Indian journal of cancer最新文献

{"title":"Salivary interleukin-10 and interleukin-17 - Potential biomarkers for assessing oral cancer and oral potentially malignant disorders - A comparative study.","authors":"S Jayachandran, Manoharan Preethi, Nivethitha Nagarajan","doi":"10.4103/ijc.ijc_610_21","DOIUrl":"https://doi.org/10.4103/ijc.ijc_610_21","url":null,"abstract":"<p><strong>Background: </strong>Staging of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) is considered as the most important prognostic indicator, but salivary proteins such as interleukins (ILs) can serve as potential biomarkers. The aim of this study was to assess the presence of salivary IL-10 and IL-17 in OSCC and OPMD (oral submucous fibrosis and oral leukoplakia).</p><p><strong>Materials and methods: </strong>This was a hospital-based, in vivo, cross-sectional, comparative study. A total of 90 patients (N = 90) were included in the study. Whole unstimulated saliva was collected and subjected to enzyme-linked immunosorbent assay (ELISA): 30 from histopathologically confirmed OSCC (Group 1, n = 30), 15 from clinically diagnosed OSMF (Group 2, n = 15), 15 from clinically diagnosed OL (Group 3, n = 15), 15 from patients who had tobacco habits but no clinical lesions of OSCC/OL/OSMF (Group 4, n = 15), and 15 from healthy controls (Group 5, n = 15).</p><p><strong>Results: </strong>Statistical analysis was performed by SPSS®25.0 (analysis of variance [ANOVA], Tukey's post hoc test, and Mann-Whitney U test). Both IL-10 and IL-17 were found in saliva. One-way ANOVA between groups showed IL-10 did not vary significantly within groups (P = 0.853), but IL-17 varied significantly between groups (P = 0.000). Mann-Whitney U test used to compare IL-10 and IL-17 between stage III and IV of OSCC showed that they did not vary significantly.</p><p><strong>Conclusion: </strong>IL-17 can indicate the presence of ongoing inflammation toward developing OPMD/OSCC, proving it as a potent diagnostic biomarker. An increase in IL-17 with successive stages of OSCC proves it as a prognostic biomarker for OSCC.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"61 4","pages":"781-788"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between surgical compliance and survival outcome in patients with Ewing sarcoma.","authors":"Bin Chen, Hong-Zhuo Li, Xiao-Feng He","doi":"10.4103/ijc.IJC_138_21","DOIUrl":"https://doi.org/10.4103/ijc.IJC_138_21","url":null,"abstract":"<p><strong>Background: </strong>The impact of surgical compliance on survival outcomes in patients with Ewing sarcoma (ES) is unclear, so this study was performed to explore the association between them.</p><p><strong>Methods: </strong>We used the SEER*Stat software (version 8.3.6.1) to extract information on ES patients from the SEER database. Patients were divided into two groups based on their adherence to surgical recommendations: the surgical compliance group and the surgical noncompliance group. Categorical variables were expressed as percentages. Multivariate logistic regression and Chi-square test were used to explore variables related to surgical compliance. Univariate Cox regression analysis was used to initially select potential prognostic factors, and then the factors selected in the univariate Cox regression analysis were further analyzed in a multivariate Cox proportional risk model to ultimately determine the risk prognostic factors significantly related to the survival of patients with ES.</p><p><strong>Results: </strong>Multiple logistic regression analysis suggested that adults (OR = 0.373, 95% confidence interval (CI): 0.164-0.849), Grade IV (OR = 0.373, 95% CI: 0.164-0.849), and unmarried patients (OR = 0.568, 95% CI: 0.339-0.954) were more inclined to accept surgery recommendations, while patients from 2001 to 2010 were less compliant with surgery. Multifactorial Cox regression analysis suggested that surgical compliance was an independent prognostic factor for patients with ES. Through the Kaplan-Meier survival curves, we could clearly observe that the overall survival was higher in the surgical compliance group than in the surgical noncompliance group. Furthermore, subgroup analysis also reached similar conclusions.</p><p><strong>Conclusion: </strong>In this study, we found that surgical compliance was an independent predictor of patient prognosis. Furthermore, we found that age, tumor grade, year of diagnosis, and marital status may be related to surgical compliance.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"61 4","pages":"749-758"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective analysis of 26 cases of duodenal neuroendocrine tumor treated by endoscopic submucosal dissection.","authors":"Kehan Li, Tao Chen, Bensong Duan, Yingjie Ji, Jingze Li, Meidong Xu","doi":"10.4103/ijc.ijc_265_24","DOIUrl":"https://doi.org/10.4103/ijc.ijc_265_24","url":null,"abstract":"<p><strong>Background: </strong>Duodenal neuroendocrine tumors (D-NETs) are rare but clinically significant tumors that can occur in various parts of the duodenum, including the duodenal papilla. Endoscopic submucosal dissection (ESD) has emerged as a minimally invasive treatment option for D-NETs, offering potential advantages in terms of tumor removal and postoperative recovery. We aimed to retrospectively analyze the clinical characteristics and prognosis of ESD for D-NETs.</p><p><strong>Methods: </strong>A total of 26 cases of duodenal neuroendocrine tumors (27 lesions), including duodenal papillary neuroendocrine tumors, were studied retrospectively.</p><p><strong>Results: </strong>A total of 26 patients with D-NETs (27 lesions) were pathologically diagnosed, and 27 lesions were found by chance during endoscopy. The lesions included duodenal bulbar, descending part, and duodenal papilla. Nineteen tumors were <1 cm (70.4%) in diameter, and eight tumors were 1-2 cm (29.6%) in diameter. There were five cases of duodenal papilla NETs. G1: 24 (88.8%) and G2: 3 (11.1%). Endoscopic ultrasonography showed that 27 lesions were confined to the submucosa. One case was a neuroendocrine tumor 2 mm inside a tubular adenoma at the papilla. All operations were performed by senior doctors in the department. The total resection rate was 100%, and the incidence of intraoperative bleeding and perforation was 0. Delayed bleeding and perforation were 0. The shortest operation time was 25 min, and the longest was 70 min. Burning tumor cells at the basal resection margin were noted in 11 lesions, necessitating careful pathological assessment. There were 24 cases of G1 type and 3 cases of G2 type. All 26 patients underwent abdominal CT before operation to confirm the absence of lymph node and distal metastasis. One patient with papillary lesion had positive lesion base resection and was treated with additional operation. Temporary biliary and pancreatic duct stents were placed before or after ESD in all five cases of duodenal papillary lesions, and no biliary and pancreatic complications occurred after surgery. Postoperative follow-up gastroscopy and abdominal CT confirmed no recurrence or metastasis during a follow-up period of 3 months to 4.5 years. There was no recurrence or metastasis during a follow-up period of 3 months to 4 ½ years.</p><p><strong>Conclusion: </strong>ESD may be an effective and safe intervention for D-NETs ≤20 mm confined to the mucosa or submucosa of the duodenum, including the papilla. Clinicians should remain vigilant about potential complications during and after surgery. Duodenal ESD treatment NET has high requirements in terms of treatment technology, and clinicians should pay attention to the potential complications of ESD during operation.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"61 4","pages":"849-857"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"News in oncology.","authors":"Amol Rathod, Ritika Harjani Hinduja, Paul Simon","doi":"10.4103/ijc.ijc_1_25","DOIUrl":"https://doi.org/10.4103/ijc.ijc_1_25","url":null,"abstract":"","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"61 4","pages":"847-848"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of the long noncoding RNA CASC2 in acute myeloid leukemia and its prognostic significance.","authors":"Sida Peng, Qingqing Yang, Yuhang Pan, Huan Li, Jiani Wang, Pan Hu, Nana Zhang","doi":"10.4103/ijc.IJC_1365_20","DOIUrl":"https://doi.org/10.4103/ijc.IJC_1365_20","url":null,"abstract":"<p><strong>Background: </strong>Cancer susceptibility candidate 2 (CASC2) was found underexpressed in multiple types of human malignancies. However, the specific role of CASC2 in AML remains uncertain. The purpose of this study is to explore the expression of CASC2 in patients with AML and healthy donors and its prognostic significance in AML.</p><p><strong>Methods: </strong>Total RNA was isolated from bone marrow samples or peripheral blood samples of 87 patients with AML and 26 healthy adult donors. The expression of long noncoding RNA CASC2 was detected by quantitative real-time polymerase chain reaction. The association between CASC2 expression and other clinicopathological factors as well as its prognosis significance were analyzed.</p><p><strong>Results: </strong>The peripheral blood mononuclear cell (PBMC) expression level of CASC2 in AML was significantly lower than that in the healthy control cohort (P = 0.0048), and in the bone marrow samples, CASC2 was significantly upregulated in patients with AML after the achievement of CR (median value: 0.041, range: 0.015-0.064) compared with that at newly diagnosis (median value: 0.017, range: 0.008-0.041) (P = 0.002). The expression of CASC2 had a significant relationship with complete remission (P = 0.019). Survival data assessed by Kaplan-Meier curves showed that patients with lower CASC2 expression had shorter overall survival and disease-free survival than patients with higher CASC2 expression. Finally, Cox proportional hazards analysis demonstrated that CASC2 was an independent prognostic indicator for both OS (P = 0.013) and DFS (P = 0.001) of AML.</p><p><strong>Conclusions: </strong>LncRNA CASC2 may serve as a new molecular biomarker for the early diagnosis and of AML, and may be an independent prognostic factor affecting the survival of patients with AML.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"61 4","pages":"728-735"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated CNS blast crisis in pediatric CML - A case report and review of case reports of CNS blast crisis in adults.","authors":"Sangeeta S Mudaliar, Purva R Kanvinde, Minnie Bodhanwala, Archana Swami","doi":"10.4103/ijc.IJC_184_21","DOIUrl":"https://doi.org/10.4103/ijc.IJC_184_21","url":null,"abstract":"<p><strong>Abstract: </strong>Chronic myeloid leukemia is a myeloproliferative neoplasm which can present in chronic phase, accelerated phase, or blast crisis. Most of the children present in chronic phase. Tyrosine kinase inhibitors are used as a targeted therapy. Few children progress to blast crisis on therapy. The blast crisis occurs in the marrow. Very few cases are reported in adults with isolated central nervous system (CNS) blast crisis. Here we are reporting a rare case of isolated CNS relapse in a child.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"61 4","pages":"829-831"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of distress among cancer patients assessed during new patient counseling: A cross-sectional study.","authors":"Satheesan Balasubramanian, Jisha Abraham, V K Sobhith, Riyas Malodan","doi":"10.4103/ijc.ijc_797_21","DOIUrl":"https://doi.org/10.4103/ijc.ijc_797_21","url":null,"abstract":"<p><strong>Background: </strong>Distress is an unpleasant emotional feeling of uneasiness, sadness, worry, anger, helplessness, or guilt and is considered as the sixth vital sign of cancer. Understanding and managing distress at an early stage helps the patient to deal with cancer in a better way. The objective of the study is to estimate the pattern of distress among cancer patients assessed during new patient counseling and its association with demographic factors.</p><p><strong>Methods: </strong>This is a cross-sectional retrospective study conducted by reviewing the case record forms of patients for a period of 4 months. The study included cancer patients between the age of 18 and 75 who attended new patient counseling and reported a score on the NCCN distress thermometer. Those with incomplete information and history of known psychiatric or neurological disorders were excluded.</p><p><strong>Results: </strong>Among the 348 patients, 39.9% had a distress score of 4 or above, which is clinically significant distress. Nearly 75% of them reported that their distress has a psycho-social reason, and 25% reported that distress is due to physical reasons. Analysis of the association of gender and age with clinically significant distress revealed that women and younger age groups had higher distress. In our study, Christians had a higher association with clinically significant distress.</p><p><strong>Conclusion: </strong>More than one-third of the patients reported to have clinically significant distress. This emphasizes the key role of distress screening and new patient counseling in an oncology setting. This also stresses the need for a psychotherapeutic approach in managing psycho-social concerns of cancer patients.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"61 4","pages":"818-822"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant basal cell carcinoma of the back - A tumor of the neglect.","authors":"Deepika Malik, S V S Bala, Laxman Pandey, Rajeev K Seam","doi":"10.4103/ijc.ijc_361_21","DOIUrl":"https://doi.org/10.4103/ijc.ijc_361_21","url":null,"abstract":"<p><strong>Abstract: </strong>Giant basal cell carcinomas (GBCCs) represent only 0.5-1% of all basal carcinomas and are known to occur and behave differently than other basal cell carcinomas. We report a 93-year-old gentleman with GBCC of the back of superficial spreading histological type who we treated with radical radiotherapy with excellent local control. Nonaggressive histological subtypes of GBCC particularly the superficial type can be well managed with radiotherapy, especially in the elderly, and should be adequately utilized in carefully selected patients.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"61 4","pages":"842-844"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic myeloid leukemia during pregnancy complicated by dengue infection and pulmonary embolism.","authors":"Wasanthi Wickramasinghe, Anoma Weerawardena, Prabhodhana Ranaweera, Lallindra Gooneratne, Chandrika Wijeyaratne","doi":"10.4103/ijc.IJC_192_21","DOIUrl":"https://doi.org/10.4103/ijc.IJC_192_21","url":null,"abstract":"<p><strong>Abstract: </strong>Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the rearrangement of long arm of chromosomes 9 and 22, resulting in the Philadelphia chromosome, creating the fusion oncogene BCR-ABL1. Median age of onset of CML is 67 years. However, approximately a third of patients are of reproductive age at diagnosis. CML presenting during pregnancy is extremely rare, and there are no randomized controlled trials to address the optimal management of CML during pregnancy. We report a 38-year-old woman diagnosed with CML during her routine antenatal clinic booking visit, which was further complicated by dengue fever and pulmonary embolism during pregnancy. She was successfully managed by a multidisciplinary team, which resulted in the delivery of a healthy baby boy. This case adds to the literature on CML in pregnancy and reflects the importance of a multidisciplinary team approach when managing complicated patients who require timely rational interventions.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"61 4","pages":"832-835"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot study on inguinofemoral lymphadenectomy by sealing device - Ilsede study.","authors":"Ignacio Beamonte, Myriam Gracia, Jaime Siegrist, Yolanda Perez, Alicia Hernandez, Ignacio Zapardiel","doi":"10.4103/ijc.IJC_1408_20","DOIUrl":"https://doi.org/10.4103/ijc.IJC_1408_20","url":null,"abstract":"<p><strong>Objective: </strong>Our objective was to evaluate the impact of the use of a sealing device during inguinofemoral lymphadenectomy on the reduction of postoperative complications.</p><p><strong>Methods: </strong>A single-institution, prospective, nonrandomized study was carried out. Fifteen patients with vulvar cancer underwent wide excision and inguinal lymphadenectomy between May 2017 and April 2019. Five patients underwent lymphadenectomy with a bipolar sealing device, whereas the remaining 10 patients received the standard procedure. Postoperative complications including wound infection, seroma, and lymphedema were selected as the primary outcome.</p><p><strong>Results: </strong>Patients who underwent surgery using a sealing device showed significantly lower wound infection rate (0 cases, 0%) compared with patients who underwent the standard procedure (7 cases, 70%; P = 0.026). Incidence of seroma and lymphedema did not show statistically significant differences between groups.</p><p><strong>Conclusions: </strong>The use of a sealing device to perform the inguinofemoral lymphadenectomy in vulvar cancer could reduce the rate of wound infection compared with the standard procedure.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"61 4","pages":"736-740"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}