Indian Journal of Gastroenterology最新文献

{"title":"Primary non-hepatoblastoma liver tumors in children-Defining the profile of a very rare subset of childhood tumors.","authors":"Abha Mehta, Badira Cheriyalinkal Parambil, Akshay Baheti, Venkata Ram Mohan Gollamudi, Maya Prasad, Vasundhara Patil, Sajid Qureshi, Mukta Ramadwar, Poonam Panjwani, Kunal Gala, Siddhartha Laskar, Nehal Khanna, Jifmi Jose Manjali, Sneha Shah, Girish Chinnaswammy","doi":"10.1007/s12664-025-01823-2","DOIUrl":"10.1007/s12664-025-01823-2","url":null,"abstract":"<p><strong>Background: </strong>Primary pediatric non-hepatoblastoma (n-HB) liver tumors are rare with limited literature on their clinical-epidemiological profile and outcomes. We audit the above in this study.</p><p><strong>Methods: </strong>Children diagnosed with n-HB primary liver tumors from January 2012 to December 2023 were analyzed retrospectively. Patients underwent contrast-enhanced computed tomography (CECT) of the abdomen and computed tomography (CT) of the thorax or fluorodeoxyglucosepositron emission tomography/computed tomography (FDG-PET/CT) for staging of malignant tumors. Treatment was administered based on the definitive diagnosis.</p><p><strong>Results: </strong>Sixty-nine patients formed the study cohort. The most common tumors in various age groups were infantile hepatic hemangioma (IHH)-66.7%, malignant rhabdoid tumor (MRT)-25%; six months to three years: MRT-25.0%, mesenchymal hamartoma and hemangioendothelioma-18.7% each; three to 10 years: hepatocellular carcinoma (HCC)-31.6%, undifferentiated embryonal sarcoma of the liver (UESL)-26.3%; and > = 10 years: HCC-45.4%, UESL-22.7%. Median alpha-fetoprotein (AFP) level in HCC was 131,249 ng/mL. Treatment was delivered to 65.8% patients. Chemotherapy for treated malignant tumors was administered in 81.5%, surgery in 85.2% and radiotherapy in 18.5%, alone or combined. In the different malignant cancer sub-types, the proportion of relapse/deaths in treated patients was HCC-22.2%, UESL-33.3%, rhabdoid-25%, hemangioendotheliomas-25% and sarcomas-25%.</p><p><strong>Conclusions: </strong>There was a high proportion of malignant rhabdoid tumors and higher serum AFP levels in HCC in our cohort. The overall outcomes of treated malignant tumors were relatively favorable, though limited by the sample size in this rare cohort.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"697-705"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13272263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in liver fat content in patients following pancreatic resections.","authors":"Agestino V Antony, Manoj T Pillai, Roby Das, Ramesh Rajan, Ananthakrishna V R","doi":"10.1007/s12664-025-01777-5","DOIUrl":"10.1007/s12664-025-01777-5","url":null,"abstract":"<p><strong>Objectives: </strong>Metabolic sequelae of pancreatic resections, especially hepatic steatosis, has seldom been studied in detail. This study aims to examine the change in liver fat content following pancreatic resections, specifically pancreaticoduodenectomy, distal pancreatectomy and to identify potential predictors of post-pancreatectomy hepatic steatosis.</p><p><strong>Methods: </strong>This prospective observational study was conducted from December 2022 to July 2024 and included patients who underwent pancreatic resections at a single tertiary care centre in southern India. Exclusion criteria included chronic liver disease and excessive alcohol consumption. Liver fat content was assessed using non-contrast computed tomography at baseline, six months and 12 months post-surgery. Liver fat was quantified using the liver attenuation index and liver attenuation in Hounsfield Units (HU). Liver fat content was defined as normal when liver attenuation index was more than + 5, mild to moderate (6% to 30%) when + 5 to -10 HU and severe (> 30%) when less than -10 HU.</p><p><strong>Results: </strong>Total 37 patients were included in this study (males:16, females: 21). Mean age was 50.4 years. Adenocarcinoma was the major etiology (43%) followed by neuroendocrine tumors (21.6%) and cystic neoplasms of pancreas (18.9%). Pre-operatively, 89.2% of patients had normal liver fat content. By six months post-surgery, 54% of patients had increased liver fat, with 20% exhibiting severe steatosis. At 12 months, 51.3% showed elevated liver fat. The increase in liver fat content was statistically significant (p-value = 0.00007). Patients undergoing pancreaticoduodenectomy had a higher incidence of hepatic steatosis at six months compared to those undergoing distal pancreatectomy (p-value = 0.019).</p><p><strong>Conclusions: </strong>Post-pancreatectomy hepatic steatosis is common, particularly in patients undergoing pancreaticoduodenectomy. Metabolic dysfunction does not seem to be directly linked to factors such as diabetes, body mass index or chemotherapy. Further studies with larger cohorts and extended follow-up are needed to assess the long-term clinical significance of these changes, including progression to conditions such as non-alcoholic fatty liver disease.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"756-763"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastro-intestinal infections and stewardship practices-A call for action to practising GI professionals.","authors":"Prasan Kumar Panda, Ujjala Ghosal, Rohit Gupta","doi":"10.1007/s12664-026-01991-9","DOIUrl":"10.1007/s12664-026-01991-9","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"634-636"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-reflux mucosal ablation: A good method for proton pump inhibitor dependent gastroesophageal reflux disease.","authors":"Jing-Yu Zhu, Yi-Heng Yao, Ming Qi, Liang Liu","doi":"10.1007/s12664-025-01867-4","DOIUrl":"10.1007/s12664-025-01867-4","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"788-789"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of dermatological manifestations in patients with chronic hepatitis C infections.","authors":"Sayan Malakar, Saurabh Mishra, Sumit Rungta, Arvind Kumar, Amar Deep","doi":"10.1007/s12664-025-01843-y","DOIUrl":"10.1007/s12664-025-01843-y","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"775-777"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-hepatoblastoma pediatric liver tumors: Unravelling of a lesser-known entity.","authors":"Srinivas Srinidhi Vadlapudi, Ujjal Poddar","doi":"10.1007/s12664-025-01903-3","DOIUrl":"10.1007/s12664-025-01903-3","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"627-631"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ways to improve the negative impact of proton pump inhibitors on biopsy-based test accuracy for Helicobacter pylori detection.","authors":"Peter Malfertheiner, Christian Schulz","doi":"10.1007/s12664-025-01841-0","DOIUrl":"10.1007/s12664-025-01841-0","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"632-633"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13272270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of a conservative approach in the management of groove pancreatitis.","authors":"Ajith Thomas, Anand Vimal Dev, Anoop John, Reetu Amrita John, Lalji Patel, Reuben Thomas Kurien, Anu Eapen, Ebby George Simon, Amit Kumar Dutta, Rajeeb Jaleel, Anjilivelil Joseph Joseph, Sudipta Dhar Chowdhury","doi":"10.1007/s12664-024-01715-x","DOIUrl":"10.1007/s12664-024-01715-x","url":null,"abstract":"<p><strong>Background: </strong>Groove pancreatitis (GP) is a form of pancreatitis that affects the pancreaticoduodenal groove area, which lies between the head of the pancreas, the second part of the duodenum and the distal bile duct, presenting as abdominal pain and gastric outlet obstruction. In this study, we present the clinical and radiological characteristics of individuals diagnosed with groove pancreatitis at our center and discuss the use of a conservative treatment approach in managing GP.</p><p><strong>Methods: </strong>The data of patients with groove pancreatitis treated at our center between January 2012 and December 2021 was analyzed. The clinical, laboratory and radiological features were recorded and patients were followed up for at least six months in the pancreatic clinic by a specialist doctor.</p><p><strong>Results: </strong>Fifty patients were included in the study. Most patients were males (98%) in the middle age group (35 to 55 years) (70%) with chronic alcohol use and/or smoking noted in 48 (96%) of them. Ninety-six per cent presented with recurrent abdominal pain. The most common imaging features were the thickening of the medial duodenal wall (100%) followed by enhancement of the scar tissue in the groove (98%). All patients were initially treated conservatively with advice to abstain from addictions, of whom 35 patients were followed up. Twenty per cent of the patients (seven out of 35) did not respond and required a step-up approach with endoscopic retrograde cholangiopancreatography (for biliary obstruction), celiac block (for ongoing abdominal pain) and surgery (gastrojejunostomy for gastric outlet obstruction, Frey's procedure for abdominal pain). Most patients were asymptomatic at follow-up (mean follow-up of 30 months).</p><p><strong>Conclusion: </strong>The diagnosis of GP continues to be a challenge. A step-up approach appears to be a reasonable strategy in managing GP as most of them can be managed conservatively.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"715-722"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emphysematous spleen due to gastrosplenic fistula: A rare complication of celiac artery thrombosis.","authors":"Saurabh Deshpande, Pratyaksha Rana, Megha M Sheth, Dinesh Patel","doi":"10.1007/s12664-024-01607-0","DOIUrl":"10.1007/s12664-024-01607-0","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"794-795"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical profile and manometry characteristics of patients with motor dysphagia.","authors":"Mayank Jain","doi":"10.1007/s12664-025-01810-7","DOIUrl":"10.1007/s12664-025-01810-7","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"770-771"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}