Indian Journal of Gastroenterology最新文献

{"title":"Intestinal fatty acid-binding protein in celiac disease: Finding its place in diagnosis and monitoring.","authors":"Rishi Bolia","doi":"10.1007/s12664-025-01837-w","DOIUrl":"https://doi.org/10.1007/s12664-025-01837-w","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse filiform polyposis in a patient with ulcerative colitis.","authors":"Arshia Bhardwaj, Arshdeep Singh, Aminder Singh, Ajit Sood","doi":"10.1007/s12664-025-01829-w","DOIUrl":"https://doi.org/10.1007/s12664-025-01829-w","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of endoscopic findings, histopathological features and Helicobacter pylori infection in adult dyspeptic patients from the cold desert tribal region of Spiti Valley, Himachal Pradesh.","authors":"Neetu Sharma, Vishal Bodh, Dinesh Kumar, Brij Sharma, Anchana Gulati, Rajesh Sharma, Ashish Chauhan, Amit Sachdeva, Keshu Jindal, Tenzin Norbu, Sidhant Sharma","doi":"10.1007/s12664-025-01816-1","DOIUrl":"https://doi.org/10.1007/s12664-025-01816-1","url":null,"abstract":"<p><strong>Introduction: </strong>Globally, 20% of the populations have dyspeptic symptoms with an extensive differential diagnosis. Endoscopy is a gold standard investigation for finding the etiology of dyspepsia but can miss mucosal lesions in 15% to 30% of cases. The study aims to determine the endoscopic findings, histopathological features and H. pylori infection in adult dyspeptic patients from the tribal area of Himachal Pradesh (H.P.), India.</p><p><strong>Methods: </strong>This cross-sectional observational study retrospectively analyzed the data collected during a health camp in the remote Spiti Valley of H.P. Patients aged 18 years and above were included and data of 106 dyspepsia patients who underwent endoscopic examination was analyzed. Endoscopic gastric biopsies taken in each patient were subjected to rapid urease testing (RUT) and histopathological examination. Data analyzed included basic socio-demographic features, endoscopic and histopathological features.</p><p><strong>Results: </strong>Total 106 patients of dyspepsia were included with a mean age of 46.9 ± 13.4 years and a male to female ratio of 1.4:1. The most common endoscopic abnormality was erosive gastritis followed by peptic ulcer disease. The most common histopathological finding was chronic active gastritis with H. pylori (83.0%). Gastric intestinal metaplasia (GIM) was seen in 48.1%. While endoscopy demonstrated high sensitivity (76.5%), specificity (75.0%) and positive predictive value (PPV, 98.7%) for identifying histopathological abnormalities in gastric biopsy, its negative predictive value (NPV, 11.1%) remained low. The correlation between RUT and histopathological examination for H. pylori was statistically significant.</p><p><strong>Conclusion: </strong>Erosive gastritis and peptic ulcer disease are prevalent endoscopic findings among adult dyspeptic patients from the tribal region of Spiti Valley in Himachal Pradesh. Histopathologically, H. pylori-related chronic active gastritis and gastric intestinal metaplasia are commonly observed abnormalities. Although endoscopy exhibits high sensitivity, specificity and PPV for detecting histopathological changes in gastric biopsies, its NPV is notably low.</p><p><strong>Clinical trial registry number: </strong>NA.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of infected pancreatic necrosis: A review of the role of blood biomarkers.","authors":"Niharika Dutta, Pankaj Gupta, Amit Rawat, Saroj K Sinha","doi":"10.1007/s12664-025-01820-5","DOIUrl":"https://doi.org/10.1007/s12664-025-01820-5","url":null,"abstract":"<p><p>Infected pancreatic necrosis (IPN) is a serious and critical complication of acute pancreatitis (AP), often arising in the later stages of the disease. Early detection of high-risk individuals with IPN is essential because it may enable clinicians to implement more efficient management strategies. This review explores the key biomarkers currently used to predict and diagnose IPN. Established markers such as procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) play a vital role in detecting infection and inflammation. Non-invasive markers, including corticosteroid-binding globulin (CBG), neutrophil CD64 index (nCD64), soluble PD-L1 (sPD-L1) and human leukocytes antigen-DR (HLA-DR), further contribute to identifying immune suppression and infection risks. While these tools show promise, no single biomarker has proven to be sufficiently accurate. A combination of clinical assessment, imaging and multiple biomarkers is essential for a comprehensive diagnosis. This review emphasizes the need for further research to refine and validate these markers, making them more accessible and reliable for routine clinical use. By advancing our ability to identify IPN early, we can improve patient outcomes and reduce the severe impacts of this complication in individuals suffering from AP.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overlap of 'disorders of gut-brain interaction': A type of diseases that require special attention.","authors":"Yi-Heng Yao, Guo-Lei Shi, Ming Qi, Liang Liu","doi":"10.1007/s12664-025-01840-1","DOIUrl":"https://doi.org/10.1007/s12664-025-01840-1","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exocrine pancreatic insufficiency and pancreatic enzyme supplementation after gastric resection-A scoping review.","authors":"Suprabhat Giri, Prasanna Gore, Gaurav Khatana, Sridhar Sundaram, Vaishali Bhardwaj","doi":"10.1007/s12664-025-01806-3","DOIUrl":"https://doi.org/10.1007/s12664-025-01806-3","url":null,"abstract":"<p><p>Exocrine pancreatic insufficiency (EPI) frequently occurs following gastric resection, although it remains underdiagnosed and insufficiently managed. While pancreatic enzyme supplementation (PES) is the cornerstone of the management of EPI, substantial evidence endorsing its application post-gastric surgery is scarce. This scoping review assesses the occurrence of EPI following gastric resection and the influence of PES in managing these patient populations. All relevant studies related to EPI and PES in patients with gastric resection were reviewed until November 2024. Patient demographics, clinical profiles, method of assessment and prevalence of EPI and the effect of PES were analyzed. Total 14 studies reported EPI after gastric resection and three analyzed the outcome of PES after gastric resection. There was considerable variability in the methodologies employed to evaluate EPI following gastric resection. Earlier studies employed direct tests; however, newer studies have utilized indirect tests, predominantly the fecal elastase test. Both studies employing direct tests indicated an EPI prevalence rate of 100%, whereas those utilizing indirect tests revealed a prevalence rate between 26.8% and 100% (26.8% to 63.8% with fecal elastase). Only four studies reported on the severity of EPI following stomach resection, with significant variability. Lastly, there was a lack of high-quality evidence indicating the benefits of PES following gastric resection. Future studies are needed to develop criteria that facilitate the diagnosis of EPI in individuals who have undergone gastrectomy. Robust clinical trials are necessary to provide definitive proof of PES's efficacy in enhancing patient outcomes.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of fecal calprotectin to differentiate between treatment-naive intestinal tuberculosis and Crohn's disease: A pilot study.","authors":"Sayan Malakar, Uday C Ghoshal, Umair Samshul Hoda, Srikant Kothalkar, Vishwas Kapoor, Gourav Jyoti Borah, Piyush Mishra","doi":"10.1007/s12664-025-01812-5","DOIUrl":"https://doi.org/10.1007/s12664-025-01812-5","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal stromal tumors: Clinicopathological features and outcome-Real-world experience.","authors":"Suriya Nedunchezhian, Vikas Pemmada, Divija Sharma, Athish Shetty, Shiran Shetty, Balaji Musunuri, Jegan Mohan S, Ganesh Bhat","doi":"10.1007/s12664-025-01800-9","DOIUrl":"https://doi.org/10.1007/s12664-025-01800-9","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal stromal tumors (GISTs) are rare neoplasms with diverse clinical profiles and treatment outcomes. This study aims to evaluate the clinical characteristics, treatment modalities and survival outcomes of patients with GISTs treated at a tertiary care hospital in India.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 51 patients with GISTs. Data collected included tumor location, gender, presenting complaints, staging, pathological data, National Institutes of Health (NIH) risk category, treatment offered and outcome. Statistical analyses were performed using SPSS Statistics version 23. Descriptive statistics were used to summarize data and significance was determined with p-values < 0.05.</p><p><strong>Results: </strong>Total 51 patients of GIST were included in this study. Mean age of presentation was 54.38 ± 13.2 and 61% (31/51) patients were male. In this study, most common site of involvement was the small bowel (25/51), followed by stomach (24/51). Most common presenting feature was  pain in abdomen (59% 30/51), followed by gastrointestinal bleed. At diagnosis, localized disease was present in a majority of patients and metastasis was present in only 10% (5/51) of cases. Among non-metastatic disease, spindle cell morphology was predominant (71.7%) and in metastatic disease; mixed cell morphology was more common (60%). Mitotic activity (0.034) and CD34 positivity (p = 0.046) were significantly associated with metastasis. According to NIH risk classification, 33% were low risk, 27% intermediate risk and 39% high risk. Imatinib was given to 75% of patients, while 25% received no drug therapy.</p><p><strong>Conclusion: </strong>GISTs predominantly affect proximal bowel and metastatic disease is very uncommon. Surgical resection with adjuvant tyrosine kinase inhibitor in selected patient is the main treatment with good survival rate. CD34 positivity and mitotic activity was significantly associated with metastasis, indicating its potential as a marker for predicting metastatic spread.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic median arcuate ligament release: Outcomes of 59 cases.","authors":"Fahri Yetişir, Oguzhan Özdemir, Ömer Kurt, Ramazan Tiken, Osman Yüksel","doi":"10.1007/s12664-025-01825-0","DOIUrl":"https://doi.org/10.1007/s12664-025-01825-0","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ultrasound-guided portal venous thrombolysis: A promising avenue.","authors":"Venkatesh Vaithiyam, Lalit Chandra Kummetha, Ravi Teja Reddy, Ujjwal Sonika, Ashok Dalal, Ajay Kumar, Sanjeev Sachdeva, Siddharth Srivastava","doi":"10.1007/s12664-025-01807-2","DOIUrl":"https://doi.org/10.1007/s12664-025-01807-2","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}