Indian journal of cancer最新文献

{"title":"Programmed-death 1/programmed-death ligand 1 inhibitors plus chemotherapy versus chemotherapy for first-line treatment of advanced driver-gene negative non-squamous non-small cell lung cancer: An updated systematic review and meta-analysis.","authors":"Zhifei Zhao, Wenfu Shi, Meng Yu, Xuefei Cheng","doi":"10.4103/ijc.ijc_225_24","DOIUrl":"10.4103/ijc.ijc_225_24","url":null,"abstract":"<p><strong>Background: </strong>To assess the efficacy and safety of first-line programmed-death 1 (PD-1)/programmed-death ligand 1 (PD-L1) inhibitors + chemotherapy for driver-gene negative advanced non-squamous non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>Eligible literature was identified following a systematic search of four electronic databases (PubMed, Embase, Ovid, and Cochrane library databases) from their inception to June, 2023. Unpublished research was searched from the American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), and the World Conference on Lung Cancer (WCLC) meeting abstracts. Review Manager 5.3 software was used for analysis.</p><p><strong>Results: </strong>Nine randomized controlled trials (RCTs) were identified and included, involving 3443 driver-gene negative advanced non-squamous NSCLC patients. PD-1/PD-L1 inhibitors + chemotherapy had significantly longer progression-free survival (PFS) (hazard ratio [HR] = 0.57, 95% CI = 0.52-0.61, P < 0.00001), and overall survival (OS) (HR = 0.69, 95% confidence interval = 0.63-0.76, P < 0.00001) compared with chemotherapy alone. Analysis was performed based on PD-L1 expression levels; patients with any PD-L1 expression had PFS benefit ( P < 0.00001), while only patients with PD-L1 ≥50% ( P = 0.02) and PD-L1 ≤1% ( P = 0.0009) had OS benefit. Regarding liver metastases, there was no statistically significant benefit of PD-1/PD-L1 inhibitors + chemotherapy regimens for the liver metastases cohort in OS ( P = 0.08). In brain metastasis patients, PD-1/PD-L1 inhibitors + chemotherapy regimens demonstrated an improvement in PFS compared to chemotherapy ( P = 0.03).</p><p><strong>Conclusion: </strong>Our results show that PD-1/PD-L1 inhibitors + chemotherapy showed better survival benefits than chemotherapy in driver-gene negative advanced non-squamous NSCLC patients.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"9-17"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of the frequency of micronucleated cells with the severity of disease process in oral submucous fibrosis and oral squamous cell carcinoma patients: A descriptive, cross-sectional study.","authors":"Naga Bhushanam, Shaik Farha Sultana, Praveena Raman, Mohammed Thamer Alqahtani, Saeed Mohammed Alqahtani, Mohammed Abdullah Alshareef, J Suresh Babu, C Swarnalatha, Abhishek Singh Nayyar","doi":"10.4103/ijc.ijc_1006_23","DOIUrl":"10.4103/ijc.ijc_1006_23","url":null,"abstract":"<p><strong>Background: </strong>Exposure of a cell to carcinogens leads to an increase in the chromosomal aberrations, while such karyotypic anomalies and elevated deoxyribonucleic acid content have been observed in a plethora of oral precancerous lesions and conditions, and are expressed in the form of micronuclei. The aim of the present study was to correlate the frequency of these micronucleated cells (MNCs) with the severity of the disease process in oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC) patients.</p><p><strong>Methods: </strong>The present cross-sectional, hospital-based study consisted of 150 subjects in an age range from 15 to 80 years including patients who were clinically diagnosed and histopathologically proven as OSMF and OSCC patients, along with age and sex matched, normal, healthy controls. Also, cytological analysis was carried out using the oral exfoliative cytology procedure, while the frequency of MNCs was calculated using a differential counter.</p><p><strong>Results: </strong>The mean MNC% in the control group was calculated as 0.3% ± 0.35% in the present study as against the mean MNC% of 1.22% ± 0.37% in the OSMF, and 2.0% ± 0.60% in the OSCC groups, while the difference was statistically significant ( P < 0.001). Also, the mean MNC% was calculated to be 0.71% ± 0.08% in Stage I OSMF as against 1.31% ± 0.18% and 1.59% ± 0.17% in Stage II and Stage III OSMF, respectively, with the difference being statistically significant ( P < 0.001). Similarly, the difference in the mean MNC% when calculated between the different stages of OSCC was, also, statistically significant ( P < 0.001) with the mean MNC% in Stage I OSCC being 1.15% ± 0.11% as against 1.59% ± 0.25% in Stage II, and 2.23% ± 0.30% in Stage III and 2.68% ± 0.19% in Stage IV OSCC, respectively.</p><p><strong>Conclusions: </strong>Based on the results obtained in the present study, it can, thus, be concluded that the mean MNC% increased significantly in OSCC patients when compared with the control and OSMF groups, and in the OSMF group in comparison with control group, thus, suggesting micronuclei assay as a useful diagnostic adjunct for screening populations which are at high risk for developing various oral precancerous lesions and conditions, and frank oral cancers.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"41-51"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of sexual life quality and vaginal dose-volume relationship in female rectal cancer patients treated with pelvic radiotherapy.","authors":"Gul Kanyilmaz, Hatice Halis, Ozlem Ay, Oztun Temelli, Eda Yirmibesoglu Erkal, Durmus Etiz, Haldun Sukru Erkal","doi":"10.4103/ijc.ijc_764_24","DOIUrl":"10.4103/ijc.ijc_764_24","url":null,"abstract":"<p><strong>Background: </strong>There are very limited studies examining the sexual dysfunction in female rectal cancer treated with curative chemoradiotherapy (CRT). So, we aimed to evaluate the self-related sexual life quality and vaginal dose-volume relationship in female rectal cancer patients.</p><p><strong>Methods: </strong>The patients who had been treated with chemoradiotherpay between January 2012 and January 2019 were included. Vaginal contouring was performed according to the Radiation Therapy Oncology Group female pelvic normal tissue contouring atlas. Sexual functioning was evaluated by the European Organization for Research and Treatment Quality of life Questionnaire for Sexual Function Modules (EORTC QOL).</p><p><strong>Results: </strong>Fourty five disease-free female patients volunteered to participate in this study were evaluated. The mean total EORTC QOL score of patients was 19.44 points. The score was <19.44 points accepted as worse sexual functioning and ≥19.44 points accepted as better sexual functioning. We did not find any relationship between sexual functioning and radiotherapy sequence, radiotherapy technique, and total radiotherapy doses. The proximity to anal verge and older patients age were the associated factors for worse sexual functioning in female rectal cancer. Dmin, Dmean, V35, V40, V45, and V50 of vagina were the predictive factors for sexual functioning. According to multivariate regression analyses only the primary tumor distance to anal verge ( P = 0.01), and V50 ( P = 0.02) of vagina were the predictive factors for sexual functioning.</p><p><strong>Conclusions: </strong>Sexual dysfunctions in female rectal cancer were associated with tumor distance to anal verge, patients age, Dmean, Dmin, and V35-50 of vagina in female rectal cancer treated with curative radiochemotherapy.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"76-81"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"District cancer control program: A white paper to optimize cancer care in rural India by developing a uniform, modular, and multi-tier system.","authors":"Nirav P Trivedi, T D Balamurugan, R Ravi Kannan, Harit K Chaturvedi, Sanjeev Kulgod, Asit Arora, Shehnaz Kantharia, Aksat Malik, Nirali N Trivedi, Yash Merchant, Debashish Chaudhary","doi":"10.4103/ijc.ijc_436_24","DOIUrl":"10.4103/ijc.ijc_436_24","url":null,"abstract":"<p><strong>Purpose: </strong>In India, less than 10% of cancer care is accessible to the country's 70% of rural residents. Providing all-encompassing cancer care in a remote setting with limited resources is a difficult undertaking. Despite having the best of intentions, many centers struggle to treat patients in accordance with current standards because they lack the necessary resources and guidance. This leads to a worsened prognosis for millions of cancer patients, with detrimental effects on the person, the family, and society at large. The situation is presumably similar in other developing countries. The purpose of this article is to identify challenges and try to find their solutions that suits practical situation.</p><p><strong>Methods: </strong>The contents of this article were the result of deliberations in a recently concluded Indian Cancer Congress 2023, Mumbai, which was one of the largest conglomerations of around 6000 oncologists across India and the world. The session included clinicians and other stakeholders with years of experience working in rural India. The contributors worked in groups based on their strengths and experience for the past few months to develop appropriate recommendations for each section.</p><p><strong>Summary: </strong>The ideal system to deliver comprehensive cancer treatment should include various aspects like prevention, early detection, protocol-based treatment, rehabilitation, palliation, data collection, and research. As of now, there are no clear guidelines or structure available for stakeholders in rural areas to build their care delivery. This article proposes a district-based cancer control program that covers all aspects of cancer care using available resources, with the aim of creating a uniform, modular, and multi-tier structure to establish a care delivery pathway for districts that can be replicated in any region.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"90-98"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PI-RADS v2 score may be as a predictor of bone metastasis in prostate cancer.","authors":"Ting Liu, Cheng H Zhu, Kang Yang, Yang Du, Fan Cheng","doi":"10.4103/ijc.ijc_1015_22","DOIUrl":"10.4103/ijc.ijc_1015_22","url":null,"abstract":"<p><strong>Background: </strong>To explore the independent influencing factors of PCa bone metastasis and evaluate the role of prostate imaging.</p><p><strong>Methods: </strong>The clinic data such as age, prostate volume, tPSA and fPSA . Univariate and multivariate analyses were performed to investigate the independent influencing point of the risk factors. Nomogram and ROC curve were generated to establish the prediction model. The calibration curve, leave-one-out cross validation and independent external validation were performed to evaluate the prediction model.</p><p><strong>Results: </strong>This study enrolled 325 newly diagnosed PCa patients at two hospitals. Univariate and multivariate analyses showed only tPSA , cTx, ALP, and PI-RADS v2 score were the independent influencing factors of PCa bone metastasis. The cut-off points of PI-RADS v2 score to distinguish bone metastasis was 5. The nomogram was established with a sensitivity of 81.3% and a specificity of 74.5% to predict the probability of PCa bone metastasis. The calibration curve and ROC curve displayed a good value of the prediction model. Leave-one-outcross validation showed the prediction model could classify 79.8% cases accurately. External data validation displayed sensitivity of 78.4% and a specificity of 79.1%.</p><p><strong>Conclusions: </strong>PI-RADS v2 score could predict PCa bone metastasis, the prediction model may help discovered PCa bone metastasis.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"63 1","pages":"82-89"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-dose rate intraluminal brachytherapy in ano-rectum for haemostasis in a case of metastatic infiltrating cancer prostate.","authors":"Ashok Kumar, Manoj K Semwal, Bhanu Prakash, Prabhjeet Bhatla, Nilima Mishra","doi":"10.4103/ijc.ijc_280_22","DOIUrl":"10.4103/ijc.ijc_280_22","url":null,"abstract":"<p><strong>Abstract: </strong>Management of rectal bleeding due to various underlying malignant pathologies is a difficult situation, especially in the setting of metastatic disease. Palliative radiation is generally offered to such patients to achieve hemostasis. We report a patient diagnosed with metastatic prostate carcinoma which was infiltrating the rectal mucosa. Fifty-four year old patient, with a case of metastatic prostate carcinoma presented with rectal bleeding. On evaluation, he had a friable growth from the anal verge to 10 cm with severe bleeding. We gave intraluminal high-dose rate brachytherapy using an endoluminal vaginal/rectal cylinder applicator. A dose of 6 Gy, weekly for three weeks was delivered. High-dose-rate brachytherapy was immediately well tolerated. The bleeding stopped completely by day 4 and by day 7 patient was passing yellow stools. Intraluminal high-dose-rate brachytherapy has been proven as an effective palliative treatment in achieving hemostasis from rectal bleeding.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 4","pages":"565-568"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult-type epithelial neoplasms in children and adolescents-A retrospective analysis on a subgroup of very rare tumors.","authors":"Gazel Sainulabdin, V P Krishnan, Smitha Bhaskaran, Yamini Krishnan","doi":"10.4103/ijc.ijc_96_25","DOIUrl":"10.4103/ijc.ijc_96_25","url":null,"abstract":"<p><strong>Background: </strong>Epithelial malignancies, which constitute the majority of adult cancers, are relatively rare in the pediatric population, accounting for only 2% of all childhood tumors. In contrast to common childhood cancers-which typically arise from embryonal or mesenchymal tissues-epithelial malignancies originate from the epithelial lining of glands and include carcinomas of the lung, breast, colon, and genitourinary tract. Understanding the occurrence, behavior, and treatment outcomes of adult-type epithelial malignancies in children is essential for developing age-appropriate management strategies and improving long-term survival. This emerging subset of pediatric cancers warrants further investigation and collaborative efforts to establish optimal diagnostic criteria, staging systems, and therapeutic approaches tailored to younger patients. We undertook a 5-year retrospective analysis of children diagnosed with adult-type epithelial malignancies at our center.</p><p><strong>Methods: </strong>Study Design: This is a retrospective data analysis conducted at MVR Cancer Centre and Research Institute (MVRCCRI), focusing on pediatric patients below 18 years of age who presented between the years January 2019 and December 2024. Inclusion criteria: All children under 18 years of age who presented to MVRCCRI provided they had an adult-type neoplasm of epithelial origin were included in this study. Statistical analysis was performed. The mean, intervals and percentages in each group were calculated. Institutional ethical committee approval was obtained for this retrospective review.</p><p><strong>Results: </strong>A total of 69 children who were younger than 18 years were included in the study. There were 18 males and 51 females in the study giving a male to female ratio of 1:2.8. Three children had a family history of malignancy: one had a history of consanguinity was diagnosed with CMMRD on genetic evaluation, and the other had a mother with breast cancer and a pathological variant in the ATM gene. The third child with adrenocortical carcinoma had a pathological variant in TP53 diagnosed in mother. The children were analyzed based on the primary diagnosis. The largest group of epithelial malignancies in our cohort was thyroid malignancy, and the second largest group was carcinoma of the salivary glands. Children who presented with early stages of disease fared well in all the groups.</p><p><strong>Conclusion: </strong>Adult-type epithelial neoplasms in children and adolescents are distinct entities, characterized by unique biological behaviors and genetic signatures. Treatment approaches should integrate principles from adult oncology and collaborative studies are essential to define the epidemiology, for staging and prognostic markers, and also to develop pediatric-specific treatment protocols for these malignancies.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 4","pages":"528-534"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolving burden of pediatric solid tumors: A global analysis from 1990 to 2021.","authors":"Gang Xiao, Qidong Ye","doi":"10.4103/ijc.ijc_82_25","DOIUrl":"10.4103/ijc.ijc_82_25","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the global incidence and mortality trends of seven major solid tumors (brain cancer, hepatoblastoma, kidney cancer, malignant bone tumors [MNBAC], neuroblastoma, retinoblastoma, and soft tissue sarcomas) in individuals aged 0-19 years from 1990 to 2021.</p><p><strong>Methods: </strong>Using data from the Global Burden of Disease Study 2021, analyses were stratified by age, region, and sociodemographic index (SDI). Temporal trends were quantified via estimated annual percentage change (EAPC). A linear regression model evaluated the correlation between childhood meningitis mortality and SDI.</p><p><strong>Results: </strong>In 2021, these tumors accounted for 96,913 new cases and 42,869 deaths worldwide. Brain cancer and MNBAC were the most common and fatal. Retinoblastoma showed the largest incidence increase, while neuroblastoma was the only tumor with rising mortality. Major regional disparities were observed, with East Asia having the highest brain cancer burden and sub-Saharan Africa experiencing the greatest retinoblastoma mortality. Incidence peaked in infants for hepatoblastoma, neuroblastoma, and soft tissue sarcomas, and in adolescents for bone tumors. Higher SDI correlated with higher neuroblastoma incidence, while lower-SDI regions had elevated mortality for multiple tumors.</p><p><strong>Conclusion: </strong>Substantial global and regional disparities persist in the burden of pediatric solid tumors. Enhancing early detection in low-SDI regions and implementing targeted strategies for high-burden tumors such as brain cancer and MNBAC are essential to reducing mortality.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 4","pages":"493-512"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing the enhanced recovery after surgery (ERAS) protocol for oncosurgeries in a tertiary level hospital in South India: Key steps and early outcomes.","authors":"Ashu S Mathai, Jithin M Abraham, Gincy A Lukachan, Nimmy Raju, Neethu Thankam, Litty B George, Sangeetha M Varghese","doi":"10.4103/ijc.ijc_706_24","DOIUrl":"10.4103/ijc.ijc_706_24","url":null,"abstract":"<p><strong>Background: </strong>The enhanced recovery after surgery (ERAS) pathway is the standard of perioperative care for major surgeries globally. However, integrating it into practice can be challenging, especially given the variety of healthcare systems in low- and middle-income countries. At our hospital, we aimed to establish the ERAS pathway phase-wise for oncosurgeries.</p><p><strong>Methods: </strong>We initiated the ERAS pathway in incremental steps, namely, drafting and team-building, trial run, consolidation, and expansion, with regular auditing and feedback at every stage. Six months after initiation (January to June 2024), we assessed our compliance rates and compared outcomes with historical controls (matched for age, surgical procedure, and ASA classification).</p><p><strong>Results: </strong>In the oncosurgical patients managed under the ERAS protocol, overall compliance was 70.4%, with maximum compliance for preoperative (77.17%) and least for postoperative elements (54.16%). Compared to matched cohorts, ERAS patients had significantly lower rates of postoperative complications (median ± IQR, 1.00 ± 0.00 versus 1.50 ± 1.00, P = 0.035) and duration of ICU (median ± IQR, 0.00 ± 2.00 versus 2.00 ± 3.00, P = 0.017) and hospital stay (median ± IQR, 7.00 ± 2.00 versus 8.00 ± 4.00, P = 0.035).</p><p><strong>Conclusions: </strong>Anesthesiologists can champion and build ERAS care pathways in hospitals by assembling a core team and systematically applying ERAS components during each surgical stage.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 4","pages":"513-520"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of miRNA in diagnosis of Wilms tumor and neuroblastoma.","authors":"Disha Kakkar, Saumyaranjan Mallick, Aijaz Ahmad, Ansh Goswami, Sandeep Agarwala, Aditya K Gupta, Sameer Bakhshi, K Devasenathipathy, Sandeep Mathur, Jagdish Prasad, Deepali Jain, Rachana Seth, Venkateswaran K Iyer","doi":"10.4103/ijc.ijc_1255_22","DOIUrl":"10.4103/ijc.ijc_1255_22","url":null,"abstract":"<p><strong>Background: </strong>Wilms tumor (WT) and Neuroblastoma (Nb) are the two most common pediatric abdominal tumors that are difficult to differentiate due to anatomical proximity and often need an invasive procedure such as fine needle aspiration or biopsy. Pediatric tumors have differential expression of miRNA that can be used as a non invasive method to differentiate. Based upon the existing published literature, we designed a panel of four miRNAs (miR1180, miR143, miR124, and miR34a) to differentiate WT from Nb.</p><p><strong>Methods: </strong>This was a prospective study conducted over 2 years (2019-2021) at our center. A total of 17 cases, including 10 cases of WT and seven cases of Nb, were included in this study. Ribonucleic acid (RNA) extraction was conducted after confirmation of diagnosis, which was reverse transcribed to complementary deoxyribonucleic acid (cDNA). Real time polymerase chain reaction using cDNA was performed for analyzing expression levels of miR1180, 143, 124, and 34a.</p><p><strong>Results: </strong>The two biomarkers differentially expressed between these patients are miR143 and miR124 3p. miR143 is down regulated in WT (80% of cases), while up regulated in Nb (71.4% of cases), while miR124 3p is up regulated in WT (6/10:60%) and down-regulated in Nb cases.</p><p><strong>Conclusions: </strong>We conclude that miR143 and 124 might prove as useful biomarkers to differentiate between WT and Nb; however, more comprehensive evaluation is required for confirmation of the same.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 4","pages":"521-527"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}