Immunopathologia Persa最新文献_第6页

Evaluation of humoral immune responses, effective factors on responses and re-infection in recovered COVID-19 patients 新冠肺炎康复患者体液免疫反应、反应有效因素和再感染的评估

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Immunopathologia Persa Pub Date : 2022-08-02 DOI: 10.34172/ipp.2022.33411

M. Asadi-Samani, Marziyeh Soltani, Dhiya Altememy, Fatemeh Imani, M. Moradi, S. Kheiri, Fatemeh Asadi-Samani

{"title":"Evaluation of humoral immune responses, effective factors on responses and re-infection in recovered COVID-19 patients","authors":"M. Asadi-Samani, Marziyeh Soltani, Dhiya Altememy, Fatemeh Imani, M. Moradi, S. Kheiri, Fatemeh Asadi-Samani","doi":"10.34172/ipp.2022.33411","DOIUrl":"https://doi.org/10.34172/ipp.2022.33411","url":null,"abstract":"Introduction: Despite large studies on the COVID-19 pandemic, little evidence is available on immune response in recovered patients. Objectives: The aim of this study was to investigate the humoral immune responses (IgM and IgG antibodies) in recovered COVID-19 patients and the role of risk factors and symptoms with respect to the immune responses. Patients and Methods: In this descriptive-analytical study, which was conducted by call-out method, the serum levels of IgM and IgG antibodies were measured using enzyme-linked immunosorbent assay (ELISA) in 248 recovered patients. Effective factors on immune response were determined. Re-infection was investigated through patient follow-up and using information drawn from the hospital information system. Chi-square, t test, ANOVA, and regression analysis in SPSS 15 and Stata 14 were conducted to investigate the relationship between variables. Results: IgG positivity was 86.3% among our participants. Among those who did not show antibody response to COVID-19 (IgM- and IgG-), the most common symptoms at admission were fever, muscle pain (90.9%), chills and anorexia (81.8%). IgG levels remained positive in recovered patients for over seven months. IgG response showed a significant relationship with body mass index, hospital stay length, smoking, residence place, mortality rate, vomiting, and appetite (P<0.05). The re-infection rate after recovery was only 1.6%. Conclusion: High seroprevalence of IgG antibody against COVID-19 and low re-infection rate in Chaharmahal and Bakhtiari province was observed. In addition, the effects of factors such as fever, muscle pain, chills, vomiting, and anorexia on immune responses were demonstrated. These results can be used to manage disease control efficiently, and follow up the treatment process and re-infection in the recovered patients.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45393661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of methacholine challenge test results in patients with chronic unexplained cough 慢性不明原因咳嗽患者的甲胆碱激发试验结果评价

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Immunopathologia Persa Pub Date : 2022-08-02 DOI: 10.34172/ipp.2022.31351

M. Rabieepour, Mahsa Sharifi Namin, M. Pashaei

{"title":"Evaluation of methacholine challenge test results in patients with chronic unexplained cough","authors":"M. Rabieepour, Mahsa Sharifi Namin, M. Pashaei","doi":"10.34172/ipp.2022.31351","DOIUrl":"https://doi.org/10.34172/ipp.2022.31351","url":null,"abstract":"Introduction: Asthma is one of the most common chronic diseases in adults characterized by variable airway obstruction. Asthma is diagnosed with wheezing and shortness of breath, however it sometimes manifests as a chronic cough that is difficult to diagnose and requires spirometry stimulation tests. Objectives: This study aimed to investigate the relationship between methacholine test results and respiratory symptoms in patients with chronic unexplained cough. Patients and Methods: In this cross-sectional study, 102 patients with chronic cough and normal basal spirometry were included. All patients underwent a methacholine challenge test, and their airway irritabilities were assessed. Then, the relationship between methacholine test results and clinical symptoms and also demographic characteristics were investigated. Results: Of 102 patients, 69 (67.6 %) and 33 (32.4%) were female and male, respectively. Most of patients were non-smoker (90.2%). Around 25 (24.5%) patients had a positive methacholine test. Rhinitis had a statistically significant difference between patients with positive and negative tests (positive test group: 48%, negative test group: 23.4%; P = 0.01). Postnasal discharge was reported in 60% of positive methacholine test patients, which was significant compared to the negative group (36.4%; P = 0.03). Most patients who had positive tests were housewives (76%). Logistic regression showed that female gender (OR: 7.75, 95% CI: 1.7-35.2), postnasal discharge (OR: 3.19, 95% CI: 1.25-8.2), rhinitis (OR: 3.02, 95% CI: 1.17-7.79), and allergy symptoms OR: 3.51, 95% CI: 1.35-9.18) were directly associated with a positive methacholine test. Conclusion: The presence of airway hypersensitivity, postnasal discharge, allergic rhinitis, female gender and the housewife’s job were strongly associated with a positive methacholine test.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49007549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidural abscess; a case report 硬膜外脓肿;病例报告

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Immunopathologia Persa Pub Date : 2022-07-20 DOI: 10.34172/ipp.2022.29315

Majid Zamani Alavijeh, Farhad Heydari, Ali R. Abootalebi

引用次数: 0

Evaluation of FLANG versus mitoxantrone and etoposide for the treatment of refractory/relapsed acute leukemia FLANG与米托蒽醌和依托泊苷治疗难治性/复发性急性白血病的疗效评价

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Immunopathologia Persa Pub Date : 2022-07-05 DOI: 10.34172/ipp.2022.27272

V. Mehrzad, M. Mirpourian, P. Farrokhi

{"title":"Evaluation of FLANG versus mitoxantrone and etoposide for the treatment of refractory/relapsed acute leukemia","authors":"V. Mehrzad, M. Mirpourian, P. Farrokhi","doi":"10.34172/ipp.2022.27272","DOIUrl":"https://doi.org/10.34172/ipp.2022.27272","url":null,"abstract":"Introduction: Failure to respond to the chemotherapy and relapse occurrence is considerably high in acute leukemia as one of the most common hematologic malignancies requiring emergent efficacious well-tolerated salvage therapy. However, varieties of regimens have been investigated, since the best approach with an optimal response is a question. Objectives: In our study, we aimed to compare the efficacy of FLANG (fludarabine, cytosine arabinoside, mitoxantrone and G-CSF) versus mitoxantrone and etoposide for the treatment of refractory/relapsed acute leukemia. Patients and Methods: In this retrospective cohort study, 45 patients with acute leukemia were randomly divided into two groups of salvage therapy with FLANG (n=23) and mitoxantrone and etoposide (n=22). The patients were followed for five years. Progression-free survival, response to the treatment, chemotherapy-induced toxicity based on Criteria for Adverse Effects version 4 (CTCAE-4), and mortality were compared between the groups. Besides, to estimate the survival Kaplan-Meier curve and Cox regression were used. Results: Comparison of the two regimens revealed insignificant differences in terms of response rate (P=0.87), chemotherapy-induced toxicity (P=0.22) and mortality rate (P=0.26) and etiology of mortality (P=0.98). The median progression-free survival following FALNG and the latter regimen was four months (95% CI: 3.183, 4.862) versus three months (95% CI: 1.777, 4.223; P=0.38 ), respectively. Conclusion: Based on this study, the two salvage regimens of mitoxantrone plus etoposide and FLANG were similar in terms of complete remission, progression-free survival, and toxicity for the cases with refractory/ relapsed acute leukemia. Trial Registration: This study has been registered in the Iranian Registry of Clinical Trials and obtained code IRCT20190618043939N1 (https://en.irct.ir/trial/40272, Ethical code# IR.MUI.MED.REC.1398.586).","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45806078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing a data set for registry of patients with adrenal insufficiency 设计肾上腺功能不全患者登记数据集

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Immunopathologia Persa Pub Date : 2022-07-02 DOI: 10.34172/ipp.2022.29324

Mehrnoosh Zakerkish, Mahboubeh Taghipour, H. Shahbazian, S. Nouhjah, Shirin Moazen, S. Latifi

{"title":"Designing a data set for registry of patients with adrenal insufficiency","authors":"Mehrnoosh Zakerkish, Mahboubeh Taghipour, H. Shahbazian, S. Nouhjah, Shirin Moazen, S. Latifi","doi":"10.34172/ipp.2022.29324","DOIUrl":"https://doi.org/10.34172/ipp.2022.29324","url":null,"abstract":"Introduction: Adrenal insufficiency is one of the most important life-threatening disorders with serious complications. Establishing a standard data element can provide earlier diagnosis, timely treatment, and follow-up to reduce disease crisis. Objectives: This study aimed to draft a data set for the registry of patients with adrenal insufficiency. Patients and Methods: The present cross-sectional study developed data elements for the registry of patients with adrenal insufficiency using a two-round Delphi technique of 2015. The informational elements selected by more than 75% of participants with a value of \"very high\" and \"high\" were accepted as the main elements. Results: The final data set included four main groups, 15 subclass and 114 data elements for the registry of patients with adrenal insufficiency. Our results have demonstrated that the primary data groups include administrative data; signs, symptoms, medical and family history data elements; paraclinical diagnostic data, treatment, and follow-up data to improve patient management. Conclusion: This study designed data set registry forms for patients with adrenal insufficiency using a standard method. Our finding indicated that, applying a uniform data set can provide better data management, patient care, and prevention of disease complications, especially in adrenal insufficiency disorder.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43895706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The positive association between various demographic characteristics and peak expiratory flow in employees of Zanjan university of medical sciences 赞詹医科大学员工不同人口学特征与呼气峰流量呈正相关

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Immunopathologia Persa Pub Date : 2022-06-24 DOI: 10.34172/ipp.2022.33402

Samad Ghodrati, Jafar Kiasatfar, N. Parsamanesh, Shohre Alian Samakkhah, M. Asadi-Khiavi, A. Pezeshgi

{"title":"The positive association between various demographic characteristics and peak expiratory flow in employees of Zanjan university of medical sciences","authors":"Samad Ghodrati, Jafar Kiasatfar, N. Parsamanesh, Shohre Alian Samakkhah, M. Asadi-Khiavi, A. Pezeshgi","doi":"10.34172/ipp.2022.33402","DOIUrl":"https://doi.org/10.34172/ipp.2022.33402","url":null,"abstract":"Introduction: Peak expiratory flow (PEF) is a reliable criterion for assessing respiratory capacity, and has a wide range of clinical application as a marker of asthma control. However, its wide variability undermines its efficacy. Objectives: This study was designed to evaluate PEF changes in staff of Zanjan University of Medical Sciences. Patients and Methods: Four hundred employees of this university participated in this cross-sectional study. Their PEF values were measured using peak flow meter in the morning at 8 AM and in the afternoon at 2 PM by three times for each individual, and then the highest amount of PEF was recorded about for measurement. Results: Obviously, PEF values were higher in the afternoon (43865 L/min) in comparison to the morning measurements (404.60 L/min) by paired t test (P<0.001). In addition, mean of PEF in the males was higher than the females in the morning (469.77 L/min, versus 355.94 L/min; independent t test, P<0.001), and also PEF mean of the morning and afternoon was higher in the males than females (404.6 L/min, versus 338.65 L/min, independent t test, P<0.001). Additionally, the variability level in the males and females was 8.39±6 and 8.47±4 L/min, respectively. There was a high correlation between the level of PEF variability and height (5.1). Meanwhile, a moderate correlation between PEF level and body mass index (BMI) was detected (1.47). There was not any correlation between the level of PEF and age. Conclusion: Based on our findings, PEF inter-individual variability depends on age, gender height, and BMI however, it is worthwhile that this PEF inter-individual variability to be measured just until 4 PM. All these variables were obtained under the range of 20%; however, relying on references, the variability of 20% is considered as normal.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43796828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum level of interleukin-17 in patients with psoriasis 银屑病患者血清白细胞介素-17水平的变化

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Immunopathologia Persa Pub Date : 2022-06-19 DOI: 10.34172/ipp.2022.29269

M. Sobhan, Hamid Reza Ghasemi Basir, Mohammad Ali Seif Rabiee, Fariba Shadfar

{"title":"Serum level of interleukin-17 in patients with psoriasis","authors":"M. Sobhan, Hamid Reza Ghasemi Basir, Mohammad Ali Seif Rabiee, Fariba Shadfar","doi":"10.34172/ipp.2022.29269","DOIUrl":"https://doi.org/10.34172/ipp.2022.29269","url":null,"abstract":"Introduction: Psoriasis is one of the most common chronic and disabling dermatoses. Recent studies showed that interleukin-17 (IL-17) may play a role in the development of psoriasis. Objectives: In this study, serum levels of IL-17 in psoriatic patients was compared with healthy controls; besides, in patients with psoriasis, serum levels of IL-17 were compared with pre-treatment levels, after topical treatments. Patients and Methods: In this case-control study, serum levels of IL-17 were measured and compared in 30 psoriatic patients and 30 healthy individuals matched to age, gender and body mass index. After evaluating the severity of psoriasis with PASI (Psoriasis Area Severity Index), they were treated with psoriasis topical corticosteroids for four weeks. IL-17 and PASI levels were re-evaluated after the treatment without any intervention. Results: Before the start of treatment, the mean±SD of serum level of IL-17 was 6.24±4.65 pg/mL and 2.0 ± 0.75 pg/mL in psoriatic patients and control group, respectively (P=0.001). The mean±SD of PASI severity scale of patients was 10.68 ± 6.65 and 6.16±4.2 before and after treatment, respectively (P<0.001). The mean±SD of serum level of IL-17 of patients before and one month after treatment were 6.24±4.65 and 3.34±1.77 pg/mL, respectively. Conclusion: In psoriatic patients, serum levels of IL-17 increased significantly compared to healthy subjects. Treatment of psoriasis with topical corticosteroids for four weeks reduced the serum level of IL-17 and the severity of disease.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44498215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Tumor budding in gastric adenocarcinoma; reflections on tumor microenvironment and programmed death ligand 1 (PD-L1) expression 胃腺癌的肿瘤出芽；对肿瘤微环境和程序性死亡配体1表达的思考

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Immunopathologia Persa Pub Date : 2022-06-19 DOI: 10.34172/ipp.2022.31365

Safaa M.M. Abd El Khalek, M. I. Halim

{"title":"Tumor budding in gastric adenocarcinoma; reflections on tumor microenvironment and programmed death ligand 1 (PD-L1) expression","authors":"Safaa M.M. Abd El Khalek, M. I. Halim","doi":"10.34172/ipp.2022.31365","DOIUrl":"https://doi.org/10.34172/ipp.2022.31365","url":null,"abstract":"Introduction: The significance of tumor budding and programmed death ligand 1 (PD-L1) has not been established in gastric adenocarcinoma (GAC). Objectives: This study evaluated tumor budding and PD-L1 expression with regard to tumor microenvironment, clinicopathologic parameters, and overall survival in GAC. Patients and Methods: Totally, 102 GAC cases were assessed immunohistochemically. The associations of tumor budding and PD-L1 with clinicopathologic features, tumor-infiltrating lymphocytes (TILs), tumor stroma percentage (TSP), and overall survival were analyzed. Results: High tumor budding (42.2% of cases) was correlated with distal tumor location, large tumor size, Helicobacter pylori infection, poor differentiation (P = 0.0008, 0.033, 0.011, and 0.005, respectively), lymphovascular invasion, high tumor and nodal stages, and TSP (all P < 0.0001). Tumor budding was highest in the low TILs/high TSP group. PD-L1 expression (43.1% of cases) was correlated with proximal location (p = 0.00021), poor differentiation (P = 0.036), N stage (P = 0.049), high TILs (P < 0.0001), and low tumor budding (P = 0.002). PD-L1 expression was highest in the low tumor budding / high TILs category (P < 0.0001). Cox regression showed that high tumor budding (hazard ratio [HR]: 15.282, P = 0.024, 95% confidence interval [CI]: 1.441–162.069) and positive PD-L1 (HR: 7.502, P = 0.015, 95% CI: 1.469–38.31) were independent prognostic factors for overall survival. Conclusion: Tumor budding is correlated with poor prognostic parameters, whereas PD-L1 expression is inversely correlated with tumor budding. Both are independent predictors of short overall survival. Anti-PD-L1 immunotherapy could be effective in GAC with nodal metastasis, especially cases with high TILs and low tumor budding.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44672637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Rate of clinically significant prostate cancer on repeated biopsy after a diagnosis of atypical small acinar proliferation 诊断为非典型小腺泡增生后反复活检的有临床意义的前列腺癌的比率

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Immunopathologia Persa Pub Date : 2022-06-14 DOI: 10.34172/ipp.2022.94

M. Yazdani, Payam Riahi Samani, H. Mazdak, Amid Yazdani

{"title":"Rate of clinically significant prostate cancer on repeated biopsy after a diagnosis of atypical small acinar proliferation","authors":"M. Yazdani, Payam Riahi Samani, H. Mazdak, Amid Yazdani","doi":"10.34172/ipp.2022.94","DOIUrl":"https://doi.org/10.34172/ipp.2022.94","url":null,"abstract":"Introduction: Current guidelines recommend repeat biopsy within 3-6 months for the diagnosis of atypical small acinar proliferation (ASAP) on prostate biopsy. Objectives: We aimed to evaluate the rate of progression of ASAP to clinically significant prostate cancer on repeat biopsy specimens and determine prognostic factors associated with progression. Patients and Methods: In a retrospective study we reviewed data of patients who had a prostate biopsy in our institution from March 2014 to March 2018. Gleason grade group (GGG) was conducted for pathology reporting. Logistic regression analysis was conducted for statistical analysis. Results: A total of 981 patients were identified of which 117 (12%) of them had a diagnosis of ASAP on their index biopsy. Out of these 16 (14%) patients underwent re-biopsy. Baseline clinicopathologic factors included a median age of 61 years, median pre-biopsy prostate-specific antigen (PSA) of 6.75 ng/mL and a mode of 1 core with ASAP. Median time interval between index and repeat biopsy was 10.5 months. The results of repeat biopsies were distributed across GGG system as follows; 12(75%) benign, 2 (12.5%) GG1, 1 (6.25%) GG2, and 1 (6.25%). We found no association between age, pre-biopsy PSA, and number of cores with ASAP, and progression of ASAP to clinically significant prostate cancer. Conclusion: Our study showed that patients with a diagnosis of ASAP are more likely to have a benign pathology on repeat biopsy. This finding supports previous studies regarding rethinking current guidelines for utility of repeat biopsy in patients with the diagnosis of ASAP.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42473911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between green tea drinking and the risk of colorectal cancer; a systematic review and meta-analysis 饮用绿茶与结直肠癌风险的关系系统回顾和荟萃分析

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Immunopathologia Persa Pub Date : 2022-06-09 DOI: 10.34172/ipp.2022.29287

M. Fakhri, S. Yousefi, M. Moosazadeh, M. Azadbakht, H. Fakheri

{"title":"Relationship between green tea drinking and the risk of colorectal cancer; a systematic review and meta-analysis","authors":"M. Fakhri, S. Yousefi, M. Moosazadeh, M. Azadbakht, H. Fakheri","doi":"10.34172/ipp.2022.29287","DOIUrl":"https://doi.org/10.34172/ipp.2022.29287","url":null,"abstract":"Introduction: Green tea drinking is one of the traditional methods to prevent colorectal cancer (CRC). The present study proposes a systematic review and meta-analysis approach to investigate the relationship between green tea drinking and CRC risk. Materials and Methods: The literature survey has been carried out using the previously published studies in the Google Scholar search engine and various electronic databases, including Scopus, Cochrane, Web of Science, Embase, and PubMed. The review process has continued until July 13, 2021. Besides, the Q test and I2 index were employed to evaluate the heterogeneity of the studies. STATA 14 software has been conducted to analyze the gathered dataset. It is essential to note that the significance level for statistical tests was set to 5% (P value < 0.05). Results: The results of 18 studies accomplished on 44,992 patients aged 19-80 years have been used to compute the relative risk of green tea consumption in CRC (OR [odds ratio] = 0.99; 95% CI: 0.83-1.18), colon (OR=0.97; 95% CI: 0.85-1.10), and rectum (OR=1; 95% CI: 0.86-1.16). Although green tea consumption was a protective factor in Asia and the United States, it was considered a risk factor in Australia. The general population studies classified green tea as a risk factor for CRC, while hospital studies considered this product as a protective factor. Conclusion: The findings showed that green tea had the most significant effect on reducing the colon cancer risk, while it had the minimum influence on CRC. Additionally, it did not affect rectal cancer. It is essential to note that these relationships were not statistically significant. Registration: The current protocol was also registered on PROSPERO (#CRD42021276257, https://www.crd.york. ac.uk/prospero/display_record.php?ID=CRD42021276257).","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47626097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0