the combination of TACE and apatinib group (35 [70%] versus 45 [90%], P < 0.05). The ORR of the TACE group was also significantly lower than that of the combination of TACE and apatinib group (22 [44%] versus 34 [68%], P < 0.05). Patients who received the combined treatment of TACE and apatinib had longer PFS compared with those in the TACE monotherapy group ( P < 0.001). Moreover, hypertension, hand-foot syndrome, and albuminuria were more common in the combination of TACE and apatinib group ( P < 0.05), although all adverse events were well tolerated.Conclusions: The combined treatment of TACE and apatinib showed beneficial effects on tumor response, survival outcomes, and tolerance to treatment, which may be used as a routine regimen for advanced HCC patients.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"390-395"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10805742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer pattern in Varanasi district from Uttar Pradesh state of India, a foundation for cancer control based on the first report of the population-based cancer registry. 印度北方邦瓦拉纳西地区的癌症模式--基于首份人口癌症登记报告的癌症控制基础。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-09-11 DOI: 10.4103/ijc.IJC_44_21

Atul M Budukh, Satyajit Pradhan, Virendra B Singh, Divya Khanna, Sonali S Bagal, Priyal S Chakravarti, Anand N Sharma, Rajesh K Vishwakarma, Shraddha S Shinde, Naveen C Khargekar, Pankaj Chaturvedi, Rajesh P Dikshit, Vijay K Shukla, Rajendra A Badwe

{"title":"Cancer pattern in Varanasi district from Uttar Pradesh state of India, a foundation for cancer control based on the first report of the population-based cancer registry.","authors":"Atul M Budukh, Satyajit Pradhan, Virendra B Singh, Divya Khanna, Sonali S Bagal, Priyal S Chakravarti, Anand N Sharma, Rajesh K Vishwakarma, Shraddha S Shinde, Naveen C Khargekar, Pankaj Chaturvedi, Rajesh P Dikshit, Vijay K Shukla, Rajendra A Badwe","doi":"10.4103/ijc.IJC_44_21","DOIUrl":"10.4103/ijc.IJC_44_21","url":null,"abstract":"Background: The cancer registry provides reliable data from the population. In this article, we provide cancer burden and its patterns from the Varanasi district.Methods: The method adopted by the Varanasi cancer registry is community interaction along with regular visits to more than 60 sources to collect data on cancer patients. The cancer registry was established by the Tata Memorial Centre, Mumbai, in 2017 covering 4 million population (57% rural and 43% urban population).Results: The registry has recorded 1,907 incidence cases (1,058 male and 849 female). The age-adjusted incidence rate per 100,000 population in male and female of Varanasi district is 59.2 and 52.1, respectively. One in 15 male and one in 17 female are at risk of developing the disease. Mouth and tongue cancers are the predominant cancers in male, whereas breast, cervix uteri, and gallbladder are the leading cancer sites among the female. In female, cervix uteri cancer is significantly higher (double) in rural areas when compared with urban areas (rate ratio [RR] 0.5, 95% confidence interval [CI; 0.36, 0.72]), whereas in male, mouth cancer is higher in urban areas when compared with rural areas (RR 1.4, 95% CI [1.11, 1.72]). More than 50% of cancer cases in male are due to tobacco consumption. There may be underreporting of the cases.Conclusion: The results of the registry warrant policies and activities related to early detection services for the mouth, cervix uteri, and breast cancers. The Varanasi cancer registry is the foundation for cancer control and will play an important role in the evaluation of the interventions.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"383-389"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10815015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of tobacco counseling training module (TCTM) in enhancing the knowledge, attitude, ability to identify oral manifestations, self-confidence, and skills (KAASS) in tobacco counseling among undergraduate dental students - An interventional study. 烟草咨询培训模块（TCTM）在提高口腔医学本科生烟草咨询知识、态度、识别口腔表现能力、自信心和技能（KAASS）方面的效果--一项干预性研究。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-09-11 DOI: 10.4103/ijc.ijc_405_21

Byalakere R Chandrashekar, Thomas V Chacko, H P Jayashankar, S Suma, K M Anand, Suvetha Kannappan

{"title":"Effectiveness of tobacco counseling training module (TCTM) in enhancing the knowledge, attitude, ability to identify oral manifestations, self-confidence, and skills (KAASS) in tobacco counseling among undergraduate dental students - An interventional study.","authors":"Byalakere R Chandrashekar, Thomas V Chacko, H P Jayashankar, S Suma, K M Anand, Suvetha Kannappan","doi":"10.4103/ijc.ijc_405_21","DOIUrl":"10.4103/ijc.ijc_405_21","url":null,"abstract":"Background: Tobacco use has emerged as a major public health issue with increasing tobacco-related morbidity and mortality. Despite evidence that even brief tobacco counseling by health care professionals is effective in motivating a tobacco user to quit, there was a lack of customized tobacco counseling training module (TCTM) for students of dentistry in their existing curriculum. This study was undertaken to evaluate the effectiveness of a customized TCTM in improving KAASS in tobacco counseling among undergraduate dental students.Methods: TCTM that was previously pilot tested was implemented as a value addition in Public Health Dentistry for two academic years. Changes in knowledge, attitude, ability to identify oral manifestations, self-confidence, and skills (KAASS) in tobacco counseling were assessed before and after implementation of TCTM. Mean pre and post intervention scores were compared.Results: Mean scores for knowledge, attitude, ability to identify oral manifestations, and self-confidence (KAAS) at baseline were 4.4 ± 0.9, 5.1 ± 0.7, 4.5 ± 1.1, and 1.3 ± 0.4, respectively. Mean KAAS scores post intervention were 13.5 ± 1.0, 8.7 ± 0.4, 9.4 ± 0.7, and 3.5 ± 0.5, respectively. There was a significant improvement in the mean KAAS score post intervention compared to baseline. Tobacco counseling skills also significantly improved among the participants following implementation of the training module (68.8%) did well compared to the baseline (0%).Conclusion: TCTM was effective in enhancing knowledge, attitude, ability to identify oral manifestations, and self-confidence in tobacco counseling among undergraduate dental students.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"230-237"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum 25-hydroxy vitamin-D levels in head and neck cancer chemoradiation therapy: Potential in cancer therapeutics. 头颈癌化学放疗中的血清 25- 羟基维生素-D 水平：癌症治疗的潜力

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-09-11 DOI: 10.4103/ijc.IJC_358_20

Arya Bhanu, Chaitali M Waghmare, Vandana S Jain, Hemant J Pawar

{"title":"Serum 25-hydroxy vitamin-D levels in head and neck cancer chemoradiation therapy: Potential in cancer therapeutics.","authors":"Arya Bhanu, Chaitali M Waghmare, Vandana S Jain, Hemant J Pawar","doi":"10.4103/ijc.IJC_358_20","DOIUrl":"10.4103/ijc.IJC_358_20","url":null,"abstract":"Background: To evaluate the relation between serum-25-hydroxy Vitamin-D levels (S25OHVDL) and concurrent chemoradiation therapy (CTRT) toxicities in patients of head and neck squamous cell cancer (HNSCC).Methods: After an institutional ethics committee approval, consecutive HNSCC patients who received radical/adjuvant CTRT were prospectively evaluated. Patients were assessed for CTRT toxicities using Common Terminology Criteria for Adverse Events version 5.0 (CTCAE-v5.0) and the response was evaluated according to Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST-1.1). S25OHVDL was assessed at the time of the first follow-up. Patients were divided into group A (Optimal) and group B (suboptimal) according to S25OHVDL. The treatment toxicities were correlated with S25OHVDL.Results: Twenty-eight patients were evaluated for the study. S25OHVDL was optimal in eight (28.57%) and suboptimal in 20 patients (71.42%). Mucositis and radiation dermatitis were significantly more in subgroup B ( P -value 0.0011 and 0.0505, respectively). Relatively lower but nonsignificant hemoglobin and peripheral white blood cell counts were observed in subgroup B.Conclusion: Suboptimal S25OHVDL was associated with significantly more skin and mucosal toxicities in HNSCC patients treated with CTRT.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"403-407"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10805743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of pathological complete response to neoadjuvant chemotherapy in breast cancer: A single-institution experience. 乳腺癌新辅助化疗病理完全反应的决定因素：单一机构的经验。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-09-11 DOI: 10.4103/ijc.IJC_813_20

Shalaka Joshi, Qurratulain Chougle, Jarin Noronha, Rohini Hawaldar, Nita Nair, Vaibhav Vanmali, Vani Parmar, Purvi Thakkar, Garvit Chitkara, Tanuja Shet, Rajendra A Badwe

{"title":"Determinants of pathological complete response to neoadjuvant chemotherapy in breast cancer: A single-institution experience.","authors":"Shalaka Joshi, Qurratulain Chougle, Jarin Noronha, Rohini Hawaldar, Nita Nair, Vaibhav Vanmali, Vani Parmar, Purvi Thakkar, Garvit Chitkara, Tanuja Shet, Rajendra A Badwe","doi":"10.4103/ijc.IJC_813_20","DOIUrl":"10.4103/ijc.IJC_813_20","url":null,"abstract":"Background: Neoadjuvant chemotherapy (NACT) is routinely used in all cases of locally advanced breast cancer and some cases of early breast cancer. We previously reported a pathological complete response (pCR) rate of 8.3%. With the increasing use of taxanes and human epidermal growth factor receptor 2 (HER2)-directed NACT, we conducted this study to understand the current pCR rate and its determinants.Methods: A prospective database of breast cancer patients who underwent NACT followed by surgery between January and December 2017 was evaluated.Results: Of the 664 patients, 87.7% were cT3/T4, 91.6% were grade III, and 89.8% were node-positive at presentation (54.4% cN1, 35.4% cN2). The median age was 47 years; median pre-NACT clinical tumor size was 5.5 cm. Molecular subclassification was 30.3% hormone receptor positive (HR+) HER2-, 18.4% HR+HER2+, 14.9% HR-HER2+, and 31.6% triple negative (TN). Both anthracyclines and taxanes were given preoperatively in 31.2% patients whereas 58.5% of HER2 positive patients received HER2-targeted NACT. The overall pCR rate was 22.4% (149/664), 9.3% in HR+HER2-, 15.6% in HR+HER2+, 35.4% in HR-HER2+, and 33.4% in TN. On univariate analysis, duration of NACT ( P < 0.001), cN stage at presentation ( P = 0.022), HR status ( P < 0.001), and lymphovascular invasion ( P < 0.001) were associated with pCR. On logistic regression, HR negative status (Odds ratio [OR] 3.314, P < 0.001), longer duration of NACT (OR 2.332, P < 0.001), cN2 stage (OR 0.57, P = 0.012), and HER2 negativity (OR 1.583, P = 0.034) were significantly associated with pCR.Conclusion: Response to chemotherapy depends on molecular subtype and duration of NACT. A low rate of pCR in the HR+ subgroup of patients warrants reconsideration of neoadjuvant strategies.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"324-331"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10819155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of mtDNA common deletion in esophageal squamous cell carcinoma. 评估食管鳞状细胞癌中的 mtDNA 共同缺失。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-07-23 DOI: 10.4103/ijc.ijc_324_23

Fatemeh Ghadyani, Shahrbanoo Sharif, Saeid Morovvati

{"title":"Evaluation of mtDNA common deletion in esophageal squamous cell carcinoma.","authors":"Fatemeh Ghadyani, Shahrbanoo Sharif, Saeid Morovvati","doi":"10.4103/ijc.ijc_324_23","DOIUrl":"10.4103/ijc.ijc_324_23","url":null,"abstract":"Background: Mitochondrial defects are thought to play a role in cancer initiation and progression for a long time. Because of the absence of protective histones and an inefficiency in the DNA repair process, mitochondrial DNA is known to be prone to mutations. The deletion of 4977bp is one of the most common mutations in human cancers. This study aimed to investigate the relationship between 4977bp common deletion and Esophageal Squamous Cell Carcinoma Disease (SCC) to provide prognostic information.Methods: By using a PCR protocol, this study identified the 4977bp deletion of mtDNA. A PCR method was used on tumor samples from 41 squamous cell carcinoma patients and blood samples from 50 healthy individuals to detect DNA.Results: Among the 41 tumor samples (80.5%), 33 were found to have the 4977bp deletion, while none of the blood samples from healthy individuals contained it.Conclusions: It is shown that the deletion of 4977bp of mtDNA correlates significantly with SCC in this study. A 4977bp deletion could be used as an effective cancer screening indicator and biomarker for early diagnosis and prevention of cancer.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"363-367"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative pain management following minimally invasive abdominal cancer surgeries -An audit. 腹部癌症微创手术后的术后疼痛管理 - 审计。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-07-27 DOI: 10.4103/ijc.IJC_169_21

Sumitra G Bakshi, Sheetal Gupta, P N Jain

{"title":"Postoperative pain management following minimally invasive abdominal cancer surgeries -An audit.","authors":"Sumitra G Bakshi, Sheetal Gupta, P N Jain","doi":"10.4103/ijc.IJC_169_21","DOIUrl":"10.4103/ijc.IJC_169_21","url":null,"abstract":"Background: There is limited data comparing pain management following various minimally invasive oncological surgeries (MIOS). This retrospective audit was planned to determine the severity of pain and to study the analgesic modalities offered to these patients. Secondary objectives included studying opioid requirements, non-opioid analgesics, their side effects, and the influence of comorbidities on the choice of pain modalities.Methods: Following approval and registration of trial (CTRI/2018/10/016220), data were collected retrospectively from adult patients who underwent elective MIOS for abdominal tumors from August 2017 to July 2018. Pain scores (PS) on the day of surgery, and the average, worst PS, and the morphine equivalent (ME) dose in the perioperative period was recorded. Emergency surgeries and thoracic-abdominal MIOS were excluded. The association between the type of surgery, pain modalities, and PS were compared using Chi-square test. ME dose consumption of patients and type of surgery were compared using ANOVA with Bonferroni's correction.Results: Out of the 349 patients' data that were analyzed, 76% had mild, 22% had moderate, and 2% had severe pain after surgery. Port site infiltration was done in 27% of cases and epidural analgesia in 46 patients (13%). PS and opioid consumption (ME = 5.7 ± 5.2 mg) was significantly higher following pelvic surgeries when compared to other urological and diagnostic MIOS. American Society of Anesthesiologists Physical Status did not affect PS or choice of pain management technique.Conclusion: Most of the patients experience mild pain at movement in the immediate postoperative period, pelvic MIOS (abdominoperineal resection/exenteration surgeries) have higher PS and opioid consumption than other MIOS.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"368-374"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epithelioid angiosarcoma of the pericardium: Case report of the challenges in the management of a rare malignancy with poor prognosis. 心包上皮样血管肉瘤：预后不良的罕见恶性肿瘤治疗挑战的病例报告。

IF 1 4区医学

Indian journal of cancer Pub Date : 2024-03-22 DOI: 10.4103/ijc.ijc_1010_21

Bhupesh Guleria, Prerna Guleria, Azhar Husain, Anurag Jain, Jes Raphael, Prasanta Sengupta

引用次数: 0

Psychometric analysis of Marathi version of an updated European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Module (EORTC QLQ-H&N43). 马拉地语版欧洲癌症研究和治疗组织生活质量问卷头颈部模块（EORTC QLQ-H&N43）的心理计量分析。

IF 1 4区医学

Indian journal of cancer Pub Date : 2024-03-20 DOI: 10.4103/ijc.ijc_617_21

Chaitali M Waghmare, Hemant J Pawar, Rajvir Bhalwar, Pradeep Kumar Thakur

{"title":"Psychometric analysis of Marathi version of an updated European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Module (EORTC QLQ-H&N43).","authors":"Chaitali M Waghmare, Hemant J Pawar, Rajvir Bhalwar, Pradeep Kumar Thakur","doi":"10.4103/ijc.ijc_617_21","DOIUrl":"https://doi.org/10.4103/ijc.ijc_617_21","url":null,"abstract":"Background: The aim of this study was to perform a psychometric analysis of the Marathi version of an updated European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Module (EORTC QLQ-H&N43) in patients of head and neck squamous cell carcinoma (HNSCC).Material and methods: After an institutional ethics committee approval and linguistic validation, the Marathi version of EORTC QLQ-H&N43 was served to consecutive eligible, Marathi-speaking HNSCC patients of oral cavity, oropharynx, hypopharynx and larynx, registered from August 2019 to March 2021 and who consented to the study. Performance status scale was used for perceptive assessment of organ function. Psychometric analysis was performed using SYSTAT v. 12 (Cranes software, Bengaluru).Results: A total of 129 patients participated in the study with a median age of 67 years and the man-to-woman ratio of 100:29. The commonest sub-site reported was the oral cavity (61.24%) and the majority were in stage IV disease (69.76%). Ninety patients completed the questionnaire before being started on active oncology treatment at our center. 39 patients completed the questionnaire at pre-treatment and first follow-up. The questionnaire was filled on their own (module) by 32.55% of patients while 67.44% of patients required some kind of assistance (schedule). Internal consistency was moderate to high. The criterion and construct validities were acceptable. The questionnaire was sensitive to change with stage and time. No significant difference was observed in module versus schedule subgroup except for 2 out of 19 item-scales.Conclusion: Marathi translation of EORTC QLQ-H&N43 is a sensitive, reliable and valid tool when applied to patients of HNSCC. It can be considered as a schedule.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Varied presentations of primary cutaneous lymphoma: A case series from a tertiary care center in South India. 原发性皮肤淋巴瘤的各种表现：南印度一家三级医疗中心的系列病例。

IF 1 4区医学

Indian journal of cancer Pub Date : 2024-03-12 DOI: 10.4103/ijc.ijc_841_21

Baby Shana, Betsy Ambooken, Sunitha Balakrishnan, Asokan Neelakandan, Kidangazhiyathmana Ajithkumar

{"title":"Varied presentations of primary cutaneous lymphoma: A case series from a tertiary care center in South India.","authors":"Baby Shana, Betsy Ambooken, Sunitha Balakrishnan, Asokan Neelakandan, Kidangazhiyathmana Ajithkumar","doi":"10.4103/ijc.ijc_841_21","DOIUrl":"https://doi.org/10.4103/ijc.ijc_841_21","url":null,"abstract":"Background: Recent studies indicate an upsurge of primary cutaneous lymphoma (PCL) in the Indian population. Of late, we too have come across varied presentations of PCL in relatively younger individuals. Hence, we decided to study the clinical and immunohistological profile of patients with PCL in our department.Methods: All cases diagnosed as PCL from October 2016 to October 2019 were included. Clinical details, complete blood count, peripheral smear, imaging, histopathology, and immunohistochemistry of skin specimens were analyzed. Lymph node biopsy and bone marrow studies were done in most cases. Human T lymphotropic virus-1 (HTLV1) serology was done in 10 cases.Results: Of the 24 patients with PCL, 12 were below 50 years of age. Twenty-three patients (95.8%) had T-cell lymphoma and only one had B-cell PCL. Mycosis fungoides (MF) (n = 17; 71%) was the most common type of PCL. There were two (8.3%) cases each of adult T-cell lymphoma/leukemia (ATLL) and Sezary syndrome. MF had varied clinical morphology at presentation and variable clinical outcomes. Both cases of ATLL had features of immunosuppression in the form of infective dermatoses.Conclusion: We observed an increased proportion of T-cell type of PCL, with the age of onset being relatively early. HTLV-1 positivity was noted in three out of the 10 cases tested. More studies are needed to determine the factors responsible for the younger age of onset of PCL and the role of HTLV-1 infection in the development of PCL.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0