Indian journal of cancer最新文献

{"title":"Can preoperative 18F-fluorodeoxyglucose positron emission tomography parameters predict the molecular subtype of breast cancer?","authors":"Mehmet Esat Duymus, Abdullah Bulgurcu, Umit Ogur, Sirma Ercan, Abidin Kilincer","doi":"10.4103/ijc.ijc_1412_21","DOIUrl":"10.4103/ijc.ijc_1412_21","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the predictive value of metabolic parameters in detecting invasive breast cancer molecular subtypes.</p><p><strong>Methods: </strong>We enrolled 112 patients who had a preoperative 18F-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG PET-CT) scan and were operated on with a diagnosis of invasive breast cancer between January 2017 and August 2020. We evaluated associations among maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and clinicopathological findings by dividing the specimen into three tumor subtypes according to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER-2) expressions.</p><p><strong>Results: </strong>There was a significant difference between the three groups in the SUVmax value of axillary lymph node metastasis (P = 0.014), but no significant difference was revealed for TLG and MTV (P = 0.858 and P = 0.083, respectively). There was a significant difference between groups in SUVmax and TLG (P < 0.001 and P = 0.001, respectively) for the primary tumor, but no significant difference was observed in MTV (P = 0.051).</p><p><strong>Conclusion: </strong>We suggest that primary tumor SUVmax can be used to differentiate triple-negative patients from other subgroups, and primary tumor TLG can be used to distinguish hormone receptor positive (HR+) patients from other subgroups.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"96-103"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Streamlining the radiotherapy practice through multidisciplinary peer review rounds: An initial 4-year experience from an Indian radiotherapy department.","authors":"Vysakh Raveendran, Ganapathi Raman Rajendran, Dinesh Makuni, Niyas Puzhakkal","doi":"10.4103/ijc.ijc_1391_21","DOIUrl":"10.4103/ijc.ijc_1391_21","url":null,"abstract":"<p><strong>Aim and background: </strong>Multidisciplinary peer review is a proven and effective quality control method in radiotherapy. This study reports and analyzes the impact of the peer review rounds of a modern radiotherapy department during the first 4 years.</p><p><strong>Subjects and methods: </strong>Prospectively documented data for 183 peer review sessions consisting of 3725 patients from June 2017 to May 2021 were obtained. The proportion of cases that required major (unacceptable and requires an immediate correction before delivery) and minor plan changes (not ideal, but still allowable for delivery) were analyzed on a site-specific basis. Pareto charts were plotted for each site to demonstrate the reasons for plan changes.</p><p><strong>Results: </strong>Among the cases reviewed, 197 plans (5.29%) required any plan modifications; among these, 111 (2.98%) were major changes, while 86 (2.31%) cases required minor changes. The major changes suggested had decreased from 5.84% to 1.58% over time. The reasons for plan changes were site dependent. Frequent reasons for major plan change were modification in clinical target volume (63.06%), followed by a change in dose or fractionation (24.32%). Minor plan changes were mainly due to changes in normal tissue contour or dose (32.56%), followed by field port or MLCs (23.26%).</p><p><strong>Conclusions: </strong>Adherence to peer review practices since the establishment of the department has led to a considerable reduction in plan modifications with time as a result of consistent improvement in the radiotherapy processes.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"89-95"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of cognitive-behavioral therapy on distress management among head and neck cancer patients undergoing surgery at a tertiary care center in Eastern India.","authors":"Debiprasad Mohanty, Venkatarao Epari, Aalapti Singh, Suvendu Narayan Mishra, Twinkle Rout, Sunil Agrawala","doi":"10.4103/ijc.ijc_1137_21","DOIUrl":"10.4103/ijc.ijc_1137_21","url":null,"abstract":"<p><strong>Background: </strong>A diagnosis of cancer increases susceptibility to stress; thus, cancer patients are at high risk for a variety of emotional disorders, including anxiety, traumatic stress, and depression. Psychological distress may have multiple negative impacts on health outcomes. Surgical cancer patients are at an increased risk of cancer-related fatigue and psychological distress. Studies in the West have shown that there is a 40%-80% reduction in cancer-related distress if the patients are subjected to appropriate psycho-oncological interventions.</p><p><strong>Objectives: </strong>The aims of this study were to 1) screen head and neck cancer patients for distress by using a cancer-specific questionnaire, 2) to test the association of cancer-related distress with the sociodemographic characteristics of patients, and 3) to evaluate the effect of cognitive-behavioral therapy (CBT) on the distress level of head and neck cancer patients about to undergo surgery.</p><p><strong>Methods and materials: </strong>A pre-tested, semi-structured, self-administered 23-item Questionnaire on Stress in Cancer patients (QSC-R23) were used to measure the level of distress. Three sessions of CBT of 1-hour duration on every alternate day were given to elicit the response. Categorical data were analyzed using the Chi-square test. Paired sample t test was applied to compare the pre and post scores. The correlation was done to compare continuous variables by using Pearson's correlation test. Linear regression analysis was performed to elicit the effect of other associated variables.</p><p><strong>Results: </strong>The mean age of the 94 participants was 54.64 (±10.97) years. The mean pre-score was 60.06 (±20.42), and the mean post-score was 34.63 (±5.3). There was a significant improvement in the post-score (P = 0.0001), implying a reduction in stress among the study participants after the three sessions of CBT. Participants with middle/high monthly family income (P = 0.35, 95% CI = 0.639-17.418), with no past medical history (P = 0.35, 95% CI = 0.639-17.418) and no past psychiatric history (P = 0.005, 95% CI = 3.621-20.162) were more likely to benefit from the intervention.</p><p><strong>Conclusion: </strong>Owing to the lack of supportive literature from India, it is assumed that the prevalence rates of cancer-related distress in patients may be underestimated, resulting in a lack of availability of suitable intervention(s). However, this study has successfully reported that CBT can reduce the distress levels among cancer patients. However, there is still a need to explore this research and produce more relevant evidence-based literature.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"52-56"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delay in the diagnosis of oral cancer in India, time to focus toward capacity building of physicians: A prospective observational study.","authors":"Guru C Sahu, Ravi Shankar, Hitesh R Singhavi, Dipti Daga, Dharmendra K Rai, Monika Gupta, Aseem Mishra","doi":"10.4103/ijc.ijc_44_22","DOIUrl":"10.4103/ijc.ijc_44_22","url":null,"abstract":"<p><strong>Background: </strong>Delay in diagnosis of head and neck cancers is responsible for advanced presentation of the disease leading to increased morbidity and mortality.</p><p><strong>Methods: </strong>A questionnaire-based prospective observational study consisting of 150 patients was performed in a tertiary care center established in North India. The factors responsible for professional and patient delay including demographic details and the clinical examination findings, health-related behavior, socio-economic status based on modified Kuppuswamy's scale, and the health care factors were also evaluated.</p><p><strong>Results: </strong>The mean age of the patients at the time of diagnosis was 48.32 years (S.D: 12.467 and range 27-80 years). Male patients showed predominance with a ratio of 11.5:1. Buccoalveolar cancers were the most common sites, whereas 55% had nodal metastasis and 70% were advanced stage cancers. Overall advanced stage patients (p < 0.02) and node positive patients (p < 0.04) were present significantly more in those with the physician's delay (P1D). There was higher P1D in patients with no tobacco habits (76.9% vs 53.3%) (p < 0.05). Self-motivated individuals had significantly shorter patient delay (p < 0.00); however, physician delay was similar.</p><p><strong>Conclusion: </strong>Circumventing physicians delay by training and capacity building of the general physicians will lead to early diagnosis and timely treatment of the head and neck cancer patients.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"128-134"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus infection in non-Hodgkin lymphoma: A case series.","authors":"Kunal Jobanputra, Rahul Ravind, Yashwant Kashyap, Avinash Bonda, Bhausaheb Bagal","doi":"10.4103/ijc.ijc_439_21","DOIUrl":"10.4103/ijc.ijc_439_21","url":null,"abstract":"<p><strong>Abstract: </strong>Cytomegalovirus, a common infection in immunocompromised hosts, can cause clinical manifestations ranging from asymptomatic or mild infection to severe end-organ involvement. Cytomegalovirus infection in hematologic malignancies is often reported in patients receiving allogeneic stem-cell transplant and less commonly in nontransplant settings. Disease-related impaired host immunity and drug-induced immunosuppression are important risk factors. We describe three cases of cytomegalovirus end-organ disease - one case of life-threatening encephalitis, possibly due to cytomegalovirus, and two cases of treated cytomegalovirus retinitis.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"145-148"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence versus practice involving universal acceptance of neoadjuvant chemotherapy in muscle-invasive bladder cancer: Results from a tertiary care center in India.","authors":"Shivcharan Navriya, Harkirat Singh Talwar, Ankur Mittal, Sunil Kumar, Vikas Kumar Panwar, Amit Sehrawat, Arup Kumar Mandal","doi":"10.4103/ijc.ijc_1529_21","DOIUrl":"10.4103/ijc.ijc_1529_21","url":null,"abstract":"<p><strong>Background: </strong>We reviewed the pattern of neoadjuvant chemotherapy (NACT) utilization at our center for patients with muscle-invasive bladder cancer (MIBC) to analyze the reasons behind the delay in cystectomy.</p><p><strong>Methods: </strong>A retrospective study was planned to review all the cases of carcinoma bladder cT2-T4, N0-3, and M0 with muscle invasion, planned for NACT followed by radical cystectomy (RC) from September 2019 to March 2021. The aim of the study was to identify the barriers and factors that cause a delay in the initiation and continuation of neoadjuvant chemotherapy as well as a delay in radical cystectomy masking the proposed survival advantage of neoadjuvant chemotherapy.</p><p><strong>Results: </strong>A total of 41 patients with MIBC were planned for NACT. The mean age was 53.75 years (range: 24-68 years). The average time from diagnosis to Transurethral resection of bladder tumor (TURBT), from TURBT to initiation of NACT, for completion of NACT, and from completion to NACT to RC were 17.25, 45.28, 73.15, and 20.12 days, respectively. Out of the 41 patients, 32 (78.1%) received at least the first cycle of NACT, 19 (46.3%) completed NACT, and eight (19.5%) underwent RC. Reasons for delay were attributed to poor compliance, financial reasons, adverse events, subjective feeling of well-being, and COVID-19-associated lockdown.</p><p><strong>Conclusion: </strong>Several patient-related, treatment-related, and disease-related factors have been identified that result in the underutilization of NAC and unnecessary delay in radical cystectomy. In view of a logistical delay due to these factors, NAC can be avoided in those patients who are expected to have poor compliance, who come from remote areas, or have poor access to health care.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"111-119"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haploidentical stem cell transplantation in newly diagnosed high-risk neuroblastoma: Results from a single-arm, prospective study from India.","authors":"Venkateswaran V Swaminathan, Ramya Uppuluri, Satish K Meena, Harika Varla, Rumesh Chandar, Revathi Raj","doi":"10.4103/ijc.ijc_999_21","DOIUrl":"10.4103/ijc.ijc_999_21","url":null,"abstract":"<p><strong>Background: </strong>With increasing data on graft-versus-tumor (GVT) effect in neuroblastoma, we aimed to evaluate the possibility of haploidentical stem cell transplantation (HSCT) as a technique to induce GVT and thereby improve outcomes in high-risk neuroblastoma.</p><p><strong>Patients and methods: </strong>We performed a prospective, single-arm study and included children from 18 months to 18 years of age diagnosed with high-risk neuroblastoma and who underwent a haploidentical HSCT from a parent donor. All children were started on induction chemotherapy as per the SIOP-Europa-Neuroblastoma (SIOPEN) protocol, followed by assessment and surgery when feasible. Conditioning in the unmanipulated graft included thiotepa/fludarabine/busulfan. With a T-depleted graft, conditioning included rabbit anti-thymocyte globulin/fludarabine/thiotepa/melphalan.</p><p><strong>Results: </strong>Of the five children, one child received T-depleted and four children received T-replete stem cells with posttransplant cyclophosphamide, with 100% engraftment, no regimen-related toxicities, and documented remission. Grade I/II skin GVHD occurred in all children who responded to steroids. We administered involved-field radiotherapy in four children around D + 60-75 post-HSCT, followed by 13-cis retinoic acid. At 1 year post-HSCT, three had isolated central nervous system relapse; one child had isolated pelvic bone relapse. One child relapsed 2 months post-HSCT. Progression-free survival was 12 months in 4/5 children and 6 months in one child. All except one child succumbed to progressive disease post relapse.</p><p><strong>Conclusion: </strong>Children with high-risk neuroblastoma continued to relapse within a year post-HSCT in our cohort. Significant improvement in outcomes was not demonstrated with haploidentical HSCT. We urgently need new strategies including deeper remission induction with upfront metaiodobenzylguanidine (MIBG) therapy followed by HSCT to improve the outcomes.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"32-36"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral monocyte count is associated with the risk of liver metastasis: A study of 7187 newly diagnosed patients with colorectal cancer.","authors":"Yue Yang, Lijie Song, Jingyu Cao, Wanting Zeng, Jing Liu, Xuetao Shi, Lei Zhao","doi":"10.4103/ijc.ijc_1126_21","DOIUrl":"10.4103/ijc.ijc_1126_21","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of the absolute peripheral blood monocyte count (AMC) on the risk of synchronous colorectal liver metastasis (synCRLM).</p><p><strong>Materials and methods: </strong>AMC as well as other baseline clinical characteristics between the synCRLM+ group (with synCRLM) and the synCRLM - group (without synCRLM) were measured. Taking AMC of 0.47 × 109/L as the cut-off value, the prevalence of synCRLM was compared between AMC-high level group (AMC ≥ 0.47 × 109/L) and AMC-low level group (AMC ≥ 0.47 × 109/L); significant predictors for synCRLM were analyzed by logistic regression analysis.</p><p><strong>Results: </strong>The AMC value of the synCRLM- group was significantly lower than that in the synCRLM+ group. The difference was statistically significant (Mann-Whitney U test, Z = -6.546, P = 0.001). There was no significant difference in age, the primary site of tumor, and tumor size between the two groups. The prevalence of synCRLM in the AMC-low group was lower than that in the AMC-high group, and the difference was statistically significant (χ2 = 34.861, P = 0.001). At the same time, univariate and multivariate regression analyses showed that (elevated) AMC, eosinophil, basophil, triglyceride, alanine transaminase (ALT), alkaline phosphatase (ALP), carbohydrate antigen 19-9 (CA19-9), tumor stage, and distant metastasis status were risk factors of synCRLM, with AMC found to be an independent and the highest risk factor for synCRLM (hazard ratio [HR]: 1.455, [95% confidence interval {CI}: 1.012-2.093], P = 0.043).</p><p><strong>Conclusion: </strong>In conclusion, elevated AMC is highly associated with an increased risk of colorectal liver metastasis (CRLM).</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"45-51"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare complication of chylous ascites following surgery and radiotherapy in endometrial carcinoma managed by diet modification: Case report.","authors":"Rujuta N Hantodkar, Bijal Patel, Pariseema S Dave, Neil Palkhiwala","doi":"10.4103/ijc.ijc_503_21","DOIUrl":"10.4103/ijc.ijc_503_21","url":null,"abstract":"<p><strong>Abstract: </strong>Chylous ascites is an uncommon complication seen in gynecological malignancies. The incidence of postoperative chylous ascites in gynecological malignancies is 0.17%. It is the extravasation of milky chyle into the peritoneal cavity due to lymphatic obstruction or injury and is diagnosed by the detection of triglyceride levels greater than 200 mg/dl in ascitic fluid. The site of leakage can be determined by lymphangiography or lymphoscintigraphy. The majority of the cases of chylous ascites can be treated by conservative methods, such as a dietary modification to a low-fat high-protein diet, bowel rest, total parenteral nutrition, medications, and large-volume paracentesis. If these measures fail, surgical modalities such as laparotomy or peritoneovenous shunting are employed. In our case, the patient was successfully managed on dietary modification alone. This case report emphasizes the importance of conservative management for chylous ascites following surgery and radiotherapy in endometrial carcinoma.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"153-155"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin and soft tissue manifestations in amyloid light-chain amyloidosis.","authors":"Rup J Sarma, Lingaraj Nayak, Bhausaheb P Bagal","doi":"10.4103/ijc.ijc_1489_21","DOIUrl":"10.4103/ijc.ijc_1489_21","url":null,"abstract":"","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"173-174"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}