Indian journal of cancer最新文献

{"title":"Multidimensional analysis of rectal cancer: Survival analysis and its trend with multiple variables - Single institutional ambispective study II.","authors":"Shaqul Qamar Wani, Talib Khan, Saiful Yamin Wani, Misba Hameed Baba, Aijaz Khan, Sajad Ahmad Rather, Mushtaq Ahmad Sofi, Nazir Ahmad Dar","doi":"10.4103/ijc.ijc_394_23","DOIUrl":"10.4103/ijc.ijc_394_23","url":null,"abstract":"<p><strong>Introduction: </strong>Rectal cancer is a significant health problem. The study was conducted to analyze the overall survival (OS) and disease-free survival (DFS) and their relation to multiple patient-related clinicodemographic factors.</p><p><strong>Materials and methods: </strong>This ambispective study was conducted at a tertiary care referral and university teaching hospital. The data from the patient records were collected for the year 2014-2016 and followed till June 2021. OS and DFS and their relation with multiple clinicodemographic factors like smoking habits, marital status, stage of the disease, circumferential resection margin (CRM), and the treatment received were assessed.</p><p><strong>Results: </strong>The overall 5-year mean DFS and OS for all stages were 59.13 and 56.81 months, respectively. The mean DFS and OS were significantly better for stage I disease at 83.96 and 84.16 months and least for stage IV at 27.72 and 32.61 months, respectively, (P = 0.001). The mean 5-year DFS and OS in patients undergoing upfront surgery were significantly higher at 59.93 and 62.70 months compared with patients who received other treatment options at 51.11 and 49.85 months (P = 0.002 and P = 0.001), respectively. The association of CRM and 5-year DFS was statistically significant (P = 0.001) with improved survival in CRM-negative at 62.91 months compared with 43.68 months in CRM-positive patients. Similarly, there was a significant 5-year OS benefit in CRM-negative patients (P = 0.001). The 5-year DFS and OS were statistically significant (P = 0.028 and P = 0.053) among married patients, respectively.</p><p><strong>Conclusions: </strong>The study revealed the impact of stage, CRM, upfront surgery as well as marital status on the OS and DFS. This study reveals that survival patterns can be improved if cancer is detected early and receive proper treatment at proper time.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"257-264"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary renal neuroendocrine with lymph nodal metastasis occurring in a horseshoe kidney: Report of a rare case with discussion on grading issues.","authors":"Prachi Gupta, Nilesh Sable, Gagan Prakash, Santosh Menon","doi":"10.4103/ijc.ijc_879_21","DOIUrl":"10.4103/ijc.ijc_879_21","url":null,"abstract":"<p><strong>Abstract: </strong>Primary renal well-differentiated neuroendocrine tumors (WDNETs) are uncommon tumors that differ in histological pattern, biological behavior, and response to treatment. There is a considerable correlation between WDNETs and congenital or acquired renal anomalies. We report a WDNET in a horseshoe kidney with lymph nodal metastasis in a 35-year-old male. This rare occurrence is discussed, especially the grading of these tumors and the value and vagaries of Mib-1 labeling index.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"316-319"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary undifferentiated pleomorphic sarcoma of biceps femoris.","authors":"Ravikanth Reddy","doi":"10.4103/ijc.ijc_851_21","DOIUrl":"10.4103/ijc.ijc_851_21","url":null,"abstract":"<p><strong>Abstract: </strong>Malignant fibrous histiocytoma-currently known as undifferentiated pleomorphic sarcoma-is the most common soft tissue sarcoma of mesenchymal origin. Undifferentiated pleomorphic sarcoma is commonly located in the extremities, trunk, head, and neck in decreasing order of frequency. We report a case of primary undifferentiated pleomorphic sarcoma of the biceps femoris muscle in a 50-year-old man complicated by hemorrhage. Diagnostic workup included imaging, histopathology, and positive results on immunohistochemistry, especially CD68. High-grade liposarcoma and rhabdomyosarcoma were regarded as differential diagnosis of undifferentiated pleomorphic sarcoma. Demonstration of spontaneous hemorrhage within the lesion on follow-up ultrasonography done at one month from the time of diagnosis deserves special mention in this report. Radical excision with tumor-free margins of the biceps femoris and tendon reconstruction were undertaken. MRI at six-month follow-up did not reveal tumor recurrence at the site of surgery and CT chest did not reveal metastases.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"312-315"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic multicentric Castleman disease with TAFRO syndrome: A rare case report.","authors":"Deepak Kumar, Rahul Kumar, Tanvi Batra, Atul Kakar","doi":"10.4103/ijc.ijc_5_25","DOIUrl":"10.4103/ijc.ijc_5_25","url":null,"abstract":"<p><strong>Abstract: </strong>Castleman disease is a rare lymphoproliferative disorder. It presents with localized or generalized lymph node enlargement with a multitude of inflammatory symptoms. The etiology is largely unknown; however, human herpes virus 8 and Interleukin 6 have been found to be associated with some of these cases. We hereby report a case of a 60-year male, with no known comorbidities, who presented with complaints of dry cough and breathlessness for 25 days and low-grade fever for 15 days. The patient also had anemia, thrombocytopenia, and anasarca. Infective work-up was negative, and imaging revealed generalized lymphadenopathy. An excisional biopsy from the lymph node helped in clinching the diagnosis.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"324-326"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bladder preserving approach for treatment of primary osteogenic sarcoma of bladder: A rare case report.","authors":"Ravi Batra, Sneha Yadav, Mayur Chaure, Shreyak Garg, Saurabh Uplenchwar, Dilip Gupta","doi":"10.4103/ijc.ijc_823_21","DOIUrl":"10.4103/ijc.ijc_823_21","url":null,"abstract":"<p><strong>Abstract: </strong>Here, we present a rare case of a 74-year-old woman with intermittent haematuria for 6 months. Computed tomography urography showed an ill-defined heterogeneously enhancing soft tissue lesion near the neck of the bladder. The patient was advised of radical cystectomy with an ileal conduit for which the patient was unwilling. Hence, transurethral resection of bladder tumor was performed. Histopathological evaluation of surgical specimen revealed it to be primary osteosarcoma of the urinary bladder. The patient was given radiotherapy. Regular follow-up revealed no abnormality, and the patient showed excellent response with normal urinary tract function. Primary urinary bladder sarcomas are extremely rare clinical entities. To date, in scientific literature, fewer than 50 primary bladder osteosarcomas have been reported.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"305-307"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and outcomes of isolated myeloid sarcoma without bone marrow involvement: An experience from a tertiary cancer care center in India.","authors":"A H Rudresha, Antony G F Thottian, Sreevalli Anantharamu, L K Rajeev, Pravin Ashok Khandare, K Govind Babu, D Lokanatha, Linu Abraham Jacob, M C Suresh Babu, K N Lokesh, Smitha Saldanha, G V Giri, C S Premalatha, Geeta V Patil Okaly","doi":"10.4103/ijc.ijc_84_22","DOIUrl":"10.4103/ijc.ijc_84_22","url":null,"abstract":"<p><strong>Background: </strong>Myeloid sarcoma (MS) refers to extramedullary proliferation of blasts of myeloid lineages that disrupts the normal architecture of the tissue in which it is found. Due to its rarity, prognostic factors and optimal management are yet unknown.</p><p><strong>Materials and methods: </strong>Medical records of patients diagnosed with MS without marrow involvement and with no history of previous acute myeloid leukemia (AML) were retrieved. Diagnosis was made by immunohistochemical analysis of fixed paraffin tissue. Clinical features and treatment outcomes were recorded. Our aim was to study the clinical features and outcomes of cases of isolated MS diagnosed at our institute from 2010 to 2018.</p><p><strong>Results: </strong>Ten cases of isolated MS were diagnosed between 2010 and 2018. Median age was 29 years. Common sites of disease were soft tissues (40%) and lymph nodes (30%). Two patients refused treatment, one patient was treated with surgery followed by radiotherapy, and seven patients were treated with intensive chemotherapy. Also, 57.1% had complete response and 28.6% had partial response. The median survival for the entire cohort was 6.5 months. The median progression-free survival (PFS) and overall survival (OS) of patients treated with chemotherapy were 7 and 8 months, respectively.</p><p><strong>Conclusion: </strong>Isolated MS is a rare presentation of AML. It has a better prognosis than MS with concomitant marrow involvement. Systemic chemotherapy is an essential component of treatment, but the optimal timing is debatable, that is, at diagnosis or if it can be safely deferred until relapse.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"179-183"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of cell cycle-related kinase and SII with FIGO stage, lymph node metastasis, and prognosis of serous ovarian cancer.","authors":"Yu Chen, Li Yuan, Jianchao Meng, Zhiguo Luo, Li Gong","doi":"10.4103/ijc.ijc_723_23","DOIUrl":"10.4103/ijc.ijc_723_23","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ovarian cancer has no specific manifestations in the early stage, and most patients have advanced to the advanced stage when diagnosed for the first time. The 5-year survival rate for patients receiving standardized treatment is still low. The systemic immune inflammation index (SII) can comprehensively reflect host inflammation and immune balance status, and has good application value in evaluating the condition and prognosis of various malignant tumors. Cell cycle related kinase (CCRK) can regulate cell cycle, promote cell proliferation and division, and is closely related to the occurrence and development of various malignant tumors. Therefore, to detect the positive expression of CCRK and the level of SII index in serous ovarian cancer tissue, and to explore the relationship between CCRK and SII with the pathological characteristics and prognosis of serous ovarian cancer, analyze the possible mechanisms of CCRK and SII in the occurrence and development of serous ovarian cancer, and provide reference for clinical diagnosis and treatment of ovarian cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The malignant group included 315 patients with serous ovarian cancer who were hospitalized by us from January 2018 to January 2019, and 158 patients with ovarian serous cystadenoma were enrolled in the benign group. During the operation, the cancerous foci and lesion tissues of the two groups were collected. The expression of CCRK in pathological tissues was detected by immunohistochemistry. CCRK expression and SII levels in the benign and malignant groups, and patients with different clinicopathologic features of serous ovarian cancer were compared. Taking the average SII level of the malignant group as the grouping standard, the invalids were divided into SII high- and low-expression groups and observed until January 2022. To analyze the correlation between CCRK expression, SII, FIGO stage, lymph node metastasis, and prognosis of serous ovarian cancer. The survival of patients with CCRK-positive and -negative expression of this disease, and SII high and low expressions were statistically analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Positive CCRK expression was more prevalent in serous ovarian cancer tissues than in serous cystadenoma tissues, and the CCRK-positive grade in serous ovarian cancer was higher than that of cystadenoma. SII of patients with this disease was greater than that of those with serous cystadenoma and the difference was statistically significant (P &lt; 0.05). FIGO stage and lymph node metastases were associated with positive expression of CCRK in serous ovarian cancer (P &lt; 0.05). SII was correlated with FIGO stage, differentiation degree, lymph node metastasis, and serum CA125 level (P &lt; 0.05). Spearman correlation analysis showed that the expression of CCRK in invalids with serous ovarian cancer was positively correlated with FIGO stage and lymph node metastasis of serous ovarian cancer (r = 0.538, r = 0.605, P","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"273-280"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New approach to retroperitoneal laparoscopic adrenal surgeries: A new set of anesthetic challenges.","authors":"Gauri R Gangakhedkar, Rajendra D Patel, Madhavi Buddhi, Sameer A Rege","doi":"10.4103/ijc.ijc_802_21","DOIUrl":"10.4103/ijc.ijc_802_21","url":null,"abstract":"<p><strong>Abstract: </strong>Posterior retroperitoneoscopic surgeries for adrenal lesions are steadily gaining popularity over the transperitoneal approach because it allows easier surgical access and reduces the intraoperative and postoperative morbidity. Martin Walz et al. has been a pioneer in describing the modified prone jack-knife position which provides the surgeons a distinct advantage over the conventional prone jack-knife position. The technique has shown a distinct advantage in terms of reduced blood loss, lesser postoperative pain, and shorter length of hospital stay. However, this unconventional position makes some unconventional demands from the anesthetist in terms of the resources required, potential hemodynamic instability, and difficulty in ventilation. To the best of the author's knowledge, this case series is the first attempt at describing the anesthetic challenges faced during retroperitoneal laparoscopic adrenalectomy performed in this novel position. Through these five cases, we aim to provide insight into the intricacies of anesthetic management for this surgical approach with byzantine anesthetic implications.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"301-304"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leiomyomatosis peritonealis disseminata associated with large uterine myoma without history of surgery: A case report and review of literature.","authors":"Jung M Byun, Hwa J Cho, Ye S Kim, Tae I Ku","doi":"10.4103/ijc.ijc_843_21","DOIUrl":"10.4103/ijc.ijc_843_21","url":null,"abstract":"<p><strong>Abstract: </strong>Leiomyomatosis peritonealis disseminata (LPD) is a rare benign disease characterized by multiple smooth muscle nodules disseminated on the omental and peritoneal surfaces. Its pathogenesis remains unknown. Parasitic LPD is thought to result from uterine myoma surgery and myoma morcellation. Here, we report the first case of LPD associated with a large uterine myoma without a history of surgery. A 47-year-old woman presented with abdominal distension and a palpable abdominal mass at an outpatient clinic. During surgery, a myoma of approximately 30 cm and multifocal myofibroblastic tissue spreading on the omentum, which was compressed by uterine myoma, were observed. The patient underwent a total hysterectomy and omental resection. The pathological examination confirmed the diagnosis of LPD. This report reveals that LPD can be detected in a patient with a large uterine myoma that developed in a nulligravida woman who was not administered exogenous hormones and had no history of uterine surgery. Therefore, we should examine the intraperitoneal cavity closely to identify LPD during large myoma surgeries.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"308-311"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary pulmonary paraganglioma: Report of two cases with one case showing cytokeratin positivity.","authors":"Sunil Pasricha, Ankur Kumar, Ankush Jajodia, Laleng Darlong, Anurag Mehta","doi":"10.4103/ijc.ijc_902_21","DOIUrl":"10.4103/ijc.ijc_902_21","url":null,"abstract":"<p><strong>Abstract: </strong>Primary pulmonary paraganglioma (PPP) is a rare tumor, with few cases described in the literature. Here, we report two cases of PPP, one of which shows cytokeratin (CK) positivity, along with a literature review. In the first case, a 76-year-old male patient presented with a right-lung peribronchial mass, while in the second case, a 53-year-old male, presented with a right middle lobe mass. In both cases, the guided biopsy revealed a similar morphology comprising a tumor with polygonal cells in a back-to-back nested pattern, showing strong immunoexpression with synaptophysin and chromogranin. In the first case, a heterogenous immunoexpression of CK was observed, which was an unusual finding. In small biopsy specimens, PPPs with an aberrant CK expression can be misdiagnosed as pulmonary carcinoids or non-small cell lung carcinoma, which have distinct prognostic and therapeutic implications. Both cases underwent lobectomy, and the findings were confirmed on the resection specimen. The presented cases highlight the role of diligent histomorphological examination, coupled with clinico-radiological input and a judicious immunohistochemistry panel, to avoid erroneous interpretation and management.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 2","pages":"320-323"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}