Indian Journal of Gastroenterology最新文献

{"title":"Utility of spleen volume to body mass index ratio in Crohn's disease-A retrospective cohort study.","authors":"Mohammed Bilal Azam, Kuppusamy Senthamizhselvan, Pazhanivel Mohan, G Ramkumar","doi":"10.1007/s12664-024-01704-0","DOIUrl":"10.1007/s12664-024-01704-0","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"102-104"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk score for malignancy in patients with suspicious gallbladder lesions: Retrospective analysis of 175 cases.","authors":"Dhiraj John Sonbare, Betty Simon, Anu Eapen, Thenmozhi Mani, Thambu David, Philip Joseph","doi":"10.1007/s12664-024-01567-5","DOIUrl":"10.1007/s12664-024-01567-5","url":null,"abstract":"<p><strong>Background: </strong>Among cancers, carcinoma gallbladder has one of the most dismal prognosis. Early lesions are difficult to biopsy because of proximity to luminal structures and risk of biliary peritonitis. However, early surgery offers the only chance of a complete cure. Utilizing a risk score would allow characterization of the risk of malignancy and early referral to an oncology centre thereby resulting in better outcomes for patients with carcinoma gallbladder.</p><p><strong>Methods: </strong>The aim of this study was to develop a risk score for carcinoma in patients with suspicious gallbladder lesions based on clinical presentation and imaging. All patients with suspicious gallbladder lesions on radiological imaging who underwent surgery were analyzed. Patients were considered for scoring if the ultrasound showed the gallbladder wall thickening (more than 4 mm) and computed tomography scan showed operable disease. Statistical analysis was done to derive a score for malignancy.</p><p><strong>Results: </strong>Total 175 patients underwent an operation for suspicious gallbladder lesions from January 2005 to December 2014. The factors analyzed were clinical biochemical and imaging findings. Of these, 71 were benign on the final histopathology and 104 were malignant. The score was constructed with the following variables: female sex, high total bilirubin (≥ 1 mg/dL), presence of a mass, focal location of the lesion, presence of gallbladder stones and nodal involvement in the hepatoduodenal region on imaging. A model score and modified score were obtained. In this modified score, score of more than 8 out of 20 predicted malignancy with a sensitivity of 78% and specificity of 70.4%. Receiver operating characteristic (ROC) curve constructed with these variables had an area under curve of 0.828. There was no statistically significant difference between the model score and the modified score.</p><p><strong>Conclusions: </strong>A pre-operative risk score was obtained for carcinoma gallbladder, which needs to be validated prospectively in future.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"75-82"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very long-chain acyl-coenzyme A dehydrogenase deficiency -A rare monogenic steatotic liver disease presenting with acute liver injury in adulthood: A case report and brief review on nutrition management.","authors":"Leenath Thomas, Kausala Sithamparapillai, Thomas Alex Kodiatte, Felix Jebasingh, Sumita Danda, Santhosh E Kumar, Ashish Goel","doi":"10.1007/s12664-025-01739-x","DOIUrl":"10.1007/s12664-025-01739-x","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"108-111"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal fatty acid-binding protein in celiac disease: Finding its place in diagnosis and monitoring.","authors":"Rishi Bolia","doi":"10.1007/s12664-025-01837-w","DOIUrl":"10.1007/s12664-025-01837-w","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"3-4"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Overlap of 'disorders of gut-brain interaction' and their impact on quality of life and somatization in a tertiary care center\".","authors":"Yu Yan, Tingting Ji, Jingyu Zhu, Xingjie Shen","doi":"10.1007/s12664-025-01844-x","DOIUrl":"10.1007/s12664-025-01844-x","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"123-124"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of gastrointestinal PCR in inflammatory bowel disease flares: A double-edged sword or a diagnostic breakthrough?","authors":"Manjeet Kumar Goyal, Elliot Berinstein, Priyata Dutta, Vineet Ahuja, Peter D R Higgins, Jeffrey Berinstein, Shrinivas Bishu","doi":"10.1007/s12664-025-01811-6","DOIUrl":"10.1007/s12664-025-01811-6","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is characterized by chronic gastrointestinal inflammation, leading to unpredictable flares and substantial morbidity. Gastrointestinal polymerase chain reaction (GI-PCR) testing has emerged as a widely used diagnostic tool to identify enteric pathogens during IBD exacerbations. It is a novel, quick and sensitive diagnostic test to detect Clostridioides difficile infection (CDI), as well as other enteric pathogens. However, the clinical significance of non-C. difficile pathogens detected by GI-PCR remains uncertain, raising concerns about the over-interpretation of positive results and the potential for unnecessary antimicrobial therapy. While traditional stool culture and microscopy offered limited sensitivity, GI-PCR has dramatically improved pathogen detection rates, identifying infections in up to 26% of IBD patients compared to 5% with conventional methods. Beyond C. difficile, pathogens such as Escherichia coli (especially adherent-invasive strains), Campylobacter, Salmonella, Norovirus and Yersinia enterocolitica are frequently detected in IBD flares. However, whether these microbes actively drive disease exacerbations or merely reflect inflammation-associated dysbiosis remains unclear. Enterobacteriaceae, in particular, bloom in inflamed intestines, raising critical questions regarding their pathogenic role vs. colonization. The high sensitivity of GI-PCR further complicates clinical decision-making, as distinguishing active infection from harmless microbial presence is challenging. This review explores the current literature on GI-PCR in IBD, emphasizing its benefits and limitations. While GI-PCR provides rapid, comprehensive pathogen detection, its indiscriminate application may lead to unnecessary antibiotic use and therapeutic missteps. Understanding the ecological shifts in IBD-associated dysbiosis and refining clinical interpretation of GI-PCR results are essential to optimizing patient management. Future research should aim to delineate the pathogenic significance of non-C. difficile microbes and establish evidence-based protocols for the appropriate use of GI-PCR in IBD care.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"5-14"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colonic dilatation mimicking Ogilvie syndrome in acute pancreatitis.","authors":"Brij Sharma, Vishal Bodh, Rajesh Sharma, Anshul Bhateja","doi":"10.1007/s12664-023-01470-5","DOIUrl":"10.1007/s12664-023-01470-5","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"127-128"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71481089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical applications of hyperspectral imaging in gastroenterology and hepatology: A systematic review.","authors":"Qilang Xiang, Yanting Ao, Qian Jia, Muhan Lü","doi":"10.1007/s12664-025-01836-x","DOIUrl":"10.1007/s12664-025-01836-x","url":null,"abstract":"<p><strong>Background: </strong>Hyperspectral imaging (HSI), a high-throughput, three-dimensional technology initially developed for remote sensing, has recently garnered increasing interest in applications in gastroenterology and hepatology. We focus on the aspects of HSI clinical research in gastroenterology and hepatology from a more clinically oriented perspective, discussing its prospective trajectories in this field and delving into the current challenges encountered with HSI.</p><p><strong>Methods: </strong>A comprehensive systematic search was carried out in PubMed, Embase and Web of Science, encompassing studies published up to June 30, 2024. Following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 guidelines, a systematic review was then conducted to evaluate the identified studies. Two independent reviewers screened the retrieved articles based on pre-defined inclusion and exclusion criteria, followed by an independent data extraction process to ensure accuracy and reliability.</p><p><strong>Results: </strong>Total 63 studies met the inclusion criteria. Among the 63 included studies, HSI demonstrated significant potential in cancer diagnosis (65.1%), intra-operative monitoring (33.3%) and H. pylori detection (1.6%), with most studies integrating artificial intelligence (AI) for enhanced data analysis. Most studies integrated HSI with AI, enabling efficient analysis and processing of complex hyperspectral data. Additionally, advancements in medical devices, including hyperspectral endoscopes and hyperspectral microscopes, have enhanced the practicality and clinical utility of HSI in gastroenterology and hepatology.</p><p><strong>Discussion: </strong>HSI shows promising performance and significant potential in gastroenterology and hepatology by enhancing the detection of gastrointestinal cancers, improving intra-operative decision-making through real-time tissue characterization, and facilitating tissue assessment during surgery. HSI offers non-invasive, real-time tissue analysis, but its clinical adoption is hindered by high costs, technical complexity and lack of standardized protocols.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"40-59"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: \"Overlap of 'disorders of gut-brain interaction': A type of diseases that require special attention\" and \"Comment on \"Overlap of 'disorders of gut-brain interaction' and their impact on quality of life and somatization in a tertiary care center\".","authors":"Manjeet Kumar Goyal, Prerna Goyal, Omesh Goyal, Ajit Sood","doi":"10.1007/s12664-025-01857-6","DOIUrl":"10.1007/s12664-025-01857-6","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"125-126"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transjugular intra-hepatic approach for portal vein stenting in post-inflammatory portal vein stenosis.","authors":"Kymentie Ferdinande, Stefano Groff, Alberto Zanetto, Francesco Labella, Michele Battistel, Giulio Barbiero, Marco Senzolo","doi":"10.1007/s12664-025-01873-6","DOIUrl":"10.1007/s12664-025-01873-6","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"116-118"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}