Inflammation-related polymorphisms IFNG-AS1 rs1558744 and CCAT2 rs6983267: Potential risk factors for ulcerative colitis.

IF 2 Q3 GASTROENTEROLOGY & HEPATOLOGY

Indian Journal of Gastroenterology Pub Date : 2025-06-18 DOI:10.1007/s12664-025-01801-8

Dilek Sari-Tiric, Seda Orenay-Boyacioglu, Elmas Kasap

{"title":"Inflammation-related polymorphisms IFNG-AS1 rs1558744 and CCAT2 rs6983267: Potential risk factors for ulcerative colitis.","authors":"Dilek Sari-Tiric, Seda Orenay-Boyacioglu, Elmas Kasap","doi":"10.1007/s12664-025-01801-8","DOIUrl":null,"url":null,"abstract":"Background: Recent research indicates that long non-coding RNAs (lncRNAs) may have a regulatory role in inflammatory processes, potentially influencing the development of inflammatory bowel diseases such as ulcerative colitis (UC). However, the relationship between UC and lncRNAs remains unclear, highlighting the need for further research in this area.Aim: This study aimed to define the possible roles of inflammation-related lncRNA polymorphisms in the pathogenesis of UC.Method: The study included adult patients over 18 years of age diagnosed with UC (n = 73) and a control group consisting of age-matched healthy individuals without any gastrointestinal complaints (n = 73). The inflammation-related ANRIL (rs10757278, rs1333048), IFNG-AS1 (rs1558744, rs7134599), LINC01430 (rs6017342), LOC101926945 (rs561722) and CCAT2 (rs6983267) polymorphisms were examined using the Fluidigm SNP Type method.Results: Of UC patients, 34.25% (n = 25) had proctitis, 28.77% (n = 21) had distal colon involvement and 36.98% (n = 27) had total colon involvement. Also, of the UC patients, 45.20% (n = 33) had suffered for 0-5 years, 41.10% (n = 30) for 5-10 years and 13.70% (n = 10) for 10-16 years. According to the pathology results of the most recent colonoscopy performed on UC patients, the disease was active in 60.27% (n = 44) and in remission in 39.73% (n = 29). The genotype distributions of the IFNG-AS1 rs1558744 and CCAT2 rs6983267 polymorphisms between the two groups revealed statistically significant results (p = 0.042 and p = 0.033, respectively). Allele frequency distributions of the IFNG-AS1 rs1558744 polymorphism between the UC and control groups were also statistically significant (p = 0.040). No statistically significant differences were observed when the examined polymorphisms were analyzed in relation to the location of involvement, disease activity state or disease duration in UC patients (p > 0.05).Conclusion: IFNG-AS1 rs1558744 and CCAT2 rs6983267 polymorphisms may be significant risk factors for the development of UC.","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Gastroenterology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12664-025-01801-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Recent research indicates that long non-coding RNAs (lncRNAs) may have a regulatory role in inflammatory processes, potentially influencing the development of inflammatory bowel diseases such as ulcerative colitis (UC). However, the relationship between UC and lncRNAs remains unclear, highlighting the need for further research in this area.

Aim: This study aimed to define the possible roles of inflammation-related lncRNA polymorphisms in the pathogenesis of UC.

Method: The study included adult patients over 18 years of age diagnosed with UC (n = 73) and a control group consisting of age-matched healthy individuals without any gastrointestinal complaints (n = 73). The inflammation-related ANRIL (rs10757278, rs1333048), IFNG-AS1 (rs1558744, rs7134599), LINC01430 (rs6017342), LOC101926945 (rs561722) and CCAT2 (rs6983267) polymorphisms were examined using the Fluidigm SNP Type method.

Results: Of UC patients, 34.25% (n = 25) had proctitis, 28.77% (n = 21) had distal colon involvement and 36.98% (n = 27) had total colon involvement. Also, of the UC patients, 45.20% (n = 33) had suffered for 0-5 years, 41.10% (n = 30) for 5-10 years and 13.70% (n = 10) for 10-16 years. According to the pathology results of the most recent colonoscopy performed on UC patients, the disease was active in 60.27% (n = 44) and in remission in 39.73% (n = 29). The genotype distributions of the IFNG-AS1 rs1558744 and CCAT2 rs6983267 polymorphisms between the two groups revealed statistically significant results (p = 0.042 and p = 0.033, respectively). Allele frequency distributions of the IFNG-AS1 rs1558744 polymorphism between the UC and control groups were also statistically significant (p = 0.040). No statistically significant differences were observed when the examined polymorphisms were analyzed in relation to the location of involvement, disease activity state or disease duration in UC patients (p > 0.05).

Conclusion: IFNG-AS1 rs1558744 and CCAT2 rs6983267 polymorphisms may be significant risk factors for the development of UC.

查看原文本刊更多论文

炎症相关多态性IFNG-AS1 rs1558744和CCAT2 rs6983267：溃疡性结肠炎的潜在危险因素

背景：最近的研究表明，长链非编码rna （lncRNAs）可能在炎症过程中具有调节作用，可能影响溃疡性结肠炎（UC）等炎症性肠病的发展。然而，UC与lncrna之间的关系尚不清楚，这表明该领域需要进一步研究。目的：本研究旨在确定炎症相关lncRNA多态性在UC发病机制中的可能作用。方法：该研究包括18岁以上诊断为UC的成年患者（n = 73）和由年龄匹配且无任何胃肠道疾病的健康个体组成的对照组（n = 73）。采用Fluidigm SNP Type方法检测与炎症相关的ANRIL （rs10757278, rs1333048）、IFNG-AS1 （rs1558744, rs7134599）、LINC01430 （rs6017342）、LOC101926945 （rss561722）和CCAT2 （rs6983267）多态性。结果：UC患者中，34.25% （n = 25）有直肠炎，28.77% （n = 21）有远端结肠受累，36.98% （n = 27）有全结肠受累。在UC患者中，45.20% （n = 33）为0-5年，41.10% （n = 30）为5-10年，13.70% （n = 10）为10-16年。根据UC患者最近一次结肠镜检查的病理结果，60.27% （n = 44）的患者病情活跃，39.73% （n = 29）的患者病情缓解。两组间IFNG-AS1 rs1558744和CCAT2 rs6983267多态性的基因型分布差异有统计学意义（p = 0.042和p = 0.033）。UC组与对照组之间IFNG-AS1 rs1558744多态性的等位基因频率分布也有统计学意义（p = 0.040）。当分析检测的多态性与UC患者的受损伤部位、疾病活动状态或疾病持续时间的关系时，无统计学意义差异（p < 0.05）。结论：IFNG-AS1 rs1558744和CCAT2 rs6983267多态性可能是UC发生的重要危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Indian Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

3.90

自引率

10.00%

发文量

期刊介绍： The Indian Journal of Gastroenterology aims to help doctors everywhere practise better medicine and to influence the debate on gastroenterology. To achieve these aims, we publish original scientific studies, state-of -the-art special articles, reports and papers commenting on the clinical, scientific and public health factors affecting aspects of gastroenterology. We shall be delighted to receive articles for publication in all of these categories and letters commenting on the contents of the Journal or on issues of interest to our readers.